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Gene:
Camk2d ( Rattus norvegicus )
calcium/calmodulin-dependent protein kinase II delta
Description:subunit of calcium/calmodulin dependent protein kinase II; regulates potassium currents in brain capillary endothelial cells under hypoxic conditions; expressed as different isoforms in different tissues
Synonyms:Camk2; calcium/calmodulin-dependent protein kinase II, delta; Camki; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; Ca++/calmodulin-dependent protein kinase II, delta subunit; Ca++/calmodulin-dependent protein kinase 2 delta subunit; CAMK1; MGC124639; RATCAMKI; Ca++/calmodulin-dependent protein kinase II delta subunit;  (details...)
ArrayIDs:J05072_at; 1368834_at; 1368833_at; rc_AA894330_s_at; rc_AA925495_at; L13407_i_at; rc_AI009268_at; L13406_s_at; 1371263_a_at;  (details...)
Gene Type:protein-coding
 
Additional Data
Candidate gene for: Eau5 - Experimental allergic uveoretinitis QTL 5
Bp132 - Blood pressure QTL 132
Markers: D2Arb25 D2Mco44
primer pair: 70103
 
Homologs
Homo sapiens: CAMK2D     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Camk2d     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusCamk2dgenome assembly 3.12223827329 - 224097854
  Rat Celera Assembly2207356625 - 207621364
  RGSC genome assembly v3.42223840650 - 224111174
  Cytogenetic2q42-q43
Mus musculusCamk2dMouse genome assembly build 36.13126299891 - 126547972
  Cytogenetic33 G1-G2
Homo sapiensCAMK2Dhuman genome assembly4114731176 - 115040332
  Human genome assembly build 36.24114593021 - 114902177
  Cytogenetic4q26
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
Other Map Data:
Associated SSLP Map Locations
No mapping information currently available in RGD for D2Arb25
STSD2Mco44RH 3.421547
  Rat cytogenetic map2
 
 Annotation
Molecular Function
Gene Ontology
calmodulin-dependent protein kinase activity,  protein serine/threonine kinase activity (details...)
Biological Process
NoteReference
regulates potassium currents in brain capillary endothelial cells under hypoxic conditions724615
may play a role in neurotransmission or synaptic plasticity 
Gene Ontology
cardiac muscle contraction,  G1/S transition of mitotic cell cycle,  positive regulation of cell proliferation ...  (details...)
Cellular Component
Gene Ontology
nucleus,  endocytic vesicle membrane,  neuromuscular junction ...  (details...)
Expression
NoteReference
delta 1 isoform expressed in brain; delta 2 and delta 3 isoforms expressed in aorta; delta 4 isoform expressed in skeletal muscle1298725
expressed most abundantly in nervous tissue61038, 68909
Transcript structure
NoteReference
alternatively spliced isoforms expressed in different tissues1298725
Protein
NoteReference
autophosphorylated upon exposure to hypoxic conditions724615
 
 External Links
Databases
DATABASEIDSOURCE
SMART:S_TKcIPI
PROSITE:PROTEIN_KINASE_STIPI
PROSITE:PROTEIN_KINASE_ATPIPI
PROSITE:PROTEIN_KINASE_DOMIPI
UNIPARC:UPI0001B7BC40IPI
UNIPARC:UPI0001B7BC44IPI
UNIPARC:UPI000002AC95IPI
UNIPARC:UPI000002AC96IPI
UNIPARC:UPI0001B7BC45IPI
UNIPARC:UPI000002AC97IPI
UNIPARC:UPI0000470EC6IPI
UNIPARC:UPI0000470EC8IPI
UNIPARC:UPI0001B7BC42IPI
UNIPARC:UPI0001B7BC46IPI
UNIPARC:UPI0000470EC7IPI
UNIPARC:UPI000012DC94IPI
KEGG Report:rno:24246ENTREZGENE
HomoloGene Group ID:55561ENTREZGENE
Germonline:2263
Pfam:PkinaseIPI
Pfam:CaMKII_ADIPI
KEGG Pathway:04310ENTREZGENE
KEGG Pathway:04740ENTREZGENE
KEGG Pathway:04916ENTREZGENE
KEGG Pathway:04720ENTREZGENE
KEGG Pathway:05214ENTREZGENE
KEGG Pathway:04020ENTREZGENE
KEGG Pathway:04012ENTREZGENE
KEGG Pathway:04912ENTREZGENE
InterPro:Ser/Thr_prot_kinase_dom.IPI
InterPro:Kinase-like_dom.IPI
InterPro:Ca/CaM-dep_prot_kinase_2.IPI
InterPro:Ca/CaM-dep_prot_kinase-assoc.IPI
InterPro:Ca/CaM-dep_prot_kinase-like.IPI
InterPro:Ser/Thr_prot_kinase_AS.IPI
InterPro:Se/Thr_prot_kinase-like_dom.IPI
InterPro:Protein_kinase_ATP_BS.IPI
InterPro:Prot_kinase_cat_dom.IPI
Ensembl Protein:ENSRNOP00000015457IPI
Ensembl Protein:ENSRNOP00000059270IPI
Ensembl Protein:ENSRNOP00000060342IPI
Ensembl Protein:ENSRNOP00000062118IPI
Ensembl Protein:ENSRNOP00000016035IPI
Ensembl Protein:ENSRNOP00000062625IPI
Ensembl Protein:ENSRNOP00000015559IPI
Ensembl Protein:ENSRNOP00000016026IPI
IPI:IPI00949215IPI
IPI:IPI00212226IPI
IPI:IPI00779028IPI
IPI:IPI00213583IPI
IPI:IPI00231613IPI
IPI:IPI00778148IPI
IPI:IPI00327885IPI
IPI:IPI00231614IPI
IPI:IPI00480796IPI
IPI:IPI00947890IPI
IPI:IPI00480684IPI
IPI:IPI00950482IPI
Entrez Gene:Camk2dENTREZGENE
IMAGE_CLONE:IMAGE:7939424IMAGE-MGC_LOAD
MGC_CLONE:MGC:124639IMAGE-MGC_LOAD
Ensembl Genes:ENSRNOG00000011589IPI
UniProt:KCC2D_RATIPI
UniProt:KCC2D_RATIPI
UniProt:KCC2D_RATIPI
UniProt:KCC2D_RATIPI
UniProt:KCC2D_RATIPI
UniProt:KCC2D_RATIPI
UniProt:KCC2D_RATIPI
RatMap:32905ENTREZGENE
Superfamily-SCOP:Kinase_likeIPI
PANTHER:Ca/CaM-dep_prot_kinase-likeIPI
PANTHER:CaMKIIIPI
Sequences
Nucleotide:S81421Get FASTASearch GEO Profiles
Nucleotide:S69672Get FASTASearch GEO Profiles
Nucleotide:S69671Get FASTASearch GEO Profiles
Nucleotide:S69668Get FASTASearch GEO Profiles
Nucleotide:L13408Get FASTASearch GEO Profiles
Nucleotide:L13407Get FASTASearch GEO Profiles
Nucleotide:L13406Get FASTASearch GEO Profiles
Nucleotide:J05072Get FASTASearch GEO Profiles
Nucleotide:BC107562Get FASTASearch GEO Profiles
Nucleotide:X77195Get FASTASearch GEO Profiles
Nucleotide:X77194Get FASTASearch GEO Profiles
Nucleotide:X77193Get FASTASearch GEO Profiles
Nucleotide:X77192Get FASTASearch GEO Profiles
Nucleotide:X75774Get FASTASearch GEO Profiles
Nucleotide:CH473952Get FASTASearch GEO Profiles
Nucleotide:NM_012519Get FASTASearch GEO Profiles
(View all 16 Nucleotide Accessions)
Protein:P15791Get FASTA
Protein:AAB36089Get FASTA
Protein:AAB30237Get FASTA
Protein:AAB30236Get FASTA
Protein:AAB30235Get FASTA
Protein:AAA41481Get FASTA
Protein:AAA41480Get FASTA
Protein:AAA41479Get FASTA
Protein:AAA40866Get FASTA
Protein:AAI07563Get FASTA
Protein:CAA54415Get FASTA
Protein:CAA54414Get FASTA
Protein:CAA54413Get FASTA
Protein:CAA54412Get FASTA
Protein:CAA53395Get FASTA
Protein:EDL82146Get FASTA
Protein:EDL82145Get FASTA
Protein:EDL82144Get FASTA
Protein:NP_036651Get FASTA
(View all 19 Protein Accessions)
Clusters
UniGene:87208
 
 References
Curated References
12 references in RGD related to Camk2d
Other References
21 other references at PubMed related to Camk2d
 
 Database Information
RGD ID2263
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
11-NOV-08: Camk2d calcium/calmodulin-dependent protein kinase II delta Camk2d calcium/calmodulin-dependent protein kinase (CaM kinase) II delta APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863
23-OCT-08: Camk2d calcium/calmodulin-dependent protein kinase (CaM kinase) II delta Camk2d calcium/calmodulin-dependent protein kinase II, delta APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863
09-APR-03: Camk2d calcium/calmodulin-dependent protein kinase II, delta Ca++/calmodulin-dependent protein kinase 2 delta subunit APPROVED Name updated 629478
10-JUN-02: Camk2d Ca++/calmodulin-dependent protein kinase 2 delta subunit APPROVED Symbol and Name status set to approved 70586

       

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