Drd4 (dopamine receptor D4) - Rat Genome Database

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Gene: Drd4 (dopamine receptor D4) Rattus norvegicus
Analyze
Symbol: Drd4
Name: dopamine receptor D4
RGD ID: 2522
Description: Enables dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and heterocyclic compound binding activity. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and regulation of signal transduction. Located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and perikaryon. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Biomarker of attention deficit hyperactivity disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human DRD4 (dopamine receptor D4); PARTICIPATES IN dopamine signaling pathway; excitatory synaptic transmission pathway; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (+)-butaclamol; 1,2-dimethylhydrazine; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: d(2C) dopamine receptor; D(4) dopamine receptor; D4RA; dopamine D4 receptor; dopamine receptor 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,825,937 - 205,829,124 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1205,826,049 - 205,830,458 (+)EnsemblGRCr8
mRatBN7.21196,396,366 - 196,400,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,396,366 - 196,399,553 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1204,741,809 - 204,744,982 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,868,591 - 211,871,768 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,542,729 - 204,545,906 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,278,296 - 214,282,818 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,278,296 - 214,281,483 (+)Ensemblrn6Rnor6.0
Rnor_5.01221,195,844 - 221,200,366 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41201,485,597 - 201,488,784 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1194,030,237 - 194,033,424 (+)NCBICelera
RGSC_v3.11201,636,931 - 201,640,119 (+)NCBI
RH 3.4 Map11437.21RGD
Cytogenetic Map1q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-butaclamol  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethylphosphate  (ISO)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fucoxanthin  (ISO)
glyphosate  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
GSK-J4  (ISO)
haloperidol  (EXP,ISO)
hydralazine  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
maneb  (ISO)
mercaptopurine  (EXP)
mercury atom  (EXP)
mercury dibromide  (ISO)
mercury(0)  (EXP)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
morphine  (EXP)
N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide  (ISO)
N-Methylspiperone  (EXP)
naloxone  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
paraquat  (EXP,ISO)
phenylmercury acetate  (ISO)
picrotoxin  (EXP)
progesterone  (ISO)
purine-6-thiol  (EXP)
pyridaben  (ISO)
quercetin  (EXP)
quinpirole  (EXP)
resveratrol  (ISO)
ropinirole  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium chloride  (EXP)
spiperone  (EXP,ISO)
temozolomide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IEA,ISO,ISS)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IBA)
adult locomotory behavior  (ISO)
arachidonate secretion  (IEA,ISO)
associative learning  (IMP)
behavioral fear response  (IMP)
behavioral response to cocaine  (ISO)
chemical synaptic transmission  (IBA)
circadian rhythm  (IEP)
fear response  (IEA,ISO)
G protein-coupled dopamine receptor signaling pathway  (IDA)
G protein-coupled receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA)
G protein-coupled serotonin receptor signaling pathway  (IEA)
inhibitory postsynaptic potential  (ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
modulation of inhibitory postsynaptic potential  (IDA)
negative regulation of protein secretion  (IEA,ISO)
negative regulation of synaptic transmission  (IDA)
negative regulation of synaptic transmission, GABAergic  (IDA)
negative regulation of vascular associated smooth muscle cell migration  (IDA)
negative regulation of vascular associated smooth muscle cell proliferation  (IDA)
olfactory learning  (IMP)
phospholipase C-activating dopamine receptor signaling pathway  (IEA,ISO)
photoperiodism  (IEP)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of penile erection  (IDA)
prepulse inhibition  (IMP)
presynaptic modulation of chemical synaptic transmission  (EXP,IDA)
regulation of calcium-mediated signaling  (IMP)
regulation of circadian rhythm  (IEA,ISO,ISS)
regulation of dopamine metabolic process  (ISO)
regulation of locomotion  (IEA)
regulation of neurotransmitter secretion  (IMP)
regulation of postsynaptic membrane neurotransmitter receptor levels  (EXP,IDA,IEP)
regulation of postsynaptic neurotransmitter receptor internalization  (IEA,ISO)
regulation of transport  (IEA)
response to amphetamine  (ISO)
response to epinephrine  (IEP)
response to ethanol  (IEP)
response to histamine  (IEA,ISO)
response to light stimulus  (IEP)
response to steroid hormone  (IEP)
response to thyroid hormone  (IEP)
retina development in camera-type eye  (IEP)
rhythmic process  (IEA)
short-term memory  (IMP)
signal transduction  (IEA)
synaptic transmission, dopaminergic  (IEA,IMP)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Asghari V, etal., Mol Pharmacol. 1994 Aug;46(2):364-73.
2. Dopamine D4 receptor-mediated presynaptic inhibition of GABAergic transmission in the rat supraoptic nucleus. Azdad K, etal., J Neurophysiol 2003 Aug;90(2):559-65. Epub 2003 Apr 23.
3. Daily oscillation of gene expression in the retina is phase-advanced with respect to the pineal gland. Bai L, etal., Brain Res. 2008 Apr 8;1203:89-96. Epub 2008 Feb 9.
4. No evidence for a major gene effect of the dopamine D4 receptor gene in the susceptibility to Gilles de la Tourette syndrome in five Canadian families. Barr CL, etal., Am J Med Genet. 1996 May 31;67(3):301-5.
5. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
6. A gene x gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males. Beaver KM, etal., Behav Brain Funct. 2007 Jun 22;3:30.
7. The dopamine D4 receptor gene exon III polymorphism is associated with novelty seeking in 15-year-old males from a high-risk community sample. Becker K, etal., J Neural Transm (Vienna). 2005 Jun;112(6):847-58. Epub 2004 Oct 27.
8. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
9. DRD4 gene variants and sustained attention in attention deficit hyperactivity disorder (ADHD): effects of associated alleles at the VNTR and -521 SNP. Bellgrove MA, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):81-6.
10. The anabolic androgenic steroid nandrolone decanoate affects mRNA expression of dopaminergic but not serotonergic receptors. Birgner C, etal., Brain Res. 2008 Nov 13;1240:221-8. doi: 10.1016/j.brainres.2008.09.003. Epub 2008 Sep 13.
11. Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder. Chawla A, etal., Physiol Behav. 2017 Oct 15;180:78-90. doi: 10.1016/j.physbeh.2017.08.004. Epub 2017 Aug 15.
12. DRD4 Exon 3 Gene Polymorphisms in Patients Diagnosed with Polysubstance Use Disorder and Co-Occurrence of a Depressive Episode. Chmielowiec K, etal., Genes (Basel). 2021 Nov 20;12(11):1834. doi: 10.3390/genes12111834.
13. The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants. Cleveland HH, etal., Dev Psychopathol. 2015 Feb;27(1):51-67. doi: 10.1017/S0954579414001291.
14. Studies of the 48 bp repeat polymorphism of the DRD4 gene in impulsive, compulsive, addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse. Comings DE, etal., Am J Med Genet. 1999 Aug 20;88(4):358-68.
15. Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics. Cruz C, etal., Neurosci Lett. 1997 Aug 1;231(1):1-4.
16. [Relationship between dopamine D4 receptor gene polymorphisms and primary nocturnal enuresis]. Dai XM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2008 Oct;10(5):607-10.
17. The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans. Du Y, etal., Psychiatry Res. 2010 May 30;177(3):358-60. doi: 10.1016/j.psychres.2010.02.021. Epub 2010 Apr 1.
18. A haplotype relative risk study of the dopamine D4 receptor (DRD4) exon III repeat polymorphism and attention deficit hyperactivity disorder (ADHD). Eisenberg J, etal., Am J Med Genet. 2000 Jun 12;96(3):258-61.
19. Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder. Faraone SV, etal., Am J Psychiatry. 2001 Jul;158(7):1052-7.
20. Dopamine D4 receptors inhibit depolarization-induced GABA release in the rat subthalamic nucleus. Floran B, etal., Eur J Pharmacol. 2004 Sep 13;498(1-3):97-102.
21. Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway. Floresco SB and Tse MT, J Neurosci. 2007 Feb 21;27(8):2045-57.
22. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
23. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
24. Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland. González S, etal., PLoS Biol. 2012;10(6):e1001347. doi: 10.1371/journal.pbio.1001347. Epub 2012 Jun 19.
25. Dopamine D4 receptor excitation of lateral habenula neurons via multiple cellular mechanisms. Good CH, etal., J Neurosci. 2013 Oct 23;33(43):16853-64. doi: 10.1523/JNEUROSCI.1844-13.2013.
26. Differential Susceptibility: The Genetic Moderation of Peer Pressure on Alcohol Use. Griffin AM, etal., J Youth Adolesc. 2015 Oct;44(10):1841-53. doi: 10.1007/s10964-015-0344-7. Epub 2015 Aug 26.
27. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. Griffon N, etal., Brain Res Mol Brain Res 2003 Sep 10;117(1):47-57.
28. Bidirectional regulation of Ca2+/calmodulin-dependent protein kinase II activity by dopamine D4 receptors in prefrontal cortex. Gu Z and Yan Z, Mol Pharmacol. 2004 Oct;66(4):948-55. doi: 10.1124/mol.104.001404. Epub 2004 Jun 30.
29. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Gu Z, etal., Mol Pharmacol. 2006 Mar;69(3):813-22. Epub 2005 Dec 19.
30. [Association analysis of dopamine D4 receptor gene polymorphism and attention deficit hyperactivity disorder with/without disruptive behavior disorder]. Guan LL, etal., Beijing Da Xue Xue Bao. 2007 Jun 18;39(3):233-6.
31. Impulsivity and Concussion in Juvenile Rats: Examining Molecular and Structural Aspects of the Frontostriatal Pathway. Hehar H, etal., PLoS One. 2015 Oct 8;10(10):e0139842. doi: 10.1371/journal.pone.0139842. eCollection 2015.
32. Dopamine receptor D4 gene -521C/T polymorphism is associated with opioid dependence through cold-pain responses. Ho AM, etal., Ann N Y Acad Sci. 2008 Oct;1139:20-6. doi: 10.1196/annals.1432.054.
33. Dopaminergic and noradrenergic gene polymorphisms and response to methylphenidate in korean children with attention-deficit/hyperactivity disorder: is there an interaction? Hong SB, etal., J Child Adolesc Psychopharmacol. 2012 Oct;22(5):343-52. doi: 10.1089/cap.2011.0076.
34. A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5. Hsiung GY, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Feb 15;125B(1):112-9.
35. Association between the 120-bp duplication of the dopamine D4 receptor gene and attention deficit hyperactivity disorder: genetic and molecular analyses. Kereszturi E, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 5;144B(2):231-6.
36. Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4). Kim JS, etal., Mol Cell Endocrinol. 2010 Jan 15;314(1):128-35. doi: 10.1016/j.mce.2009.05.013. Epub 2009 May 29.
37. Localization and regulation of dopamine receptor D4 expression in the adult and developing rat retina. Klitten LL, etal., Exp Eye Res. 2008 Nov;87(5):471-7. Epub 2008 Aug 20.
38. Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain. Kortagere S, etal., Mol Pharmacol. 2004 Dec;66(6):1491-9. Epub 2004 Sep 24.
39. Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain. Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19.
40. Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5. Kustanovich V, etal., Mol Psychiatry 2004 Jul;9(7):711-7.
41. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
42. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. LaHoste GJ, etal., Mol Psychiatry 1996 May;1(2):121-4.
43. Novelty seeking: interaction between parental alcohol use and dopamine D4 receptor gene exon III polymorphism over 17 years. Lahti J, etal., Psychiatr Genet. 2005 Jun;15(2):133-9. doi: 10.1097/00041444-200506000-00010.
44. Dopamine D4 receptor (DRD4) gene polymorphism is associated with attachment disorganization in infants. Lakatos K, etal., Mol Psychiatry. 2000 Nov;5(6):633-7. doi: 10.1038/sj.mp.4000773.
45. A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala input. Laviolette SR, etal., J Neurosci. 2005 Jun 29;25(26):6066-75.
46. The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
47. Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects. Li T, etal., Am J Med Genet. 2000 Oct 9;96(5):616-21. doi: 10.1002/1096-8628(20001009)96:5<616::aid-ajmg6>3.0.co;2-7.
48. Variable number tandem repeats in dopamine receptor D4 in Tourette's syndrome. Liu S, etal., Mov Disord. 2014 Nov;29(13):1687-91. doi: 10.1002/mds.26027. Epub 2014 Sep 25.
49. Multiple marker analysis at the promoter region of the DRD4 gene and ADHD: evidence of linkage and association with the SNP -616. Lowe N, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Nov 15;131B(1):33-7.
50. Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition. Mansbach RS, etal., Psychopharmacology (Berl). 1998 Jan;135(2):194-200. doi: 10.1007/s002130050501.
51. Effects of neonatal 6-hydroxydopamine lesion on the gene expression profile in young adult rats. Masuo Y, etal., Neurosci Lett. 2002 Dec 25;335(2):124-8. doi: 10.1016/s0304-3940(02)01167-9.
52. PD-168077, a selective dopamine D4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats. Melis MR, etal., Neurosci Lett. 2005 Apr 29;379(1):59-62. Epub 2005 Jan 12.
53. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
54. Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder. Mill J, etal., Neuroreport. 2003 Aug 6;14(11):1463-6.
55. Fibrosis progression in HCV carriers with mild hepatitis who possess the high-repetition variant of the DRD4 gene, a genetic marker for binge-drinking and risk-seeking behavior: a longitudinal study. Minisini R, etal., Alcohol Clin Exp Res. 2013 Jun;37(6):891-5. doi: 10.1111/acer.12047. Epub 2013 Jan 8.
56. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
57. Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity. Nothen MM, etal., Hum Mol Genet. 1994 Dec;3(12):2207-12.
58. The rat dopamine D4 receptor: sequence, gene structure, and demonstration of expression in the cardiovascular system. O'Malley KL, etal., New Biol 1992 Feb;4(2):137-46.
59. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
60. Prefrontal dopamine D4 receptors are involved in encoding fear extinction. Pfeiffer UJ and Fendt M, Neuroreport. 2006 May 29;17(8):847-50.
61. Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain. Rajput PS, etal., Neurosci Res. 2009 Sep;65(1):53-63. Epub 2009 May 22.
62. GOA pipeline RGD automated data pipeline
63. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
64. Dopamine D4 receptor expression in rat kidney: evidence for pre- and postjunctional localization. Ricci A, etal., J Histochem Cytochem. 2002 Aug;50(8):1091-6. doi: 10.1177/002215540205000811.
65. Expression of D4 dopamine receptors in striatonigral and striatopallidal neurons in the rat striatum. Rivera A, etal., Brain Res. 2003 Oct 31;989(1):35-41.
66. Dopamine D4 receptors are heterogeneously distributed in the striosomes/matrix compartments of the striatum. Rivera A, etal., J Neurochem 2002 Jan;80(2):219-29.
67. Tonic modulation of inhibition by dopamine D4 receptors in the rat hippocampus. Romo-Parra H, etal., Hippocampus. 2005;15(2):254-9.
68. Witnessing substance use increases same-day antisocial behavior among at-risk adolescents: Gene-environment interaction in a 30-day ecological momentary assessment study. Russell MA, etal., Dev Psychopathol. 2016 Nov;28(4pt2):1441-1456. doi: 10.1017/S0954579415001182. Epub 2015 Dec 9.
69. Dopamine D4 receptor exon III alleles and variation of novelty seeking in alcoholics. Sander T, etal., Am J Med Genet. 1997 Sep 19;74(5):483-7. doi: 10.1002/(sici)1096-8628(19970919)74:5<483::aid-ajmg5>3.0.co;2-p.
70. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
71. Dopamine D4 receptors elevated in schizophrenia. Seeman P, etal., Nature. 1993 Sep 30;365(6445):441-5.
72. Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder. Shaw P, etal., Arch Gen Psychiatry. 2007 Aug;64(8):921-31.
73. Catechol-O-methyltransferase and dopamine receptor D4 gene variants: Possible association with substance abuse in Bangladeshi male. Sonia JA, etal., PLoS One. 2021 Feb 5;16(2):e0246462. doi: 10.1371/journal.pone.0246462. eCollection 2021.
74. Presynaptic dopamine D(4) receptor localization in the rat nucleus accumbens shell. Svingos AL, etal., Synapse. 2000 Jun 1;36(3):222-32.
75. Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder. Taurines R, etal., World J Biol Psychiatry. 2011 Sep;12 Suppl 1:104-8.
76. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
77. Lack of association of dopamine D4 receptor gene polymorphisms with ADHD subtypes in a population sample of twins. Todd RD, etal., Am J Med Genet. 2001 Jul 8;105(5):432-8.
78. Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking Status in Turkish Population. Uysal MA, etal., Noro Psikiyatr Ars. 2019 Oct 4;56(4):248-252. doi: 10.29399/npa.23408. eCollection 2019 Dec.
79. Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype. Vaughn MG, etal., Alcohol. 2009 May;43(3):179-84. doi: 10.1016/j.alcohol.2009.02.001.
80. Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. Vereczkei A, etal., PLoS One. 2013 Jun 28;8(6):e66592. doi: 10.1371/journal.pone.0066592. Print 2013.
81. Reduction of renal dopamine receptor expression in obese Zucker rats: role of sex and angiotensin II. Wang X, etal., Am J Physiol Renal Physiol. 2010 Nov;299(5):F1164-70. doi: 10.1152/ajprenal.00604.2009. Epub 2010 Sep 1.
82. Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex. Wang X, etal., J Neurosci. 2002 Nov 1;22(21):9185-93. doi: 10.1523/JNEUROSCI.22-21-09185.2002.
83. Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex. Wang X, etal., J Neurosci. 2003 Oct 29;23(30):9852-61.
84. Cortical localization of dopamine D4 receptors in the rat brain--immunocytochemical study. Wedzony K, etal., J Physiol Pharmacol. 2000 Jun;51(2):205-21.
85. Dopamine D4 receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin receptor expression. Yu C, etal., Cardiovasc Diabetol. 2014 Jun 2;13:97. doi: 10.1186/1475-2840-13-97.
86. Cellular mechanisms for dopamine D4 receptor-induced homeostatic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Yuen EY and Yan Z, J Biol Chem. 2011 Jul 15;286(28):24957-65. doi: 10.1074/jbc.M111.221416. Epub 2011 May 27.
87. Plasticity of dopamine D4 receptors in rat forebrain: temporal association with motor hyperactivity following neonatal 6-hydroxydopamine lesioning. Zhang K, etal., Neuropsychopharmacology 2002 May;26(5):625-33.
88. Regulation of working memory by dopamine D4 receptor in rats. Zhang K, etal., Neuropsychopharmacology. 2004 Sep;29(9):1648-55.
89. A family-based association study of dopamine receptor D4 and mental retardation in Qinba region of China. Zhang K, etal., Neurosci Lett. 2012 May 10;516(1):1-4. doi: 10.1016/j.neulet.2012.02.017. Epub 2012 Feb 15.
90. Effects of dopamine D4 receptor-selective antagonists on motor hyperactivity in rats with neonatal 6-hydroxydopamine lesions. Zhang K, etal., Psychopharmacology (Berl). 2002 Apr;161(1):100-6. doi: 10.1007/s00213-002-1018-1. Epub 2002 Mar 6.
91. Methylation quantitative locus rs3758653 in the DRD4 gene is associated with duration from first heroin exposure to addiction. Zhang R, etal., Brain Res. 2022 Jan 15;1775:147746. doi: 10.1016/j.brainres.2021.147746. Epub 2021 Dec 2.
Additional References at PubMed
PMID:1319557   PMID:1840645   PMID:7512953   PMID:7921596   PMID:9003072   PMID:9323127   PMID:9843378   PMID:11356863   PMID:11860516   PMID:12544452   PMID:12783155   PMID:14684868  
PMID:15197646   PMID:15755724   PMID:16198123   PMID:16839358   PMID:17593530   PMID:18620029   PMID:18662324   PMID:18832154   PMID:19103603   PMID:19179335   PMID:19598175   PMID:20531939  
PMID:20884758   PMID:21135234   PMID:21184734   PMID:21320289   PMID:21599953   PMID:22815864   PMID:22822214   PMID:23884421   PMID:24048828   PMID:24599469   PMID:25832920   PMID:26775821  
PMID:27275521   PMID:27659709   PMID:28212942   PMID:31447121   PMID:32891683  


Genomics

Comparative Map Data
Drd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,825,937 - 205,829,124 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1205,826,049 - 205,830,458 (+)EnsemblGRCr8
mRatBN7.21196,396,366 - 196,400,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,396,366 - 196,399,553 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1204,741,809 - 204,744,982 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,868,591 - 211,871,768 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,542,729 - 204,545,906 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,278,296 - 214,282,818 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,278,296 - 214,281,483 (+)Ensemblrn6Rnor6.0
Rnor_5.01221,195,844 - 221,200,366 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41201,485,597 - 201,488,784 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1194,030,237 - 194,033,424 (+)NCBICelera
RGSC_v3.11201,636,931 - 201,640,119 (+)NCBI
RH 3.4 Map11437.21RGD
Cytogenetic Map1q41NCBI
DRD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811637,269 - 640,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11637,269 - 640,706 (+)Ensemblhg38GRCh38
GRCh3711637,269 - 640,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611627,305 - 630,703 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411627,304 - 630,703NCBI
Celera11702,422 - 705,821 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11452,513 - 456,039 (+)NCBIHuRef
CHM1_111636,234 - 639,634 (+)NCBICHM1_1
T2T-CHM13v2.011685,792 - 689,369 (+)NCBIT2T-CHM13v2.0
Drd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,871,931 - 140,874,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,871,919 - 140,876,377 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387141,291,974 - 141,296,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,292,006 - 141,296,464 (+)Ensemblmm10GRCm38
MGSCv377148,477,905 - 148,480,900 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367141,143,326 - 141,146,321 (+)NCBIMGSCv36mm8
Celera7141,085,754 - 141,088,749 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.6NCBI
Drd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,424,411 - 11,426,960 (-)Ensembl
ChiLan1.0NW_00495547611,424,347 - 11,426,962 (-)NCBIChiLan1.0ChiLan1.0
DRD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,007,058 - 3,019,627 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,222,678 - 2,235,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011640,401 - 646,775 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111671,445 - 674,412 (+)NCBIPanPan1.1PanPan1.1panPan2
DRD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1825,378,476 - 25,381,179 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01826,314,100 - 26,316,803 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,314,085 - 26,316,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,823,586 - 25,826,358 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,468,566 - 25,471,386 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,081,003 - 26,083,706 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Drd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947468,387 - 471,254 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888468,403 - 471,205 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936888468,334 - 471,254 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2398,766 - 402,433 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12398,766 - 401,539 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22272,619 - 275,757 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11454,018 - 459,582 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603897,516,746 - 97,520,656 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,834,169 - 21,836,710 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476621,834,093 - 21,837,314 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Drd4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v128,183,864 - 8,187,103 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Drd4
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:40
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000024137
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Wox57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,397,155 - 196,397,369 (+)MAPPERmRatBN7.2
Rnor_6.01214,279,086 - 214,279,299NCBIRnor6.0
Rnor_5.01221,196,634 - 221,196,847UniSTSRnor5.0
RGSC_v3.41201,486,387 - 201,486,600UniSTSRGSC3.4
Celera1194,031,027 - 194,031,240UniSTS
Cytogenetic Map1q41UniSTS
RH94697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,396,059 - 196,396,256 (+)MAPPERmRatBN7.2
Rnor_6.01214,277,990 - 214,278,186NCBIRnor6.0
Rnor_5.01221,195,538 - 221,195,734UniSTSRnor5.0
RGSC_v3.41201,485,291 - 201,485,487UniSTSRGSC3.4
Celera1194,029,931 - 194,030,127UniSTS
Cytogenetic Map1q41UniSTS
RH142302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,396,372 - 196,396,564 (+)MAPPERmRatBN7.2
Rnor_6.01214,278,303 - 214,278,494NCBIRnor6.0
Rnor_5.01221,195,851 - 221,196,042UniSTSRnor5.0
RGSC_v3.41201,485,604 - 201,485,795UniSTSRGSC3.4
Celera1194,030,244 - 194,030,435UniSTS
RH 3.4 Map11437.21UniSTS
Cytogenetic Map1q41UniSTS
BI284462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,399,051 - 196,399,214 (+)MAPPERmRatBN7.2
Rnor_6.01214,280,982 - 214,281,144NCBIRnor6.0
Rnor_5.01221,198,530 - 221,198,692UniSTSRnor5.0
RGSC_v3.41201,488,283 - 201,488,445UniSTSRGSC3.4
Celera1194,032,923 - 194,033,085UniSTS
RH 3.4 Map11436.4UniSTS
Cytogenetic Map1q41UniSTS
Drd4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,396,688 - 196,398,331 (+)MAPPERmRatBN7.2
Rnor_6.01214,278,619 - 214,280,261NCBIRnor6.0
Rnor_5.01221,196,167 - 221,197,809UniSTSRnor5.0
RGSC_v3.41201,485,920 - 201,487,562UniSTSRGSC3.4
Celera1194,030,560 - 194,032,202UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:142868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,398,343 - 196,398,500 (+)MAPPERmRatBN7.2
Rnor_6.01214,280,274 - 214,280,430NCBIRnor6.0
Rnor_5.01221,197,822 - 221,197,978UniSTSRnor5.0
RGSC_v3.41201,487,575 - 201,487,731UniSTSRGSC3.4
Celera1194,032,215 - 194,032,371UniSTS
Cytogenetic Map1q41UniSTS
Drd4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,399,334 - 196,399,437 (+)MAPPERmRatBN7.2
Rnor_6.01214,281,265 - 214,281,367NCBIRnor6.0
Rnor_5.01221,198,813 - 221,198,915UniSTSRnor5.0
RGSC_v3.41201,488,566 - 201,488,668UniSTSRGSC3.4
Celera1194,033,206 - 194,033,308UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 50 81 33 39 10 33 10 6 150 100 5 66 32 40 29 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000024137   ⟹   ENSRNOP00000024137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1205,826,049 - 205,830,458 (+)Ensembl
mRatBN7.2 Ensembl1196,396,366 - 196,399,553 (+)Ensembl
Rnor_6.0 Ensembl1214,278,296 - 214,281,483 (+)Ensembl
RefSeq Acc Id: NM_012944   ⟹   NP_037076
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,825,937 - 205,829,124 (+)NCBI
mRatBN7.21196,396,366 - 196,399,553 (+)NCBI
Rnor_6.01214,278,296 - 214,281,483 (+)NCBI
Rnor_5.01221,195,844 - 221,200,366 (+)NCBI
RGSC_v3.41201,485,597 - 201,488,784 (+)RGD
Celera1194,030,237 - 194,033,424 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230521   ⟹   XP_006230583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,826,037 - 205,829,099 (+)NCBI
mRatBN7.21196,396,496 - 196,400,824 (+)NCBI
Rnor_6.01214,278,426 - 214,282,818 (+)NCBI
Rnor_5.01221,195,844 - 221,200,366 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_037076 (Get FASTA)   NCBI Sequence Viewer  
  XP_006230583 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18588 (Get FASTA)   NCBI Sequence Viewer  
  AAA96716 (Get FASTA)   NCBI Sequence Viewer  
  EDM12018 (Get FASTA)   NCBI Sequence Viewer  
  EDM12019 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024137
GenBank Protein P30729 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037076   ⟸   NM_012944
- UniProtKB: Q62610 (UniProtKB/Swiss-Prot),   P30729 (UniProtKB/Swiss-Prot),   F1LLX2 (UniProtKB/TrEMBL),   A6HXT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230583   ⟸   XM_006230521
- Peptide Label: isoform X1
- UniProtKB: Q62610 (UniProtKB/Swiss-Prot),   P30729 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024137   ⟸   ENSRNOT00000024137
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30729-F1-model_v2 AlphaFold P30729 1-387 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2522 AgrOrtholog
BioCyc Gene G2FUF-56963 BioCyc
Ensembl Genes ENSRNOG00000017927 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024137 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Dopamine_D4_rcpt UniProtKB/Swiss-Prot
  Dopamine_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
NCBI Gene 25432 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  PTHR24248:SF143 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB DRD4 RGD
PhenoGen Drd4 PhenoGen
PRINTS DOPAMINED4R UniProtKB/Swiss-Prot
  DOPAMINER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017927 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC226919
UniProt A6HXT7 ENTREZGENE, UniProtKB/TrEMBL
  A6HXT8_RAT UniProtKB/TrEMBL
  DRD4_RAT UniProtKB/Swiss-Prot
  F1LLX2 ENTREZGENE, UniProtKB/TrEMBL
  P30729 ENTREZGENE
  Q62610 ENTREZGENE
UniProt Secondary Q62610 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Drd4  dopamine receptor D4    dopamine receptor 4  Name updated 1299863 APPROVED
2002-06-10 Drd4  Dopamine receptor D4      Symbol and Name status set to approved 70586 APPROVED