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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2483
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7b1
Name: cytochrome P450 family 7 subfamily B member 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7b1decreases expressionISOCyp7b1 (Mus musculus)6480464CTDOzone results in decreased expression of CYP7B1 mRNAPMID:16183385
Cyp7b1increases expressionISOCyp7b1 (Mus musculus)6480464CTDOzone results in increased expression of CYP7B1 mRNAPMID:21543283
Cyp7b1multiple interactionsISOCyp7b1 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of CYP7B1 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of CYP7B1 mRNA; [NOTCH3 gene mutant form affects the susceptibility to Ozone] which results in increased expression of CYP7B1 mRNAPMID:24381131 PMID:25658374 PMID:34911549
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