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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrm4
Name: cholinergic receptor, muscarinic 4
Acc ID: CHEBI:3193
Term: brucine
Definition: A monoterpenoid indole alkaloid that has formula C23H26N2O4.
Chemical ID: MESH:C083806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm4affects bindingISOCHRM4 (Homo sapiens)6480464CTDbrucine binds to CHRM4 proteinPMID:16709648
Chrm4multiple interactionsISOCHRM4 (Homo sapiens)6480464CTDbrucine analog affects the reaction [Acetylcholine binds to CHRM4 protein]; brucine analog affects the reaction [N-Methylscopolamine binds to CHRM4 protein]; brucine promotes the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM4 protein]; brucine promotes the reaction [5-methylfurtrethonium binds to CHRM4 protein]; brucine promotes the reaction [Bethanechol binds to CHRM4 protein]; brucine promotes the reaction [Carbachol binds to CHRM4 protein]; brucine promotes the reaction [furtrethonium binds to CHRM4 protein]; brucine promotes the reaction [oxotremorine M binds to CHRM4 protein]; brucine promotes the reaction [Pilocarpine binds to CHRM4 protein]; WIN 62577 inhibits the reaction [brucine binds to CHRM4 protein]PMID:10069518 PMID:16709648 PMID:9224827
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