Glud1 (glutamate dehydrogenase 1) - Rat Genome Database

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Gene: Glud1 (glutamate dehydrogenase 1) Rattus norvegicus
Analyze
Symbol: Glud1
Name: glutamate dehydrogenase 1
RGD ID: 2708
Description: Enables enzyme binding activity and glutamate dehydrogenase (NAD+) activity. Involved in cerebellum development; long-term memory; and response to aluminum ion. Predicted to be located in endoplasmic reticulum and mitochondrial matrix. Predicted to be active in mitochondrion. Biomarker of brain ischemia; childhood absence epilepsy; fascioliasis; hepatic encephalopathy; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-pilocarpine; 1,1,2-trichloroethane; 1,2-dichlorobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac2-281; GDH 1; Gdh1; Glud; Gludeha; glutamate dehydrogenase; glutamate dehydrogenase 1, mitochondrial; memory related gene 2; memory-related gene 2; memory-related protein 2; MGC93608; MRG-2; RNGLUDEHA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   BpQTLcluster13  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,646,569 - 9,680,215 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl169,646,509 - 9,680,210 (+)EnsemblGRCr8
mRatBN7.2169,640,312 - 9,673,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,640,312 - 9,673,957 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx169,661,045 - 9,694,118 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,805,759 - 10,838,834 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,656,127 - 9,689,198 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,661,486 - 10,695,557 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,662,021 - 10,695,557 (+)Ensemblrn6Rnor6.0
Rnor_5.0168,980,352 - 9,014,005 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4169,965,718 - 9,999,254 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera165,542,860 - 5,576,454 (-)NCBICelera
RGSC_v3.1169,965,715 - 9,999,248 (+)NCBI
Cytogenetic Map16p15NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(aminooxy)acetic acid  (ISO)
1,1,2-trichloroethane  (EXP)
1,2-dichlorobenzene  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2-hydroxyglutaric acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butan-2-one  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
casticin  (ISO)
ceruletide  (EXP)
citric acid  (ISO)
clofibrate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclohexanone  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
dipicolinic acid  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
elemental selenium  (EXP)
enalaprilat dihydrate  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
flucloxacillin  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
ginsenoside Rg1  (EXP)
glafenine  (EXP)
glucose  (EXP)
hexadecanoic acid  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lithium chloride  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
Methyl isobutyl ketone  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-acetyl-L-methionine  (EXP)
N-nitrosomorpholine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
Propiverine  (EXP)
propofol  (ISO)
quercetin  (ISO)
Repaglinide  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (ISO)
selenium atom  (EXP)
sevoflurane  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
styrene  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
endoplasmic reticulum  (IEA,ISO,ISS)
mitochondrial matrix  (ISO)
mitochondrion  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Nucleotide sequence of rat liver glutamate dehydrogenase cDNA. Amuro N, etal., Nucleic Acids Res 1989 Mar 25;17(6):2356.
2. Glutamate metabolizing enzymes in prefrontal cortex of Alzheimer's disease patients. Burbaeva GSh, etal., Neurochem Res. 2005 Nov;30(11):1443-51.
3. Late memory-related genes in the hippocampus revealed by RNA fingerprinting. Cavallaro S, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9669-73.
4. Identification and analysis of a matrix-attachment region 5' of the rat glutamate-dehydrogenase-encoding gene. Das AT, etal., Eur J Biochem 1993 Aug 1;215(3):777-85.
5. Isolation and characterization of the rat gene encoding glutamate dehydrogenase. Das AT, etal., Eur J Biochem 1993 Feb 1;211(3):795-803.
6. Nucleotide sequence of rat liver glutamate dehydrogenase cDNA. Das AT, etal., Nucleic Acids Res 1989 Mar 25;17(6):2355.
7. Specific alteration in the expression of glial fibrillary acidic protein, glutamate dehydrogenase, and glutamine synthetase in rats with genetic absence epilepsy. Dutuit M, etal., Glia. 2000 Oct;32(1):15-24.
8. Altered activities of rat brain metabolic enzymes in electroconvulsive shock-induced seizures. Erakovic V, etal., Epilepsia. 2001 Feb;42(2):181-9.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy. Hammer J, etal., Glia. 2008 Jun;56(8):856-68.
12. Glutamate metabolism is down-regulated in astrocytes during experimental allergic encephalomyelitis. Hardin-Pouzet H, etal., Glia. 1997 May;20(1):79-85.
13. Accumulation of ammonia and changes in the activity of some ammonia metabolizing enzymes during brain ischemia/reperfusion injury in rats. Holownia A, etal., Mater Med Pol. 1994 Jan-Mar;26(1):25-7.
14. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
15. Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain. Korolainen MA, etal., Neurobiol Aging. 2006 Jan;27(1):42-53. Epub 2005 Jan 23.
16. Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. Li C, etal., J Biol Chem. 2010 Oct 8;285(41):31806-18. Epub 2010 Jul 29.
17. Histochemical study of glutamic dehydrogenase (GLD) and GABA-transaminase (GABA-T) activities in the rat cerebellum during postnatal development. Martinez-Rodriguez R, etal., Cell Mol Biol. 1982;28(6):513-20.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Novel missense mutations in the glutamate dehydrogenase gene in the congenital hyperinsulinism-hyperammonemia syndrome. Miki Y, etal., J Pediatr. 2000 Jan;136(1):69-72.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Subclass profile of specific IgG antibodies in rats challenged during acute and chronic primary infection with Fasciola hepatica. Paz A, etal., Parasitol Res. 1999 Aug;85(8-9):770-5.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. pH-responsive stabilization of glutamate dehydrogenase mRNA in LLC-PK1-F+ cells. Schroeder JM, etal., Am J Physiol Renal Physiol. 2003 Aug;285(2):F258-65. Epub 2003 Apr 8.
29. Identification of the CoA-modified forms of mitochondrial acetyl-CoA acetyltransferase and of glutamate dehydrogenase as nearest-neighbour proteins. Schwerdt G, etal., Biochem J. 1991 Dec 1;280 ( Pt 2):353-7.
30. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. Stanley CA, etal., N Engl J Med 1998 May 7;338(19):1352-7.
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Mental retardation and hypotonia seen in the knock out mouse for Canavan disease is not due to succinate semialdehyde dehydrogenase deficiency. Surendran S, etal., Neurosci Lett. 2004 Mar 18;358(1):29-32.
33. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Changes in glutamate-cycle enzyme mRNA levels in a rat model of hepatic encephalopathy. Thomas JW, etal., Metab Brain Dis. 1988 Jun;3(2):81-90.
35. Effects of aluminum on activity of krebs cycle enzymes and glutamate dehydrogenase in rat brain homogenate. Zatta P, etal., Eur J Biochem. 2000 May;267(10):3049-55.
36. A mechanism of sulfite neurotoxicity: direct inhibition of glutamate dehydrogenase. Zhang X, etal., J Biol Chem. 2004 Oct 8;279(41):43035-45. Epub 2004 Jul 23.
Additional References at PubMed
PMID:6121377   PMID:11032875   PMID:11502802   PMID:11792727   PMID:11903050   PMID:12193607   PMID:12742085   PMID:12865426   PMID:14651853   PMID:14760703   PMID:15489334   PMID:15578726  
PMID:16959573   PMID:17923681   PMID:18614015   PMID:18688271   PMID:19858196   PMID:20332361   PMID:22926577   PMID:23281078   PMID:23663782   PMID:24319738   PMID:24625528   PMID:26767982  
PMID:29784783   PMID:32357304   PMID:35904584  


Genomics

Comparative Map Data
Glud1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,646,569 - 9,680,215 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl169,646,509 - 9,680,210 (+)EnsemblGRCr8
mRatBN7.2169,640,312 - 9,673,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,640,312 - 9,673,957 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx169,661,045 - 9,694,118 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,805,759 - 10,838,834 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,656,127 - 9,689,198 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,661,486 - 10,695,557 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,662,021 - 10,695,557 (+)Ensemblrn6Rnor6.0
Rnor_5.0168,980,352 - 9,014,005 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4169,965,718 - 9,999,254 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera165,542,860 - 5,576,454 (-)NCBICelera
RGSC_v3.1169,965,715 - 9,999,248 (+)NCBI
Cytogenetic Map16p15NCBI
GLUD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381087,050,202 - 87,094,843 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1087,050,202 - 87,095,049 (-)Ensemblhg38GRCh38
GRCh371088,809,959 - 88,854,600 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,800,223 - 88,844,603 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341088,800,224 - 88,844,603NCBI
Celera1082,812,987 - 82,857,799 (-)NCBICelera
Cytogenetic Map10q23.2NCBI
HuRef1082,663,600 - 82,708,547 (-)NCBIHuRef
CHM1_11089,091,700 - 89,136,514 (-)NCBICHM1_1
T2T-CHM13v2.01087,933,838 - 87,978,476 (-)NCBIT2T-CHM13v2.0
Glud1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391434,032,684 - 34,066,990 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1434,032,684 - 34,067,222 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381434,310,727 - 34,345,033 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,310,727 - 34,345,265 (+)Ensemblmm10GRCm38
MGSCv371435,123,913 - 35,158,219 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361433,139,843 - 33,173,999 (+)NCBIMGSCv36mm8
Celera1430,576,519 - 30,610,613 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.8NCBI
Glud1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555105,988,965 - 6,020,995 (-)Ensembl
ChiLan1.0NW_0049555105,987,811 - 6,021,001 (-)NCBIChiLan1.0ChiLan1.0
GLUD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2899,065,241 - 99,107,679 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11099,070,556 - 99,112,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01083,498,338 - 83,540,730 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GLUD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,629,046 - 34,662,711 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,620,536 - 34,654,550 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0434,989,453 - 35,023,479 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl434,989,457 - 35,023,767 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1434,834,668 - 34,868,716 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0435,003,687 - 35,037,703 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0435,510,039 - 35,544,117 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Glud1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721343,783,257 - 43,803,587 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366015,404,887 - 5,438,683 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366015,415,857 - 5,435,964 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLUD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1487,968,850 - 88,005,520 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11487,968,850 - 88,005,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,361,081 - 95,397,604 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GLUD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,653,044 - 44,690,142 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl944,653,289 - 44,688,954 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660484,464,625 - 4,502,426 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glud1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624841133,267 - 171,324 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Glud1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11310,083,001 - 10,115,660 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Glud1
331 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:806
Count of miRNA genes:283
Interacting mature miRNAs:341
Transcripts:ENSRNOT00000013788, ENSRNOT00000074601
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16423421216278352Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16423421216278352Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421216061395Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16423433317730812Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
D16Mgh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,638,913 - 9,639,137 (+)MAPPERmRatBN7.2
Rnor_6.01610,660,513 - 10,660,736NCBIRnor6.0
Rnor_5.0168,978,954 - 8,979,177UniSTSRnor5.0
RGSC_v3.4169,964,209 - 9,964,433RGDRGSC3.4
RGSC_v3.4169,964,210 - 9,964,433UniSTSRGSC3.4
Celera165,577,625 - 5,577,848UniSTS
RGSC_v3.1169,964,207 - 9,964,431RGD
Cytogenetic Map16p16UniSTS
D16Mco9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,638,921 - 9,639,125 (+)MAPPERmRatBN7.2
Rnor_6.01610,660,521 - 10,660,724NCBIRnor6.0
Rnor_5.0168,978,962 - 8,979,165UniSTSRnor5.0
RGSC_v3.4169,964,217 - 9,964,421RGDRGSC3.4
RGSC_v3.4169,964,218 - 9,964,421UniSTSRGSC3.4
Celera165,577,637 - 5,577,840UniSTS
RGSC_v3.1169,964,215 - 9,964,419RGD
Cytogenetic Map16p16UniSTS
D16Arb11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,639,189 - 9,639,391 (+)MAPPERmRatBN7.2
Rnor_6.01610,660,789 - 10,660,990NCBIRnor6.0
Rnor_5.0168,979,230 - 8,979,431UniSTSRnor5.0
RGSC_v3.4169,964,485 - 9,964,687RGDRGSC3.4
RGSC_v3.4169,964,486 - 9,964,687UniSTSRGSC3.4
Celera165,577,371 - 5,577,572UniSTS
RGSC_v3.1169,964,483 - 9,964,685RGD
Cytogenetic Map16p16UniSTS
RH127502  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,673,547 - 9,673,747 (+)MAPPERmRatBN7.2
Rnor_6.01610,695,144 - 10,695,343NCBIRnor6.0
Rnor_5.0169,013,592 - 9,013,791UniSTSRnor5.0
RGSC_v3.4169,998,841 - 9,999,040UniSTSRGSC3.4
Celera165,543,074 - 5,543,273UniSTS
RH 3.4 Map1694.9UniSTS
Cytogenetic Map16p16UniSTS
RH127664  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,673,037 - 9,673,217 (+)MAPPERmRatBN7.2
Rnor_6.01610,694,634 - 10,694,813NCBIRnor6.0
Rnor_5.0169,013,082 - 9,013,261UniSTSRnor5.0
RGSC_v3.4169,998,331 - 9,998,510UniSTSRGSC3.4
Celera165,543,604 - 5,543,783UniSTS
RH 3.4 Map1696.4UniSTS
Cytogenetic Map16p16UniSTS
RH94868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,673,648 - 9,673,819 (+)MAPPERmRatBN7.2
Rnor_6.01610,695,245 - 10,695,415NCBIRnor6.0
Rnor_5.0169,013,693 - 9,013,863UniSTSRnor5.0
RGSC_v3.4169,998,942 - 9,999,112UniSTSRGSC3.4
Celera165,543,002 - 5,543,172UniSTS
Cytogenetic Map16p16UniSTS
RH94869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,673,651 - 9,673,834 (+)MAPPERmRatBN7.2
Rnor_6.01610,695,248 - 10,695,430NCBIRnor6.0
Rnor_5.0169,013,696 - 9,013,878UniSTSRnor5.0
RGSC_v3.4169,998,945 - 9,999,127UniSTSRGSC3.4
Celera165,542,987 - 5,543,169UniSTS
Cytogenetic Map16p16UniSTS
GDB:277890  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8169,646,883 - 9,647,143 (+)Marker Load Pipeline
Celera165,575,880 - 5,576,138UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083446   ⟹   ENSRNOP00000075032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,646,513 - 9,680,210 (+)Ensembl
mRatBN7.2 Ensembl169,640,312 - 9,673,957 (+)Ensembl
Rnor_6.0 Ensembl1610,662,021 - 10,695,557 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108378   ⟹   ENSRNOP00000091891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,646,509 - 9,679,630 (+)Ensembl
mRatBN7.2 Ensembl169,640,312 - 9,673,957 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000137721   ⟹   ENSRNOP00000104584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,646,509 - 9,679,630 (+)Ensembl
RefSeq Acc Id: NM_012570   ⟹   NP_036702
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,646,569 - 9,680,215 (+)NCBI
mRatBN7.2169,640,312 - 9,673,961 (+)NCBI
Rnor_6.01610,661,911 - 10,695,557 (+)NCBI
Rnor_5.0168,980,352 - 9,014,005 (+)NCBI
RGSC_v3.4169,965,718 - 9,999,254 (+)RGD
Celera165,542,860 - 5,576,454 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036702   ⟸   NM_012570
- Peptide Label: precursor
- UniProtKB: Q66HI8 (UniProtKB/Swiss-Prot),   Q6LC16 (UniProtKB/Swiss-Prot),   P10860 (UniProtKB/Swiss-Prot),   A6KFS5 (UniProtKB/TrEMBL),   A0A8I6AGI7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075032   ⟸   ENSRNOT00000083446
Ensembl Acc Id: ENSRNOP00000091891   ⟸   ENSRNOT00000108378
Ensembl Acc Id: ENSRNOP00000104584   ⟸   ENSRNOT00000137721
Protein Domains
Glutamate/phenylalanine/leucine/valine/L-tryptophan

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10860-F1-model_v2 AlphaFold P10860 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699956
Promoter ID:EPDNEW_R10480
Type:multiple initiation site
Name:Glud1_1
Description:glutamate dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01610,662,013 - 10,662,073EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2708 AgrOrtholog
BioCyc Gene G2FUF-12064 BioCyc
BioCyc Pathway GLUDEG-I-PWY [GABA shunt] BioCyc
  GLUTAMATE-DEG1-PWY [L-glutamate degradation I] BioCyc
  GLUTAMATE-SYN2-PWY [L-glutamate biosynthesis II] BioCyc
  GLUTSYNIII-PWY [L-glutamate biosynthesis III] BioCyc
  PWY-5766 [L-glutamate degradation X] BioCyc
BioCyc Pathway Image GLUDEG-I-PWY BioCyc
  GLUTAMATE-DEG1-PWY BioCyc
  GLUTAMATE-SYN2-PWY BioCyc
  GLUTSYNIII-PWY BioCyc
  PWY-5766 BioCyc
Ensembl Genes ENSRNOG00000057367 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083446.2 UniProtKB/Swiss-Prot
  ENSRNOT00000137721 ENTREZGENE
Gene3D-CATH 1.10.287.140 UniProtKB/Swiss-Prot
  Leucine Dehydrogenase, chain A, domain 1 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107138 IMAGE-MGC_LOAD
InterPro Aminiacid_DH-like_N_sf UniProtKB/Swiss-Prot
  Glu/Leu/Phe/Val_DH UniProtKB/Swiss-Prot
  Glu/Leu/Phe/Val_DH_AS UniProtKB/Swiss-Prot
  Glu/Leu/Phe/Val_DH_C UniProtKB/Swiss-Prot
  Glu/Leu/Phe/Val_DH_dimer_dom UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  NAD_bind_Glu_DH UniProtKB/Swiss-Prot
KEGG Report rno:24399 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93608 IMAGE-MGC_LOAD
NCBI Gene 24399 ENTREZGENE
PANTHER GLUTAMATE DEHYDROGENASE UniProtKB/Swiss-Prot
  GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam ELFV_dehydrog UniProtKB/Swiss-Prot
  ELFV_dehydrog_N UniProtKB/Swiss-Prot
PhenoGen Glud1 PhenoGen
PRINTS GLFDHDRGNASE UniProtKB/Swiss-Prot
PROSITE GLFV_DEHYDROGENASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000057367 RatGTEx
SMART ELFV_dehydrog UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
  SSF53223 UniProtKB/Swiss-Prot
TIGR TC216839
UniProt A0A8I6AGI7 ENTREZGENE, UniProtKB/TrEMBL
  A6KFS4_RAT UniProtKB/TrEMBL
  A6KFS5 ENTREZGENE, UniProtKB/TrEMBL
  DHE3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HI8 ENTREZGENE
  Q6LC16 ENTREZGENE
UniProt Secondary Q66HI8 UniProtKB/Swiss-Prot
  Q6LC16 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Glud1  glutamate dehydrogenase 1    Glutamate dehydrogenase  Name updated 625702 APPROVED
2002-06-10 Glud1  Glutamate dehydrogenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript contains 13 exons and spans approximately 34 kb pairs 632876
gene_transcript promoter contains binding sites of the transcription factors Sp1 and Zif268 632876