Chrm4 (cholinergic receptor, muscarinic 4) - Rat Genome Database

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Gene: Chrm4 (cholinergic receptor, muscarinic 4) Rattus norvegicus
Analyze
Symbol: Chrm4
Name: cholinergic receptor, muscarinic 4
RGD ID: 2344
Description: Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; and chemical synaptic transmission. Located in several cellular components, including asymmetric synapse; neuronal cell body; and sarcolemma. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Biomarker of congestive heart failure. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholinergic receptor, muscarin 4; M4; muscarinic acetylcholine receptor M4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,349,080 - 98,356,821 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl398,348,650 - 98,358,771 (+)EnsemblGRCr8
mRatBN7.2377,893,425 - 77,901,166 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,893,425 - 77,901,159 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx381,368,613 - 81,376,348 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,967,641 - 89,975,378 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,818,870 - 87,826,600 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,833,272 - 80,841,165 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,833,272 - 80,841,006 (+)Ensemblrn6Rnor6.0
Rnor_5.0387,531,619 - 87,539,681 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4376,301,988 - 76,309,729 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera377,096,073 - 77,103,815 (+)NCBICelera
RGSC_v3.1376,203,520 - 76,206,094 (+)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(+)-trans-(S)-allethrin  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
acetylcholine  (ISO)
aflatoxin B1  (ISO)
alcuronium  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atropine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bethanechol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
brucine  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbachol  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cocaine  (EXP)
Cuprizon  (EXP)
DDT  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
Eburnamonine  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furtrethonium  (ISO)
haloperidol  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methoctramine tetrahydrochloride  (ISO)
methscopolamine  (ISO)
mevinphos  (EXP)
N-acetyl-L-cysteine  (ISO)
nickel atom  (EXP,ISO)
okadaic acid  (ISO)
oxotremorine M  (ISO)
pancuronium  (ISO)
paracetamol  (EXP)
parathion-methyl  (EXP)
perfluorooctanoic acid  (EXP)
Pipecuronium  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
risperidone  (ISO)
rocuronium  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
scopolamine  (ISO)
silicon dioxide  (EXP)
sotorasib  (ISO)
sparteine  (EXP)
strychnine  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
tiotropium bromide  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichlorfon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tropicamide  (ISO)
valproic acid  (ISO)
vecuronium bromide  (ISO)
wogonin  (ISO)
xanomeline  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
2. Identification of a family of muscarinic acetylcholine receptor genes. Bonner TI, etal., Science 1987 Jul 31;237(4814):527-32.
3. Neuronal damage and changes in the expression of muscarinic acetylcholine receptor subtypes in the neonatal rat cerebral cortical upon exposure to sparteine, a quinolizidine alkaloid. Flores-Soto ME, etal., Int J Dev Neurosci. 2006 Oct;24(6):401-10. Epub 2006 Jul 14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function. Guo ML, etal., EMBO J. 2010 Jun 16;29(12):2070-81. doi: 10.1038/emboj.2010.93. Epub 2010 May 11.
7. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
8. Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies. Hersch SM, etal., J Neurosci. 1994 May;14(5 Pt 2):3351-63.
9. Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2. McClatchy DB, etal., J Biol Chem 2002 Aug 9;277(32):29268-74.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Loss of muscarinic M4 receptors in spinal cord of arthritic rats: implications for a role of M4 receptors in pain response. Mulugeta E, etal., Brain Res 2003 Aug 29;982(2):284-7.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
17. Muscarinic signaling in the brain. Thiele A Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.
Additional References at PubMed
PMID:7916637   PMID:8617799   PMID:12433399   PMID:15200951   PMID:15326124   PMID:15927789   PMID:15951192   PMID:15979279   PMID:16758365   PMID:17709264   PMID:17845913   PMID:18816796  
PMID:19070673   PMID:20551968   PMID:21883220   PMID:21913336   PMID:22803069   PMID:29577888   PMID:31325565   PMID:32798726  


Genomics

Comparative Map Data
Chrm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,349,080 - 98,356,821 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl398,348,650 - 98,358,771 (+)EnsemblGRCr8
mRatBN7.2377,893,425 - 77,901,166 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,893,425 - 77,901,159 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx381,368,613 - 81,376,348 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,967,641 - 89,975,378 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,818,870 - 87,826,600 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,833,272 - 80,841,165 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,833,272 - 80,841,006 (+)Ensemblrn6Rnor6.0
Rnor_5.0387,531,619 - 87,539,681 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4376,301,988 - 76,309,729 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera377,096,073 - 77,103,815 (+)NCBICelera
RGSC_v3.1376,203,520 - 76,206,094 (+)NCBI
Cytogenetic Map3q24NCBI
CHRM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,383,789 - 46,391,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1146,383,589 - 46,391,990 (-)Ensemblhg38GRCh38
GRCh371146,405,339 - 46,413,326 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,363,216 - 46,364,683 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341146,363,215 - 46,364,683NCBI
Celera1146,554,217 - 46,555,684 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,113,598 - 46,115,064 (-)NCBIHuRef
CHM1_11146,405,093 - 46,406,560 (-)NCBICHM1_1
T2T-CHM13v2.01146,539,864 - 46,547,851 (-)NCBIT2T-CHM13v2.0
Chrm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,752,531 - 91,760,180 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,757,594 - 91,759,033 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl291,752,345 - 91,764,863 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38291,922,189 - 91,929,835 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,927,249 - 91,928,688 (+)Ensemblmm10GRCm38
MGSCv37291,762,346 - 91,769,986 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36291,728,088 - 91,729,527 (+)NCBIMGSCv36mm8
Celera293,312,590 - 93,320,231 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
Chrm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,647,663 - 1,655,363 (+)Ensembl
ChiLan1.0NW_0049554221,647,663 - 1,655,363 (+)NCBIChiLan1.0ChiLan1.0
CHRM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2948,596,916 - 48,606,737 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11148,603,743 - 48,611,729 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,342,384 - 46,350,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11146,893,292 - 46,901,074 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,894,615 - 46,896,054 (-)EnsemblpanPan2panpan1.1
CHRM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11843,077,115 - 43,084,298 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1843,082,404 - 43,083,840 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1841,805,766 - 41,813,475 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01843,733,324 - 43,740,846 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,733,289 - 43,741,042 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11843,218,330 - 43,226,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,770,212 - 42,777,904 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,503,419 - 43,510,935 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Chrm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,567,540 - 20,576,257 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,493,774 - 2,689,731 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365622,685,209 - 2,687,751 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl216,122,704 - 16,130,810 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1216,119,794 - 16,131,080 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,468,644 - 17,476,868 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHRM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,937,455 - 18,945,390 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,942,643 - 18,944,079 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038116,222,834 - 116,230,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247672,162,712 - 2,171,012 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247672,162,719 - 2,170,921 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Chrm4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1566,066,028 - 66,073,861 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Chrm4
38 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:111
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000023583
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH134207  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,900,850 - 77,901,058 (+)MAPPERmRatBN7.2
Rnor_6.0380,840,698 - 80,840,905NCBIRnor6.0
Rnor_5.0387,539,366 - 87,539,573UniSTSRnor5.0
RGSC_v3.4376,309,414 - 76,309,621UniSTSRGSC3.4
Celera377,103,500 - 77,103,707UniSTS
Cytogenetic Map3q32-q35UniSTS
UniSTS:481077  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,898,580 - 77,900,017 (+)MAPPERmRatBN7.2
Rnor_6.0380,838,428 - 80,839,864NCBIRnor6.0
Rnor_5.0387,537,096 - 87,538,532UniSTSRnor5.0
RGSC_v3.4376,307,144 - 76,308,580UniSTSRGSC3.4
Celera377,101,230 - 77,102,666UniSTS
Cytogenetic Map3q32-q35UniSTS
UniSTS:492564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,898,549 - 77,900,106 (+)MAPPERmRatBN7.2
Rnor_6.0380,838,397 - 80,839,953NCBIRnor6.0
Rnor_5.0387,537,065 - 87,538,621UniSTSRnor5.0
RGSC_v3.4376,307,113 - 76,308,669UniSTSRGSC3.4
Celera377,101,199 - 77,102,755UniSTS
Cytogenetic Map3q32-q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 3 32 141 41 41 12 58 12 3 164 108 2 127 27 79 29 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000023583   ⟹   ENSRNOP00000023586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,348,650 - 98,358,771 (+)Ensembl
mRatBN7.2 Ensembl377,893,425 - 77,901,159 (+)Ensembl
Rnor_6.0 Ensembl380,833,272 - 80,841,006 (+)Ensembl
RefSeq Acc Id: NM_031547   ⟹   NP_113735
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,349,080 - 98,356,821 (+)NCBI
mRatBN7.2377,893,425 - 77,901,166 (+)NCBI
Rnor_6.0380,833,272 - 80,841,013 (+)NCBI
Rnor_5.0387,531,619 - 87,539,681 (+)NCBI
RGSC_v3.4376,301,988 - 76,309,729 (+)RGD
Celera377,096,073 - 77,103,815 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113735 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40663 (Get FASTA)   NCBI Sequence Viewer  
  EDL79547 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023586
GenBank Protein P08485 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113735   ⟸   NM_031547
- UniProtKB: P08485 (UniProtKB/Swiss-Prot),   G3V894 (UniProtKB/TrEMBL),   A6HNE6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023586   ⟸   ENSRNOT00000023583
Protein Domains
G-protein coupled receptors family 1 profile

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2344 AgrOrtholog
BioCyc Gene G2FUF-48718 BioCyc
Ensembl Genes ENSRNOG00000017556 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023583 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Musac_Ach_M4_rcpt UniProtKB/Swiss-Prot
  Musac_Ach_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25111 UniProtKB/Swiss-Prot
NCBI Gene 25111 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  MUSCARINIC ACETYLCHOLINE RECEPTOR M4 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB CHRM4 RGD
PhenoGen Chrm4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  MUSCARINICR UniProtKB/Swiss-Prot
  MUSCRINICM4R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017556 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6HNE6 ENTREZGENE, UniProtKB/TrEMBL
  ACM4_RAT UniProtKB/Swiss-Prot
  G3V894 ENTREZGENE, UniProtKB/TrEMBL
  P08485 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Chrm4  cholinergic receptor, muscarinic 4    cholinergic receptor, muscarin 4  Name updated 1299863 APPROVED
2002-06-10 Chrm4  cholinergic receptor, muscarin 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalized in the soma and neuropil 625569
gene_domains the m4i3 loop acts as a guanine exchange factor for eEF1A2 (essential GTP-binding protein) 625569
gene_expression predominant in the central nervous system, also found in exocrine glands and smooth muscle 61489
gene_expression expressed in the rat striatum 625569
gene_function G-protein coupled receptor 625569
gene_process mediates effects of acetylcholine in the central and peripheral nervous system 625569
gene_process inhibits adenylate cyclase 61489
gene_process breaks down phosphoinositides & modulates potassium channels 61489
gene_process may be involved in cholinergic mechanisms of pain relieg 1298759
gene_product member of the GPCR (G-protein-coupled-receptor) family 625569