Cyp7b1 (cytochrome P450 family 7 subfamily B member 1) - Rat Genome Database

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Gene: Cyp7b1 (cytochrome P450 family 7 subfamily B member 1) Rattus norvegicus
Analyze
Symbol: Cyp7b1
Name: cytochrome P450 family 7 subfamily B member 1
RGD ID: 2483
Description: Predicted to enable steroid hydroxylase activity. Involved in several processes, including circadian rhythm; memory; and response to cAMP. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (cytochrome P450 family 7 subfamily B member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 25-hydroxycholesterol 7-alpha-hydroxylase; Cytochrom P450; cytochrome P450 7B1; cytochrome P450, family 7, subfamily b, polypeptide 1; cytochrome P450, subfamily 7B, polypeptide 1; HCT-1; hippocampal transcript 1 protein; oxysterol 7-alpha-hydroxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi
Genetic Models: F344-Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82102,419,011 - 102,586,047 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2102,419,011 - 102,451,804 (-)EnsemblGRCr8
mRatBN7.22100,502,791 - 100,669,713 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2100,502,791 - 100,669,698 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2107,017,449 - 107,190,606 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02105,138,553 - 105,311,712 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02100,132,313 - 100,164,609 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02102,701,903 - 102,871,257 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2102,701,903 - 102,871,257 (-)Ensemblrn6Rnor6.0
Rnor_5.02122,442,002 - 122,610,354 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42103,102,679 - 103,271,273 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera295,908,860 - 96,075,269 (-)NCBICelera
RGSC_v3.12103,048,320 - 103,073,714 (-)NCBI
RH 3.4 Map2606.1RGD
Cytogenetic Map2q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-arachidonoylglycerol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetaldehyde  (ISO)
Acetyl tributyl citrate  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
androstane-3,17-diol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
chlorotoluron  (ISO)
cholesterol  (EXP)
cholic acid  (ISO)
choline  (ISO)
ciprofibrate  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
fenofibrate  (EXP)
flumequine  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
griseofulvin  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
herbicide  (ISO)
hexachlorobenzene  (EXP)
ibuprofen  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lycopene  (ISO)
MeIQx  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxyacetic acid  (EXP)
methylmercury chloride  (EXP)
metronidazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
oleanolic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phytosterols  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
resveratrol  (ISO)
rifaximin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
taurocholic acid  (EXP)
taurodeoxycholic acid  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zaragozic acid A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. Pandak WM, etal., Hepatology 2002 Jun;35(6):1400-8.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat. Ren S, etal., Metabolism 2003 May;52(5):636-42.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. A novel cytochrome P450 expressed primarily in brain. Stapleton G, etal., J Biol Chem 1995 Dec 15;270(50):29739-45.
17. [Clinical consideration with special reference to autopsy cases of malignant tumor in the oral cavity, treated with Bleomycin (author's transl)] Tanaka S, etal., Hiroshima Daigaku Shigaku Zasshi 1975;8(2):168-75.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats. Yau JL, etal., J Neurosci. 2006 Oct 25;26(43):11034-40.
Additional References at PubMed
PMID:10748047   PMID:12370428   PMID:12914530   PMID:18395092   PMID:21029595   PMID:22384504   PMID:22999953   PMID:25263657  


Genomics

Comparative Map Data
Cyp7b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82102,419,011 - 102,586,047 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2102,419,011 - 102,451,804 (-)EnsemblGRCr8
mRatBN7.22100,502,791 - 100,669,713 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2100,502,791 - 100,669,698 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2107,017,449 - 107,190,606 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02105,138,553 - 105,311,712 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02100,132,313 - 100,164,609 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02102,701,903 - 102,871,257 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2102,701,903 - 102,871,257 (-)Ensemblrn6Rnor6.0
Rnor_5.02122,442,002 - 122,610,354 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42103,102,679 - 103,271,273 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera295,908,860 - 96,075,269 (-)NCBICelera
RGSC_v3.12103,048,320 - 103,073,714 (-)NCBI
RH 3.4 Map2606.1RGD
Cytogenetic Map2q24NCBI
CYP7B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38864,586,575 - 64,798,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl864,587,763 - 64,799,145 (-)Ensemblhg38GRCh38
GRCh37865,499,132 - 65,711,294 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36865,671,246 - 65,873,902 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34865,671,245 - 65,873,902NCBI
Celera861,498,536 - 61,701,760 (-)NCBICelera
Cytogenetic Map8q12.3NCBI
HuRef860,998,772 - 61,201,422 (-)NCBIHuRef
CHM1_1865,562,219 - 65,765,057 (-)NCBICHM1_1
T2T-CHM13v2.0865,011,997 - 65,224,254 (-)NCBIT2T-CHM13v2.0
Cyp7b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39318,126,108 - 18,298,054 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl318,126,114 - 18,297,502 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38318,071,944 - 18,243,890 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl318,071,950 - 18,243,338 (-)Ensemblmm10GRCm38
MGSCv37317,971,950 - 18,143,338 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36318,264,101 - 18,435,480 (-)NCBIMGSCv36mm8
Celera318,067,760 - 18,239,527 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map34.98NCBI
LOC102022645
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544414,275,345 - 14,444,426 (+)Ensembl
ChiLan1.0NW_00495544414,274,818 - 14,446,068 (+)NCBIChiLan1.0ChiLan1.0
CYP7B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2780,323,834 - 80,531,320 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1855,962,915 - 56,170,378 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0861,135,307 - 61,335,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1862,806,129 - 63,006,450 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl862,806,637 - 63,006,386 (-)EnsemblpanPan2panpan1.1
CYP7B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12914,443,036 - 14,613,839 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2914,444,853 - 14,613,755 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2914,762,658 - 14,936,799 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02914,537,942 - 14,712,338 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2914,537,947 - 14,712,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12914,550,483 - 14,724,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02914,664,658 - 14,838,558 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02914,932,049 - 15,106,453 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101955077
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530365,707,508 - 65,885,081 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364968,899,965 - 9,072,089 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364968,900,320 - 9,072,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP7B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl469,616,049 - 69,806,496 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1469,615,953 - 69,793,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2475,915,950 - 75,973,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP7B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1860,496,607 - 60,691,457 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl860,496,733 - 60,524,238 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603981,044,277 - 81,069,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101721563
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474426,792,890 - 26,991,425 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474426,791,829 - 26,999,584 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116895947
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13135,891,008 - 135,999,449 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyp7b1
1542 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:87
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000013116
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
D2Got54  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02102,774,990 - 102,775,099NCBIRnor6.0
Rnor_5.02122,515,089 - 122,515,198UniSTSRnor5.0
RGSC_v3.42103,176,564 - 103,176,680UniSTSRGSC3.4
RGSC_v3.42103,176,563 - 103,176,680RGDRGSC3.4
Celera295,981,934 - 95,982,050UniSTS
RGSC_v3.12103,121,526 - 103,121,642RGD
RH 3.4 Map2623.3RGD
RH 3.4 Map2623.3UniSTS
RH 2.0 Map2506.9RGD
Cytogenetic Map2q24UniSTS
RH94670  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82102,419,692 - 102,419,855 (+)Marker Load Pipeline
mRatBN7.22100,503,471 - 100,503,635 (+)MAPPERmRatBN7.2
Rnor_6.02102,702,584 - 102,702,747NCBIRnor6.0
Rnor_5.02122,442,683 - 122,442,846UniSTSRnor5.0
RGSC_v3.42103,103,573 - 103,103,736UniSTSRGSC3.4
Celera295,909,541 - 95,909,704UniSTS
RH 3.4 Map2606.1UniSTS
Cytogenetic Map2q24UniSTS
AU049273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22100,554,056 - 100,554,228 (+)MAPPERmRatBN7.2
Rnor_6.02102,753,172 - 102,753,343NCBIRnor6.0
Rnor_5.02122,493,271 - 122,493,442UniSTSRnor5.0
RGSC_v3.42103,154,747 - 103,154,918UniSTSRGSC3.4
Celera295,960,122 - 95,960,293UniSTS
Cytogenetic Map2q24UniSTS
ECD14651  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02122,514,089 - 122,515,145UniSTSRnor5.0
RGSC_v3.42103,175,565 - 103,176,628UniSTSRGSC3.4
Celera295,980,935 - 95,981,998UniSTS
Cytogenetic Map2q24UniSTS


Genetic Models
This gene Cyp7b1 is modified in the following models/strains:
F344-Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 63 59 6 326 163 11 141 80 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000013116   ⟹   ENSRNOP00000013116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2100,502,791 - 100,669,698 (-)Ensembl
Rnor_6.0 Ensembl2102,701,903 - 102,871,257 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082084   ⟹   ENSRNOP00000073111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2102,419,011 - 102,451,804 (-)Ensembl
mRatBN7.2 Ensembl2100,502,791 - 100,535,586 (-)Ensembl
Rnor_6.0 Ensembl2102,702,689 - 102,838,745 (-)Ensembl
RefSeq Acc Id: NM_019138   ⟹   NP_062011
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82102,419,011 - 102,585,905 (-)NCBI
mRatBN7.22100,502,791 - 100,669,698 (-)NCBI
Rnor_6.02102,701,903 - 102,871,257 (-)NCBI
Rnor_5.02122,442,002 - 122,610,354 (-)NCBI
RGSC_v3.42103,102,679 - 103,271,273 (-)RGD
Celera295,908,860 - 96,075,269 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101794   ⟹   XP_038957722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82102,419,477 - 102,586,047 (-)NCBI
mRatBN7.22100,503,928 - 100,669,713 (-)NCBI
RefSeq Acc Id: XM_063281357   ⟹   XP_063137427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82102,419,477 - 102,585,800 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062011 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957722 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137427 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA92616 (Get FASTA)   NCBI Sequence Viewer  
  EDM01054 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073111
GenBank Protein Q63688 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062011   ⟸   NM_019138
- UniProtKB: A6IHA6 (UniProtKB/TrEMBL),   G3V787 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073111   ⟸   ENSRNOT00000082084
Ensembl Acc Id: ENSRNOP00000013116   ⟸   ENSRNOT00000013116
RefSeq Acc Id: XP_038957722   ⟸   XM_039101794
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137427   ⟸   XM_063281357
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4N5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63688-F1-model_v2 AlphaFold Q63688 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691251
Promoter ID:EPDNEW_R1776
Type:initiation region
Name:Cyp7b1_1
Description:cytochrome P450 family 7 subfamily B member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02102,871,237 - 102,871,297EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2483 AgrOrtholog
BioCyc Gene G2FUF-53640 BioCyc
Ensembl Genes ENSRNOG00000009730 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000082084 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro CYP450_sterol_14alpha_dmase UniProtKB/Swiss-Prot
  Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report rno:25429 UniProtKB/Swiss-Prot
NCBI Gene 25429 ENTREZGENE
PANTHER CYTOCHROME P450 7B1 UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 7 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp7b1 PhenoGen
PRINTS EP450IV UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009730 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
TIGR TC220574
UniProt A0A0G2K4N5 ENTREZGENE, UniProtKB/TrEMBL
  A6IHA6 ENTREZGENE, UniProtKB/TrEMBL
  CP7B1_RAT UniProtKB/Swiss-Prot
  G3V787 ENTREZGENE
  Q63688 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp7b1  cytochrome P450, family 7, subfamily b, polypeptide 1    cytochrome P450, subfamily 7B, polypeptide 1  Name updated 1299863 APPROVED
2002-11-06 Cyp7b1  cytochrome P450, subfamily 7B, polypeptide 1    Cytochrom P450  Name updated 625702 APPROVED
2002-06-10 Cyp7b1  Cytochrom P450      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains possesses a steroidogenic domain 1298867
gene_expression expressed at low levels in testis, ovary and adrenal gland 1298867
gene_expression taurocholic acid and taurodeoxycholic acid decrease expression in primary hepatocytes 1298868
gene_expression expression is enriched in brain, liver and kidney 1298867
gene_expression expression is sexually dimorphic in liver but not in brain 1298867
gene_process may metabolize steroids in brain 1298867
gene_regulation squalestatin added to primary hepatocytes decreases enzymatic activity 1298868
gene_regulation cholesterol, phorbol myristate acetate (PMA) or cyclic AMP (cAMP) added to primary hepatocytes increase enzymatic activity 1298868