CD4 (CD4 molecule) - Rat Genome Database

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Keyword

Gene: CD4 (CD4 molecule) Homo sapiens

Symbol:

CD4

Name:

CD4 molecule

Description:

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

cd4 antigen; CD4 antigen (p55); CD4 receptor; CD4mut; OTTHUMP00000238897; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Orthologs:

Mus musculus : Cd4 (CD4 antigen) MGI
Rattus norvegicus : Cd4 (Cd4 molecule)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	12	6,830,164 - 6,861,216	+	NCBI
Human Genome Assembly HuRef	12	6,751,975 - 6,783,457	+	NCBI
Human Genome Assembly GRCh37	12	6,898,638 - 6,929,976	+	NCBI
Human Genome Assembly Build 36	12	6,768,912 - 6,800,237	+	NCBI
Human Cytogenetic Map	12	p13.31		NCBI
Human Genome Assembly	12	6,769,004 - 6,800,235		NCBI