Ephb1 (Eph receptor B1) - Rat Genome Database

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Gene: Ephb1 (Eph receptor B1) Rattus norvegicus
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Symbol: Ephb1
Name: Eph receptor B1
RGD ID: 2556
Description: Enables protein tyrosine kinase activity. Involved in hindbrain tangential cell migration. Acts upstream of or within dendritic spine development and immunological synapse formation. Predicted to be located in several cellular components, including early endosome membrane; filopodium tip; and membrane raft. Predicted to be active in dendrite; glutamatergic synapse; and plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human EPHB1 (EPH receptor B1); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: elk; ELK-related protein tyrosine kinase; Eph receptor B2; Eph receptor B2 (ELK-related protein tyrosine kinase); Ephb2; ephrin type-B receptor 1; Erk; tyrosine-protein kinase receptor EPH-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88111,386,432 - 111,823,759 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8111,386,432 - 111,823,759 (-)EnsemblGRCr8
mRatBN7.28102,507,549 - 102,944,839 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8102,507,549 - 102,944,839 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8108,174,355 - 108,610,838 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08106,373,671 - 106,810,017 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08104,216,189 - 104,652,675 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08110,376,954 - 110,813,193 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8110,376,954 - 110,813,000 (-)Ensemblrn6Rnor6.0
Rnor_5.08109,782,848 - 110,218,328 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48106,871,856 - 107,328,156 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8101,892,152 - 102,327,473 (-)NCBICelera
RGSC_v3.18106,892,184 - 107,347,611 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO,ISS)
animal organ development  (IEA)
axon guidance  (IBA,ISO,ISS)
camera-type eye morphogenesis  (ISO)
cell activation  (IEA)
cell adhesion  (IEA)
cell chemotaxis  (IEA,ISO,ISS)
cell migration  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cell-substrate adhesion  (IEA,ISO,ISS)
central nervous system development  (IEA)
central nervous system projection neuron axonogenesis  (ISO,ISS)
cranial nerve development  (ISO)
dendritic spine development  (IEA,IGI,ISO,ISS)
dendritic spine morphogenesis  (IEA,ISO,ISS)
detection of temperature stimulus involved in sensory perception of pain  (IEA,ISO,ISS)
ephrin receptor signaling pathway  (IBA,IEA,ISO,ISS)
establishment of cell polarity  (IEA,ISO,ISS)
hindbrain tangential cell migration  (IMP)
immunological synapse formation  (IGI)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation of satellite cell differentiation  (IEA,ISO,ISS)
negative regulation of skeletal muscle satellite cell proliferation  (IEA,ISO,ISS)
nervous system development  (IEA)
neural precursor cell proliferation  (IEA,ISO,ISS)
neurogenesis  (IEA,ISO,ISS)
optic nerve morphogenesis  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of protein localization to plasma membrane  (IMP)
positive regulation of synapse assembly  (IEA,ISO,ISS)
protein autophosphorylation  (IDA,ISO)
regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
regulation of JNK cascade  (IEA,ISO,ISS)
retinal ganglion cell axon guidance  (ISO,ISS)
skeletal muscle satellite cell activation  (IEA,ISO,ISS)

Cellular Component
axon  (IEA,ISO)
cytoplasm  (IEA,ISO)
dendrite  (IBA,IEA)
early endosome membrane  (IEA,ISO,ISS)
filopodium tip  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
membrane  (IEA,ISO)
membrane raft  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Cissé M, etal., Nature. 2011 Jan 6;469(7328):47-52. doi: 10.1038/nature09635. Epub 2010 Nov 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer. Kataoka H, etal., J Cancer Res Clin Oncol. 2002 Jul;128(7):343-8. doi: 10.1007/s00432-002-0355-0. Epub 2002 Jun 26.
5. Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody. Letwin K, etal., Oncogene 1988 Dec;3(6):621-7.
6. Characterization of elk, a brain-specific receptor tyrosine kinase. Lhotak V, etal., Mol Cell Biol 1991 May;11(5):2496-502.
7. Larch Arabinogalactan Attenuates Myocardial Injury by Inhibiting Apoptotic Cascades in a Rat Model of Ischemia-Reperfusion. Lim SH, J Med Food. 2017 Jul;20(7):691-699. doi: 10.1089/jmf.2016.3886. Epub 2017 Jun 16.
8. Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon. Liu YH, etal., Sci Rep. 2017 Mar 9;7:42895. doi: 10.1038/srep42895.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. EphB2 SNPs and sporadic prostate cancer risk in African American men. Robbins CM, etal., PLoS One. 2011;6(5):e19494. doi: 10.1371/journal.pone.0019494. Epub 2011 May 16.
16. Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Segura I, etal., Nat Neurosci. 2007 Mar;10(3):301-10. Epub 2007 Feb 18.
17. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
18. Downregulation of miR143/145 gene cluster expression promotes the aortic media degeneration process via the TGF-β1 signaling pathway. Zhang M and Wang Z, Am J Transl Res. 2019 Jan 15;11(1):370-378. eCollection 2019.
Additional References at PubMed
PMID:8559144   PMID:9430661   PMID:9499402   PMID:11532925   PMID:11580899   PMID:11799243   PMID:12093895   PMID:12543452   PMID:12925710   PMID:12944508   PMID:12971893   PMID:14691139  
PMID:14999078   PMID:15502157   PMID:15821731   PMID:16049340   PMID:16394100   PMID:16407335   PMID:16701205   PMID:17621205   PMID:17982879   PMID:18034775   PMID:18057206   PMID:18321739  
PMID:18448254   PMID:19011585   PMID:19025592   PMID:19523204   PMID:19864302   PMID:20333303   PMID:20458337   PMID:20633976   PMID:21085126   PMID:21791939   PMID:22265865   PMID:24253595  
PMID:24305805   PMID:24997765   PMID:26110816   PMID:27446912   PMID:27903584   PMID:33356837   PMID:33678127   PMID:36918107  


Genomics

Comparative Map Data
Ephb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88111,386,432 - 111,823,759 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8111,386,432 - 111,823,759 (-)EnsemblGRCr8
mRatBN7.28102,507,549 - 102,944,839 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8102,507,549 - 102,944,839 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8108,174,355 - 108,610,838 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08106,373,671 - 106,810,017 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08104,216,189 - 104,652,675 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08110,376,954 - 110,813,193 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8110,376,954 - 110,813,000 (-)Ensemblrn6Rnor6.0
Rnor_5.08109,782,848 - 110,218,328 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48106,871,856 - 107,328,156 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8101,892,152 - 102,327,473 (-)NCBICelera
RGSC_v3.18106,892,184 - 107,347,611 (-)NCBI
Cytogenetic Map8q32NCBI
EPHB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383134,795,260 - 135,260,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3134,795,260 - 135,260,467 (+)Ensemblhg38GRCh38
GRCh373134,514,102 - 134,979,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363135,996,950 - 136,461,999 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343135,996,957 - 136,462,003NCBI
Celera3132,940,535 - 133,405,242 (+)NCBICelera
Cytogenetic Map3q22.2NCBI
HuRef3131,890,822 - 132,356,715 (+)NCBIHuRef
CHM1_13134,478,274 - 134,942,745 (+)NCBICHM1_1
T2T-CHM13v2.03137,540,631 - 138,005,927 (+)NCBIT2T-CHM13v2.0
Ephb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399101,799,327 - 102,231,892 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9101,799,327 - 102,231,892 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389101,922,128 - 102,354,693 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9101,922,128 - 102,354,693 (-)Ensemblmm10GRCm38
MGSCv379101,824,458 - 102,257,023 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369101,778,391 - 102,210,896 (-)NCBIMGSCv36mm8
Celera9101,458,328 - 101,902,746 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map954.15NCBI
Ephb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555013,423,977 - 3,821,890 (-)Ensembl
ChiLan1.0NW_0049555013,424,112 - 3,821,727 (-)NCBIChiLan1.0ChiLan1.0
EPHB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22132,721,019 - 133,188,676 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13132,725,745 - 133,193,405 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03131,841,459 - 132,309,082 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13139,312,933 - 139,778,166 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3139,313,387 - 139,776,802 (+)EnsemblpanPan2panpan1.1
EPHB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12331,485,701 - 31,918,754 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2331,485,534 - 31,917,393 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2331,423,133 - 31,897,303 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02332,297,984 - 32,440,415 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2332,322,030 - 32,439,750 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12331,656,516 - 32,130,657 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02331,717,030 - 32,191,562 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02331,963,973 - 32,438,568 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ephb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560271,079,838 - 71,501,438 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365297,839,768 - 8,261,942 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365298,006,780 - 8,261,923 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1375,905,676 - 76,345,534 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11375,904,678 - 76,351,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21383,511,907 - 83,816,698 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11555,144,178 - 55,592,252 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1555,143,630 - 55,589,862 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604128,194,516 - 28,305,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ephb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473011,119,909 - 11,565,293 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473011,120,018 - 11,564,972 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ephb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1893,235,114 - 93,668,695 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ephb1
4501 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:256
Count of miRNA genes:161
Interacting mature miRNAs:199
Transcripts:ENSRNOT00000010634
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
D8Rat167  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88111,499,292 - 111,499,466 (+)Marker Load Pipeline
mRatBN7.28102,620,359 - 102,620,533 (+)MAPPERmRatBN7.2
Rnor_6.08110,489,404 - 110,489,577NCBIRnor6.0
Rnor_5.08109,895,298 - 109,895,471UniSTSRnor5.0
RGSC_v3.48106,985,056 - 106,985,228RGDRGSC3.4
RGSC_v3.48106,985,055 - 106,985,228UniSTSRGSC3.4
Celera8102,004,235 - 102,004,394UniSTS
RGSC_v3.18107,004,401 - 107,004,689RGD
FHH x ACI Map872.37UniSTS
FHH x ACI Map872.37RGD
Cytogenetic Map8q32UniSTS
D8Got161  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88111,745,131 - 111,745,285 (+)Marker Load Pipeline
mRatBN7.28102,866,210 - 102,866,364 (+)MAPPERmRatBN7.2
Rnor_6.08110,735,476 - 110,735,631NCBIRnor6.0
Rnor_5.08110,140,864 - 110,141,019UniSTSRnor5.0
RGSC_v3.48107,249,045 - 107,249,201RGDRGSC3.4
RGSC_v3.48107,249,046 - 107,249,201UniSTSRGSC3.4
Celera8102,249,085 - 102,249,240UniSTS
RGSC_v3.18107,268,501 - 107,268,656RGD
RH 3.4 Map81168.3RGD
RH 3.4 Map81168.3UniSTS
RH 2.0 Map8864.8RGD
Cytogenetic Map8q32UniSTS
D8Got317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28102,806,200 - 102,806,372 (+)MAPPERmRatBN7.2
Rnor_6.08110,675,724 - 110,675,895NCBIRnor6.0
Rnor_5.08110,081,382 - 110,081,553UniSTSRnor5.0
RGSC_v3.48107,188,178 - 107,188,349UniSTSRGSC3.4
Celera8102,189,503 - 102,189,674UniSTS
Cytogenetic Map8q32UniSTS
AW535067  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28102,507,590 - 102,507,741 (+)MAPPERmRatBN7.2
Rnor_6.08110,376,996 - 110,377,146NCBIRnor6.0
Rnor_5.08109,782,890 - 109,783,040UniSTSRnor5.0
RGSC_v3.48106,871,898 - 106,872,048UniSTSRGSC3.4
Celera8101,892,194 - 101,892,344UniSTS
RH 3.4 Map81173.4UniSTS
Cytogenetic Map8q32UniSTS
RH138061  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28102,508,066 - 102,508,217 (+)MAPPERmRatBN7.2
Rnor_6.08110,377,472 - 110,377,622NCBIRnor6.0
Rnor_5.08109,783,366 - 109,783,516UniSTSRnor5.0
RGSC_v3.48106,872,374 - 106,872,524UniSTSRGSC3.4
Celera8101,892,670 - 101,892,820UniSTS
RH 3.4 Map81180.9UniSTS
Cytogenetic Map8q32UniSTS
Ephb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28102,508,639 - 102,508,876 (+)MAPPERmRatBN7.2
Rnor_6.08110,378,045 - 110,378,281NCBIRnor6.0
Rnor_5.08109,783,939 - 109,784,175UniSTSRnor5.0
RGSC_v3.48106,872,947 - 106,873,183UniSTSRGSC3.4
Celera8101,893,243 - 101,893,479UniSTS
Cytogenetic Map8q32UniSTS
AU048713  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28102,546,895 - 102,547,029 (+)MAPPERmRatBN7.2
Rnor_6.08110,416,523 - 110,416,656NCBIRnor6.0
Rnor_5.08109,822,417 - 109,822,550UniSTSRnor5.0
RGSC_v3.48106,911,105 - 106,911,238UniSTSRGSC3.4
Celera8101,931,310 - 101,931,443UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 161 86 85 54 30 54 6 288 130 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010634   ⟹   ENSRNOP00000010634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8111,386,432 - 111,823,759 (-)Ensembl
mRatBN7.2 Ensembl8102,507,549 - 102,944,839 (-)Ensembl
Rnor_6.0 Ensembl8110,376,954 - 110,813,000 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089574   ⟹   ENSRNOP00000070517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8111,386,833 - 111,823,759 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101328   ⟹   ENSRNOP00000077984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8111,386,432 - 111,823,759 (-)Ensembl
mRatBN7.2 Ensembl8102,507,549 - 102,944,839 (-)Ensembl
RefSeq Acc Id: NM_001104528   ⟹   NP_001097998
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88111,386,432 - 111,823,759 (-)NCBI
mRatBN7.28102,507,549 - 102,944,839 (-)NCBI
Rnor_6.08110,376,954 - 110,813,000 (-)NCBI
Rnor_5.08109,782,848 - 110,218,328 (-)NCBI
RGSC_v3.48106,871,856 - 107,328,156 (-)RGD
Celera8101,892,152 - 102,327,473 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001097998 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77405 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010634
  ENSRNOP00000010634.7
GenBank Protein P09759 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001097998   ⟸   NM_001104528
- Peptide Label: precursor
- UniProtKB: P09759 (UniProtKB/Swiss-Prot),   A6I2H2 (UniProtKB/TrEMBL),   A0A8I5Y8D1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010634   ⟸   ENSRNOT00000010634
Ensembl Acc Id: ENSRNOP00000077984   ⟸   ENSRNOT00000101328
Ensembl Acc Id: ENSRNOP00000070517   ⟸   ENSRNOT00000089574
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09759-F1-model_v2 AlphaFold P09759 1-984 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696224
Promoter ID:EPDNEW_R6747
Type:single initiation site
Name:Ephb1_1
Description:Eph receptor B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08110,813,085 - 110,813,145EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2556 AgrOrtholog
BioCyc Gene G2FUF-29352 BioCyc
Ensembl Genes ENSRNOG00000007865 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010634 ENTREZGENE
  ENSRNOT00000010634.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
  ephrin a2 ectodomain UniProtKB/Swiss-Prot
  Galactose-binding domain-like UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot
InterPro Eph_TM UniProtKB/Swiss-Prot
  EphB1_rcpt_lig-bd UniProtKB/Swiss-Prot
  EphB1_SAM UniProtKB/Swiss-Prot
  Ephrin_rcpt_lig-bd_dom UniProtKB/Swiss-Prot
  Ephrin_rcpt_TKs UniProtKB/Swiss-Prot
  FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Galactose-bd-like_sf UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_ephrin_rcpt UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_V_CS UniProtKB/Swiss-Prot
KEGG Report rno:24338 UniProtKB/Swiss-Prot
NCBI Gene 24338 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/Swiss-Prot
  EPHRIN TYPE-B RECEPTOR 1 UniProtKB/Swiss-Prot
Pfam EphA2_TM UniProtKB/Swiss-Prot
  Ephrin_lbd UniProtKB/Swiss-Prot
  fn3 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  SAM_1 UniProtKB/Swiss-Prot
PhenoGen Ephb1 PhenoGen
PIRSF TyrPK_ephrin_receptor UniProtKB/Swiss-Prot
PRINTS FNTYPEIII UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE EGF_2 UniProtKB/Swiss-Prot
  EPH_LBD UniProtKB/Swiss-Prot
  FN3 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_V_1 UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_V_2 UniProtKB/Swiss-Prot
  SAM_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007865 RatGTEx
SMART EPH_lbd UniProtKB/Swiss-Prot
  Ephrin_rec_like UniProtKB/Swiss-Prot
  FN3 UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
  SSF49785 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A0G2JY48_RAT UniProtKB/TrEMBL
  A0A8I5Y8D1 ENTREZGENE, UniProtKB/TrEMBL
  A6I2H2 ENTREZGENE, UniProtKB/TrEMBL
  EPHB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-03-05 Ephb1  Eph receptor B1  Ephb2  Eph receptor B2  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2001-06-12 Erk  ELK-related protein tyrosine kinase      Symbol withdrawn, duplicate entry of Ephb2 (RGD:2556) 62408 WITHDRAWN
2001-06-12 Ephb2  Eph receptor B2      Name updated 62408 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an N-terminal signal sequence, a cysteine-rich extracellular domain, a membrane-spanning segment, a cytoplasmic tyrosine kinase domain, and a C-terminal tail 632705
gene_expression expressed in the brain and testis 632705
gene_function capable of autophosphorylation 632705
gene_process may be involved in cell-cell interactions in the nervous system 632705
gene_product member of the eph subfamily 632705