Calm2 (calmodulin 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Calm2 (calmodulin 2) Rattus norvegicus
Analyze
Symbol: Calm2
Name: calmodulin 2
RGD ID: 2258
Description: Enables several functions, including nitric-oxide synthase binding activity; transmembrane transporter binding activity; and type 3 metabotropic glutamate receptor binding activity. Involved in several processes, including establishment of protein localization to mitochondrial membrane; regulation of vesicle-mediated transport; and response to corticosterone. Located in several cellular components, including chromatin; growth cone; and myelin sheath. Is active in Schaffer collateral - CA1 synapse; postsynaptic cytosol; and presynaptic cytosol. Colocalizes with mitochondrial membrane and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in long QT syndrome 15. Orthologous to human CALM2 (calmodulin 2); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calmodulin; calmodulin 2 (phosphorylase kinase delta); calmodulin 2 (phosphorylase kinase, delta); calmodulin-2; caM; Cam2; Camb; CaMII
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Calm2-ps1   Calm2-ps2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,845,170 - 12,857,830 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1564,519,554 - 64,520,657 (-)EnsemblGRCr8
GRCr8 Ensembl612,844,845 - 12,860,744 (+)EnsemblGRCr8
mRatBN7.267,091,624 - 7,104,284 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1558,110,595 - 58,111,720 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl67,091,567 - 7,104,287 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,374,045 - 7,386,699 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,683,473 - 7,696,127 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,210,591 - 7,223,245 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,067,675 - 11,080,078 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1565,506,874 - 65,507,968 (-)Ensemblrn6Rnor6.0
Rnor_5.0621,052,945 - 21,068,133 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4664,161,641 - 64,162,751 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera66,842,934 - 6,855,590 (+)NCBICelera
RGSC_v3.11564,177,420 - 64,178,531 (-)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
3,3'-diindolylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
afatinib  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (EXP)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
D-glucose  (EXP)
dextran sulfate  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
disulfiram  (ISO)
diuron  (EXP)
ethanol  (EXP,ISO)
fenthion  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glyphosate  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
maneb  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
nitroglycerin  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
risperidone  (EXP)
rotenone  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagosome membrane docking  (ISO,ISS)
calcineurin-mediated signaling  (IBA,IEA,ISO)
cellular response to interferon-beta  (ISO)
cellular response to type II interferon  (ISO)
detection of calcium ion  (IBA,IEA,ISO)
establishment of localization in cell  (IEA)
establishment of protein localization to membrane  (IMP)
establishment of protein localization to mitochondrial membrane  (IEA,IMP)
G2/M transition of mitotic cell cycle  (ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO,ISS)
negative regulation of calcium ion export across plasma membrane  (IEA,ISO)
negative regulation of high voltage-gated calcium channel activity  (ISO,ISS)
negative regulation of ryanodine-sensitive calcium-release channel activity  (ISO,ISS)
organelle localization by membrane tethering  (ISO,ISS)
positive regulation of nitric-oxide synthase activity  (IDA)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
presynaptic endocytosis  (IEA,ISO)
regulation of calcium-mediated signaling  (ISO)
regulation of cardiac muscle cell action potential  (IEA,ISO,ISS)
regulation of cardiac muscle contraction  (IEA,ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (IEA,ISO)
regulation of cell communication by electrical coupling involved in cardiac conduction  (IEA,ISO)
regulation of cytokinesis  (IEA,ISO)
regulation of heart rate  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IBA,IEA,ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (IDA,ISO,ISS)
regulation of store-operated calcium channel activity  (IC)
regulation of synaptic vesicle endocytosis  (IEA,IMP)
regulation of synaptic vesicle exocytosis  (IEA,IMP)
response to amphetamine  (IEA,IEP)
response to calcium ion  (IEA,ISO)
response to corticosterone  (IEP)
substantia nigra development  (ISO)

Cellular Component
calcium channel complex  (IEA,ISO)
calyx of Held  (IEA,ISO)
catalytic complex  (IEA,ISO)
centrosome  (IBA,IEA,ISO)
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO,TAS)
distal axon  (IEA)
growth cone  (IDA,IEA)
membrane  (IEA,ISO)
mitochondrial membrane  (IMP)
mitochondrion  (IEA)
motile cilium  (IEA)
myelin sheath  (IBA,IDA,IEA,ISO)
nucleoplasm  (TAS)
nucleus  (IBA,IDA)
postsynaptic cytosol  (IDA,IEA,NAS)
presynaptic cytosol  (IDA,IEA,ISO,NAS)
protein-containing complex  (IEA,ISO)
sarcomere  (IEA,ISO)
Schaffer collateral - CA1 synapse  (IDA,IEA,NAS)
sperm midpiece  (IEA)
spindle  (IEA)
spindle microtubule  (IEA,ISO)
spindle pole  (IEA,ISO)
synaptic vesicle membrane  (IMP)
vesicle  (IEA,ISO)
voltage-gated potassium channel complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. The NMDA receptor NR1 C1 region bound to calmodulin: structural insights into functional differences between homologous domains. Ataman ZA, etal., Structure. 2007 Dec;15(12):1603-17. doi: 10.1016/j.str.2007.10.012.
2. Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis. Barbelanne M, etal., Hum Mol Genet. 2013 Jun 15;22(12):2482-94. doi: 10.1093/hmg/ddt100. Epub 2013 Feb 27.
3. Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin. Boczek T, etal., Mol Cell Biochem. 2012 Jan;360(1-2):89-102. doi: 10.1007/s11010-011-1047-3. Epub 2011 Sep 13.
4. Heme oxygenase-2 is activated by calcium-calmodulin. Boehning D, etal., J Biol Chem. 2004 Jul 23;279(30):30927-30. Epub 2004 Jun 2.
5. Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure. Brushia RJ and Walsh DA, Front Biosci. 1999 Sep 15;4:D618-41.
6. Rad GTPase deficiency leads to cardiac hypertrophy. Chang L, etal., Circulation. 2007 Dec 18;116(25):2976-83. Epub 2007 Dec 3.
7. Calmodulin: a prototypical calcium sensor. Chin D and Means AR, Trends Cell Biol. 2000 Aug;10(8):322-8.
8. Calcium signaling. Clapham DE, Cell. 2007 Dec 14;131(6):1047-58.
9. FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel. Cornea RL, etal., Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6128-33. doi: 10.1073/pnas.0813010106. Epub 2009 Mar 30.
10. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
11. Calmodulin activates electron transfer through neuronal nitric-oxide synthase reductase domain by releasing an NADPH-dependent conformational lock. Craig DH, etal., J Biol Chem 2002 Sep 13;277(37):33987-94.
12. Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase. Dai Y, etal., Psychopharmacology (Berl). 2011 Feb;213(2-3):403-12. doi: 10.1007/s00213-010-1984-7. Epub 2010 Aug 18.
13. Calmodulin binds to specific sequences in the cytoplasmic domain of C-CAM and down-regulates C-CAM self-association. Edlund M, etal., J Biol Chem. 1996 Jan 19;271(3):1393-9.
14. Interaction of calmodulin with Sec61alpha limits Ca2+ leakage from the endoplasmic reticulum. Erdmann F, etal., EMBO J. 2011 Jan 5;30(1):17-31. doi: 10.1038/emboj.2010.284. Epub 2010 Nov 23.
15. Direct detection of calmodulin tuning by ryanodine receptor channel targets using a Ca2+-sensitive acrylodan-labeled calmodulin. Fruen BR, etal., Biochemistry. 2005 Jan 11;44(1):278-84.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Calcium- and calmodulin-dependent inactivation of calcium channels in inner hair cells of the rat cochlea. Grant L and Fuchs P, J Neurophysiol. 2008 May;99(5):2183-93. doi: 10.1152/jn.01174.2007. Epub 2008 Mar 5.
18. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Hawley SA, etal., Cell Metab. 2005 Jul;2(1):9-19.
19. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Hou W, etal., PLoS Biol. 2015 Sep 3;13(9):e1002233. doi: 10.1371/journal.pbio.1002233. eCollection 2015.
20. Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Kang HJ, etal., Nat Med. 2012 Aug 12. doi: 10.1038/nm.2886.
21. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
22. Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. Kosenko A, etal., EMBO J. 2012 May 29;31(14):3147-56. doi: 10.1038/emboj.2012.156.
23. IQ-motif proteins influence intracellular free Ca2+ in hippocampal neurons through their interactions with calmodulin. Kubota Y, etal., J Neurophysiol. 2008 Jan;99(1):264-76. Epub 2007 Oct 24.
24. Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. Lehrmann E, etal., PLoS One. 2006 Dec 27;1(1):e114. doi: 10.1371/journal.pone.0000114.
25. Evidence for the direct interaction between calmodulin and the human epidermal growth factor receptor. Li H and Villalobo A, Biochem J. 2002 Mar 1;362(Pt 2):499-505.
26. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Li H, etal., Nat Cell Biol. 2013 Jul;15(7):773-85. doi: 10.1038/ncb2791. Epub 2013 Jun 23.
27. The adaptor Grb7 is a novel calmodulin-binding protein: functional implications of the interaction of calmodulin with Grb7. Li H, etal., Oncogene. 2005 Jun 16;24(26):4206-19.
28. Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode. Liu Y, etal., J Biol Chem. 2012 Dec 14;287(51):43030-41. doi: 10.1074/jbc.M112.380964. Epub 2012 Oct 29.
29. Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition. Macdougall DA, etal., J Biol Chem. 2009 Jun 5;284(23):15573-88. doi: 10.1074/jbc.M809585200. Epub 2009 Mar 21.
30. Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Majava V, etal., Amino Acids. 2010 Jun;39(1):59-71. doi: 10.1007/s00726-009-0364-2. Epub 2009 Oct 24.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Differential regulation of calmodulin content and calmodulin messenger RNA levels by acute and repeated, intermittent amphetamine in dopaminergic terminal and midbrain areas. Michelhaugh SK and Gnegy ME, Neuroscience. 2000;98(2):275-85.
33. Acute activation of hippocampal glucocorticoid receptors results in different waves of gene expression throughout time. Morsink MC, etal., J Neuroendocrinol. 2006 Apr;18(4):239-52.
34. STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels. Mullins FM, etal., Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15495-500. doi: 10.1073/pnas.0906781106. Epub 2009 Aug 21.
35. Immunocytochemical localization of calmodulin in PC12 cells and its possible interaction with histones. Natsukari N, etal., Neurochem Int. 1995 May;26(5):465-76.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Multiple calmodulin mRNA species are derived from two distinct genes. Nojima H, etal., Mol Cell Biol 1987 May;7(5):1873-80.
38. In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding. Oda T, etal., Circ Res. 2013 Feb 1;112(3):487-97. doi: 10.1161/CIRCRESAHA.111.300290. Epub 2012 Dec 11.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
41. Calmodulin-dependent gating of Ca(v)1.2 calcium channels in the absence of Ca(v)beta subunits. Ravindran A, etal., Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8154-9. doi: 10.1073/pnas.0711624105. Epub 2008 Jun 5.
42. GOA pipeline RGD automated data pipeline
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Comprehensive gene review and curation RGD comprehensive gene curation
45. New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
46. Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation. Russo LC, etal., FEBS J. 2009 Aug;276(16):4358-71. doi: 10.1111/j.1742-4658.2009.07144.x. Epub 2009 Jul 15.
47. Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3epsilon and calmodulin. Russo LC, etal., Proteomics. 2012 Aug;12(17):2641-55. doi: 10.1002/pmic.201200032. Epub 2012 Jul 26.
48. Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. Schumacher MA, etal., Nature. 2001 Apr 26;410(6832):1120-4.
49. Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex. Schumacher MA, etal., Structure. 2004 May;12(5):849-60.
50. Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species. SenGupta B, etal., J Biol Chem 1987 Dec 5;262(34):16663-70.
51. Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Sorensen SD, etal., Mol Pharmacol. 2002 Jun;61(6):1303-12.
52. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
53. A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism. Tejero J, etal., J Biol Chem. 2010 Aug 20;285(34):25941-9. doi: 10.1074/jbc.M110.126797. Epub 2010 Jun 7.
54. Multiple calmodulin genes exhibit systematically differential responses to chronic ethanol treatment and withdrawal in several regions of the rat brain. Vizi S, etal., Brain Res Mol Brain Res. 2000 Nov 10;83(1-2):63-71. doi: 10.1016/s0169-328x(00)00185-6.
55. Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein. Yurimoto S, etal., Biochemistry. 2009 May 12;48(18):3946-55. doi: 10.1021/bi900260y.
56. Structural basis for calmodulin as a dynamic calcium sensor. Zhang M, etal., Structure. 2012 May 9;20(5):911-23. doi: 10.1016/j.str.2012.03.019.
57. Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation. Zhong L and Gerges NZ, PLoS One. 2012;7(7):e41275. doi: 10.1371/journal.pone.0041275. Epub 2012 Jul 25.
Additional References at PubMed
PMID:201628   PMID:1315919   PMID:2469574   PMID:2527998   PMID:2885164   PMID:3035194   PMID:3145979   PMID:3990807   PMID:7607248   PMID:8631777   PMID:10629061   PMID:11573098  
PMID:11807546   PMID:11980920   PMID:11984006   PMID:12032157   PMID:12223552   PMID:12392717   PMID:15294163   PMID:15489334   PMID:15632291   PMID:16556866   PMID:16760425   PMID:17482793  
PMID:17492691   PMID:20103772   PMID:20226167   PMID:20668654   PMID:21091651   PMID:21167176   PMID:21855531   PMID:22067155   PMID:22926577   PMID:23040497   PMID:25441029   PMID:26084473  
PMID:26164367   PMID:26399481   PMID:26969752   PMID:27165696   PMID:27516456   PMID:27564677   PMID:28153703   PMID:30225708   PMID:30361391   PMID:31429119  


Genomics

Comparative Map Data
Calm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,845,170 - 12,857,830 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1564,519,554 - 64,520,657 (-)EnsemblGRCr8
GRCr8 Ensembl612,844,845 - 12,860,744 (+)EnsemblGRCr8
mRatBN7.267,091,624 - 7,104,284 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1558,110,595 - 58,111,720 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl67,091,567 - 7,104,287 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,374,045 - 7,386,699 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,683,473 - 7,696,127 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,210,591 - 7,223,245 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,067,675 - 11,080,078 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1565,506,874 - 65,507,968 (-)Ensemblrn6Rnor6.0
Rnor_5.0621,052,945 - 21,068,133 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4664,161,641 - 64,162,751 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera66,842,934 - 6,855,590 (+)NCBICelera
RGSC_v3.11564,177,420 - 64,178,531 (-)NCBI
Cytogenetic Map6q12NCBI
CALM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38247,160,082 - 47,176,936 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl247,160,084 - 47,176,921 (-)Ensemblhg38GRCh38
GRCh37247,387,221 - 47,404,075 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,240,809 - 47,257,154 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34247,298,955 - 47,315,301NCBI
Celera247,226,054 - 47,242,551 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef247,124,359 - 47,140,853 (-)NCBIHuRef
CHM1_1247,317,465 - 47,333,922 (-)NCBICHM1_1
T2T-CHM13v2.0247,165,201 - 47,182,048 (-)NCBIT2T-CHM13v2.0
Calm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,740,829 - 87,754,363 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,740,840 - 87,754,363 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381787,433,401 - 87,446,935 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12100,199,435 - 100,209,814 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl1787,433,412 - 87,446,935 (-)Ensemblmm10GRCm38
MGSCv371787,832,741 - 87,846,275 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361787,341,743 - 87,355,168 (-)NCBIMGSCv36mm8
Celera1791,831,455 - 91,844,939 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.49NCBI
Calm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574672,300 - 680,924 (+)Ensembl
ChiLan1.0 EnsemblNW_00495543812,842,437 - 12,854,028 (+)Ensembl
ChiLan1.0NW_00495544113,973,147 - 13,988,665 (-)NCBIChiLan1.0ChiLan1.0
CALM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21279,211,929 - 79,230,855 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A79,218,722 - 79,234,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A47,274,722 - 47,290,861 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A48,204,518 - 48,220,697 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,204,518 - 48,220,697 (-)EnsemblpanPan2panpan1.1
CALM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,299,698 - 49,314,533 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,299,897 - 49,314,457 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1049,152,937 - 49,167,816 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01050,169,941 - 50,184,842 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1050,169,946 - 50,184,929 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11049,877,637 - 49,892,535 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01050,167,136 - 50,182,012 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01050,351,274 - 50,366,152 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Calm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,779,344 - 33,795,171 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365085,207,904 - 5,223,780 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365085,207,909 - 5,223,780 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,372,045 - 93,386,218 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1393,371,765 - 93,386,378 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,567,552 - 99,582,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CALM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,027,884 - 60,042,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1460,027,801 - 60,044,951 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl639,957,320 - 39,966,581 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl2468,133,428 - 68,145,180 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604551,803,526 - 51,818,114 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Calm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473828,525,285 - 28,541,514 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473828,525,290 - 28,541,562 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Calm2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v175,532,140 - 5,544,874 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Calm2
157 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI19188439

Predicted Target Of
Summary Value
Count of predictions:645
Count of miRNA genes:283
Interacting mature miRNAs:344
Transcripts:ENSRNOT00000046240
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat

Markers in Region
RH137765  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.267,106,934 - 7,107,084 (-)MAPPERmRatBN7.2
Rnor_6.0611,064,877 - 11,065,026NCBIRnor6.0
Rnor_5.0621,053,072 - 21,053,221UniSTSRnor5.0
RGSC_v3.4610,949,517 - 10,949,666UniSTSRGSC3.4
Celera66,858,239 - 6,858,388UniSTS
Cytogenetic Map6q11-q12UniSTS
PMC18246P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21558,111,449 - 58,111,691 (+)MAPPERmRatBN7.2
Rnor_6.01565,507,716 - 65,507,957NCBIRnor6.0
Rnor_5.01569,147,488 - 69,147,729UniSTSRnor5.0
RGSC_v3.41564,162,483 - 64,162,724UniSTSRGSC3.4
Celera1557,664,694 - 57,664,935UniSTS
Cytogenetic Map6q11-q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
22 34 153 329 205 210 141 130 141 6 674 338 11 292 149 174 69 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC058485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000046240   ⟹   ENSRNOP00000040477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1564,519,554 - 64,520,657 (-)Ensembl
mRatBN7.2 Ensembl1558,110,595 - 58,111,720 (-)Ensembl
Rnor_6.0 Ensembl1565,506,874 - 65,507,968 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112676   ⟹   ENSRNOP00000088419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl612,844,845 - 12,857,833 (+)Ensembl
mRatBN7.2 Ensembl67,091,567 - 7,104,287 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118114   ⟹   ENSRNOP00000076629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl612,845,174 - 12,860,744 (+)Ensembl
mRatBN7.2 Ensembl67,091,567 - 7,104,287 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132580   ⟹   ENSRNOP00000104559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl612,849,991 - 12,860,744 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139616   ⟹   ENSRNOP00000099263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl612,855,076 - 12,860,744 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156120   ⟹   ENSRNOP00000109037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl612,845,242 - 12,860,744 (+)Ensembl
RefSeq Acc Id: NM_017326   ⟹   NP_059022
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8612,845,170 - 12,857,830 (+)NCBI
mRatBN7.267,091,624 - 7,104,284 (+)NCBI
Rnor_6.0611,067,675 - 11,080,078 (-)NCBI
Rnor_5.0621,052,945 - 21,068,133 (-)NCBI
RGSC_v3.4664,161,641 - 64,162,751 (-)RGD
Celera66,842,934 - 6,855,590 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_059022 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40862 (Get FASTA)   NCBI Sequence Viewer  
  AAA40863 (Get FASTA)   NCBI Sequence Viewer  
  AAH58485 (Get FASTA)   NCBI Sequence Viewer  
  EDM02639 (Get FASTA)   NCBI Sequence Viewer  
  EDM02640 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063822.1
  ENSRNOP00000076629
GenBank Protein P0DP30 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059022   ⟸   NM_017326
- UniProtKB: P62161 (UniProtKB/Swiss-Prot),   P0DP31 (UniProtKB/Swiss-Prot),   P0DP30 (UniProtKB/Swiss-Prot),   P0DP29 (UniProtKB/Swiss-Prot),   A6JEH0 (UniProtKB/TrEMBL),   A0A8I5XV89 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040477   ⟸   ENSRNOT00000046240
Ensembl Acc Id: ENSRNOP00000076629   ⟸   ENSRNOT00000118114
Ensembl Acc Id: ENSRNOP00000088419   ⟸   ENSRNOT00000112676
Ensembl Acc Id: ENSRNOP00000109037   ⟸   ENSRNOT00000156120
Ensembl Acc Id: ENSRNOP00000104559   ⟸   ENSRNOT00000132580
Ensembl Acc Id: ENSRNOP00000099263   ⟸   ENSRNOT00000139616
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DP29-F1-model_v2 AlphaFold P0DP29 1-149 view protein structure
AF-P0DP30-F1-model_v2 AlphaFold P0DP30 1-149 view protein structure
AF-P0DP31-F1-model_v2 AlphaFold P0DP31 1-149 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2258 AgrOrtholog
BioCyc Gene G2FUF-38727 BioCyc
Ensembl Genes ENSRNOG00000004060 UniProtKB/Swiss-Prot
  ENSRNOG00000030871 Ensembl
  ENSRNOG00000067086 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064679.3 UniProtKB/Swiss-Prot
  ENSRNOT00000118114 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6921326 IMAGE-MGC_LOAD
InterPro CALM/Myosin/TropC-like UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
KEGG Report rno:24242 UniProtKB/Swiss-Prot
  rno:24244 UniProtKB/Swiss-Prot
  rno:50663 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72870 IMAGE-MGC_LOAD
NCBI Gene 50663 ENTREZGENE
PANTHER CALMODULIN LIKE 3 UniProtKB/Swiss-Prot
  MYOSIN LIGHT CHAIN 1, 3 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot
PhenoGen Calm2 PhenoGen
PRINTS RECOVERIN UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004060 RatGTEx
  ENSRNOG00000030871 RatGTEx
  ENSRNOG00000067086 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A0A8I5XV89 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GG73_RAT UniProtKB/TrEMBL
  A0ABK0L4L4_RAT UniProtKB/TrEMBL
  A0ABK0L5Z1_RAT UniProtKB/TrEMBL
  A0ABK0LUW3_RAT UniProtKB/TrEMBL
  A6JEH0 ENTREZGENE, UniProtKB/TrEMBL
  CALM1_RAT UniProtKB/Swiss-Prot
  CALM2_RAT UniProtKB/Swiss-Prot
  P0DP29 ENTREZGENE
  P0DP30 ENTREZGENE
  P0DP31 ENTREZGENE
  P62161 ENTREZGENE
UniProt Secondary P02593 UniProtKB/Swiss-Prot
  P62161 UniProtKB/Swiss-Prot
  P70667 UniProtKB/Swiss-Prot
  P99014 UniProtKB/Swiss-Prot
  Q61379 UniProtKB/Swiss-Prot
  Q61380 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Calm2  Calmodulin 2 (phosphorylase kinase, delta)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed mainly in brain 634684
gene_function bovine homolog binds and activates the reductase domain of Nos 634685
gene_transcript 1.4 kb 634684