Gene:	Cd4 ( Rattus norvegicus ) Cd4 molecule
Description:	MHC class II binding protein that may be a candidate gene for collagen-induced arthritis; human CD4 is a receptor required for HIV infection
Synonyms:	CD4 antigen; W3/25; p55; CD4 antigen (p55);
ArrayIDs:	6038973; 1377908_at; 6555776; 5986969; 5620623; M15768_at; 6002086; 6274421; GE19913; 5942189; 5991411; rc_AI044225_at; 6682372; 1369483_at; A_43_P11522; 6648950; 6029987; 6600382; 6411147; 6719676;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Ciaa4 - CIA Autoantibody QTL 4 Cia24 - Collagen induced arthritis QTL 24
primer pair:	634886
Homologs
Homo sapiens: CD4     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Cd4     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Cd4 genome assembly 3.1 4 161250744 - 161258974     Rat Celera Assembly 4 146407680 - 146432465     RH 3.4 4 1003.4     RGSC genome assembly v3.4 4 160988512 - 161014038     Cytogenetic 4 q42 Mus musculus Cd4 Mouse genome assembly build 36.1 6 124814711 - 124838227     Cytogenetic 6 6 F2 Homo sapiens CD4 human genome assembly 12 6769004 - 6800235     Human genome assembly build 36.2 12 6768912 - 6800237     Cytogenetic 12 12pter-p12   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology zinc ion binding,  protein kinase binding,  protein homodimerization activity ...  (details...)
Biological Process	Note Reference has a role as receptor necessary for HIV infection in humans 632390 Gene Ontology protein amino acid N-linked glycosylation,  immune response,  positive regulation of calcium-mediated signaling ...  (details...)
Cellular Component	Gene Ontology membrane raft,  integral to membrane,  plasma membrane ...  (details...)
External Links
Databases	DATABASE ID SOURCE SMART: IG IPI PROSITE: IG_LIKE IPI UNIPARC: UPI000012737B IPI KEGG Report: rno:24932 ENTREZGENE HomoloGene Group ID: 513 ENTREZGENE Germonline: 2306 Pfam: ig IPI Pfam: CD4-extracel IPI Pfam: C2-set IPI KEGG Pathway: 05340 ENTREZGENE KEGG Pathway: 04514 ENTREZGENE KEGG Pathway: 04612 ENTREZGENE KEGG Pathway: 04640 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE InterPro: Ig_C2-set. IPI InterPro: Ag_CD4. IPI InterPro: Ig_sub. IPI InterPro: Ig. IPI InterPro: Ig-like. IPI InterPro: Ig-like_fold. IPI InterPro: CD4-extracel. IPI IPI: IPI00200583 IPI Ensembl Protein: ENSRNOP00000021915 IPI Gene3D-CATH: Ig-like_fold IPI Entrez Gene: Cd4 ENTREZGENE UniProt: CD4_RAT IPI Ensembl Genes: ENSRNOG00000016294 IPI RatMap: 35122 ENTREZGENE PRINTS: CD4TCANTIGEN. IPI
Sequences	Nucleotide: CH473964 Get FASTA Search GEO Profiles Nucleotide: M15768 Get FASTA Search GEO Profiles Nucleotide: NM_012705 Get FASTA Search GEO Profiles (View all 3 Nucleotide Accessions) Protein: EDM01913 Get FASTA Protein: EDM01912 Get FASTA Protein: EDM01911 Get FASTA Protein: NP_036837 Get FASTA Protein: AAA40901 Get FASTA Protein: P05540 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 10748
References
Curated References	9 references in RGD related to Cd4
Other References	15 other references at PubMed related to Cd4
Database Information
RGD ID	2306
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 29-SEP-08: Cd4 Cd4 molecule Cd4 CD4 antigen APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 06-NOV-02: Cd4 CD4 antigen CD4 antigen (p55) APPROVED Name updated 625702 10-JUN-02: Cd4 CD4 antigen (p55) APPROVED Symbol and Name status set to approved 70586