RGD Reference Report - Complement activation and CD59 expression in the motor facial nucleus following intracranial transection of the facial nerve in the adult rat. - Rat Genome Database

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Complement activation and CD59 expression in the motor facial nucleus following intracranial transection of the facial nerve in the adult rat.

Authors: Mattsson, P  Morgan, BP  Svensson, M 
Citation: Mattsson P, etal., J Neuroimmunol. 1998 Nov 2;91(1-2):180-9.
RGD ID: 1600495
Pubmed: PMID:9846834   (View Abstract at PubMed)

Intracranial transection of the facial nerve has been shown to cause a massive neuronal cell death in the motor facial nucleus. Complement activation has been proposed to contribute to neuronal degeneration following axotomy. Using immunocytochemistry and in situ hybridization we show in the present study that there is complement activation in the facial nucleus after intracranial facial nerve transection as well as increase of the complement regulators CD59 and clusterin. We propose a neuroprotective role for the complement regulators CD59 and clusterin against homologous attack of complement to facial motor neurons.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Facial Nerve Injuries  ISOCd59b (Rattus norvegicus)1600495; 1600495mRNA and protein:increased expression:facial VII nucleusRGD 
Facial Nerve Injuries  IEP 1600495mRNA and protein:increased expression:facial VII nucleusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd59b  (CD59b molecule)

Genes (Mus musculus)
Cd59a  (CD59a antigen)

Genes (Homo sapiens)
CD59  (CD59 molecule (CD59 blood group))


Additional Information