Cd4 (Cd4 molecule) - Rat Genome Database

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Gene: Cd4 (Cd4 molecule) Rattus norvegicus
Analyze
Symbol: Cd4
Name: Cd4 molecule
RGD ID: 2306
Description: Enables immunoglobulin binding activity; protein tyrosine kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ionomycin; positive regulation of calcium ion transport into cytosol; and response to vitamin D. Located in external side of plasma membrane. Used to study septic arthritis and sialadenitis. Biomarker of amphetamine abuse. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule); PARTICIPATES IN Arf family mediated signaling pathway; interleukin-12 signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD4 antigen; CD4 antigen (p55); p55; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; W3/25; W3/25 antigen
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Ciaa4 Cia24
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,355,147 - 159,381,636 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,356,337 - 159,381,461 (-)EnsemblGRCr8
mRatBN7.24157,668,878 - 157,695,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,668,878 - 157,695,191 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,898,594 - 163,923,791 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,681,509 - 159,706,706 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,316,780 - 158,341,976 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,381,862 - 157,408,357 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,383,052 - 157,408,176 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,399,640 - 224,426,134 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,988,512 - 161,014,038 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,407,680 - 146,432,465 (-)NCBICelera
RGSC_v3.14161,250,744 - 161,258,974 (-)NCBI
RH 3.4 Map41003.4RGD
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-naphthylamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (EXP)
dienogest  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
ethylbenzene  (EXP)
gentamycin  (EXP)
immunological adjuvant  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
mifepristone  (ISO)
Moniliformin  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
naled  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
Ptaquiloside  (ISO)
resveratrol  (ISO)
rimexolone  (ISO)
rotenone  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sulindac sulfide  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-caffeic acid  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Prolongation of rat corneal graft survival by treatment with anti-CD4 monoclonal antibody. Ayliffe W, etal., Br J Ophthalmol. 1992 Oct;76(10):602-6.
2. Comparison of CD22 binding to native CD45 and synthetic oligosaccharide. Bakker TR, etal., Eur J Immunol. 2002 Jul;32(7):1924-32. doi: 10.1002/1521-4141(200207)32:7<1924::AID-IMMU1924>3.0.CO;2-N.
3. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Beyers AD, etal., Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2945-9.
4. Non-depleting anti-CD4, but not anti-CD8, antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1,3-galactosyltransferase knockout (GT-Ko) mice. Chong AS, etal., Xenotransplantation. 2000 Nov;7(4):275-83.
5. Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains. Clark SJ, etal., Proc Natl Acad Sci U S A 1987 Mar;84(6):1649-53.
6. Crystallization of a soluble form of the rat T-cell surface glycoprotein CD4 complexed with Fab from the W3/25 monoclonal antibody. Davis SJ, etal., J Mol Biol. 1990 May 5;213(1):7-10.
7. Down-regulation of cell-surface CD4 co-receptor expression and modulation of experimental allergic encephalomyelitis. Fiori P, etal., Int Immunol. 1997 Apr;9(4):541-5.
8. The level of CD4 surface protein influences T cell selection in the thymus. Frank GD and Parnes JR, J Immunol. 1998 Jan 15;160(2):634-42.
9. Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Experimental autoallergic sialadenitis in the LEW rat. III. Role of CD4+ T cells in EAS induction. Greiner DL, etal., Cell Immunol. 1991 Jul;135(2):354-9.
13. Sex differences and the effects of alcohol on immune response in male and female rats. Grossman CJ, etal., Alcohol Clin Exp Res. 1993 Aug;17(4):832-40. doi: 10.1111/j.1530-0277.1993.tb00850.x.
14. Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis. Habasque C, etal., Mol Hum Reprod 2002 May;8(5):419-25.
15. Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages. Jefferies WA, etal., J Exp Med. 1985 Jul 1;162(1):117-27.
16. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
17. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
18. Clinical and pathological investigation of severe COVID-19 patients. Li S, etal., JCI Insight. 2020 May 19. pii: 138070. doi: 10.1172/jci.insight.138070.
19. Host response to mycobacterial infection in the alcoholic rat: male and female dimorphism. Li X, etal., Alcohol. 1998 Oct;16(3):207-12. doi: 10.1016/s0741-8329(98)00004-4.
20. Methamphetamine decreases CD4 T cell frequency and alters pro-inflammatory cytokine production in a model of drug abuse. Mata MM, etal., Eur J Pharmacol. 2015 Apr 5;752:26-33. doi: 10.1016/j.ejphar.2015.02.002. Epub 2015 Feb 10.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Suppression in murine experimental autoimmune thyroiditis: in vivo inhibition of CD4+ T cell-mediated resistance by a nondepleting rat CD4 monoclonal antibody. Nabozny GH, etal., Cell Immunol. 1991 Nov;138(1):185-96.
23. Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts. Nakatsuji T Tohoku J Exp Med. 1999 Mar;187(3):215-25.
24. 1,25 Dihydroxyvitamin D3 exerts regional effects in the central nervous system during experimental allergic encephalomyelitis. Nataf S, etal., J Neuropathol Exp Neurol. 1996 Aug;55(8):904-14.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen induced arthritis: influence on macrophage activation. Nissler K, etal., Ann Rheum Dis. 2004 Nov;63(11):1470-7.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-kappaB binding activity and TNF-alpha secretion of T cells. Pohlers D, etal., Arthritis Res. 2002;4(3):184-9. Epub 2002 Jan 8.
31. CD4 expression decrease by antisense oligonucleotides: inhibition of rat T CD4+ cell reactivity. Rabanal M, etal., Oligonucleotides. 2003;13(4):217-28.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Function of CD4 molecules in LEC rat thymocytes. Sakai T, etal., J Vet Med Sci. 1996 Nov;58(11):1125-7.
36. Effects of BWH-4 anti-CD4 monoclonal antibody on rat vascularized cardiac allografts before and after engraftment. Sayegh MH, etal., Transplantation. 1991 Feb;51(2):296-9.
37. The mechanism of inhibition of experimental allergic encephalomyelitis in the rat by monoclonal antibody against CD4. Sedgwick JD and Mason DW, J Neuroimmunol. 1986 Dec;13(2):217-32.
38. Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Seong RH, etal., Nature. 1992 Apr 23;356(6371):718-20.
39. Brain macrophage surface marker expression with HIV-1 infection and drug abuse: a preliminary study. Shapshak P, etal., J NeuroAIDS. 2002;2(3):37-50. doi: 10.1300/j128v02n03_03.
40. Suppression of experimental antiphospholipid syndrome and systemic lupus erythematosus in mice by anti-CD4 monoclonal antibodies. Tomer Y, etal., Arthritis Rheum. 1994 Aug;37(8):1236-44.
41. Treatment of rats with monoclonal anti-CD4 induces long-term resistance to streptococcal cell wall-induced arthritis. Van den Broek MF, etal., Eur J Immunol. 1992 Jan;22(1):57-61.
42. Phenotype and function of GM-CSF independent dendritic cells generated by long-term propagation of rat bone marrow cells. Yan H, etal., Cell Immunol. 2004 Jun;229(2):117-29. doi: 10.1016/j.cellimm.2004.07.006.
43. Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2. Yao Z, etal., Aging (Albany NY). 2020 May 2;12(9):7639-7651. doi: 10.18632/aging.103101. Epub 2020 May 2.
44. Differential expression of estrogen-regulated CD4 and Ia positive cells in the immature rat uterus. Zheng Y, etal., J Leukoc Biol. 1989 Nov;46(5):493-6.
Additional References at PubMed
PMID:1832488   PMID:1901411   PMID:2113054   PMID:2118992   PMID:2784195   PMID:2823150   PMID:3262426   PMID:7477352   PMID:7477353   PMID:7486703   PMID:7589135   PMID:7630421  
PMID:7688139   PMID:7930593   PMID:8124721   PMID:8493535   PMID:8512039   PMID:8524870   PMID:8612131   PMID:8755570   PMID:8769481   PMID:8788039   PMID:9133426   PMID:9166430  
PMID:9168119   PMID:9208839   PMID:9668045   PMID:10072077   PMID:10704459   PMID:10943842   PMID:11390434   PMID:11535811   PMID:12421911   PMID:12444132   PMID:14517216   PMID:14609575  
PMID:14688352   PMID:15128768   PMID:15322158   PMID:15368291   PMID:15728238   PMID:15795238   PMID:15843532   PMID:16223484   PMID:16287714   PMID:16455951   PMID:16973387   PMID:17082577  
PMID:17213291   PMID:17357106   PMID:17604280   PMID:18622289   PMID:18641307   PMID:18776904   PMID:18836449   PMID:19008373   PMID:19246105   PMID:19333378   PMID:19344468   PMID:19349303  
PMID:19376373   PMID:19723499   PMID:19838199   PMID:19934022   PMID:20399120   PMID:20706986   PMID:20709950   PMID:21460847   PMID:21508411   PMID:21745657   PMID:22072979   PMID:24942581  
PMID:26467126   PMID:29772575   PMID:34944007  


Genomics

Comparative Map Data
Cd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,355,147 - 159,381,636 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,356,337 - 159,381,461 (-)EnsemblGRCr8
mRatBN7.24157,668,878 - 157,695,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,668,878 - 157,695,191 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,898,594 - 163,923,791 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,681,509 - 159,706,706 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,316,780 - 158,341,976 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,381,862 - 157,408,357 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,383,052 - 157,408,176 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,399,640 - 224,426,134 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,988,512 - 161,014,038 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,407,680 - 146,432,465 (-)NCBICelera
RGSC_v3.14161,250,744 - 161,258,974 (-)NCBI
RH 3.4 Map41003.4RGD
Cytogenetic Map4q42NCBI
CD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,789,528 - 6,820,799 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,786,858 - 6,820,807 (+)Ensemblhg38GRCh38
GRCh37126,898,694 - 6,929,965 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,768,912 - 6,800,237 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34126,769,004 - 6,800,235NCBI
Celera128,515,970 - 8,547,252 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,751,975 - 6,783,457 (+)NCBIHuRef
CHM1_1126,897,616 - 6,928,653 (+)NCBICHM1_1
T2T-CHM13v2.0126,799,096 - 6,830,079 (+)NCBIT2T-CHM13v2.0
Cd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,841,656 - 124,865,210 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,841,655 - 124,865,184 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386124,864,693 - 124,888,247 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,864,692 - 124,888,221 (-)Ensemblmm10GRCm38
MGSCv376124,814,711 - 124,838,227 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366124,830,312 - 124,853,828 (-)NCBIMGSCv36mm8
Celera6126,540,818 - 126,564,333 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Cd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,408,390 - 4,421,535 (+)Ensembl
ChiLan1.0NW_0049554134,400,326 - 4,422,110 (+)NCBIChiLan1.0ChiLan1.0
CD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,351,536 - 12,383,120 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,348,648 - 12,379,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,920,587 - 6,951,814 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,834,011 - 6,864,204 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,834,011 - 6,864,204 (+)EnsemblpanPan2panpan1.1
CD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,204,003 - 38,250,771 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,204,003 - 38,250,771 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha278,365,799 - 8,412,893 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02738,555,396 - 38,606,503 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,555,402 - 38,603,703 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,430,814 - 38,477,462 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,472,036 - 38,518,728 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,845,022 - 7,891,631 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,330,202 - 102,362,409 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709997,750 - 1,022,884 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936709997,776 - 1,022,791 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,892,137 - 63,918,519 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1563,892,129 - 63,918,547 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,326,568 - 66,353,856 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,824,797 - 6,856,440 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,825,245 - 6,853,852 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660631,369,850 - 1,398,777 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,470,631 - 3,492,846 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248603,470,886 - 3,492,247 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cd4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1623,009,495 - 23,027,872 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cd4
105 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:132
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000021915
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
RH94477  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,670,088 - 157,670,262 (+)MAPPERmRatBN7.2
Rnor_6.04157,383,077 - 157,383,250NCBIRnor6.0
Rnor_5.04224,400,855 - 224,401,028UniSTSRnor5.0
RGSC_v3.44160,988,537 - 160,988,710UniSTSRGSC3.4
Celera4146,407,705 - 146,407,878UniSTS
RH 3.4 Map41003.4UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 59 164 89 88 57 92 57 6 346 184 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021915   ⟹   ENSRNOP00000021915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4157,383,052 - 157,408,176 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120323   ⟹   ENSRNOP00000098012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,356,337 - 159,381,461 (-)Ensembl
mRatBN7.2 Ensembl4157,668,878 - 157,695,191 (-)Ensembl
RefSeq Acc Id: NM_012705   ⟹   NP_036837
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,356,337 - 159,381,461 (-)NCBI
mRatBN7.24157,670,064 - 157,695,191 (-)NCBI
Rnor_6.04157,383,052 - 157,408,176 (-)NCBI
Rnor_5.04224,399,640 - 224,426,134 (-)NCBI
RGSC_v3.44160,988,512 - 161,014,038 (-)RGD
Celera4146,407,680 - 146,432,465 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237331   ⟹   XP_006237393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,355,147 - 159,381,635 (-)NCBI
mRatBN7.24157,668,878 - 157,695,365 (-)NCBI
Rnor_6.04157,381,862 - 157,408,355 (-)NCBI
Rnor_5.04224,399,640 - 224,426,134 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107080   ⟹   XP_038963008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,357,312 - 159,381,636 (-)NCBI
mRatBN7.24157,670,979 - 157,695,366 (-)NCBI
RefSeq Acc Id: NP_036837   ⟸   NM_012705
- Peptide Label: precursor
- UniProtKB: P05540 (UniProtKB/Swiss-Prot),   A6ILM7 (UniProtKB/TrEMBL),   A0AA76ENJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237393   ⟸   XM_006237331
- Peptide Label: isoform X1
- UniProtKB: P05540 (UniProtKB/Swiss-Prot),   A6ILM7 (UniProtKB/TrEMBL),   A0AA76ENJ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021915   ⟸   ENSRNOT00000021915
RefSeq Acc Id: XP_038963008   ⟸   XM_039107080
- Peptide Label: isoform X2
- UniProtKB: A0AA76ENJ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098012   ⟸   ENSRNOT00000120323
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05540-F1-model_v2 AlphaFold P05540 1-457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2306 AgrOrtholog
BioCyc Gene G2FUF-43056 BioCyc
Ensembl Genes ENSRNOG00000016294 Ensembl
  ENSRNOG00000071219 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000120323 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  transmembrane domain of human cd4 UniProtKB/Swiss-Prot
InterPro CD4 UniProtKB/Swiss-Prot
  CD4-extracel UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_C2-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
  Tcell_CD4_Cterm UniProtKB/Swiss-Prot
KEGG Report rno:24932 UniProtKB/Swiss-Prot
NCBI Gene 24932 ENTREZGENE
PANTHER PTHR11422:SF0 UniProtKB/Swiss-Prot
  T-CELL SURFACE GLYCOPROTEIN CD4 UniProtKB/Swiss-Prot
Pfam C2-set UniProtKB/Swiss-Prot
  CD4-extracel UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
  Tcell_CD4_C UniProtKB/Swiss-Prot
PhenoGen Cd4 PhenoGen
PRINTS CD4TCANTIGEN UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016294 RatGTEx
  ENSRNOG00000071219 RatGTEx
SMART IGv UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0AA76ENJ6 ENTREZGENE, UniProtKB/TrEMBL
  A6ILM6_RAT UniProtKB/TrEMBL
  A6ILM7 ENTREZGENE, UniProtKB/TrEMBL
  A6ILM8_RAT UniProtKB/TrEMBL
  CD4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-29 Cd4  Cd4 molecule  Cd4  CD4 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cd4  CD4 antigen    CD4 antigen (p55)  Name updated 625702 APPROVED
2002-06-10 Cd4  CD4 antigen (p55)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process has a role as receptor necessary for HIV infection in humans 632390