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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2483
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7b1
Name: cytochrome P450 family 7 subfamily B member 1
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7b1decreases expressionISOCyp7b1 (Mus musculus)6480464CTDtitanium dioxide results in decreased expression of CYP7B1 mRNAPMID:31298478
Cyp7b1increases expressionISOCyp7b1 (Mus musculus)6480464CTDtitanium dioxide results in increased expression of CYP7B1 mRNAPMID:23557971 PMID:27760801
Cyp7b1multiple interactionsISOCyp7b1 (Mus musculus)6480464CTD[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CYP7B1 mRNA; Resveratrol inhibits the reaction [titanium dioxide results in decreased expression of CYP7B1 mRNA]PMID:29950665 PMID:31298478
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