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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2515
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dpp4
Name: dipeptidylpeptidase 4
Acc ID: CHEBI:71272
Term: saxagliptin
Definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes.
Chemical ID: MESH:C502994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dpp4decreases expressionEXP 6480464CTDsaxagliptin results in decreased expression of DPP4 proteinPMID:25446674
Dpp4multiple interactionsEXP 6480464CTDsaxagliptin inhibits the reaction [Rotenone results in increased expression of DPP4 protein]PMID:25446674
Dpp4decreases activityISODPP4 (Homo sapiens)6480464CTDsaxagliptin results in decreased activity of DPP4 proteinPMID:21186796 PMID:21388136
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