Cyp11b2 (cytochrome P450, family 11, subfamily b, polypeptide 2) - Rat Genome Database

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Gene: Cyp11b2 (cytochrome P450, family 11, subfamily b, polypeptide 2) Rattus norvegicus
Analyze
Symbol: Cyp11b2 (Ensembl: Cyp11b3)
Name: cytochrome P450, family 11, subfamily b, polypeptide 2 (Ensembl:cytochrome P450, family 11, subfamily b, polypeptide 3)
RGD ID: 2454
Description: Enables corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to potassium ion starvation; and steroid hormone biosynthetic process. Located in dendrite. Used to study heart disease; hypertension; and myocardial infarction. Biomarker of congestive heart failure; hypertension; myocarditis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia; glucocorticoid-remediable aldosteronism; and primary hyperaldosteronism. Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1); PARTICIPATES IN C21-steroid hormone biosynthetic pathway; 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALDOS; aldosterone synthase; aldosterone-synthesizing enzyme; corticosterone 18-monooxygenase, CYP11B2; Cp45as; Cyp11b3; CYPXIB2; CYPXIB3; cytochrome P-450 11B3; cytochrome P-450Aldo; cytochrome P-450C18; cytochrome P450 11B2, mitochondrial; cytochrome P450 11B3, mitochondrial; Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase); cytochrome P450(11beta,aldo); cytochrome P450, subfamily 11B, polypeptide 2; Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase); cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; P450(11beta,aldo); P450-Aldo-1; P450-Aldo-2; RNCP45AS; steroid 11-beta-hydroxylase; steroid 11-beta-hydroxylase, CYP11B2; steroid 18-hydroxylase
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Cyp11b2m1  
Is Marker For: Strains:   SS.LEW-(D7Rat73-D7Rat128)/Ayd   LEW.SS-(D7Rat73-D7Rat128)/Ayd  
Candidate Gene For: Eau6
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,719,349 - 108,726,024 (-)NCBIGRCr8
mRatBN7.27106,838,590 - 106,845,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,838,590 - 106,845,004 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,564,515 - 108,570,947 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,788,181 - 110,794,613 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,734,122 - 110,740,554 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,248,759 - 116,255,205 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,156,219 - 116,255,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07116,151,128 - 116,157,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,043,365 - 113,049,779 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17113,077,595 - 113,084,003 (-)NCBI
Celera7103,210,977 - 103,217,398 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
Cyp11b2Ratadrenal cortical adenoma  ISOCYP11B2 (Homo sapiens)4891170mRNA:increased expression:adrenal gland (human)RGD 
Cyp11b2RatAlbuminuria  IMP 2307307 RGD 
Cyp11b2RatCardiomegaly  IMP 2307307 RGD 
Cyp11b2Ratcongestive heart failure  IEP 4891162protein:increased expression:heart (rat)RGD 
Cyp11b2RatDiabetic Nephropathies susceptibilityISOCYP11B2 (Homo sapiens)2307295associated with Diabetes Mellitus more ...RGD 
Cyp11b2RatExperimental Diabetes Mellitus  IEP 2307289mRNA:increased expression:kidneyRGD 
Cyp11b2RatFetal Growth Retardation  IEP 4891147mRNA:increased expression:fetus and adrenal gland (rat)RGD 
Cyp11b2RatFibrosis  IEP 4891377protein:increased expression:liver (rat)RGD 
Cyp11b2Ratheart disease  IMP 2307309 RGD 
Cyp11b2Rathypertension  ISOCYP11B2 (Homo sapiens)4891152DNA:transition:5' utr:-344C>T (human)RGD 
Cyp11b2Rathypertension  IEP 4891156mRNA:increased expression:brainstem more ...RGD 
Cyp11b2Rathypertension  IMP 2307304 RGD 
Cyp11b2RatHypoaldosteronism  ISOCYP11B2 (Homo sapiens)1600824CMO II deficiency more ...RGD 
Cyp11b2RatLeft Ventricular Hypertrophy  ISOCYP11B2 (Homo sapiens)4891150DNA:transition:5' utr:-344C>T (human)RGD 
Cyp11b2RatLeft Ventricular Hypertrophy no_associationISOCYP11B2 (Homo sapiens)4891151DNA:transition:5' utr:-344C>T (human)RGD 
Cyp11b2RatMetabolic Syndrome susceptibilityISOCYP11B2 (Homo sapiens)2307294DNA:polymorphism:promoter:-344C>T (human)RGD 
Cyp11b2Ratmyocardial infarction  IMP 2307303 RGD 
Cyp11b2Ratmyocarditis  IEP 2307306protein:increased expression:myocardiumRGD 
Cyp11b2Ratpre-eclampsia  ISOCYP11B2 (Homo sapiens)1576428DNA:missense mutation:cds:p.V386A (human)RGD 
Cyp11b2Ratrenal tubular acidosis  IEP 4891416mRNA:increased expression:adrenal gland (rat)RGD 
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Original Reference(s)
Cyp11b2Ratcongenital adrenal hyperplasia  ISOCYP11B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital adrenal hyperplasiaClinVarPMID:11095433 more ...
Cyp11b2Ratcongenital adrenal hyperplasia  ISOCYP11B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital adrenal hyperplasiaClinVarPMID:11095433 more ...
Cyp11b2RatCongenital Adrenal Hyperplasia due to 11-Beta-Hydroxylase Deficiency  ISOCYP11B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10487675 more ...
Cyp11b2RatCongenital Adrenal Hyperplasia due to 11-Beta-Hydroxylase Deficiency  ISOCYP11B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10487675 more ...
Cyp11b2Ratepidermolysis bullosa simplex with muscular dystrophy  ISOCYP11B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Epidermolysis bullosa simplex 5B and with muscular dystrophyClinVarPMID:28492532
Cyp11b2Ratgenetic disease  ISOCYP11B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Cyp11b2Ratglucocorticoid-remediable aldosteronism  ISOCYP11B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10487675 more ...
Cyp11b2Ratglucocorticoid-remediable aldosteronism  ISOCYP11B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10487675 more ...
Cyp11b2Rathereditary breast ovarian cancer syndrome  ISOCYP11B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromeClinVarPMID:20529578 more ...
Cyp11b2Rathereditary breast ovarian cancer syndrome  ISOCYP11B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromeClinVarPMID:20529578 more ...
Cyp11b2Ratholoprosencephaly  ISOCYP11B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Holoprosencephaly sequenceClinVarPMID:28492532
Cyp11b2RatRecombinant Chromosome 8 Syndrome  ISOCYP11B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Recombinant 8 syndromeClinVarPMID:31690835
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Original Reference(s)
Cyp11b2RatCongenital Adrenal Hyperplasia due to 11-Beta-Hydroxylase Deficiency  ISOCYP11B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Cyp11b2Ratglucocorticoid-remediable aldosteronism  ISOCYP11B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:1472060 and PMID:1731223
Cyp11b2Ratprimary hyperaldosteronism  ISOCYP11B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11085685

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Original Reference(s)
Cyp11b2Rat(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of CYP11B1 mRNACTDPMID:24709674
Cyp11b2Rat11-deoxycorticosterone affects metabolic processingISOCYP11B1 (Homo sapiens)6480464CYP11B1 protein affects the metabolism of DesoxycorticosteroneCTDPMID:16054388
Cyp11b2Rat11-deoxycorticosterone increases chemical synthesisISOCYP11B1 (Homo sapiens)6480464CYP11B1 protein results in increased chemical synthesis of DesoxycorticosteroneCTDPMID:19900470
Cyp11b2Rat11-deoxycorticosterone multiple interactionsEXP 6480464Plant Extracts inhibits the reaction [Desoxycorticosterone binds to CYP11B1 protein]CTDPMID:15666820
Cyp11b2Rat11-deoxycortisol affects metabolic processingISOCYP11B1 (Homo sapiens)6480464CYP11B1 protein affects the metabolism of CortodoxoneCTDPMID:15522937 more ...
Cyp11b2Rat11-deoxycortisol increases metabolic processingISOCYP11B1 (Homo sapiens)6480464CYP11B1 protein results in increased metabolism of CortodoxoneCTDPMID:19900470
Cyp11b2Rat18-hydroxycortisol affects chemical synthesisISOCYP11B1 (Homo sapiens)6480464CYP11B1 protein affects the chemical synthesis of 18-hydroxycortisolCTDPMID:15356073
Cyp11b2Rat18-hydroxydeoxycorticosterone decreases activityISOCYP11B1 (Homo sapiens)648046418-hydroxydeoxycorticosterone results in decreased activity of CYP11B1 proteinCTDPMID:11549669
Cyp11b2Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOCYP11B1 (Homo sapiens)6480464[Tetrachlorodibenzodioxin co-treated with 3 more ...CTDPMID:25765474
Cyp11b2Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOCYP11B1 (Homo sapiens)6480464[Tetrachlorodibenzodioxin co-treated with 3 more ...CTDPMID:25765474
Cyp11b2Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOCYP11B1 (Homo sapiens)64804642 more ...CTDPMID:25765474
Cyp11b2Rat2,3,3',4,4',5-Hexachlorobiphenyl increases expressionISOCYP11B1 (Homo sapiens)64804642 more ...CTDPMID:16396990
Cyp11b2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CYP11B1 mRNACTDPMID:16254025 and PMID:33387578
Cyp11b2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCYP11B1 (Homo sapiens)6480464[Tetrachlorodibenzodioxin co-treated with 3 more ...CTDPMID:25765474
Cyp11b2Rat2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one multiple interactionsISOCYP11B1 (Homo sapiens)6480464Itraconazole binds to and results in decreased activity of CYP11B1 proteinCTDPMID:31982514
Cyp11b2Rat3',4'-dimethoxyflavone increases expressionISOCYP11B1 (Homo sapiens)64804643' and 4'-dimethoxyflavone results in increased expression of CYP11B1 mRNACTDPMID:16396990 and PMID:22172629
Cyp11b2Rat3',4'-dimethoxyflavone multiple interactionsISOCYP11B1 (Homo sapiens)64804643' more ...CTDPMID:16396990 and PMID:22172629
Cyp11b2Rat3',5'-cyclic AMP multiple interactionsISOCYP11B1 (Homo sapiens)6480464N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of CYP11B1 mRNA]CTDPMID:22172629
Cyp11b2Rat3',5'-cyclic AMP increases expressionISOCYP11B1 (Homo sapiens)6480464Cyclic AMP results in increased expression of CYP11B1 mRNACTDPMID:22172629
Cyp11b2Rat3,3',4,4',5-pentachlorobiphenyl multiple interactionsISOCYP11B1 (Homo sapiens)64804643' more ...CTDPMID:16396990 and PMID:25765474

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Biological Process
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Original Reference(s)
Cyp11b2Rataldosterone biosynthetic process  IDA 727991 RGD 
Cyp11b2Rataldosterone biosynthetic process acts_upstream_of_or_withinIEAUniProtKB:P15539 and ensembl:ENSMUSP000001589541600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp11b2Rataldosterone biosynthetic process involved_inIBAMGI:88584 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b2Rataldosterone biosynthetic process involved_inISOCYP11B1 (Homo sapiens)1624291 PMID:19342457 and PMID:2256920RGDPMID:19342457 and PMID:2256920
Cyp11b2RatC21-steroid hormone biosynthetic process  IDA 727991 RGD 
Cyp11b2RatC21-steroid hormone biosynthetic process involved_inISOCYP11B1 (Homo sapiens)1624291 PMID:2256920RGDPMID:2256920
Cyp11b2Ratcellular response to hormone stimulus involved_inISOCYP11B1 (Homo sapiens)1624291 PMID:19342457RGDPMID:19342457
Cyp11b2Ratcellular response to mechanical stimulus  IEP 4891163cyclic stretchingRGD 
Cyp11b2Ratcellular response to nutrient  IEP 4891413potassiumRGD 
Cyp11b2Ratcellular response to peptide hormone stimulus  IEP 4891144Angiotensin IIRGD 
Cyp11b2Ratcellular response to peptide hormone stimulus involved_inIBAPANTHER:PTN001547321 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b2Ratcellular response to potassium ion involved_inISOCYP11B1 (Homo sapiens)1624291 PMID:19342457RGDPMID:19342457
Cyp11b2Ratcellular response to potassium ion starvation  IEP 4891144 RGD 
Cyp11b2Ratcholesterol metabolic process involved_inIBAPANTHER:PTN001547321 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b2Ratcortisol biosynthetic process involved_inISOCYP11B1 (Homo sapiens)1624291 PMID:19342457 more ...RGDPMID:19342457 more ...
Cyp11b2Ratcortisol metabolic process involved_inIBAPANTHER:PTN001547321 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b2Ratdrinking behavior acts_upstream_of_or_withinIEAUniProtKB:P15539 and ensembl:ENSMUSP000001589541600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp11b2Ratglucocorticoid biosynthetic process  IDA 727991corticosterone and 18-hydroxycorticosteroneRGD 
Cyp11b2Ratglucocorticoid biosynthetic process involved_inIBAMGI:88583 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b2Ratmonoatomic ion homeostasis acts_upstream_of_or_withinIEAUniProtKB:P15539 and ensembl:ENSMUSP000001589541600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Cyp11b2Ratdendrite  IDA 1600827 RGD 
Cyp11b2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b2Ratmitochondrial inner membrane located_inIEAUniProtKB-SubCell:SL-01681600115GO_REF:0000044UniProtGO_REF:0000044
Cyp11b2Ratmitochondrial inner membrane located_inIEAUniProtKB-KW:KW-09991600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b2Ratmitochondrial inner membrane is_active_inIBAPANTHER:PTN001547321 and Cyp11a1 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b2Ratmitochondrial membrane located_inIEAUniProtKB-SubCell:SL-01711600115GO_REF:0000044UniProtGO_REF:0000044
Cyp11b2Ratmitochondrion located_inIEAInterPro:IPR0023991600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b2Ratmitochondrion located_inISOCYP11B1 (Homo sapiens)1624291 PMID:2256920RGDPMID:2256920
Cyp11b2Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Cyp11b2Ratcorticosterone 18-monooxygenase activity  IDA 727991 RGD 
Cyp11b2Ratcorticosterone 18-monooxygenase activity enablesIEARHEA:118721600115GO_REF:0000116RHEAGO_REF:0000116
Cyp11b2Ratcorticosterone 18-monooxygenase activity enablesIBAMGI:88583 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b2Ratcorticosterone 18-monooxygenase activity enablesIEAEC:1.14.15.51600115GO_REF:0000003UniProtGO_REF:0000003
Cyp11b2Ratcorticosterone 18-monooxygenase activity  IDA 727645 RGD 
Cyp11b2Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b2Ratheme binding enablesISSUniProtKB:P190991600115GO_REF:0000024UniProtGO_REF:0000024
Cyp11b2Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b2Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b2Ratmonooxygenase activity enablesIEAUniProtKB-KW:KW-05031600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b2Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Cyp11b2Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp11b2Ratsteroid 11-beta-monooxygenase activity  IDA 727656 RGD 
Cyp11b2Ratsteroid 11-beta-monooxygenase activity enablesIEAUniProtKB:P15539 and ensembl:ENSMUSP000001589541600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp11b2Ratsteroid 11-beta-monooxygenase activity enablesIEARHEA:156291600115GO_REF:0000116RHEAGO_REF:0000116
Cyp11b2Ratsteroid 11-beta-monooxygenase activity enablesIBAMGI:88584 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp11b2Ratsteroid 11-beta-monooxygenase activity enablesIEAARBA:ARBA000292641600115GO_REF:0000117UniProtGO_REF:0000117
Cyp11b2Ratsteroid 11-beta-monooxygenase activity enablesISOCYP11B1 (Homo sapiens)1624291 PMID:2022736 more ...RGDPMID:2022736 more ...
Cyp11b2Ratsteroid 11-beta-monooxygenase activity enablesIEAEC:1.14.15.41600115GO_REF:0000003UniProtGO_REF:0000003
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RGD Manual Annotations


  

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Cyp11b2Ratsteroid hormone biosynthetic pathway   IEArno:001506907045 KEGGrno:00140

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#
Reference Title
Reference Citation
1. Fetal adrenal gland alterations in a rat model of adverse intrauterine environment. Bibeau K, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R899-911. Epub 2009 Nov 18.
2. Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. Davies E, etal., Hypertension. 1999 Feb;33(2):703-7.
3. Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. Fallo F, etal., Eur J Endocrinol. 2002 Dec;147(6):795-802.
4. Metabolic acidosis has dual effects on sodium handling by rat kidney. Faroqui S, etal., Am J Physiol Renal Physiol. 2006 Aug;291(2):F322-31. Epub 2006 Feb 21.
5. Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. Fiebeler A, etal., Circulation. 2005 Jun 14;111(23):3087-94. Epub 2005 Jun 6.
6. Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats. Fujisawa G, etal., Transl Res. 2006 Sep;148(3):149-56.
7. Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice. Garnier A, etal., Circulation. 2004 Sep 28;110(13):1819-25. Epub 2004 Sep 13.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. Gomez-Sanchez EP, etal., Exp Physiol. 2010 Jan;95(1):120-30. Epub 2009 Oct 16.
11. Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats. Huang BS, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R166-72. Epub 2008 May 21.
12. Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats. Huang BS, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R994-R1000. Epub 2008 Dec 31.
13. Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction. Huang BS, etal., Cardiovasc Res. 2009 Feb 15;81(3):574-81. Epub 2008 Aug 8.
14. Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex. Imai M, etal., FEBS Lett 1990 Apr 24;263(2):299-302.
15. Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes. Ito T, etal., Circulation 2003 Feb 18;107(6):807-10.
16. Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. Keavney B, etal., J Clin Endocrinol Metab. 2005 Feb;90(2):1072-7. Epub 2004 Nov 2.
17. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
18. Polymorphism of the aldosterone synthase gene is not associated with progression of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients. Ko GJ, etal., Nephrology (Carlton). 2008 Dec;13(6):492-9. Epub 2008 Sep 1.
19. Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. Kupari M, etal., Circulation. 1998 Feb 17;97(6):569-75.
20. Aldosterone promotes fibronectin production through a Smad2-dependent TGF-beta1 pathway in mesangial cells. Lai L, etal., Biochem Biophys Res Commun. 2006 Sep 15;348(1):70-5. Epub 2006 Jul 21.
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PMID:1562515   PMID:1686470   PMID:2022736   PMID:2256920   PMID:2738055   PMID:8468320   PMID:8506298   PMID:8645611   PMID:12865309   PMID:16118390   PMID:16179417   PMID:19001524  
PMID:19418629   PMID:21818974   PMID:22217827   PMID:25957425   PMID:29739797  



Cyp11b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,719,349 - 108,726,024 (-)NCBIGRCr8
mRatBN7.27106,838,590 - 106,845,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,838,590 - 106,845,004 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,564,515 - 108,570,947 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,788,181 - 110,794,613 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,734,122 - 110,740,554 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,248,759 - 116,255,205 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,156,219 - 116,255,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07116,151,128 - 116,157,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,043,365 - 113,049,779 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17113,077,595 - 113,084,003 (-)NCBI
Celera7103,210,977 - 103,217,398 (-)NCBICelera
Cytogenetic Map7q34NCBI
CYP11B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388142,872,357 - 142,879,825 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8142,872,356 - 142,879,846 (-)EnsemblGRCh38hg38GRCh38
GRCh378143,953,773 - 143,961,241 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,950,775 - 143,958,238 (-)NCBINCBI36Build 36hg18NCBI36
Build 348143,952,217 - 143,958,238NCBI
Celera8140,263,402 - 140,270,865 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8139,206,042 - 139,213,505 (-)NCBIHuRef
CHM1_18143,994,059 - 144,001,520 (-)NCBICHM1_1
T2T-CHM13v2.08144,015,692 - 144,023,160 (-)NCBIT2T-CHM13v2.0
CYP11B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27160,309,139 - 160,316,623 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18135,835,342 - 135,842,827 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08139,584,976 - 139,592,466 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18142,628,706 - 142,634,654 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8142,629,127 - 142,634,654 (-)Ensemblpanpan1.1panPan2
CYP11B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,125,409 - 137,132,267 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660392,814,491 - 2,820,047 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Cyp11b2
67 total Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
7 116157457 116157458 G A snv IS/Kyo (KyushuU), DOB/Oda (KyushuU), IS-Tlk/Kyo (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:369
Count of miRNA genes:228
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000041774
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 36 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat

1 to 10 of 36 rows
D7Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,839,225 - 106,839,474 (+)MAPPERmRatBN7.2
Rnor_6.07116,249,395 - 116,249,643NCBIRnor6.0
Rnor_5.07116,151,764 - 116,152,012UniSTSRnor5.0
RGSC_v3.47113,044,000 - 113,044,249RGDRGSC3.4
RGSC_v3.47113,044,001 - 113,044,249UniSTSRGSC3.4
RGSC_v3.17113,078,230 - 113,078,479RGD
Celera7103,211,613 - 103,211,868UniSTS
RH 3.4 Map7772.3UniSTS
RH 3.4 Map7772.3RGD
RH 2.0 Map7606.1RGD
Cytogenetic Map7q34UniSTS
D7Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07116,151,707 - 116,151,991NCBIRnor5.0
Rnor_5.07116,098,481 - 116,098,761NCBIRnor5.0
Rnor_5.07116,058,408 - 116,058,688NCBIRnor5.0
RGSC_v3.47113,012,736 - 113,013,015RGDRGSC3.4
RGSC_v3.47113,043,945 - 113,044,228RGDRGSC3.4
RGSC_v3.47112,977,966 - 112,978,266RGDRGSC3.4
RGSC_v3.17113,012,196 - 113,012,496RGD
Celera7103,211,558 - 103,211,847UniSTS
Celera7103,180,377 - 103,180,655UniSTS
RH 3.4 Map7771.9RGD
RH 3.4 Map7771.9UniSTS
RH 2.0 Map7605.5RGD
Cytogenetic Map7q34UniSTS
D7Wox46  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,845,277 - 106,845,450 (+)MAPPERmRatBN7.2
Rnor_6.07116,255,624 - 116,255,796NCBIRnor6.0
Rnor_5.07116,157,993 - 116,158,165UniSTSRnor5.0
RGSC_v3.47113,050,053 - 113,050,225UniSTSRGSC3.4
Celera7103,217,672 - 103,217,844UniSTS
Cytogenetic Map7q34UniSTS


The following Strains have been annotated to Cyp11b2
LEW.SS-(D7Rat73-D7Rat128)/Ayd     SS.LEW-(D7Rat73-D7Rat128)/Ayd    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 9 14 72 57 55 25 25 25 6 119 60 52 18 48 30



RefSeq Acc Id: NM_012538   ⟹   NP_036670
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87108,719,349 - 108,725,763 (-)NCBI
mRatBN7.27106,838,590 - 106,845,004 (-)NCBI
Rnor_6.07116,248,759 - 116,255,173 (-)NCBI
Rnor_5.07116,151,128 - 116,157,542 (-)NCBI
RGSC_v3.47113,043,365 - 113,049,779 (-)RGD
Celera7103,210,977 - 103,217,398 (-)RGD
Sequence:
RefSeq Acc Id: XM_063262976   ⟹   XP_063119046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87108,719,355 - 108,726,024 (-)NCBI
Protein RefSeqs NP_036670 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119046 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA00445 (Get FASTA)   NCBI Sequence Viewer  
  BAA03172 (Get FASTA)   NCBI Sequence Viewer  
  CAA36978 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079048
GenBank Protein P30099 (Get FASTA)   NCBI Sequence Viewer  
  P30100 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036670   ⟸   NM_012538
- UniProtKB: P30100 (UniProtKB/Swiss-Prot),   F1LPS4 (UniProtKB/TrEMBL),   A6HRZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063119046   ⟸   XM_063262976
- Peptide Label: isoform X1
- UniProtKB: P30100 (UniProtKB/Swiss-Prot)

Name Modeler Protein Id AA Range Protein Structure
AF-P30100-F1-model_v2 AlphaFold P30100 1-500 view protein structure
AF-P30099-F1-model_v2 AlphaFold P30099 1-510 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33005 BioCyc
Ensembl Genes ENSRNOG00000030111 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000101557 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro CYP11_CYP27_families UniProtKB/Swiss-Prot
  Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_mitochondrial UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
NCBI Gene 24294 ENTREZGENE
PANTHER CYTOCHROME P450 11B2, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR24279 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP11B2 RGD
PhenoGen Cyp11b2 PhenoGen
PRINTS MITP450 UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030111 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A8I5ZMM4_RAT UniProtKB/TrEMBL
  A6HRZ3 ENTREZGENE, UniProtKB/TrEMBL
  C11B2_RAT UniProtKB/Swiss-Prot
  C11B3_RAT UniProtKB/Swiss-Prot
  F1LPS4 ENTREZGENE, UniProtKB/TrEMBL
  P30099 ENTREZGENE
  P30100 ENTREZGENE
UniProt Secondary Q64540 UniProtKB/Swiss-Prot
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp11b2  cytochrome P450, family 11, subfamily b, polypeptide 2  Cyp11b2  cytochrome P450, subfamily 11B, polypeptide 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-07   cytochrome P450, subfamily 11B, polypeptide 2  Cyp11b2  cytochrome P450, family 11, subfamily B, polypeptide 2  Name updated 1299863 APPROVED
2004-09-10 Cyp11b2  cytochrome P450, family 11, subfamily B, polypeptide 2    cytochrome P450, subfamily 11B, polypeptide 2  Name updated 1299863 APPROVED
2002-11-06 Cyp11b2  cytochrome P450, subfamily 11B, polypeptide 2    Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase)  Name updated 625702 APPROVED
2002-06-10 Cyp11b2  Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_process regulates corticosterone and aldosterone synthesis 727991
gene_protein 500 amino acid residues 727586