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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrm4
Name: cholinergic receptor, muscarinic 4
Acc ID: CHEBI:15355
Term: acetylcholine
Definition: Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Chemical ID: MESH:D000109
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm4affects bindingISOCHRM4 (Homo sapiens)6480464CTDAcetylcholine binds to CHRM4 protein; CHRM4 protein binds to AcetylcholinePMID:10069518 PMID:16709648 PMID:9224827 PMID:9495826
Chrm4multiple interactionsISOCHRM4 (Homo sapiens)6480464CTD[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Acetylcholine binds to CHRM4 protein]; Acetylcholine binds to and results in increased activity of CHRM4 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM4 protein]; brucine N-oxide promotes the reaction [Acetylcholine binds to CHRM4 protein]; brucine N-oxide promotes the reaction [Acetylcholine results in increased activity of CHRM4 protein]; eburnamonine promotes the reaction [Acetylcholine binds to CHRM4 protein]PMID:10069518 PMID:10101037 PMID:16709648 PMID:9224827 PMID:9495826
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