GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp11b2 | increases activity | ISO | CYP11B1 (Homo sapiens) | 6480464 | CTD | Colforsin results in increased activity of CYP11B1 protein | PMID:12525251 | Cyp11b2 | increases expression | ISO | CYP11B1 (Homo sapiens) | 6480464 | CTD | Colforsin results in increased expression of CYP11B1 mRNA | PMID:17080404 PMID:19164467 PMID:21256172 PMID:25765474 PMID:25871633 PMID:28235592 | Cyp11b2 | multiple interactions | ISO | CYP11B1 (Homo sapiens) | 6480464 | CTD | [1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B1 mRNA; [Colforsin co-treated with triptolide] results in decreased expression of CYP11B1 mRNA; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B1 mRNA] | PMID:17080404 PMID:19900470 PMID:31557376 | |
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