RGD Reference Report - Activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats with dopamine deficiency-dependent MPTP-induced depressive syndrome. - Rat Genome Database

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Activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats with dopamine deficiency-dependent MPTP-induced depressive syndrome.

Authors: Krupina, NA  Zolotov, NN  Bogdanova, NG  Orlova, IN  Khlebnikova, NN  Kryzhanovskii, GN 
Citation: Krupina NA, etal., Bull Exp Biol Med. 2006 Nov;142(5):554-6.
RGD ID: 1626457
Pubmed: PMID:17415460   (View Abstract at PubMed)

The development of MPTP-induced depressive syndrome in rats was accompanied by activation of prolyl endopeptidase and dipeptidyl peptidase IV in the brain frontal cortex. Prolyl endopeptidase activity in the striatum also increased under these conditions. Our results indicate that proline-specific peptidases in the target structures of the brain dopaminergic system are involved in the pathogenesis of dopamine deficiency-dependent depressive states.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
depressive disorder  ISOPrep (Rattus norvegicus)1626457; 1626457protein:altered activity:frontal cortex more ...RGD 
depressive disorder  IEP 1626457protein:altered activity:frontal cortex more ...RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases activityISODpp4 (Rattus norvegicus)1626457; 1626457MPTP increases activity of Dpp4 protein in the frontal cortex and nucleus accumbensRGD 
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases activityEXP 1626457MPTP increases activity of Dpp4 protein in the frontal cortex and nucleus accumbensRGD 
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOPrep (Rattus norvegicus)1626457; 1626457MPTP increases activity of Prep protein in the frontal cortex and striatum and MPTP decreases activity of Prep protein in the hypothalamusRGD 
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsEXP 1626457MPTP increases activity of Prep protein in the frontal cortex and striatum and MPTP decreases activity of Prep protein in the hypothalamusRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein catabolic process  IDA 1626457; 1626457 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dipeptidyl-peptidase activity  IDA 1626457 RGD 
endopeptidase activity  IDA 1626457 RGD 
peptide binding  IDA 1626457; 1626457 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dpp4  (dipeptidylpeptidase 4)
Prep  (prolyl endopeptidase)

Genes (Mus musculus)
Dpp4  (dipeptidylpeptidase 4)
Prep  (prolyl endopeptidase)

Genes (Homo sapiens)
DPP4  (dipeptidyl peptidase 4)
PREP  (prolyl endopeptidase)


Additional Information