Dcc (DCC netrin 1 receptor) - Rat Genome Database

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Gene: Dcc (DCC netrin 1 receptor) Rattus norvegicus
Analyze
Symbol: Dcc
Name: DCC netrin 1 receptor
RGD ID: 2492
Description: Enables identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in several processes, including nervous system development; positive regulation of ERK1 and ERK2 cascade; and response to amphetamine. Located in growth cone membrane. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil; androgen antagonist.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: colorectal tumor suppressor; Deleted in colcorectal cancer (rat homolog); deleted in colorectal carcinoma; netrin receptor DCC; putative colorectal tumor suppressor; tumor suppressor protein DCC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: DccTn(sb-T2/Bart3)2.205Mcwi
Genetic Models: F344-DccTn(sb-T2/Bart3)2.205Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81867,144,272 - 68,248,159 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1867,149,179 - 68,247,541 (-)EnsemblGRCr8
mRatBN7.21864,868,987 - 65,972,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1864,873,898 - 65,972,740 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1866,947,462 - 68,060,043 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01867,635,044 - 68,751,656 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01865,475,745 - 66,586,354 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01866,518,213 - 67,629,801 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1866,523,120 - 67,224,566 (-)Ensemblrn6Rnor6.0
Rnor_5.01865,688,901 - 66,793,126 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41868,026,795 - 69,140,741 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1862,907,666 - 64,001,277 (-)NCBICelera
RGSC_v3.11868,099,995 - 69,213,942 (-)NCBI
Cytogenetic Map18q12.1-q12.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
androgen antagonist  (EXP)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
DDE  (EXP)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
fonofos  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead(0)  (ISO)
levamisole  (ISO)
linuron  (EXP)
methimazole  (EXP)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
nickel atom  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
parathion  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
Rutecarpine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
terbufos  (ISO)
tetraphene  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth. Antoine-Bertrand J, etal., Mol Biol Cell. 2011 Oct;22(19):3734-46. doi: 10.1091/mbc.E10-11-0917. Epub 2011 Aug 17.
2. Presenilin-dependent receptor processing is required for axon guidance. Bai G, etal., Cell. 2011 Jan 7;144(1):106-18. doi: 10.1016/j.cell.2010.11.053.
3. Depolarization recruits DCC to the plasma membrane of embryonic cortical neurons and enhances axon extension in response to netrin-1. Bouchard JF, etal., J Neurochem. 2008 Oct;107(2):398-417. Epub 2008 Sep 18.
4. The DCC gene: structural analysis and mutations in colorectal carcinomas. Cho KR, etal., Genomics 1994 Feb;19(3):525-31.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. DCC association with lipid rafts is required for netrin-1-mediated axon guidance. Herincs Z, etal., J Cell Sci. 2005 Apr 15;118(Pt 8):1687-92.
8. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
9. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Keino-Masu K, etal., Cell 1996 Oct 18;87(2):175-85.
10. Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Lin L, etal., Mol Cell Neurosci. 2005 Mar;28(3):547-55.
11. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Ly A, etal., Cell. 2008 Jun 27;133(7):1241-54. doi: 10.1016/j.cell.2008.05.030.
12. Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase. Ma W, etal., Structure. 2010 Nov 10;18(11):1502-11. doi: 10.1016/j.str.2010.08.011.
13. Positioned to inhibit: netrin-1 and netrin receptor expression after spinal cord injury. Manitt C, etal., J Neurosci Res. 2006 Dec;84(8):1808-20.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. Miyake S, etal., Cancer Res 1994 Jun 1;54(11):3007-10.
16. Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder. Moon C, etal., J Neuroimmunol. 2006 Mar;172(1-2):66-72. Epub 2005 Dec 6.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. Shekarabi M, etal., J Neurosci. 2005 Mar 23;25(12):3132-41.
24. [Clinical consideration with special reference to autopsy cases of malignant tumor in the oral cavity, treated with Bleomycin (author's transl)] Tanaka S, etal., Hiroshima Daigaku Shigaku Zasshi 1975;8(2):168-75.
25. Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Tang X, etal., Nat Cell Biol. 2008 Jun;10(6):698-706. doi: 10.1038/ncb1732. Epub 2008 May 11.
26. Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC). Taniguchi Y, etal., J Biol Chem 2003 Aug 15;278(33):30425-8. Epub 2003 Jul 2.
27. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Tcherkezian J, etal., Cell. 2010 May 14;141(4):632-44. doi: 10.1016/j.cell.2010.04.008. Epub 2010 Apr 29.
28. Expression of netrin-1 and its receptors DCC and neogenin in rat brain after ischemia. Tsuchiya A, etal., Brain Res. 2007 Jul 23;1159:1-7. Epub 2007 Jan 20.
29. Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain. Wei Z, etal., Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3572-7. doi: 10.1073/pnas.1016567108. Epub 2011 Feb 14.
30. Regulation of netrin-1 receptors by amphetamine in the adult brain. Yetnikoff L, etal., Neuroscience. 2007 Dec 19;150(4):764-73. Epub 2007 Oct 10.
Additional References at PubMed
PMID:2294591   PMID:9126737   PMID:9331350   PMID:15044543   PMID:15494733   PMID:15730872   PMID:16267219   PMID:17898206   PMID:18479186   PMID:18616430   PMID:18653556   PMID:19362703  
PMID:19616629   PMID:19858080   PMID:20628609   PMID:21085126   PMID:21656855   PMID:21820492   PMID:23230270   PMID:23291093   PMID:30626732   PMID:33771901  


Genomics

Comparative Map Data
Dcc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81867,144,272 - 68,248,159 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1867,149,179 - 68,247,541 (-)EnsemblGRCr8
mRatBN7.21864,868,987 - 65,972,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1864,873,898 - 65,972,740 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1866,947,462 - 68,060,043 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01867,635,044 - 68,751,656 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01865,475,745 - 66,586,354 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01866,518,213 - 67,629,801 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1866,523,120 - 67,224,566 (-)Ensemblrn6Rnor6.0
Rnor_5.01865,688,901 - 66,793,126 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41868,026,795 - 69,140,741 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1862,907,666 - 64,001,277 (-)NCBICelera
RGSC_v3.11868,099,995 - 69,213,942 (-)NCBI
Cytogenetic Map18q12.1-q12.2NCBI
DCC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381852,340,197 - 53,535,899 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1852,340,197 - 53,535,899 (+)Ensemblhg38GRCh38
GRCh371849,866,567 - 51,062,269 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361848,120,569 - 49,311,780 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341848,121,155 - 49,311,286NCBI
Celera1846,722,385 - 47,918,339 (+)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1846,722,887 - 47,917,133 (+)NCBIHuRef
CHM1_11849,861,521 - 51,057,237 (+)NCBICHM1_1
T2T-CHM13v2.01852,543,078 - 53,739,020 (+)NCBIT2T-CHM13v2.0
Dcc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391871,386,703 - 72,484,299 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1871,386,705 - 72,484,140 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381871,253,613 - 72,351,228 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1871,253,634 - 72,351,069 (-)Ensemblmm10GRCm38
MGSCv371871,413,286 - 72,510,723 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361871,384,359 - 72,475,947 (-)NCBIMGSCv36mm8
Celera1872,536,536 - 73,631,393 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1845.24NCBI
Dcc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540237,123,795 - 38,218,472 (+)Ensembl
ChiLan1.0NW_00495540237,123,112 - 38,218,876 (+)NCBIChiLan1.0ChiLan1.0
DCC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21769,864,630 - 71,059,880 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11855,557,246 - 56,752,486 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01845,717,924 - 46,913,998 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11849,060,454 - 50,255,116 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1849,268,812 - 50,255,155 (+)EnsemblpanPan2panpan1.1
DCC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,788,833 - 22,494,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,793,328 - 22,494,967 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha122,784,245 - 23,871,211 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0121,687,171 - 22,774,992 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,688,158 - 22,774,948 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,742,849 - 22,829,651 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,635,199 - 22,721,696 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,906,717 - 22,993,897 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dcc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494434,878,291 - 35,930,900 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649710,122,617 - 11,169,803 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649710,122,078 - 11,169,900 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1101,846,100 - 103,083,096 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11101,518,629 - 103,087,021 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21112,538,098 - 112,878,669 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DCC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11827,437,224 - 28,623,717 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1827,442,489 - 28,212,697 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660501,432,122 - 2,644,336 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dcc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477815,979,467 - 17,222,039 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477815,979,350 - 17,225,263 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dcc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11559,597,314 - 60,671,808 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dcc
8106 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:39
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000064947
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)186438376279484311Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
7794793Mcs34Mammary carcinoma susceptibility QTL 341.54mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)186563556785897775Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186160038472538878Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186289225779484461Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)186584644786134022Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186289225779484461Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Mgh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81868,120,234 - 68,120,379 (+)Marker Load Pipeline
mRatBN7.21865,844,950 - 65,845,095 (+)MAPPERmRatBN7.2
Rnor_6.01867,502,122 - 67,502,266NCBIRnor6.0
Rnor_5.01866,665,061 - 66,665,205UniSTSRnor5.0
RGSC_v3.41869,013,304 - 69,013,448UniSTSRGSC3.4
RGSC_v3.41869,013,303 - 69,013,448RGDRGSC3.4
Celera1863,873,881 - 63,874,025UniSTS
RGSC_v3.11869,086,504 - 69,086,649RGD
RH 3.4 Map18685.3UniSTS
RH 3.4 Map18685.3RGD
RH 2.0 Map18224.7RGD
SHRSP x BN Map1838.7499RGD
FHH x ACI Map1848.5199RGD
Cytogenetic Map18q12.2UniSTS
D18Rat54  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81867,713,161 - 67,713,406 (+)Marker Load Pipeline
mRatBN7.21865,437,891 - 65,438,136 (+)MAPPERmRatBN7.2
Rnor_6.01867,088,773 - 67,089,017NCBIRnor6.0
Rnor_5.01866,259,249 - 66,259,493UniSTSRnor5.0
RGSC_v3.41868,596,212 - 68,596,646RGDRGSC3.4
RGSC_v3.41868,596,398 - 68,596,642UniSTSRGSC3.4
Celera1863,467,490 - 63,467,734UniSTS
RGSC_v3.11868,669,599 - 68,669,843RGD
RH 3.4 Map18686.6RGD
RH 3.4 Map18686.6UniSTS
RH 2.0 Map18217.9RGD
SHRSP x BN Map1838.7499RGD
FHH x ACI Map1848.6RGD
Cytogenetic Map18q12.2UniSTS
D18Rat85  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81867,421,416 - 67,421,612 (+)Marker Load Pipeline
mRatBN7.21865,146,129 - 65,146,325 (+)MAPPERmRatBN7.2
Rnor_6.01866,795,906 - 66,796,101NCBIRnor6.0
Rnor_5.01865,966,665 - 65,966,860UniSTSRnor5.0
RGSC_v3.41868,301,989 - 68,302,185RGDRGSC3.4
RGSC_v3.41868,301,990 - 68,302,185UniSTSRGSC3.4
RGSC_v3.11868,375,191 - 68,375,386RGD
RH 3.4 Map18669.7UniSTS
RH 3.4 Map18669.7RGD
RH 2.0 Map18220.8RGD
SHRSP x BN Map1838.7499RGD
Cytogenetic Map18q12.2UniSTS
D18Rat86  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81867,764,623 - 67,764,786 (+)Marker Load Pipeline
mRatBN7.21865,489,355 - 65,489,518 (+)MAPPERmRatBN7.2
Rnor_6.01867,137,630 - 67,137,792NCBIRnor6.0
Rnor_5.01866,308,106 - 66,308,268UniSTSRnor5.0
RGSC_v3.41868,648,158 - 68,648,320UniSTSRGSC3.4
RGSC_v3.41868,648,157 - 68,648,320RGDRGSC3.4
Celera1863,518,956 - 63,519,118UniSTS
RGSC_v3.11868,721,359 - 68,721,521RGD
RH 3.4 Map18668.4RGD
RH 3.4 Map18668.4UniSTS
RH 2.0 Map18218.2RGD
SHRSP x BN Map1838.7499RGD
Cytogenetic Map18q12.2UniSTS
D18Rat124  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81867,182,733 - 67,182,940 (+)Marker Load Pipeline
mRatBN7.21864,907,448 - 64,907,655 (+)MAPPERmRatBN7.2
Rnor_6.01866,556,675 - 66,556,881NCBIRnor6.0
Rnor_5.01865,727,363 - 65,727,569UniSTSRnor5.0
RGSC_v3.41868,060,350 - 68,060,556UniSTSRGSC3.4
RGSC_v3.41868,060,349 - 68,060,556RGDRGSC3.4
Celera1862,941,217 - 62,941,423UniSTS
RGSC_v3.11868,133,550 - 68,133,757RGD
SHRSP x BN Map1838.7499RGD
SHRSP x BN Map1838.7499UniSTS
Cytogenetic Map18q12.2UniSTS
D18Chm58  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81867,461,199 - 67,461,385 (+)Marker Load Pipeline
mRatBN7.21865,185,912 - 65,186,096 (+)MAPPERmRatBN7.2
Rnor_6.01866,835,772 - 66,835,959NCBIRnor6.0
Rnor_5.01866,006,531 - 66,006,718UniSTSRnor5.0
RGSC_v3.41868,344,039 - 68,344,226UniSTSRGSC3.4
Celera1863,216,536 - 63,216,723UniSTS
Cytogenetic Map18q12.2UniSTS
D18Chm59  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21865,970,331 - 65,970,689 (+)MAPPERmRatBN7.2
mRatBN7.21865,970,534 - 65,970,689 (+)MAPPERmRatBN7.2
Rnor_6.01867,627,706 - 67,628,100NCBIRnor6.0
Rnor_6.01867,627,948 - 67,628,100NCBIRnor6.0
Rnor_5.01866,790,887 - 66,791,039UniSTSRnor5.0
Rnor_5.01866,790,645 - 66,791,039UniSTSRnor5.0
RGSC_v3.41869,138,888 - 69,139,040UniSTSRGSC3.4
Celera1863,999,424 - 63,999,576UniSTS
Cytogenetic Map18q12.2UniSTS
D18Got123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21865,489,317 - 65,489,445 (+)MAPPERmRatBN7.2
Rnor_6.01867,137,592 - 67,137,719NCBIRnor6.0
Rnor_5.01866,308,068 - 66,308,195UniSTSRnor5.0
RGSC_v3.41868,648,120 - 68,648,247UniSTSRGSC3.4
Celera1863,518,918 - 63,519,045UniSTS
Cytogenetic Map18q12.2UniSTS
D18Got129  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21865,951,714 - 65,951,978 (+)MAPPERmRatBN7.2
Rnor_6.01867,608,886 - 67,609,149NCBIRnor6.0
Rnor_5.01866,771,825 - 66,772,088UniSTSRnor5.0
RGSC_v3.41869,120,068 - 69,120,331UniSTSRGSC3.4
Celera1863,980,604 - 63,980,867UniSTS
Cytogenetic Map18q12.2UniSTS
BE105775  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21865,945,491 - 65,945,643 (+)MAPPERmRatBN7.2
Rnor_6.01867,602,663 - 67,602,814NCBIRnor6.0
Rnor_5.01866,765,602 - 66,765,753UniSTSRnor5.0
RGSC_v3.41869,113,845 - 69,113,996UniSTSRGSC3.4
Celera1863,974,381 - 63,974,532UniSTS
RH 3.4 Map18669.2UniSTS
Cytogenetic Map18q12.2UniSTS
BE106373  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21865,379,460 - 65,379,610 (+)MAPPERmRatBN7.2
Rnor_6.01867,030,002 - 67,030,151NCBIRnor6.0
Rnor_5.01866,200,478 - 66,200,627UniSTSRnor5.0
RGSC_v3.41868,537,952 - 68,538,101UniSTSRGSC3.4
Celera1863,409,056 - 63,409,205UniSTS
RH 3.4 Map18686.8UniSTS
Cytogenetic Map18q12.2UniSTS
BE107748  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21864,970,751 - 64,970,930 (+)MAPPERmRatBN7.2
Rnor_6.01866,620,001 - 66,620,179NCBIRnor6.0
Rnor_5.01865,790,689 - 65,790,867UniSTSRnor5.0
RGSC_v3.41868,124,234 - 68,124,412UniSTSRGSC3.4
Celera1863,004,034 - 63,004,212UniSTS
RH 3.4 Map18669.8UniSTS
Cytogenetic Map18q12.2UniSTS
AU048327  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1863,250,217 - 63,250,356UniSTS
Cytogenetic Map18q12.2UniSTS
BE118490  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21865,418,871 - 65,419,024 (+)MAPPERmRatBN7.2
Rnor_6.01867,069,413 - 67,069,565NCBIRnor6.0
Rnor_5.01866,239,889 - 66,240,041UniSTSRnor5.0
RGSC_v3.41868,577,379 - 68,577,531UniSTSRGSC3.4
Celera1863,448,456 - 63,448,608UniSTS
RH 3.4 Map18668.4UniSTS
Cytogenetic Map18q12.2UniSTS
AW520939  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21865,920,113 - 65,920,268 (+)MAPPERmRatBN7.2
Rnor_6.01867,577,286 - 67,577,440NCBIRnor6.0
Rnor_5.01866,740,225 - 66,740,379UniSTSRnor5.0
RGSC_v3.41869,088,465 - 69,088,619UniSTSRGSC3.4
Celera1863,949,003 - 63,949,157UniSTS
RH 3.4 Map18670.3UniSTS
Cytogenetic Map18q12.2UniSTS
AU048796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21865,707,722 - 65,707,889 (+)MAPPERmRatBN7.2
Rnor_6.01867,362,348 - 67,362,514NCBIRnor6.0
Rnor_5.01866,526,004 - 66,526,170UniSTSRnor5.0
RGSC_v3.41868,875,770 - 68,875,936UniSTSRGSC3.4
Celera1863,737,244 - 63,737,413UniSTS
Cytogenetic Map18q12.2UniSTS
GDB:201899  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21865,296,271 - 65,296,426 (+)MAPPERmRatBN7.2
Rnor_6.01866,946,261 - 66,946,415NCBIRnor6.0
Rnor_5.01866,117,020 - 66,117,174UniSTSRnor5.0
RGSC_v3.41868,454,925 - 68,455,079UniSTSRGSC3.4
Celera1863,326,809 - 63,326,963UniSTS
Cytogenetic Map18q12.2UniSTS


Genetic Models
This gene Dcc is modified in the following models/strains:
F344-DccTn(sb-T2/Bart3)2.205Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 7 27 140 42 38 22 12 22 6 131 61 11 124 35 62 16 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000064947   ⟹   ENSRNOP00000063072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1867,149,179 - 67,849,042 (-)Ensembl
mRatBN7.2 Ensembl1864,873,898 - 65,573,781 (-)Ensembl
Rnor_6.0 Ensembl1866,523,120 - 67,224,566 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101171   ⟹   ENSRNOP00000096451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1867,149,179 - 68,247,541 (-)Ensembl
mRatBN7.2 Ensembl1864,873,898 - 65,972,740 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000124479   ⟹   ENSRNOP00000102890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1867,149,179 - 68,066,389 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150851   ⟹   ENSRNOP00000101128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1867,149,179 - 68,066,389 (-)Ensembl
RefSeq Acc Id: NM_012841   ⟹   NP_036973
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81867,149,179 - 68,247,674 (-)NCBI
mRatBN7.21864,873,894 - 65,972,390 (-)NCBI
Rnor_6.01866,523,120 - 67,629,801 (-)NCBI
Rnor_5.01865,688,901 - 66,793,126 (-)NCBI
RGSC_v3.41868,026,795 - 69,140,741 (-)RGD
Celera1862,907,666 - 64,001,277 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772087   ⟹   XP_008770309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81867,144,272 - 68,248,159 (-)NCBI
mRatBN7.21864,868,987 - 65,972,783 (-)NCBI
Rnor_6.01866,518,213 - 67,629,589 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096588   ⟹   XP_038952516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81867,144,272 - 68,074,273 (-)NCBI
mRatBN7.21864,868,987 - 65,790,814 (-)NCBI
RefSeq Acc Id: XM_039096590   ⟹   XP_038952518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81867,144,272 - 67,471,436 (-)NCBI
mRatBN7.21864,868,987 - 65,195,862 (-)NCBI
RefSeq Acc Id: XM_063277118   ⟹   XP_063133188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81867,144,272 - 68,074,273 (-)NCBI
RefSeq Acc Id: XM_063277119   ⟹   XP_063133189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81867,144,272 - 68,074,274 (-)NCBI
RefSeq Acc Id: XM_063277120   ⟹   XP_063133190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81867,144,272 - 68,248,110 (-)NCBI
RefSeq Acc Id: XM_063277121   ⟹   XP_063133191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81867,144,272 - 68,074,273 (-)NCBI
RefSeq Acc Id: XM_063277122   ⟹   XP_063133192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81867,144,272 - 68,074,273 (-)NCBI
RefSeq Acc Id: NP_036973   ⟸   NM_012841
- Peptide Label: precursor
- UniProtKB: Q63155 (UniProtKB/Swiss-Prot),   F1LRN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770309   ⟸   XM_008772087
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ATC8 (UniProtKB/TrEMBL),   F1LRN5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063072   ⟸   ENSRNOT00000064947
RefSeq Acc Id: XP_038952516   ⟸   XM_039096588
- Peptide Label: isoform X1
- UniProtKB: F1LRN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952518   ⟸   XM_039096590
- Peptide Label: isoform X8
Ensembl Acc Id: ENSRNOP00000096451   ⟸   ENSRNOT00000101171
RefSeq Acc Id: XP_063133190   ⟸   XM_063277120
- Peptide Label: isoform X5
- UniProtKB: F1LRN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133189   ⟸   XM_063277119
- Peptide Label: isoform X4
- UniProtKB: F1LRN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133192   ⟸   XM_063277122
- Peptide Label: isoform X7
- UniProtKB: F1LRN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133191   ⟸   XM_063277121
- Peptide Label: isoform X6
- UniProtKB: F1LRN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133188   ⟸   XM_063277118
- Peptide Label: isoform X2
- UniProtKB: F1LRN5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102890   ⟸   ENSRNOT00000124479
Ensembl Acc Id: ENSRNOP00000101128   ⟸   ENSRNOT00000150851
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type   Immunoglobulin I-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63155-F1-model_v2 AlphaFold Q63155 1-1445 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2492 AgrOrtholog
BioCyc Gene G2FUF-7064 BioCyc
Ensembl Genes ENSRNOG00000033099 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064947 ENTREZGENE
  ENSRNOT00000101171 ENTREZGENE
  ENSRNOT00000124479 ENTREZGENE
  ENSRNOT00000150851 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Neogenin_C UniProtKB/Swiss-Prot
KEGG Report rno:25311 UniProtKB/Swiss-Prot
NCBI Gene 25311 ENTREZGENE
PANTHER PROTEIN SIDEKICK UniProtKB/Swiss-Prot
  PTHR44170:SF8 UniProtKB/Swiss-Prot
Pfam fn3 UniProtKB/Swiss-Prot
  I-set UniProtKB/Swiss-Prot
  Ig_2 UniProtKB/Swiss-Prot
  Neogenin_C UniProtKB/Swiss-Prot
PhenoGen Dcc PhenoGen
PRINTS FNTYPEIII UniProtKB/Swiss-Prot
PROSITE FN3 UniProtKB/Swiss-Prot
  IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033099 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
  IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
UniProt A0A8I6ATC8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0KZX1_RAT UniProtKB/TrEMBL
  A0ABK0L2C4_RAT UniProtKB/TrEMBL
  A6IY11_RAT UniProtKB/TrEMBL
  DCC_RAT UniProtKB/Swiss-Prot
  F1LRN5 ENTREZGENE, UniProtKB/TrEMBL
  Q63153_RAT UniProtKB/TrEMBL
  Q63154_RAT UniProtKB/TrEMBL
  Q63155 ENTREZGENE
  Q78EE6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Dcc  Deleted in colcorectal cancer (rat homolog)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains transmembrane domains 729062
gene_expression expressed on spinal commissural axons 729062
gene_function receptor that mediates the guidance effects of netrin-1 on commissural axons 729062
gene_function cell surface receptor that mediates intracellular signalling pathways 1298870
gene_function gamma-secretase-dependent transcription coactivator 1298870
gene_physical_interaction binds to netrin-1 729062
gene_regulation subjected to transmembranous proteolysis processing by presenilin-gamma-secretase, resulting in membrane-bound DCC-intracellular domains (DCC-ICDs) 1298870