Gene:	Cacna1a ( Rattus norvegicus ) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Description:	voltage-gated calcium channel that may be involved in secretion coupling in pancreatic beta cells
Synonyms:	rbA-1; Cav2.1; BccA1; calcium channel, voltage-dependent, alpha 1A subunit; Calcium channel alpha 1A;
ArrayIDs:	AF051527_s_at; 1367822_at; AF051526_at; rc_AI229031_s_at; 1398459_at; 1367821_a_at; 1386939_a_at; M99222_s_at;  (details...)
Gene Type:	protein-coding
Strain:	WTC.GRY-Cacna1agry/Kyo
Additional Data
Homologs
Homo sapiens: CACNA1A     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Cacna1a     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Cacna1a genome assembly 3.1 19 25194294 - 25429321     Rat Celera Assembly 19 23077011 - 23295970     RGSC genome assembly v3.4 19 25189469 - 25424495     Cytogenetic 19 q11 Mus musculus Cacna1a Mouse genome assembly build 36.1 8 86939263 - 87164148     Cytogenetic 8 8 C3 Homo sapiens CACNA1A human genome assembly 19 13179114 - 13478317     Human genome assembly build 36.2 19 13179115 - 13478317     Cytogenetic 19 p13.2-p13.1   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference a voltage-gated calcium channel 634678 Gene Ontology voltage-gated calcium channel activity,  ion channel activity,  high voltage-gated calcium channel activity ...  (details...)
Biological Process	Note Reference involved in secretion coupling in beta cells 634678 Gene Ontology nerve-nerve synaptic transmission,  cell growth,  calcium ion-dependent exocytosis ...  (details...)
Cellular Component	Gene Ontology nucleus,  cell projection,  cytoplasm ...  (details...)
Disease	Ontology Spinocerebellar Ataxias,  Epilepsy (details...)
Expression	Note Reference expressed in central nervous system, heart and pituitary and not expressed in spleen, kidney or liver 1299846
Pathway	Ontology insulin secretion pathway (details...)
External Links
Databases	DATABASE ID SOURCE UNIPARC: UPI00015DB332 IPI UNIPARC: UPI0001B79BD5 IPI UNIPARC: UPI000002A599 IPI UNIPARC: UPI0001B79BD2 IPI UNIPARC: UPI00005EDDA3 IPI UNIPARC: UPI00005EDDA5 IPI UNIPARC: UPI00005EDDA7 IPI UNIPARC: UPI00000E8ACF IPI UNIPARC: UPI0001B79BDA IPI UNIPARC: UPI00005EDDA9 IPI UNIPARC: UPI00000E8995 IPI UNIPARC: UPI0001B79BD9 IPI KEGG Report: rno:25398 ENTREZGENE Germonline: 2244 Pfam: Ca_chan_IQ IPI Pfam: Ion_trans IPI KEGG Pathway: 04020 ENTREZGENE KEGG Pathway: 04730 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04742 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE InterPro: VDCC_a1su_IQ. IPI InterPro: VDCC_P/Q_a1su. IPI InterPro: VDCCAlpha1. IPI InterPro: Ion_trans. IPI IPI: IPI00197595 IPI IPI: IPI00950173 IPI IPI: IPI00950737 IPI IPI: IPI00231785 IPI IPI: IPI00882476 IPI IPI: IPI00882516 IPI IPI: IPI00882567 IPI IPI: IPI00949758 IPI IPI: IPI00211870 IPI IPI: IPI00882428 IPI IPI: IPI00197053 IPI IPI: IPI00197594 IPI Ensembl Protein: ENSRNOP00000059836 IPI Ensembl Protein: ENSRNOP00000059288 IPI Ensembl Protein: ENSRNOP00000003583 IPI Ensembl Protein: ENSRNOP00000063087 IPI Ensembl Protein: ENSRNOP00000003457 IPI Ensembl Protein: ENSRNOP00000003569 IPI Ensembl Protein: ENSRNOP00000003694 IPI Ensembl Protein: ENSRNOP00000059641 IPI Ensembl Protein: ENSRNOP00000062964 IPI Ensembl Protein: ENSRNOP00000029712 IPI Entrez Gene: Cacna1a ENTREZGENE TIGR: TC228655 UniProt: Q2YS33_RAT IPI UniProt: Q2YS38_RAT IPI UniProt: Q2YS36_RAT IPI UniProt: CAC1A_RAT IPI UniProt: Q2YS35_RAT IPI UniProt: Q2YS34_RAT IPI UniProt: Q2YS37_RAT IPI UniProt: Q2YS39_RAT IPI UniProt: CAC1A_RAT IPI UniProt: O70369_RAT IPI UniProt: O70368_RAT IPI Ensembl Genes: ENSRNOG00000002559 IPI RatMap: 41283 ENTREZGENE PANTHER: PQVDCCAlpha1 IPI PRINTS: PQVDCCALPHA1. IPI PRINTS: CACHANNEL. IPI
Sequences	Nucleotide: NM_012918 Get FASTA Search GEO Profiles Nucleotide: M99222 Get FASTA Search GEO Profiles Nucleotide: M64373 Get FASTA Search GEO Profiles Nucleotide: AM040234 Get FASTA Search GEO Profiles Nucleotide: AM040233 Get FASTA Search GEO Profiles Nucleotide: AM040232 Get FASTA Search GEO Profiles Nucleotide: AM040231 Get FASTA Search GEO Profiles Nucleotide: AM040230 Get FASTA Search GEO Profiles Nucleotide: AM040229 Get FASTA Search GEO Profiles Nucleotide: AM040228 Get FASTA Search GEO Profiles Nucleotide: AF051527 Get FASTA Search GEO Profiles Nucleotide: AF051526 Get FASTA Search GEO Profiles Nucleotide: CH473972 Get FASTA Search GEO Profiles Nucleotide: XM_001081900 Get FASTA Search GEO Profiles (View all 14 Nucleotide Accessions) Protein: Q2YS39 Get FASTA Protein: Q2YS38 Get FASTA Protein: Q2YS37 Get FASTA Protein: Q2YS36 Get FASTA Protein: Q2YS35 Get FASTA Protein: Q2YS34 Get FASTA Protein: Q2YS33 Get FASTA Protein: P54282 Get FASTA Protein: O70369 Get FASTA Protein: O70368 Get FASTA Protein: AAA40896 Get FASTA Protein: AAA40806 Get FASTA Protein: CAJ09869 Get FASTA Protein: CAJ09868 Get FASTA Protein: CAJ09867 Get FASTA Protein: CAJ09866 Get FASTA Protein: CAJ09865 Get FASTA Protein: CAJ09864 Get FASTA Protein: CAJ09863 Get FASTA Protein: AAC24517 Get FASTA Protein: AAC24516 Get FASTA Protein: EDL92223 Get FASTA Protein: EDL92222 Get FASTA Protein: EDL92221 Get FASTA Protein: EDL92220 Get FASTA Protein: EDL92219 Get FASTA Protein: EDL92218 Get FASTA Protein: EDL92217 Get FASTA Protein: XP_001081900 Get FASTA Protein: NP_037050 Get FASTA (View all 30 Protein Accessions)
Clusters	UniGene: 87769
References
Curated References	15 references in RGD related to Cacna1a
Other References	23 other references at PubMed related to Cacna1a
Database Information
RGD ID	2244
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit calcium channel, voltage-dependent, alpha 1A subunit APPROVED Name updated 1299863 06-NOV-02: Cacna1a calcium channel, voltage-dependent, alpha 1A subunit Calcium channel alpha 1A APPROVED Name updated 625702 10-JUN-02: Cacna1a Calcium channel alpha 1A APPROVED Symbol and Name status set to approved 70586