Gene:	Ccnd3 ( Rattus norvegicus ) cyclin D3
Description:	cyclin that binds both Cdk4 and Cdk6; involved in cell cycle regulation
Synonyms:	MGC108760; MGC93643;  (details...)
ArrayIDs:	1369935_at; rc_AI230696_at; D16309_at; D16309_g_at; U49935mRNA_s_at;  (details...)
Gene Type:	protein-coding
Additional Data
Markers:	D8Mgh14
Homologs
Homo sapiens: CCND3     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Ccnd3     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Ccnd3 Rat Celera Assembly 8 11145441 - 11151481     RGSC genome assembly v3.4 8 77060066 - 77073606     Cytogenetic 8 q24 Mus musculus Ccnd3 Mouse genome assembly build 36.1 17 47642000 - 47736638     Cytogenetic 17 17 C Homo sapiens CCND3 human genome assembly 6 42010649 - 42017530     Human genome assembly build 36.2 6 42010649 - 42017530     Cytogenetic 6 p21   View comparative maps:      NCBI MapViewer
Genome
View:
Other Map Data:	Associated SSLP Map Locations STS D8Mgh14 Rat cytogenetic map 8
Annotation
Molecular Function	Note Reference binds both cdk4 and cdk6 in hepatocytes 1298736 Gene Ontology protein binding,  cyclin-dependent protein kinase activity,  protein kinase binding (details...)
Biological Process	Note Reference plays a key role in the G1/S transition in cell cycle 70761 Gene Ontology G1/S transition of mitotic cell cycle,  T cell proliferation,  cell division ...  (details...)
Cellular Component	Gene Ontology nucleus,  cytoplasm,  cyclin-dependent protein kinase holoenzyme complex (details...)
Disease	Ontology Multiple Myeloma (details...)
Regulation	Note Reference protein amount is regulated at the transcription level and protein half-life is 25 minutes 70761
Physical interaction	Note Reference interacts with Cdk4 70761
External Links
Databases	DATABASE ID SOURCE SMART: CYCLIN IPI PROSITE: CYCLINS IPI UNIPARC: UPI00001275CA IPI KEGG Report: rno:25193 ENTREZGENE Germonline: 2293 Pfam: Cyclin_C IPI Pfam: Cyclin_N IPI KEGG Pathway: 05216 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04110 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE InterPro: CycD. IPI InterPro: Cyclin-like. IPI InterPro: Cyclin_A_B_D_E. IPI InterPro: Cyclin_C. IPI InterPro: Cyclin_N. IPI InterPro: Cyclin_related. IPI InterPro: Cyclin. IPI IPI: IPI00195574 IPI Gene3D-CATH: Cyclin_related IPI Entrez Gene: Ccnd3 ENTREZGENE PIRSF: Cyclin_A_B_D_E IPI IMAGE_CLONE: IMAGE:7189593 IMAGE-MGC_LOAD IMAGE_CLONE: IMAGE:7384331 IMAGE-MGC_LOAD MGC_CLONE: MGC:108760 IMAGE-MGC_LOAD MGC_CLONE: MGC:93643 IMAGE-MGC_LOAD TIGR: TC228844 UniProt: Q5U321_RAT IPI UniProt: CCND3_RAT IPI Superfamily-SCOP: Cyclin_like IPI RatMap: 39893 ENTREZGENE PANTHER: CycD IPI
Sequences	Nucleotide: NM_012766 Get FASTA Search GEO Profiles Nucleotide: BC085763 Get FASTA Search GEO Profiles Nucleotide: D16309 Get FASTA Search GEO Profiles Nucleotide: BC089819 Get FASTA Search GEO Profiles Nucleotide: U49935 Get FASTA Search GEO Profiles (View all 5 Nucleotide Accessions) Protein: P48961 Get FASTA Protein: NP_036898 Get FASTA Protein: AAB40713 Get FASTA Protein: AAH85763 Get FASTA Protein: AAH89819 Get FASTA Protein: BAA03816 Get FASTA Protein: Q5U321 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 3483 UniGene: 54319
References
Curated References	13 references in RGD related to Ccnd3
Other References	11 other references at PubMed related to Ccnd3
Database Information
RGD ID	2293
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Ccnd3 Cyclin D3 APPROVED Symbol and Name status set to approved 70586