Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | CD59 Deficiency | | ISO | CD59 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: CD59-mediated hemolytic anemia with or without immune-mediated polyneuropathy | ClinVar | PMID:1382994 more ... | genetic disease | | ISO | CD59 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:25741868 and PMID:28492532 | intellectual disability | | ISO | CD59 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Intellectual disability | ClinVar | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Ascitic complement system in ovarian cancer. | Bjorge L, etal., Br J Cancer. 2005 Mar 14;92(5):895-905. |
| 2. | Rafts in adult peripheral nerve myelin contain major structural myelin proteins and myelin and lymphocyte protein (MAL) and CD59 as specific markers. | Erne B, etal., J Neurochem 2002 Aug;82(3):550-62. |
| 3. | Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo. | Fraser DA, etal., J Biol Chem. 2003 Dec 5;278(49):48921-7. Epub 2003 Sep 30. |
| 4. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 5. | Membrane-bound complement regulatory proteins inhibit complement activation by an immunotherapeutic mAb in a syngeneic rat colorectal cancer model. | Gelderman KA, etal., Mol Immunol. 2003 Sep;40(1):13-23. |
| 6. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 7. | Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9. | He C, etal., J Immunol. 2005 May 1;174(9):5750-7. |
| 8. | C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis. | Hughes J, etal., Am J Physiol Renal Physiol. 2000 May;278(5):F747-57. |
| 9. | Isolation and characterization of a membrane protein from rat erythrocytes which inhibits lysis by the membrane attack complex of rat complement. | Hughes TR, etal., Biochem J. 1992 May 15;284 ( Pt 1):169-76. |
| 10. | Role of complement regulatory membrane proteins in ischaemia-reperfusion injury of rat gastric mucosa. | Iwata F, etal., J Gastroenterol Hepatol. 1999 Oct;14(10):967-72. |
| 11. | Activation of complement components and reduced regulator expression in alcohol-induced liver injury in the rat. | Jarvelainen HA, etal., Clin Immunol. 2002 Oct;105(1):57-63. |
| 12. | Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). | Jha P, etal., J Immunol. 2006 Jun 15;176(12):7221-31. |
| 13. | Binding of human and rat CD59 to the terminal complement complexes. | Lehto T, etal., Immunology. 1997 Jan;90(1):121-8. |
| 14. | CD59 and CD48 expressed by rat retinal pigment epithelial cells are major ligands for the CD2-mediated alternative pathway of T cell activation. | Liversidge J, etal., J Immunol. 1996 May 15;156(10):3696-703. |
| 15. | Loss of CD59 expression in breast tumours correlates with poor survival. | Madjd Z, etal., J Pathol. 2003 Aug;200(5):633-9. |
| 16. | Role of CD59 in experimental glomerulonephritis in rats. | Matsuo S, etal., Kidney Int. 1994 Jul;46(1):191-200. |
| 17. | Complement activation and CD59 expression in the motor facial nucleus following intracranial transection of the facial nerve in the adult rat. | Mattsson P, etal., J Neuroimmunol. 1998 Nov 2;91(1-2):180-9. |
| 18. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 19. | Expression of complement regulatory proteins-CD 35, CD 46, CD 55, and CD 59-in benign and malignant endometrial tissue. | Murray KP, etal., Gynecol Oncol. 2000 Feb;76(2):176-82. |
| 20. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 21. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 22. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 23. | GOA pipeline | RGD automated data pipeline |
| 24. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 25. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 26. | Molecular cloning of the rat analogue of human CD59: structural comparison with human CD59 and identification of a putative active site. | Rushmere NK, etal., Biochem J 1994 Dec 1;304 ( Pt 2):595-601. |
| 27. | PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. | Sahni S, etal., Biochim Biophys Acta Gen Subj. 2020 Nov;1864(11):129682. doi: 10.1016/j.bbagen.2020.129682. Epub 2020 Jul 12. |
| 28. | CD59 silencing via retrovirus-mediated RNA interference enhanced complement-mediated cell damage in ovary cancer. | Shi XX, etal., Cell Mol Immunol. 2009 Feb;6(1):61-6. |
| 29. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 30. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 31. | Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium. | Vakeva A, etal., Am J Pathol. 1994 Jun;144(6):1357-68. |
| 32. | The expression of CD59 in experimental allergic neuritis. | Vedeler CA, etal., J Neurol Sci. 1999 Jun 1;165(2):154-9. |
| 33. | Complement regulatory protein CD59 involves c-SRC related tyrosine phosphorylation of the creatine transporter in skeletal muscle during sepsis. | Wang W, etal., Surgery 2002 Aug;132(2):334-40. |
| 34. | Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. | Yao X and Verkman AS, Acta Neuropathol Commun. 2017 Feb 17;5(1):15. doi: 10.1186/s40478-017-0417-9. |
| 35. | Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis. | Zhang C, etal., World J Gastroenterol. 2005 Nov 21;11(43):6770-4. |
| 36. | Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy. | Zhang J, etal., Diabetes. 2002 Dec;51(12):3499-504. |
Additional References at PubMed
| PMID:9724629 | PMID:10946279 | PMID:11471050 | PMID:11485913 | PMID:15489334 | PMID:15907827 | PMID:16034134 | PMID:16502470 | PMID:17166698 | PMID:19056867 | PMID:19190083 | PMID:19199708 |
| PMID:20458337 | PMID:21423176 | PMID:22206666 | PMID:23376485 | PMID:23533145 | PMID:25284781 | PMID:28750658 | PMID:31412214 | PMID:31989689 |
Genomics
Comparative Map Data
| Cd59b (Rattus norvegicus - Norway rat) |
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| CD59 (Homo sapiens - human) |
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| Cd59b (Mus musculus - house mouse) |
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| Cd59 (Chinchilla lanigera - long-tailed chinchilla) |
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| CD59 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| CD59 (Canis lupus familiaris - dog) |
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| Cd59 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| CD59 (Sus scrofa - pig) |
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| CD59 (Chlorocebus sabaeus - green monkey) |
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Variants
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Variants in Cd59b
80 total Variants 
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