Ppp2cal1 (protein phosphatase 2 catalytic subunit alpha like 1) - Rat Genome Database

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Gene: Ppp2cal1 (protein phosphatase 2 catalytic subunit alpha like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ppp2cal1
Name: protein phosphatase 2 catalytic subunit alpha like 1
RGD ID: 2318135
Description: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in mitotic cell cycle. Predicted to be active in cytosol. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100362453; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like; serine/threonine-protein phosphatase 2A catalytic subunit alpha-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,782,632 - 95,784,383 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1195,782,512 - 95,784,635 (+)EnsemblGRCr8
mRatBN7.21182,278,288 - 82,280,159 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,278,292 - 82,280,174 (+)EnsemblmRatBN7.2
Rnor_6.01186,421,047 - 86,422,802 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,421,106 - 86,422,907 (+)Ensemblrn6Rnor6.0
Rnor_5.01189,521,786 - 89,523,541 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41184,270,087 - 84,271,016 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic Map11q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000002599
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
RH127380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,279,884 - 82,280,069 (+)MAPPERmRatBN7.2
mRatBN7.21036,377,586 - 36,377,771 (+)MAPPERmRatBN7.2
mRatBN7.21036,377,586 - 36,377,771 (-)MAPPERmRatBN7.2
mRatBN7.21182,279,884 - 82,280,069 (-)MAPPERmRatBN7.2
Rnor_6.01186,422,634 - 86,422,818NCBIRnor6.0
Rnor_6.01037,535,201 - 37,535,385NCBIRnor6.0
Rnor_5.01189,523,373 - 89,523,557UniSTSRnor5.0
Rnor_5.01037,343,708 - 37,343,892UniSTSRnor5.0
RGSC_v3.41037,640,731 - 37,640,915UniSTSRGSC3.4
RGSC_v3.41184,271,502 - 84,271,686UniSTSRGSC3.4
Celera1181,056,435 - 81,056,619UniSTS
Celera1035,732,660 - 35,732,844UniSTS
Cytogenetic Map10q22UniSTS
PMC22838P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,278,463 - 82,278,570 (+)MAPPERmRatBN7.2
mRatBN7.21036,358,300 - 36,358,407 (+)MAPPERmRatBN7.2
mRatBN7.21036,358,300 - 36,358,407 (-)MAPPERmRatBN7.2
mRatBN7.21182,278,463 - 82,278,570 (-)MAPPERmRatBN7.2
Rnor_6.01186,421,213 - 86,421,319NCBIRnor6.0
Rnor_6.01037,554,564 - 37,554,670NCBIRnor6.0
Rnor_5.01189,521,952 - 89,522,058UniSTSRnor5.0
Rnor_5.01037,324,424 - 37,324,530UniSTSRnor5.0
RGSC_v3.41037,621,447 - 37,621,553UniSTSRGSC3.4
RGSC_v3.41184,270,081 - 84,270,187UniSTSRGSC3.4
Celera1181,056,065 - 81,056,171UniSTS
Celera1035,713,345 - 35,713,451UniSTS
Cytogenetic Map10q22UniSTS
Ppp2ca  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,278,604 - 82,279,072 (+)MAPPERmRatBN7.2
Rnor_6.01186,421,354 - 86,421,821NCBIRnor6.0
Rnor_5.01189,522,093 - 89,522,560UniSTSRnor5.0
RGSC_v3.41184,270,222 - 84,270,689UniSTSRGSC3.4
Cytogenetic Map10q22UniSTS
Ppp2ca  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,373,858 - 36,373,905 (+)MAPPERmRatBN7.2
mRatBN7.21182,279,039 - 82,279,090 (+)MAPPERmRatBN7.2
Rnor_6.01186,421,789 - 86,421,839NCBIRnor6.0
Rnor_5.01189,522,528 - 89,522,578UniSTSRnor5.0
RGSC_v3.41184,270,657 - 84,270,707UniSTSRGSC3.4
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 354 191 10 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002599   ⟹   ENSRNOP00000070579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1195,782,512 - 95,784,635 (+)Ensembl
mRatBN7.2 Ensembl1182,278,292 - 82,280,174 (+)Ensembl
Rnor_6.0 Ensembl1186,421,106 - 86,422,907 (+)Ensembl
RefSeq Acc Id: XM_039088980   ⟹   XP_038944908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,782,632 - 95,784,383 (+)NCBI
mRatBN7.21182,278,288 - 82,280,159 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038944908 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070579
  ENSRNOP00000070579.1
Ensembl Acc Id: ENSRNOP00000070579   ⟸   ENSRNOT00000002599
RefSeq Acc Id: XP_038944908   ⟸   XM_039088980
- UniProtKB: A0A0G2JYA4 (UniProtKB/TrEMBL),   A0A8I5ZZ39 (UniProtKB/TrEMBL)
Protein Domains
Serine/threonine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JYA4-F1-model_v2 AlphaFold A0A0G2JYA4 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698301
Promoter ID:EPDNEW_R8822
Type:multiple initiation site
Name:LOC100362453_1
Description:serine/threonine-protein phosphatase 2A catalytic subunit alpha-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,421,041 - 86,421,101EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2318135 AgrOrtholog
BioCyc Gene G2FUF-20670 BioCyc
Ensembl Genes ENSRNOG00000001893 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002599 ENTREZGENE
  ENSRNOT00000002599.8 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/TrEMBL
InterPro Calcineurin-like_PHP_apaH UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/TrEMBL
  PPA2-like UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/TrEMBL
NCBI Gene 100362453 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/TrEMBL
PhenoGen Ppp2cal1 PhenoGen
PRINTS STPHPHTASE UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001893 RatGTEx
SMART PP2Ac UniProtKB/TrEMBL
Superfamily-SCOP SSF56300 UniProtKB/TrEMBL
UniProt A0A0G2JYA4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZ39 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Ppp2cal1  protein phosphatase 2 catalytic subunit alpha like 1  LOC100362453  serine/threonine-protein phosphatase 2A catalytic subunit alpha-like  Symbol and Name Changed 1299863 APPROVED
2010-05-05 LOC100362453  serine/threonine-protein phosphatase 2A catalytic subunit alpha-like      Symbol and Name status set to provisional 70820 PROVISIONAL