RGD Reference Report - Changes in glutamate-cycle enzyme mRNA levels in a rat model of hepatic encephalopathy. - Rat Genome Database

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Changes in glutamate-cycle enzyme mRNA levels in a rat model of hepatic encephalopathy.

Authors: Thomas, JW  Banner, C  Whitman, J  Mullen, KD  Freese, E 
Citation: Thomas JW, etal., Metab Brain Dis. 1988 Jun;3(2):81-90.
RGD ID: 6484661
Pubmed: PMID:2903433   (View Abstract at PubMed)

To detect possible changes in the regulation of glutamate/gamma-aminobutyric acid (GABA) enzymes at the level of gene expression in a thioacetamide-induced rat model of acute hepatic encephalopathy, we have examined changes in the mRNAs of four glutamate/GABA enzymes by quantitative RNA blot hybridization analysis. Such changes could reflect cell adaptation to excess ammonia or some other associated metabolic stress. The mRNA levels of glutamate dehydrogenase (GDH) decreased similarly in three different brain regions, whereas those of glutamine synthetase (GS) and glutaminase (GA) increased. The mRNA levels of glutamate decarboxylase (GAD) were unchanged. The results indicate that some effect of liver damage, presumably hyperammonemia, affected the expression of some, but not all, genes associated with ammonia and glutamate metabolism in the brain. This adaptation of gene expression to secondary effects of ammonia on brain amino acid neurotransmitter metabolism or brain energy metabolism could play a role in the physiological changes observed in hepatic encephalopathy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatic encephalopathy  ISOGlud1 (Rattus norvegicus)6484661; 6484661mRNA:decreased expression:brainRGD 
hepatic encephalopathy  IEP 6484661mRNA:decreased expression:brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
Glud1  (glutamate dehydrogenase 1)

Genes (Mus musculus)
Glud1  (glutamate dehydrogenase 1)

Genes (Homo sapiens)
GLUD1  (glutamate dehydrogenase 1)


Additional Information