Calm1 (calmodulin 1) - Rat Genome Database

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Gene: Calm1 (calmodulin 1) Rattus norvegicus
Analyze
Symbol: Calm1
Name: calmodulin 1
RGD ID: 2257
Description: Enables several functions, including nitric-oxide synthase binding activity; transmembrane transporter binding activity; and type 3 metabotropic glutamate receptor binding activity. Involved in several processes, including establishment of protein localization to mitochondrial membrane; regulation of vesicle-mediated transport; and response to corticosterone. Located in several cellular components, including chromatin; growth cone; and myelin sheath. Is active in Schaffer collateral - CA1 synapse; postsynaptic cytosol; and presynaptic cytosol. Colocalizes with mitochondrial membrane and synaptic vesicle membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4 and long QT syndrome 14. Orthologous to human CALM1 (calmodulin 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH (R)-lipoic acid; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Calm; calmodulin; Calmodulin 1 (phosphorylase kinase delta); Calmodulin 1 (phosphorylase kinase, delta); calmodulin I; calmodulin-1; caM; Cam1; CaMI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86125,217,191 - 125,227,855 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6125,217,246 - 125,225,381 (+)EnsemblGRCr8
mRatBN7.26119,487,691 - 119,495,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6119,487,621 - 119,498,227 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6119,649,410 - 119,657,616 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06119,946,208 - 119,954,273 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06119,281,076 - 119,289,141 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06124,217,241 - 124,225,292 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6124,217,241 - 124,225,292 (+)Ensemblrn6Rnor6.0
Rnor_5.06133,444,207 - 133,452,258 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46124,477,601 - 124,485,669 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6117,015,915 - 117,023,918 (+)NCBICelera
RGSC_v3.16124,481,414 - 124,491,549 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Brodifacoum  (EXP)
bucladesine  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (EXP)
calcium atom  (EXP,ISO)
calcium carbonate  (EXP)
calcium(0)  (EXP,ISO)
carbamazepine  (ISO)
casticin  (ISO)
chlordecone  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
deguelin  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dibutylstannane  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
etoposide  (ISO)
eugenol  (EXP)
fenofibrate  (EXP)
fenvalerate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
limonene  (EXP)
lipoic acid  (EXP)
maneb  (ISO)
mastoparan  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
melittin  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel dichloride  (EXP)
nicotine  (ISO)
nitrates  (ISO)
nitric oxide  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phencyclidine  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirarubicin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
progesterone  (EXP)
pyrimidifen  (ISO)
raloxifene  (ISO)
retinyl acetate  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagosome membrane docking  (ISO,ISS)
calcineurin-mediated signaling  (IBA,IEA,ISO)
cellular response to interferon-beta  (ISO)
cellular response to type II interferon  (ISO)
detection of calcium ion  (IBA,IEA,ISO)
establishment of localization in cell  (IEA)
establishment of protein localization to membrane  (IMP)
establishment of protein localization to mitochondrial membrane  (IEA,IMP)
G2/M transition of mitotic cell cycle  (ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO,ISS)
negative regulation of calcium ion export across plasma membrane  (IEA)
negative regulation of high voltage-gated calcium channel activity  (ISO,ISS)
negative regulation of ryanodine-sensitive calcium-release channel activity  (ISO,ISS)
organelle localization by membrane tethering  (ISO,ISS)
positive regulation of nitric-oxide synthase activity  (IDA)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
presynaptic endocytosis  (IEA,ISO)
regulation of cardiac muscle cell action potential  (IEA,ISO,ISS)
regulation of cardiac muscle contraction  (IEA,ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (IEA,ISO)
regulation of cell communication by electrical coupling involved in cardiac conduction  (IEA,ISO)
regulation of cytokinesis  (IEA,ISO)
regulation of heart rate  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IBA,IEA,ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (IDA,ISO,ISS)
regulation of store-operated calcium channel activity  (IC)
regulation of synaptic vesicle endocytosis  (IEA,IMP)
regulation of synaptic vesicle exocytosis  (IEA,IMP)
response to amphetamine  (IEA,IEP)
response to calcium ion  (IEA,ISO)
substantia nigra development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adenosine monophosphate-activated protein kinase (AMPK) signaling pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
Alzheimer's disease pathway  (IEA)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway   (IEA,ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
glioma pathway   (IEA)
glycogen degradation pathway  (ISO)
gonadotropin-releasing hormone signaling pathway  (IEA)
ibutilide pharmacodynamics pathway   (ISO)
insulin responsive facilitative sugar transporter mediated glucose transport pathway   (ISO)
insulin signaling pathway  (IEA)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term potentiation  (IEA)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
N-cadherin signaling pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
neurotrophic factor signaling pathway  (IEA)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway   (ISO)
p38 MAPK signaling pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway  (IEA)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
tuberculosis pathway  (IEA)
type II interferon signaling pathway   (ISO)
vascular endothelial growth factor signaling pathway  (ISO)
verapamil pharmacodynamics pathway   (ISO)
visual phototransduction pathway  (IEA)

References

References - curated
# Reference Title Reference Citation
1. The NMDA receptor NR1 C1 region bound to calmodulin: structural insights into functional differences between homologous domains. Ataman ZA, etal., Structure. 2007 Dec;15(12):1603-17. doi: 10.1016/j.str.2007.10.012.
2. Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis. Barbelanne M, etal., Hum Mol Genet. 2013 Jun 15;22(12):2482-94. doi: 10.1093/hmg/ddt100. Epub 2013 Feb 27.
3. Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin. Boczek T, etal., Mol Cell Biochem. 2012 Jan;360(1-2):89-102. doi: 10.1007/s11010-011-1047-3. Epub 2011 Sep 13.
4. Heme oxygenase-2 is activated by calcium-calmodulin. Boehning D, etal., J Biol Chem. 2004 Jul 23;279(30):30927-30. Epub 2004 Jun 2.
5. Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure. Brushia RJ and Walsh DA, Front Biosci. 1999 Sep 15;4:D618-41.
6. Rad GTPase deficiency leads to cardiac hypertrophy. Chang L, etal., Circulation. 2007 Dec 18;116(25):2976-83. Epub 2007 Dec 3.
7. Calmodulin: a prototypical calcium sensor. Chin D and Means AR, Trends Cell Biol. 2000 Aug;10(8):322-8.
8. Calcium signaling. Clapham DE, Cell. 2007 Dec 14;131(6):1047-58.
9. FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel. Cornea RL, etal., Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6128-33. doi: 10.1073/pnas.0813010106. Epub 2009 Mar 30.
10. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
11. Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase. Dai Y, etal., Psychopharmacology (Berl). 2011 Feb;213(2-3):403-12. doi: 10.1007/s00213-010-1984-7. Epub 2010 Aug 18.
12. Calmodulin binds to specific sequences in the cytoplasmic domain of C-CAM and down-regulates C-CAM self-association. Edlund M, etal., J Biol Chem. 1996 Jan 19;271(3):1393-9.
13. Interaction of calmodulin with Sec61alpha limits Ca2+ leakage from the endoplasmic reticulum. Erdmann F, etal., EMBO J. 2011 Jan 5;30(1):17-31. doi: 10.1038/emboj.2010.284. Epub 2010 Nov 23.
14. Direct detection of calmodulin tuning by ryanodine receptor channel targets using a Ca2+-sensitive acrylodan-labeled calmodulin. Fruen BR, etal., Biochemistry. 2005 Jan 11;44(1):278-84.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Calcium- and calmodulin-dependent inactivation of calcium channels in inner hair cells of the rat cochlea. Grant L and Fuchs P, J Neurophysiol. 2008 May;99(5):2183-93. doi: 10.1152/jn.01174.2007. Epub 2008 Mar 5.
17. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Hawley SA, etal., Cell Metab. 2005 Jul;2(1):9-19.
18. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Hou W, etal., PLoS Biol. 2015 Sep 3;13(9):e1002233. doi: 10.1371/journal.pbio.1002233. eCollection 2015.
19. Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+ signalling in young type 2 Zucker diabetic fatty rat heart. Howarth FC, etal., Exp Physiol. 2011 Mar;96(3):325-37. Epub 2011 Jan 7.
20. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
21. Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. Kosenko A, etal., EMBO J. 2012 May 29;31(14):3147-56. doi: 10.1038/emboj.2012.156.
22. IQ-motif proteins influence intracellular free Ca2+ in hippocampal neurons through their interactions with calmodulin. Kubota Y, etal., J Neurophysiol. 2008 Jan;99(1):264-76. Epub 2007 Oct 24.
23. Evidence for the direct interaction between calmodulin and the human epidermal growth factor receptor. Li H and Villalobo A, Biochem J. 2002 Mar 1;362(Pt 2):499-505.
24. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Li H, etal., Nat Cell Biol. 2013 Jul;15(7):773-85. doi: 10.1038/ncb2791. Epub 2013 Jun 23.
25. The adaptor Grb7 is a novel calmodulin-binding protein: functional implications of the interaction of calmodulin with Grb7. Li H, etal., Oncogene. 2005 Jun 16;24(26):4206-19.
26. Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode. Liu Y, etal., J Biol Chem. 2012 Dec 14;287(51):43030-41. doi: 10.1074/jbc.M112.380964. Epub 2012 Oct 29.
27. Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition. Macdougall DA, etal., J Biol Chem. 2009 Jun 5;284(23):15573-88. doi: 10.1074/jbc.M809585200. Epub 2009 Mar 21.
28. Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Majava V, etal., Amino Acids. 2010 Jun;39(1):59-71. doi: 10.1007/s00726-009-0364-2. Epub 2009 Oct 24.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Differential regulation of calmodulin content and calmodulin messenger RNA levels by acute and repeated, intermittent amphetamine in dopaminergic terminal and midbrain areas. Michelhaugh SK and Gnegy ME, Neuroscience. 2000;98(2):275-85.
31. STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels. Mullins FM, etal., Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15495-500. doi: 10.1073/pnas.0906781106. Epub 2009 Aug 21.
32. Ca2+-dependent binding of calcium-binding protein 1 to presynaptic group III metabotropic glutamate receptors and blockage by phosphorylation of the receptors. Nakajima Y Biochem Biophys Res Commun. 2011 Sep 9;412(4):602-5. doi: 10.1016/j.bbrc.2011.08.006. Epub 2011 Aug 10.
33. Immunocytochemical localization of calmodulin in PC12 cells and its possible interaction with histones. Natsukari N, etal., Neurochem Int. 1995 May;26(5):465-76.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Molecular cloning of calmodulin mRNA species which are preferentially expressed in neurons in the rat brain. Ni B, etal., Brain Res Mol Brain Res 1992 Mar;13(1-2):7-17.
36. Structure of a gene for rat calmodulin. Nojima H and Sokabe H, J Mol Biol 1987 Feb 5;193(3):439-45.
37. In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding. Oda T, etal., Circ Res. 2013 Feb 1;112(3):487-97. doi: 10.1161/CIRCRESAHA.111.300290. Epub 2012 Dec 11.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
41. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
42. Calmodulin-dependent gating of Ca(v)1.2 calcium channels in the absence of Ca(v)beta subunits. Ravindran A, etal., Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8154-9. doi: 10.1073/pnas.0711624105. Epub 2008 Jun 5.
43. GOA pipeline RGD automated data pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Comprehensive gene review and curation RGD comprehensive gene curation
47. New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
48. Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation. Russo LC, etal., FEBS J. 2009 Aug;276(16):4358-71. doi: 10.1111/j.1742-4658.2009.07144.x. Epub 2009 Jul 15.
49. Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3epsilon and calmodulin. Russo LC, etal., Proteomics. 2012 Aug;12(17):2641-55. doi: 10.1002/pmic.201200032. Epub 2012 Jul 26.
50. Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. Schumacher MA, etal., Nature. 2001 Apr 26;410(6832):1120-4.
51. Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex. Schumacher MA, etal., Structure. 2004 May;12(5):849-60.
52. Immunostaining of calmodulin and aluminium in Alzheimer's disease-affected brains. Solomon B, etal., Brain Res Bull. 2001 May 15;55(2):253-6.
53. Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Sorensen SD, etal., Mol Pharmacol. 2002 Jun;61(6):1303-12.
54. A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism. Tejero J, etal., J Biol Chem. 2010 Aug 20;285(34):25941-9. doi: 10.1074/jbc.M110.126797. Epub 2010 Jun 7.
55. Ethanol affects calmodulin and the calmodulin-binding proteins neuronal nitric oxide synthase and alphaII-spectrin (alpha-fodrin) in the nucleus of growing and differentiated rat astrocytes in primary culture. Tomás M, etal., Toxicol In Vitro. 2007 Sep;21(6):1039-49. doi: 10.1016/j.tiv.2007.03.008. Epub 2007 Mar 27.
56. Multiple calmodulin genes exhibit systematically differential responses to chronic ethanol treatment and withdrawal in several regions of the rat brain. Vizi S, etal., Brain Res Mol Brain Res. 2000 Nov 10;83(1-2):63-71. doi: 10.1016/s0169-328x(00)00185-6.
57. Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation. Xu J, etal., Hippocampus. 2007;17(7):525-37.
58. Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein. Yurimoto S, etal., Biochemistry. 2009 May 12;48(18):3946-55. doi: 10.1021/bi900260y.
59. The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. Yus-Najera E, etal., J Biol Chem 2002 Aug 9;277(32):28545-53.
60. Structural basis for calmodulin as a dynamic calcium sensor. Zhang M, etal., Structure. 2012 May 9;20(5):911-23. doi: 10.1016/j.str.2012.03.019.
61. Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation. Zhong L and Gerges NZ, PLoS One. 2012;7(7):e41275. doi: 10.1371/journal.pone.0041275. Epub 2012 Jul 25.
Additional References at PubMed
PMID:2469574   PMID:2527998   PMID:7607248   PMID:8080473   PMID:8631777   PMID:10049721   PMID:10075657   PMID:10629061   PMID:11573098   PMID:11807546   PMID:11953448   PMID:11980920  
PMID:11984006   PMID:12223552   PMID:12477932   PMID:12574113   PMID:12950461   PMID:12967988   PMID:14530275   PMID:15087548   PMID:15095369   PMID:15294163   PMID:15522886   PMID:15632090  
PMID:15632291   PMID:15670850   PMID:15686475   PMID:15817490   PMID:15851513   PMID:15860732   PMID:16503919   PMID:16556866   PMID:16760425   PMID:16854843   PMID:16893173   PMID:17959830  
PMID:18178620   PMID:18553937   PMID:18761789   PMID:19088444   PMID:19144926   PMID:19231837   PMID:19358756   PMID:19494108   PMID:19632986   PMID:20029971   PMID:20103772   PMID:20226167  
PMID:20433809   PMID:20523736   PMID:20654708   PMID:20668654   PMID:21167176   PMID:21569553   PMID:21649588   PMID:21726526   PMID:21730063   PMID:21799007   PMID:21931166   PMID:22067155  
PMID:22184217   PMID:22437832   PMID:22718765   PMID:22871113   PMID:22877078   PMID:22910094   PMID:22926577   PMID:23040497   PMID:23106098   PMID:23266515   PMID:23472081   PMID:23831686  
PMID:24018048   PMID:24420768   PMID:24489773   PMID:24627475   PMID:25077630   PMID:25417111   PMID:25441029   PMID:26092277   PMID:26164367   PMID:26969752   PMID:27132186   PMID:27165696  
PMID:27516456   PMID:27564677   PMID:29279520   PMID:29476059   PMID:30053369   PMID:31904090   PMID:32303334   PMID:34066691   PMID:35352799  


Genomics

Comparative Map Data
Calm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86125,217,191 - 125,227,855 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6125,217,246 - 125,225,381 (+)EnsemblGRCr8
mRatBN7.26119,487,691 - 119,495,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6119,487,621 - 119,498,227 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6119,649,410 - 119,657,616 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06119,946,208 - 119,954,273 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06119,281,076 - 119,289,141 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06124,217,241 - 124,225,292 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6124,217,241 - 124,225,292 (+)Ensemblrn6Rnor6.0
Rnor_5.06133,444,207 - 133,452,258 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46124,477,601 - 124,485,669 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6117,015,915 - 117,023,918 (+)NCBICelera
RGSC_v3.16124,481,414 - 124,491,549 (+)NCBI
Cytogenetic Map6q32NCBI
CALM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381490,396,502 - 90,408,268 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1490,396,502 - 90,408,268 (+)Ensemblhg38GRCh38
GRCh371490,862,846 - 90,874,612 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361489,933,126 - 89,944,363 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341489,933,129 - 89,944,148NCBI
Celera1470,910,477 - 70,921,767 (+)NCBICelera
Cytogenetic Map14q32.11NCBI
HuRef1471,038,153 - 71,049,443 (+)NCBIHuRef
CHM1_11490,801,276 - 90,812,578 (+)NCBICHM1_1
T2T-CHM13v2.01484,621,229 - 84,632,993 (+)NCBIT2T-CHM13v2.0
Calm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912100,165,694 - 100,176,083 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12100,165,694 - 100,176,073 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812100,199,435 - 100,209,824 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12100,199,435 - 100,209,814 (+)Ensemblmm10GRCm38
MGSCv3712101,437,751 - 101,448,016 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612100,600,591 - 100,610,856 (+)NCBIMGSCv36mm8
Celera12101,426,181 - 101,436,442 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1250.43NCBI
Calm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543812,842,437 - 12,854,028 (+)Ensembl
ChiLan1.0NW_00495543812,842,437 - 12,854,028 (+)NCBIChiLan1.0ChiLan1.0
CALM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21591,541,950 - 91,553,249 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11490,758,463 - 90,769,755 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01471,015,099 - 71,026,322 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11490,367,086 - 90,378,361 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,121,687 - 52,131,135 (+)EnsemblpanPan2panpan1.1
PanPan1.1 Ensembl2A48,204,518 - 48,220,697 (-)EnsemblpanPan2panpan1.1
CALM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1861,398,231 - 61,408,874 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl861,398,244 - 61,406,195 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha860,978,989 - 60,989,622 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0861,672,887 - 61,680,835 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl861,672,892 - 61,683,535 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1861,353,922 - 61,364,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0861,402,765 - 61,413,376 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0861,731,734 - 61,739,644 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Calm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864014,480,463 - 14,488,619 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648817,580,454 - 17,588,507 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648817,580,425 - 17,588,480 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7112,160,806 - 112,171,744 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17112,160,823 - 112,171,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27118,728,008 - 118,738,940 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12468,133,446 - 68,145,117 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2468,133,428 - 68,145,180 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605355,415,057 - 55,426,335 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Calm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473412,030,001 - 12,041,772 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473412,030,264 - 12,041,682 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Calm1
127 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:317
Count of miRNA genes:197
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000064679
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
AI327027  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26119,494,570 - 119,494,681 (+)MAPPERmRatBN7.2
Rnor_6.06124,224,104 - 124,224,214NCBIRnor6.0
Rnor_5.06133,451,070 - 133,451,180UniSTSRnor5.0
RGSC_v3.46124,484,481 - 124,484,591UniSTSRGSC3.4
Celera6117,022,730 - 117,022,840UniSTS
Cytogenetic Map6q31-q32UniSTS
RH127985  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26119,495,497 - 119,495,677 (+)MAPPERmRatBN7.2
Rnor_6.06124,225,031 - 124,225,210NCBIRnor6.0
Rnor_5.06133,451,997 - 133,452,176UniSTSRnor5.0
RGSC_v3.46124,485,408 - 124,485,587UniSTSRGSC3.4
Celera6117,023,657 - 117,023,836UniSTS
RH 3.4 Map6858.6UniSTS
Cytogenetic Map6q31-q32UniSTS
RH130082  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26119,498,068 - 119,498,219 (+)MAPPERmRatBN7.2
Rnor_6.06124,227,602 - 124,227,752NCBIRnor6.0
Rnor_5.06133,454,568 - 133,454,718UniSTSRnor5.0
RGSC_v3.46124,487,979 - 124,488,129UniSTSRGSC3.4
Celera6117,026,228 - 117,026,378UniSTS
RH 3.4 Map6857.7UniSTS
Cytogenetic Map6q31-q32UniSTS
AI556375  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map1191.41UniSTS
Cytogenetic Map6q31-q32UniSTS
RH136100  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26119,497,183 - 119,497,391 (+)MAPPERmRatBN7.2
Rnor_6.06124,226,717 - 124,226,924NCBIRnor6.0
Rnor_5.06133,453,683 - 133,453,890UniSTSRnor5.0
RGSC_v3.46124,487,094 - 124,487,301UniSTSRGSC3.4
Celera6117,025,343 - 117,025,550UniSTS
Cytogenetic Map6q31-q32UniSTS
CALM1  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.46124,484,804 - 124,485,624UniSTSRGSC3.4
RGSC_v3.4120,174,921 - 20,175,833UniSTSRGSC3.4
Celera118,462,180 - 18,462,440UniSTS
Cytogenetic Map6q31-q32UniSTS
Calm1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2119,711,076 - 19,711,989 (+)MAPPERmRatBN7.2
mRatBN7.26119,494,893 - 119,495,714 (+)MAPPERmRatBN7.2
Rnor_6.06124,224,427 - 124,225,247NCBIRnor6.0
Rnor_6.0120,730,080 - 20,730,992NCBIRnor6.0
Rnor_5.06133,451,393 - 133,452,213UniSTSRnor5.0
Rnor_5.0122,211,808 - 22,212,720UniSTSRnor5.0
RGSC_v3.4120,174,921 - 20,175,833UniSTSRGSC3.4
RGSC_v3.46124,484,804 - 124,485,624UniSTSRGSC3.4
Celera6117,023,053 - 117,023,873UniSTS
Celera118,461,836 - 18,462,748UniSTS
Cytogenetic Map6q31-q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
25 23 116 278 182 180 118 117 118 12 574 289 11 237 126 152 62 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF176375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF178845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000064679   ⟹   ENSRNOP00000063822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6119,487,621 - 119,498,227 (+)Ensembl
Rnor_6.0 Ensembl6124,217,241 - 124,225,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114574   ⟹   ENSRNOP00000096327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6119,491,255 - 119,498,227 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123729   ⟹   ENSRNOP00000104916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6125,217,430 - 125,225,381 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132627   ⟹   ENSRNOP00000105419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6125,217,246 - 125,225,381 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165816   ⟹   ENSRNOP00000112780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6125,220,880 - 125,225,381 (+)Ensembl
RefSeq Acc Id: NM_031969   ⟹   NP_114175
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86125,217,316 - 125,225,384 (+)NCBI
mRatBN7.26119,487,691 - 119,495,759 (+)NCBI
Rnor_6.06124,217,241 - 124,225,292 (+)NCBI
Rnor_5.06133,444,207 - 133,452,258 (+)NCBI
RGSC_v3.46124,477,601 - 124,485,669 (+)RGD
Celera6117,015,915 - 117,023,918 (+)RGD
Sequence:
RefSeq Acc Id: XM_063261543   ⟹   XP_063117613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86125,217,191 - 125,227,855 (+)NCBI
RefSeq Acc Id: NP_114175   ⟸   NM_031969
- UniProtKB: P62161 (UniProtKB/Swiss-Prot),   P0DP31 (UniProtKB/Swiss-Prot),   P0DP30 (UniProtKB/Swiss-Prot),   P0DP29 (UniProtKB/Swiss-Prot),   A6JEH0 (UniProtKB/TrEMBL),   A0A8I5XV89 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063822   ⟸   ENSRNOT00000064679
Ensembl Acc Id: ENSRNOP00000096327   ⟸   ENSRNOT00000114574
RefSeq Acc Id: XP_063117613   ⟸   XM_063261543
- Peptide Label: isoform X1
- UniProtKB: D4ABV5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105419   ⟸   ENSRNOT00000132627
Ensembl Acc Id: ENSRNOP00000104916   ⟸   ENSRNOT00000123729
Ensembl Acc Id: ENSRNOP00000112780   ⟸   ENSRNOT00000165816
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DP29-F1-model_v2 AlphaFold P0DP29 1-149 view protein structure
AF-P0DP30-F1-model_v2 AlphaFold P0DP30 1-149 view protein structure
AF-P0DP31-F1-model_v2 AlphaFold P0DP31 1-149 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694775
Promoter ID:EPDNEW_R5299
Type:initiation region
Name:Calm1_1
Description:calmodulin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06124,217,171 - 124,217,231EPDNEW
RGD ID:6850184
Promoter ID:EP23005
Type:single initiation site
Name:RN_CALM
Description:Calmodulin, (CALM1 or CAM1 or CALM or CAM) and (CALM2 or CAM2 orCAMB) and (CALM3 or CAM3 or CAMC).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Nuclease protection with homologous sequence ladder
Regulation:ubiquitous; (modulated by) cell cycle
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.46124,477,530 - 124,477,590EPD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2257 AgrOrtholog
BioCyc Gene G2FUF-36497 BioCyc
Ensembl Genes ENSRNOG00000004060 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000072513 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064679.3 UniProtKB/Swiss-Prot
  ENSRNOT00000132627 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
InterPro CALM/Myosin/TropC-like UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
KEGG Report rno:24242 UniProtKB/Swiss-Prot
  rno:24244 UniProtKB/Swiss-Prot
  rno:50663 UniProtKB/Swiss-Prot
NCBI Gene 24242 ENTREZGENE
PANTHER CALMODULIN LIKE 3 UniProtKB/Swiss-Prot
  MYOSIN LIGHT CHAIN 1, 3 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot
PhenoGen Calm1 PhenoGen
PRINTS RECOVERIN UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004060 RatGTEx
  ENSRNOG00000072513 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A0A8I5XV89 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LSE0_RAT UniProtKB/TrEMBL
  A0ABK0M5U6_RAT UniProtKB/TrEMBL
  A6JEH0 ENTREZGENE, UniProtKB/TrEMBL
  CALM1_RAT UniProtKB/Swiss-Prot
  D4ABV5 ENTREZGENE, UniProtKB/TrEMBL
  P0DP29 ENTREZGENE
  P0DP30 ENTREZGENE
  P0DP31 ENTREZGENE
  P62161 ENTREZGENE
UniProt Secondary P02593 UniProtKB/Swiss-Prot
  P62161 UniProtKB/Swiss-Prot
  P70667 UniProtKB/Swiss-Prot
  P99014 UniProtKB/Swiss-Prot
  Q61379 UniProtKB/Swiss-Prot
  Q61380 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Calm1  Calmodulin 1 (phosphorylase kinase, delta)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed strongly in neuronal cells in the adult rat brain 634682
gene_process may act as a mediator in the Ca2+-dependent modulation of KCNQ channels 634683
gene_transcript has two alternative splicing forms created by utilization of different polyadenylation addition sites 634682