Dpp4 (dipeptidylpeptidase 4) - Rat Genome Database

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Gene: Dpp4 (dipeptidylpeptidase 4) Rattus norvegicus
Analyze
Symbol: Dpp4
Name: dipeptidylpeptidase 4
RGD ID: 2515
Description: Enables several functions, including collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in B-1a B cell differentiation; protein catabolic process; and regulation of lymphocyte mediated immunity. Located in cell surface. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4); INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bile canaliculus domain-specific membrane glycoprotein; CD26; Dipeptidyl peptidase 4; dipeptidyl peptidase IV; DPP IV; DPPIV; GP110 glycoprotein; T-cell activation antigen CD26
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Dpp4DPPIV
Genetic Models: DA.F344-Dpp4DPPIV/SvH ; F344-Dpp4DPPIV-/DchcHsdRrrc
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8367,370,794 - 67,452,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl367,370,804 - 67,452,422 (-)EnsemblGRCr8
mRatBN7.2346,962,233 - 47,043,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl346,962,243 - 47,043,901 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx350,316,895 - 50,398,506 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0358,900,415 - 58,982,044 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0356,673,443 - 56,755,068 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,291,055 - 48,372,672 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,291,055 - 48,372,672 (-)Ensemblrn6Rnor6.0
Rnor_5.0354,957,146 - 55,038,628 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4344,279,255 - 44,360,283 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera346,603,336 - 46,685,074 (-)NCBICelera
RGSC_v3.1344,175,626 - 44,256,655 (-)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
adenosine  (ISO)
aflatoxin B1  (ISO)
alogliptin  (EXP,ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
amphetamine  (EXP)
anagliptin  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenic acid  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
azoxystrobin  (EXP)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
Chikusetsusaponin-V  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
ciprofibrate  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
columbamine  (ISO)
copper(II) sulfate  (ISO)
coptisine  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP)
fenthion  (ISO)
flutamide  (EXP)
formaldehyde  (EXP,ISO)
fructose  (ISO)
gentamycin  (EXP)
Ginsenoside Rg5  (ISO)
Ginsenoside Rh4  (ISO)
Ginsenoside-Rk3  (ISO)
glafenine  (EXP)
glyphosate  (EXP)
Heptachlor epoxide  (ISO)
hydrazine  (ISO)
imidacloprid  (EXP)
isoflavones  (ISO)
Kukoamine B  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
linagliptin  (EXP)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
Panaxadiol  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
Phytolaccoside E  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
pyrroles  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
rimonabant  (ISO)
rotenone  (EXP,ISO)
Salvianolic acid C  (ISO)
saxagliptin  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
Sunset Yellow FCF  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tectoridin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (EXP)
vildagliptin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
Voglibose  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease. Algaissi A, etal., J Infect Dis. 2019 Feb 15;219(5):829-835. doi: 10.1093/infdis/jiy574.
2. Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
3. Roles of cysteines in rat dipeptidyl peptidase IV/CD26 in processing and proteolytic activity. Dobers J, etal., Eur J Biochem. 2000 Aug;267(16):5093-100.
4. Domain-specific N-glycosylation of the membrane glycoprotein dipeptidylpeptidase IV (CD26) influences its subcellular trafficking, biological stability, enzyme activity and protein folding. Fan H, etal., Eur J Biochem. 1997 May 15;246(1):243-51.
5. Efficacy and Safety Comparison Between the DPP-4 Inhibitor Vildagliptin and the Sulfonylurea Gliclazide After Two Years of Monotherapy in Drug-naive Patients with Type 2 Diabetes. Foley JE and Sreenan S, Horm Metab Res. 2009 Aug 24.
6. Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions. Frerker N, etal., Clin Chem Lab Med. 2009;47(3):275-87. doi: 10.1515/CCLM.2009.064.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. cDNA cloning for a bile canaliculus domain-specific membrane glycoprotein of rat hepatocytes. Hong W and Doyle D, Proc Natl Acad Sci U S A 1987 Nov;84(22):7962-6.
10. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
11. Extreme reduction of dipeptidyl peptidase IV activity in F344 rat substrains is associated with various behavioral differences. Karl T, etal., Physiol Behav. 2003 Oct;80(1):123-34.
12. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
13. Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Kim SJ, etal., Diabetes. 2009 Mar;58(3):641-51. Epub 2008 Dec 10.
14. Activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats with dopamine deficiency-dependent MPTP-induced depressive syndrome. Krupina NA, etal., Bull Exp Biol Med. 2006 Nov;142(5):554-6.
15. CD26 (dipeptidyl-peptidase IV)-dependent recruitment of T cells in a rat asthma model. Kruschinski C, etal., Clin Exp Immunol. 2005 Jan;139(1):17-24.
16. The cysteine-rich region of dipeptidyl peptidase IV (CD 26) is the collagen-binding site. Loster K, etal., Biochem Biophys Res Commun. 1995 Dec 5;217(1):341-8.
17. The 3D structure of rat DPPIV/CD26 as obtained by cryo-TEM and single particle analysis. Ludwig K, etal., Biochem Biophys Res Commun. 2003 Apr 25;304(1):73-7.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes. Mu J, etal., Eur J Pharmacol. 2009 Sep 16.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Primary structure of rat liver dipeptidyl peptidase IV deduced from its cDNA and identification of the NH2-terminal signal sequence as the membrane-anchoring domain. Ogata S, etal., J Biol Chem 1989 Feb 25;264(6):3596-601.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. Richard E, etal., J Biol Chem 2002 May 31;277(22):19720-6.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Improvement of high fat-diet-induced insulin resistance in dipeptidyl peptidase IV-deficient Fischer rats. Yasuda N, etal., Life Sci 2002 May 31;71(2):227-38.
Additional References at PubMed
PMID:1347701   PMID:1970322   PMID:1974258   PMID:3182821   PMID:7594462   PMID:7905271   PMID:8100523   PMID:8101391   PMID:8798518   PMID:10593948   PMID:10900005   PMID:11487543  
PMID:11772392   PMID:12068294   PMID:12675219   PMID:12675233   PMID:12716896   PMID:14684150   PMID:15052268   PMID:15448155   PMID:15584901   PMID:16478473   PMID:16651416   PMID:16670267  
PMID:16712972   PMID:16802131   PMID:16962474   PMID:17010607   PMID:17175274   PMID:17287217   PMID:17549790   PMID:17583752   PMID:17897319   PMID:18047624   PMID:18077600   PMID:18538760  
PMID:18931022   PMID:18940185   PMID:18978811   PMID:19056867   PMID:19199708   PMID:19501934   PMID:19540879   PMID:19804410   PMID:19876009   PMID:19946888   PMID:20153005   PMID:20458337  
PMID:20560982   PMID:20887754   PMID:21139073   PMID:21362503   PMID:21423176   PMID:21982785   PMID:22001206   PMID:22373413   PMID:22802229   PMID:22918684   PMID:23033273   PMID:23035207  
PMID:23184393   PMID:23359639   PMID:23361237   PMID:23376485   PMID:23408696   PMID:23486063   PMID:23533145   PMID:23535306   PMID:23677473   PMID:23832365   PMID:23894014   PMID:24357522  
PMID:24416433   PMID:24874705   PMID:25122001   PMID:25635612   PMID:25656369   PMID:25823534   PMID:25936515   PMID:26187356   PMID:26259714   PMID:26359413   PMID:26399925   PMID:27083282  
PMID:27198182   PMID:27238050   PMID:27525674   PMID:28372289   PMID:28895067   PMID:29472575   PMID:29677638   PMID:30977110   PMID:31089745   PMID:32542696   PMID:33162819   PMID:34310895  
PMID:34738744   PMID:35014677  


Genomics

Comparative Map Data
Dpp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8367,370,794 - 67,452,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl367,370,804 - 67,452,422 (-)EnsemblGRCr8
mRatBN7.2346,962,233 - 47,043,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl346,962,243 - 47,043,901 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx350,316,895 - 50,398,506 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0358,900,415 - 58,982,044 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0356,673,443 - 56,755,068 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,291,055 - 48,372,672 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,291,055 - 48,372,672 (-)Ensemblrn6Rnor6.0
Rnor_5.0354,957,146 - 55,038,628 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4344,279,255 - 44,360,283 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera346,603,336 - 46,685,074 (-)NCBICelera
RGSC_v3.1344,175,626 - 44,256,655 (-)NCBI
Cytogenetic Map3q21NCBI
DPP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382161,992,245 - 162,074,215 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2161,992,244 - 162,074,394 (-)Ensemblhg38GRCh38
GRCh372162,848,755 - 162,930,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,557,001 - 162,639,298 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342162,674,263 - 162,756,559NCBI
Celera2156,458,999 - 156,541,354 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2154,730,637 - 154,813,409 (-)NCBIHuRef
CHM1_12162,854,656 - 162,936,956 (-)NCBICHM1_1
T2T-CHM13v2.02162,448,837 - 162,530,851 (-)NCBIT2T-CHM13v2.0
Dpp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39262,160,417 - 62,242,635 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,160,417 - 62,242,575 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38262,330,073 - 62,412,315 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,330,073 - 62,412,231 (-)Ensemblmm10GRCm38
MGSCv37262,168,130 - 62,250,288 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36262,132,579 - 62,212,921 (-)NCBIMGSCv36mm8
Celera264,022,145 - 64,102,355 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map235.85NCBI
Dpp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544911,795,536 - 11,875,412 (+)Ensembl
ChiLan1.0NW_00495544911,795,994 - 11,873,408 (+)NCBIChiLan1.0ChiLan1.0
DPP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21364,684,314 - 64,766,927 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B64,698,715 - 64,781,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B49,285,685 - 49,368,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B166,654,659 - 166,736,588 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B166,654,659 - 166,736,588 (-)EnsemblpanPan2panpan1.1
DPP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1367,398,713 - 7,472,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,399,643 - 7,454,204 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha367,540,277 - 7,619,076 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0367,528,186 - 7,606,978 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,529,163 - 7,606,652 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,543,394 - 7,622,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,588,175 - 7,666,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0367,695,776 - 7,774,177 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dpp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303124,555,518 - 124,638,558 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646916,979,410 - 17,061,159 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646916,979,220 - 17,062,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1568,660,521 - 68,743,663 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11568,661,764 - 68,742,961 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,153,602 - 76,234,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap15q21NCBI
DPP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11047,396,605 - 47,481,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1047,394,093 - 47,480,893 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040152,044,113 - 152,128,336 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247323,460,118 - 3,535,249 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247323,460,529 - 3,535,252 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dpp4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1539,909,382 - 39,991,415 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dpp4
703 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:33
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000040482
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)35860129171157804Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)35911940270710963Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)35986366373704481Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat

Markers in Region
DPP4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2346,964,111 - 46,964,311 (+)MAPPERmRatBN7.2
Rnor_6.0348,292,924 - 48,293,123NCBIRnor6.0
Rnor_5.0354,959,015 - 54,959,214UniSTSRnor5.0
RGSC_v3.4344,281,124 - 44,281,323UniSTSRGSC3.4
Celera346,605,205 - 46,605,404UniSTS
Cytogenetic Map3q21UniSTS


Genetic Models
This gene Dpp4 is modified in the following models/strains:
DA.F344-Dpp4DPPIV/SvH     F344-Dpp4DPPIV-/DchcHsdRrrc    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 150 91 90 59 92 59 6 356 192 11 129 81 92 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000040482   ⟹   ENSRNOP00000045536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl367,370,804 - 67,426,184 (-)Ensembl
mRatBN7.2 Ensembl346,962,243 - 47,043,901 (-)Ensembl
Rnor_6.0 Ensembl348,293,617 - 48,372,583 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077788   ⟹   ENSRNOP00000072092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl367,370,804 - 67,427,838 (-)Ensembl
mRatBN7.2 Ensembl346,962,243 - 47,019,280 (-)Ensembl
Rnor_6.0 Ensembl348,292,739 - 48,372,609 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085426   ⟹   ENSRNOP00000068881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl367,370,804 - 67,452,397 (-)Ensembl
mRatBN7.2 Ensembl346,962,243 - 47,043,775 (-)Ensembl
Rnor_6.0 Ensembl348,291,055 - 48,372,672 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144910   ⟹   ENSRNOP00000107726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl367,373,291 - 67,452,422 (-)Ensembl
RefSeq Acc Id: NM_012789   ⟹   NP_036921
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8367,370,794 - 67,452,422 (-)NCBI
mRatBN7.2346,962,233 - 47,043,870 (-)NCBI
Rnor_6.0348,291,055 - 48,372,672 (-)NCBI
Rnor_5.0354,957,146 - 55,038,628 (-)NCBI
RGSC_v3.4344,279,255 - 44,360,283 (-)RGD
Celera346,603,336 - 46,685,074 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036921 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41096 (Get FASTA)   NCBI Sequence Viewer  
  AAA41272 (Get FASTA)   NCBI Sequence Viewer  
  EDL79005 (Get FASTA)   NCBI Sequence Viewer  
  EDL79006 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068881
GenBank Protein P14740 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036921   ⟸   NM_012789
- UniProtKB: P14740 (UniProtKB/Swiss-Prot),   A6HLV5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068881   ⟸   ENSRNOT00000085426
Ensembl Acc Id: ENSRNOP00000072092   ⟸   ENSRNOT00000077788
Ensembl Acc Id: ENSRNOP00000045536   ⟸   ENSRNOT00000040482
Ensembl Acc Id: ENSRNOP00000107726   ⟸   ENSRNOT00000144910
Protein Domains
Dipeptidyl peptidase 4 low complexity region   Dipeptidylpeptidase IV N-terminal   Peptidase S9 prolyl oligopeptidase catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14740-F1-model_v2 AlphaFold P14740 1-767 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692100
Promoter ID:EPDNEW_R2623
Type:initiation region
Name:Dpp4_1
Description:dipeptidylpeptidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0348,372,675 - 48,372,735EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2515 AgrOrtholog
BioCyc Gene G2FUF-49593 BioCyc
Ensembl Genes ENSRNOG00000030763 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000085426 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
  Dipeptidylpeptidase IV, N-terminal domain UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  DPPIV_rep UniProtKB/Swiss-Prot
  Pept_S9_AS UniProtKB/Swiss-Prot
  Peptidase_S9 UniProtKB/Swiss-Prot
  Peptidase_S9B_N UniProtKB/Swiss-Prot
  Serine_Prot_S9B/DPPIV_sf UniProtKB/Swiss-Prot
KEGG Report rno:25253 UniProtKB/Swiss-Prot
NCBI Gene 25253 ENTREZGENE
PANTHER DIPEPTIDYL PEPTIDASE 4 UniProtKB/Swiss-Prot
  PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED UniProtKB/Swiss-Prot
Pfam DPPIV_N UniProtKB/Swiss-Prot
  DPPIV_rep UniProtKB/Swiss-Prot
  Peptidase_S9 UniProtKB/Swiss-Prot
PhenoGen Dpp4 PhenoGen
PROSITE PRO_ENDOPEP_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030763 RatGTEx
Superfamily-SCOP DPP6 N-terminal domain-like UniProtKB/Swiss-Prot
  SSF53474 UniProtKB/Swiss-Prot
TIGR TC229485
UniProt A0A0G2JTX5_RAT UniProtKB/TrEMBL
  A0A0G2K238_RAT UniProtKB/TrEMBL
  A0ABK0LYN6_RAT UniProtKB/TrEMBL
  A6HLV4_RAT UniProtKB/TrEMBL
  A6HLV5 ENTREZGENE, UniProtKB/TrEMBL
  DPP4_RAT UniProtKB/Swiss-Prot
  F1M7X5_RAT UniProtKB/TrEMBL
  P14740 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Dpp4  Dipeptidyl peptidase 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_other genetic deficiency of dipeptidyl peptidase IV is noted in the F344/DuCrj strain 728469