Cacna1a (calcium voltage-gated channel subunit alpha1 A) - Rat Genome Database

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Gene: Cacna1a (calcium voltage-gated channel subunit alpha1 A) Chinchilla lanigera
Analyze
Symbol: Cacna1a
Name: calcium voltage-gated channel subunit alpha1 A
RGD ID: 8866424
Description: ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); syntaxin binding (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alpha-mannosidosis (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN dendrite; neuronal cell body; cell projection (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; voltage-dependent P/Q-type calcium channel subunit alpha-1A
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,183,442 - 32,400,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,182,536 - 32,457,511 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alpha-mannosidosis  (ISO)
amyotrophic lateral sclerosis  (ISO)
Ataxia  (ISO)
attention deficit hyperactivity disorder  (ISO)
Auditory Neuropathy  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bone marrow disease  (ISO)
cerebellar ataxia  (ISO)
cerebral palsy  (ISO)
cerebral venous thrombosis  (ISO)
Charcot-Marie-Tooth disease dominant intermediate B  (ISO)
childhood absence epilepsy  (ISO)
childhood electroclinical syndrome  (ISO)
combined immunodeficiency  (ISO)
combined T cell and B cell immunodeficiency  (ISO)
developmental and epileptic encephalopathy 1  (ISO)
developmental and epileptic encephalopathy 42  (ISO)
developmental and epileptic encephalopathy 52  (ISO)
Developmental Disabilities  (ISO)
disorder of sexual development  (ISO)
epilepsy  (ISO)
episodic ataxia  (ISO)
episodic ataxia type 2  (ISO)
exfoliation syndrome  (ISO)
familial hemiplegic migraine  (ISO)
familial hemiplegic migraine 1  (ISO)
generalized dystonia  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
glutaric acidemia I  (ISO)
intellectual disability  (ISO)
Lambert-Eaton myasthenic syndrome  (ISO)
learning disability  (ISO)
Marshall-Smith syndrome  (ISO)
migraine  (ISO)
migraine with aura  (ISO)
Muscle Spasticity  (ISO)
Muscle Weakness  (ISO)
myelitis  (ISO)
Nervous System Malformations  (ISO)
neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures  (ISO)
Neurodevelopmental Disorders  (ISO)
neurogenic bladder  (ISO)
Neurologic Gait Disorders  (ISO)
progressive bulbar palsy  (ISO)
spastic ataxia  (ISO)
spinocerebellar ataxia type 6  (ISO)
Spinocerebellar Ataxias  (ISO)
Sporadic Hemiplegic Migraine  (ISO)
subependymal giant cell astrocytoma  (ISO)
sudden infant death syndrome  (ISO)
temporal lobe epilepsy  (ISO)
vascular dementia  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
behavioral response to pain  (ISO)
calcium ion import  (ISO)
calcium ion transmembrane transport  (ISO)
calcium ion transport  (ISO)
calcium ion-regulated exocytosis of neurotransmitter  (ISO)
calcium-ion regulated exocytosis  (ISO)
cellular response to amyloid-beta  (ISO)
central nervous system neuron differentiation  (ISO)
cerebellar molecular layer development  (ISO)
cerebellar Purkinje cell differentiation  (ISO)
cerebellar Purkinje cell layer development  (ISO)
cerebellum maturation  (ISO)
chemical synaptic transmission  (ISO)
dendrite morphogenesis  (ISO)
establishment of localization in cell  (ISO)
gamma-aminobutyric acid secretion  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
glucose homeostasis  (ISO)
hormone biosynthetic process  (ISO)
intracellular chloride ion homeostasis  (ISO)
membrane depolarization  (ISO)
modulation of chemical synaptic transmission  (ISO)
musculoskeletal movement, spinal reflex action  (ISO)
negative regulation of hormone biosynthetic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
nervous system process  (ISO)
neuromuscular process  (ISO)
neuromuscular process controlling balance  (ISO)
neuromuscular synaptic transmission  (ISO)
neuron apoptotic process  (ISO)
neuron cellular homeostasis  (ISO)
neuron-neuron synaptic transmission  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
receptor clustering  (ISO)
regulation of acetylcholine secretion, neurotransmission  (ISO)
regulation of axonogenesis  (ISO)
regulation of calcium ion-dependent exocytosis  (ISO)
regulation of hormone levels  (ISO)
regulation of membrane potential  (ISO)
regulation of presynaptic cytosolic calcium ion concentration  (ISO)
regulation of sulfur amino acid metabolic process  (ISO)
regulation of voltage-gated calcium channel activity  (ISO)
response to amyloid-beta  (ISO)
response to pain  (ISO)
rhythmic synaptic transmission  (ISO)
spinal cord motor neuron differentiation  (ISO)
synapse assembly  (ISO)
synaptic transmission, GABAergic  (ISO)
synaptic transmission, glutamatergic  (ISO)
transmission of nerve impulse  (ISO)
vestibular nucleus development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
gliclazide pharmacodynamics pathway  (ISO)
glyburide pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway   (ISO)
insulin secretion pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway   (ISO)
potassium channel inhibitors pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. Differential subcellular immunolocalization of voltage-gated calcium channel alpha1 subunits in the chinchilla cristae ampullaris. Lopez I, etal., Neuroscience. 1999;92(2):773-82.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cacna1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,183,442 - 32,400,595 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,182,536 - 32,457,511 (-)NCBIChiLan1.0ChiLan1.0
CACNA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381913,206,442 - 13,506,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1913,206,442 - 13,633,025 (-)EnsemblGRCh38hg38GRCh38
GRCh371913,317,256 - 13,617,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,178,256 - 13,478,274 (-)NCBINCBI36Build 36hg18NCBI36
Build 341913,179,114 - 13,478,317NCBI
Celera1913,207,639 - 13,507,772 (-)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,889,634 - 13,189,171 (-)NCBIHuRef
CHM1_11913,318,256 - 13,618,198 (-)NCBICHM1_1
T2T-CHM13v2.01913,331,719 - 13,631,840 (-)NCBIT2T-CHM13v2.0
Cacna1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,065,257 - 85,366,880 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,065,268 - 85,366,875 (+)EnsemblGRCm39 Ensembl
GRCm38884,338,631 - 84,640,251 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,338,639 - 84,640,246 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,939,263 - 87,164,148 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,305,469 - 87,530,351 (+)NCBIMGSCv36mm8
Celera888,715,985 - 88,942,662 (+)NCBICelera
Cytogenetic Map8C2- C3NCBI
cM Map840.95NCBI
Cacna1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,425,560 - 40,724,810 (-)NCBIGRCr8
mRatBN7.21923,520,741 - 23,819,971 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,520,741 - 23,823,225 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,343,968 - 30,567,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,998,339 - 31,221,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,221,032 - 33,444,209 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,453,236 - 25,749,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,526,751 - 25,749,550 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,502,533 - 36,727,039 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,188,170 - 25,424,495 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,194,294 - 25,429,321 (-)NCBI
Celera1923,074,249 - 23,295,970 (-)NCBICelera
Cytogenetic Map19q11NCBI
CACNA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22018,136,613 - 18,555,581 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11917,137,272 - 17,556,602 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,769,586 - 13,189,022 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,506,232 - 13,804,815 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,507,102 - 13,804,729 (-)Ensemblpanpan1.1panPan2
CACNA1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,747,087 - 49,036,627 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,821,025 - 49,036,032 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,694,916 - 48,910,172 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,339,396 - 49,554,755 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,280,733 - 49,553,801 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,549,923 - 48,765,101 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,976,279 - 49,191,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,219,720 - 49,435,029 (+)NCBIUU_Cfam_GSD_1.0
LOC101960999
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,078,478 - 208,143,320 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,192,610 - 2,392,638 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366592,201,606 - 2,269,625 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,514,509 - 65,871,182 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,491,784 - 65,871,068 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,921,411 - 66,176,189 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNA1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,883,353 - 12,307,023 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660747,403,914 - 7,900,327 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901708,234 - 932,643 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901707,322 - 932,658 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000019564   ⟹   ENSCLAP00000019375
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541532,183,442 - 32,400,595 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000019565   ⟹   ENSCLAP00000019376
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541532,183,442 - 32,400,595 (-)Ensembl
RefSeq Acc Id: XM_013512132   ⟹   XP_013367586
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541532,182,536 - 32,457,511 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013367586 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000019375.1
  ENSCLAP00000019376.1
Reference Protein Sequences
RefSeq Acc Id: XP_013367586   ⟸   XM_013512132
- UniProtKB: A0A8C2VRD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000019376   ⟸   ENSCLAT00000019565
RefSeq Acc Id: ENSCLAP00000019375   ⟸   ENSCLAT00000019564
Protein Domains
Voltage-dependent calcium channel alpha-1 subunit


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013282 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019564.1 UniProtKB/TrEMBL
  ENSCLAT00000019565.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  6.10.250.2180 UniProtKB/TrEMBL
  6.10.250.2500 UniProtKB/TrEMBL
InterPro GPHH_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  VDCC_a1su_IQ UniProtKB/TrEMBL
  VDCCAlpha1 UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene Cacna1a ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A UniProtKB/TrEMBL
Pfam Ca_chan_IQ UniProtKB/TrEMBL
  GPHH UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
PRINTS CACHANNEL UniProtKB/TrEMBL
SMART Ca_chan_IQ UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8C2VRD3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VYM6_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Cacna1a  calcium voltage-gated channel subunit alpha1 A    calcium channel, voltage-dependent, P/Q type, alpha 1A subunit  Symbol and/or name change 5135510 APPROVED