Cyp11b1 (cytochrome P450, family 11, subfamily b, polypeptide 1) - Rat Genome Database

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Gene: Cyp11b1 (cytochrome P450, family 11, subfamily b, polypeptide 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp11b1
Name: cytochrome P450, family 11, subfamily b, polypeptide 1
RGD ID: 2453
Description: Enables steroid 11-beta-monooxygenase activity and steroid binding activity. Involved in several processes, including cellular response to type II interferon; response to dexamethasone; and steroid hormone biosynthetic process. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial inner membrane. Used to study hypertension. Biomarker of brain infarction and hypertension. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia; glucocorticoid-remediable aldosteronism; and primary hyperaldosteronism. Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH bis(2-butoxyethyl)phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldosterone synthase; Cp11ba; CYPXIB1; cytochrome P450 11B1, mitochondrial; cytochrome P450 11B1, mitochondrial-like; cytochrome P450(11 beta)-DS; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450, subfamily XIB, polypeptide 1; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); cytochrome P450C11; LOC100910462; P450(11 beta)-DS; P450C11; RATCP11BA; steroid 11-beta-hydroxylase; steroid 11-beta-hydroxylase, CYP11B1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Is Marker For: Strains:   SD   SS.LEW-(D7Rat73-D7Rat128)/Ayd   LEW.SS-(D7Rat73-D7Rat128)/Ayd  
Candidate Gene For: Bp61 Bp335
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,653,385 - 108,660,062 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7108,653,378 - 108,660,995 (-)EnsemblGRCr8
GRCr8 Ensembl7108,607,182 - 108,612,194 (-)EnsemblGRCr8
mRatBN7.27106,772,597 - 106,780,536 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,718,274 - 106,779,278 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7108,498,616 - 108,505,298 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,722,290 - 110,728,972 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,668,224 - 110,674,905 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,195,976 - 116,201,829 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07116,098,795 - 116,104,649 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47112,977,395 - 112,984,080 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7103,180,684 - 103,186,532 (-)NCBICelera
RGSC_v3.17113,077,602 - 113,083,995 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Fetal adrenal gland alterations in a rat model of adverse intrauterine environment. Bibeau K, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R899-911. Epub 2009 Nov 18.
2. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
3. Protein kinase Cmu mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells. Chen YC, etal., FEBS Lett. 2010 Nov 5;584(21):4442-8. Epub 2010 Oct 13.
4. Linkage of 11 beta-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat. Cicila GT, etal., Nat Genet 1993 Apr;3(4):346-53.
5. Rat complement factor H: molecular cloning, sequencing and quantification with a newly established ELISA. Demberg T, etal., Scand J Immunol 2002 Aug;56(2):149-60.
6. Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. Fallo F, etal., Eur J Endocrinol. 2002 Dec;147(6):795-802.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. Gomez-Sanchez EP, etal., Exp Physiol. 2010 Jan;95(1):120-30. Epub 2009 Oct 16.
10. Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1 causes congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency. Helmberg A, etal., J Clin Endocrinol Metab 1992 Nov;75(5):1278-81.
11. Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. Huang XJ, etal., Toxicol Lett. 2009 Dec 15;191(2-3):167-73. Epub 2009 Sep 4.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Lifton RP, etal., Nature. 1992 Jan 16;355(6357):262-5.
14. Effects of bis (2-butoxyethyl) phthalate on adrenocortical function in male rats in puberty partially via down-regulating NR5A1/NR4A1/NR4A2 pathways. Liu M, etal., Environ Toxicol. 2022 Oct;37(10):2419-2433. doi: 10.1002/tox.23607. Epub 2022 Jun 28.
15. Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells. Lo MJ and Lee SD, Immunol Cell Biol. 2006 Feb;84(1):38-43.
16. Molecular cloning and expression of cDNAS encoding rat aldosterone synthase: variants of cytochrome P-450(11 beta). Matsukawa N, etal., Biochem Biophys Res Commun 1990 May 31;169(1):245-52.
17. Dahl's salt-resistant normotensive rat has mutations in cytochrome P450(11 beta), but the salt-sensitive hypertensive rat does not. Matsukawa N, etal., J Biol Chem 1993 Apr 25;268(12):9117-21.
18. Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats. Mutoh J, etal., Endocrinology. 2006 Feb;147(2):927-36. Epub 2005 Oct 27.
19. Ontogeny of immunoreactive and bioactive microsomal steroidogenic enzymes during adrenocortical development in rats. Nagaya M, etal., Mol Cell Endocrinol. 1995 Oct 30;114(1-2):27-34.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Development of relevant assay system to identify steroidogenic enzyme inhibitors. Nishizato Y, etal., Toxicol In Vitro. 2010 Mar;24(2):677-85. Epub 2009 Aug 7.
22. Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure. Ohtani T, etal., J Hypertens. 2009 May;27(5):1074-83.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Single strand conformation polymorphism (SSCP) analysis for the detection of mutations in the CYP11B1 gene. Skinner CA, etal., J Clin Endocrinol Metab. 1996 Jun;81(6):2389-93.
29. Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor. Somekawa S, etal., Endocrinology. 2009 Jul;150(7):3110-7. Epub 2009 Apr 2.
30. Expression of 11beta-hydroxylase in rat Leydig cells. Wang GM, etal., Endocrinology 2002 Feb;143(2):621-6.
31. The aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Ye P, etal., Endocrinology. 2005 Dec;146(12):5287-93. Epub 2005 Sep 22.
32. Effects of ACTH, dexamethasone, and adrenalectomy on 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system. Ye P, etal., J Endocrinol. 2008 Feb;196(2):305-11.
Additional References at PubMed
PMID:2551730   PMID:8473352   PMID:12459034   PMID:22217827  


Genomics

Variants

.
Variants in Cyp11b1
15 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D7Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,839,225 - 106,839,474 (+)MAPPERmRatBN7.2
Rnor_6.07116,249,395 - 116,249,643NCBIRnor6.0
Rnor_5.07116,151,764 - 116,152,012UniSTSRnor5.0
RGSC_v3.47113,044,000 - 113,044,249RGDRGSC3.4
RGSC_v3.47113,044,001 - 113,044,249UniSTSRGSC3.4
Celera7103,211,613 - 103,211,868UniSTS
RGSC_v3.17113,078,230 - 113,078,479RGD
RH 3.4 Map7772.3UniSTS
RH 3.4 Map7772.3RGD
RH 2.0 Map7606.1RGD
Cytogenetic Map7q34UniSTS
D7Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07116,151,707 - 116,151,991NCBIRnor5.0
Rnor_5.07116,098,481 - 116,098,761NCBIRnor5.0
Rnor_5.07116,058,408 - 116,058,688NCBIRnor5.0
RGSC_v3.47113,012,736 - 113,013,015RGDRGSC3.4
RGSC_v3.47113,043,945 - 113,044,228RGDRGSC3.4
RGSC_v3.47112,977,966 - 112,978,266RGDRGSC3.4
Celera7103,211,558 - 103,211,847UniSTS
Celera7103,180,377 - 103,180,655UniSTS
RGSC_v3.17113,012,196 - 113,012,496RGD
RH 3.4 Map7771.9RGD
RH 3.4 Map7771.9UniSTS
RH 2.0 Map7605.5RGD
Cytogenetic Map7q34UniSTS
D7Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27106,741,074 - 106,741,295 (+)MAPPERmRatBN7.2
mRatBN7.27106,773,255 - 106,773,476 (+)MAPPERmRatBN7.2
Rnor_6.07116,226,796 - 116,227,016NCBIRnor6.0
Rnor_5.07116,129,165 - 116,129,385UniSTSRnor5.0
RGSC_v3.47112,978,051 - 112,978,272RGDRGSC3.4
RGSC_v3.47112,978,052 - 112,978,272UniSTSRGSC3.4
RGSC_v3.17113,012,281 - 113,012,502RGD
RH 3.4 Map7764.8RGD
RH 3.4 Map7764.8UniSTS
RH 2.0 Map7608.7RGD
Cytogenetic Map7q34UniSTS
D7Mco7  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07116,059,683 - 116,060,096NCBIRnor5.0
Rnor_5.07116,059,684 - 116,060,096NCBIRnor5.0
Rnor_5.07116,099,756 - 116,100,169NCBIRnor5.0
RGSC_v3.47112,979,257 - 112,979,667UniSTSRGSC3.4
RGSC_v3.47112,979,256 - 112,979,667RGDRGSC3.4
RGSC_v3.47113,014,011 - 113,014,423RGDRGSC3.4
RGSC_v3.17113,048,241 - 113,048,653RGD
Cytogenetic Map7q34UniSTS


Related Rat Strains
The following Strains have been annotated to Cyp11b1
LEW.SS-(D7Rat73-D7Rat128)/Ayd     SD     SS.LEW-(D7Rat73-D7Rat128)/Ayd     SS.SR-Cyp11b1/Jr    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
6 2 15 1 12 4 1 14 2 22 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000038109   ⟹   ENSRNOP00000035538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,773,762 - 106,779,278 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000068707   ⟹   ENSRNOP00000062325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7108,653,378 - 108,660,995 (-)Ensembl
mRatBN7.2 Ensembl7106,741,581 - 106,747,485 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091401   ⟹   ENSRNOP00000075065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,740,418 - 106,779,278 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097748   ⟹   ENSRNOP00000094187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,718,274 - 106,723,103 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099698   ⟹   ENSRNOP00000078853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,718,274 - 106,747,485 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105810   ⟹   ENSRNOP00000078562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,718,274 - 106,723,103 (-)Ensembl
RefSeq Acc Id: NM_012537   ⟹   NP_036669
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87108,653,385 - 108,660,062 (-)NCBI
mRatBN7.27106,772,599 - 106,779,278 (-)NCBI
RGSC_v3.47112,977,395 - 112,984,080 (-)RGD
Protein Sequences
Protein RefSeqs NP_036669 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16081 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062325
GenBank Protein P15393 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036669   ⟸   NM_012537
- Peptide Label: precursor
- UniProtKB: Q64655 (UniProtKB/Swiss-Prot),   P15393 (UniProtKB/Swiss-Prot),   A0A0G2K9N5 (UniProtKB/TrEMBL),   A0A0G2QC14 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094187   ⟸   ENSRNOT00000097748
Ensembl Acc Id: ENSRNOP00000035538   ⟸   ENSRNOT00000038109
Ensembl Acc Id: ENSRNOP00000078853   ⟸   ENSRNOT00000099698
Ensembl Acc Id: ENSRNOP00000062325   ⟸   ENSRNOT00000068707
Ensembl Acc Id: ENSRNOP00000078562   ⟸   ENSRNOT00000105810
Ensembl Acc Id: ENSRNOP00000075065   ⟸   ENSRNOT00000091401

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15393-F1-model_v2 AlphaFold P15393 1-499 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2453 AgrOrtholog
BioCyc Gene G2FUF-33008 BioCyc
Ensembl Genes ENSRNOG00000068909 Ensembl
  ENSRNOG00000071398 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000068707 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro CYP11_CYP27_families UniProtKB/Swiss-Prot
  Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_mitochondrial UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
NCBI Gene Cyp11b1 ENTREZGENE
PANTHER PTHR24279 UniProtKB/Swiss-Prot
  STEROID 11-BETA-MONOOXYGENASE UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp11b1 PhenoGen
PRINTS MITP450 UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000068909 RatGTEx
  ENSRNOG00000071398 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A0G2K9N5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2QC14 ENTREZGENE
  A0A8I6AMK4_RAT UniProtKB/TrEMBL
  A0ABZ3NNR6_RAT UniProtKB/TrEMBL
  C11B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64655 ENTREZGENE
UniProt Secondary Q64655 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cyp11b1  cytochrome P450, family 11, subfamily b, polypeptide 1  LOC100910462  cytochrome P450 11B1, mitochondrial-like  Data merged from RGD:6498232 737654 PROVISIONAL
2012-07-05 LOC100910462  cytochrome P450 11B1, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-19 Cyp11b1  cytochrome P450, family 11, subfamily b, polypeptide 1  Cyp11b1  cytochrome P450, subfamily 11B, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cyp11b1  cytochrome P450, subfamily 11B, polypeptide 1    Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase)  Name updated 625702 APPROVED
2002-06-10 Cyp11b1  Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in Cushings syndrome 70385
gene_disease candidate gene for a QTL affecting blood pressure (Bp61) 69709
gene_expression expressed in leydig cells 70385
gene_function catalyzes 11-beta-hydroxylation of steroids to produce 11-beta-OH-steroid derivatives 70385
gene_mutations_overexpression mutant allele that may play a role in salt hypertension resistance is found in Dahl salt resistant strain SR/Jr 69709
gene_mutations_overexpression mutant allele found in SR/Jr rat encodes five amino acid substitutions and is associated with reduced synthesis of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) 69709
gene_process functions in glucocorticoid biosynthesis 70385