Atp1a3 (ATPase Na+/K+ transporting subunit alpha 3) - Rat Genome Database

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Gene: Atp1a3 (ATPase Na+/K+ transporting subunit alpha 3) Rattus norvegicus
Analyze
Symbol: Atp1a3
Name: ATPase Na+/K+ transporting subunit alpha 3
RGD ID: 2169
Description: Enables D1 dopamine receptor binding activity and amyloid-beta binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to retinoic acid; and metal ion transport. Located in several cellular components, including axon; dendritic spine; and myelin sheath. Part of sodium:potassium-exchanging ATPase complex. Is active in calyx of Held; postsynapse; and presynaptic membrane. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; bipolar disorder; developmental and epileptic encephalopathy 99; dystonia 12; and epilepsy. Orthologous to human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Atpa1a3; ATPase Na+K+ transporting alpha 3 subunit; ATPase, Na+/K+ transporting, alpha 3 polypeptide; ATPase, Na+K+ transporting, alpha 3 subunit; na(+)/K(+) ATPase alpha(III) subunit; na(+)/K(+) ATPase alpha-3 subunit; Na+/K+ -ATPase alpha 3 subunit; NA,K-ATPase alpha subunit 3; sodium pump subunit alpha-3; sodium/potassium-transporting ATPase subunit alpha-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,700,645 - 89,729,782 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl189,700,649 - 89,729,825 (-)EnsemblGRCr8
mRatBN7.2180,572,790 - 80,601,936 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,572,796 - 80,601,918 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx185,965,362 - 85,994,505 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,516,223 - 94,545,362 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,721,120 - 87,750,267 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,852,423 - 81,881,565 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,852,429 - 81,881,549 (-)Ensemblrn6Rnor6.0
Rnor_5.0183,104,725 - 83,133,845 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,280,714 - 80,309,834 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,018,852 - 75,047,865 (-)NCBICelera
RGSC_v3.1180,358,824 - 80,387,945 (-)NCBI
RH 3.4 Map1842.5RGD
RH 2.0 Map1501.2RGD
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
acetamide  (EXP)
acrolein  (EXP)
all-trans-retinoic acid  (ISO)
ammonia  (ISO)
ammonium acetate  (EXP)
atrazine  (ISO)
Azoxymethane  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
Brodifacoum  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
choline  (ISO)
cocaine  (EXP)
corticosterone  (EXP)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
digoxin  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP)
doxorubicin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
enniatin  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
haloperidol  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
losartan  (EXP)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
Mesaconitine  (EXP)
metformin  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
okadaic acid  (ISO)
ouabain  (EXP,ISO)
ozone  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
potassium chloride  (ISO)
rotenone  (EXP)
S-nitrosoglutathione  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
blood circulation  (ISO)
brain-derived neurotrophic factor receptor signaling pathway  (ISO)
calcium-mediated signaling  (ISO)
carboxylic acid transport  (ISO)
cardiac muscle contraction  (ISO)
cellular response to amyloid-beta  (IDA)
cellular response to retinoic acid  (IEP)
cellular response to thyroid hormone stimulus  (IEP)
cerebral cortex development  (IEP,ISO)
circadian rhythm  (ISO)
cognition  (ISO)
determination of adult lifespan  (ISO)
ERK1 and ERK2 cascade  (ISO)
establishment or maintenance of transmembrane electrochemical gradient  (IEA)
fear response  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
habituation  (ISO)
inhibitory chemical synaptic transmission  (ISO)
intracellular potassium ion homeostasis  (IBA,IEA,ISO)
intracellular sodium ion homeostasis  (IBA,IEA,ISO)
ionotropic glutamate receptor signaling pathway  (ISO)
L-ascorbic acid metabolic process  (ISO)
learning  (ISO)
locomotion  (ISO)
locomotory behavior  (ISO)
membrane depolarization  (ISO)
memory  (ISO)
monoatomic ion transport  (IEA)
motor behavior  (ISO)
multicellular organism growth  (ISO)
neurogenesis  (ISO)
neuromuscular process  (ISO)
neuromuscular process controlling balance  (ISO)
neuron projection maintenance  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
pore complex assembly  (ISO)
potassium ion import across plasma membrane  (IBA,IEA,ISO)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (IDA,IEA)
proton transmembrane transport  (IBA)
regulation of cardiac muscle cell membrane potential  (ISO)
regulation of short-term neuronal synaptic plasticity  (ISO)
response to activity  (ISO)
response to electrical stimulus  (ISO)
response to environmental enrichment  (ISO)
response to hormone  (ISO)
response to immobilization stress  (ISO)
response to lithium ion  (ISO)
response to methamphetamine hydrochloride  (ISO)
response to monoamine  (ISO)
response to potassium ion  (ISO)
response to stress  (ISO)
response to temperature stimulus  (ISO)
response to xenobiotic stimulus  (ISO)
sleep  (ISO)
social behavior  (ISO)
sodium ion export across plasma membrane  (IBA,IEA,ISO)
sodium ion transport  (IDA,IEA)
thalamus development  (ISO)
transmission of nerve impulse  (ISO)
visual learning  (ISO)
walking behavior  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes. Beguin P, etal., EMBO J 2002 Jul 1;21(13):3264-73.
2. Nearest neighbor analysis of dopamine D1 receptors and Na(+)-K(+)-ATPases in dendritic spines dissected by STED microscopy. Blom H, etal., Microsc Res Tech. 2012 Feb;75(2):220-8. doi: 10.1002/jemt.21046. Epub 2011 Aug 1.
3. Temporal and topographic alterations in expression of the alpha3 isoform of Na+, K(+)-ATPase in the rat freeze lesion model of microgyria and epileptogenesis. Chu Y, etal., Neuroscience. 2009 Aug 18;162(2):339-48. doi: 10.1016/j.neuroscience.2009.04.003. Epub 2009 Apr 9.
4. A novel recurrent mutation in ATP1A3 causes CAPOS syndrome. Demos MK, etal., Orphanet J Rare Dis. 2014 Jan 28;9:15. doi: 10.1186/1750-1172-9-15.
5. Stretch receptor-associated expression of alpha 3 isoform of the Na+, K+-ATPase in rat peripheral nervous system. Dobretsov M, etal., Neuroscience. 2003;116(4):1069-80.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, etal., Pflugers Arch. 2005 Oct;451(1):87-98. Epub 2005 Jul 16.
8. Primary structures of two types of alpha-subunit of rat brain Na+,K+,-ATPase deduced from cDNA sequences. Hara Y, etal., J Biochem (Tokyo) 1987 Jul;102(1):43-58.
9. Negative regulation of the rat Na-K-ATPase alpha 3-subunit gene promoter by thyroid hormone. He H, etal., Am J Physiol. 1996 Nov;271(5 Pt 1):C1750-6.
10. Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications. Herrera VL, etal., J Cell Biol 1987 Oct;105(4):1855-65.
11. Alpha3Na+/K+-ATPase is a neuronal receptor for agrin. Hilgenberg LG, etal., Cell. 2006 Apr 21;125(2):359-69.
12. Presynaptic Ca2+ buffers control the strength of a fast post-tetanic hyperpolarization mediated by the alpha3 Na(+)/K(+)-ATPase. Kim JH, etal., Nat Neurosci. 2007 Feb;10(2):196-205. doi: 10.1038/nn1839. Epub 2007 Jan 14.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Distribution of the Na,K-ATPase alpha subunit in the rat spiral ganglion and organ of corti. McLean WJ, etal., J Assoc Res Otolaryngol. 2009 Mar;10(1):37-49. doi: 10.1007/s10162-008-0152-9. Epub 2008 Dec 12.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3). Mynett-Johnson L, etal., Biol Psychiatry 1998 Jul 1;44(1):47-51.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Na, K-ATPase a3 is a death target of Alzheimer patient amyloid-ß assembly. Ohnishi T, etal., Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4465-74. doi: 10.1073/pnas.1421182112. Epub 2015 Jul 29.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Novel mutations in ATP1A3 associated with catastrophic early life epilepsy, episodic prolonged apnea, and postnatal microcephaly. Paciorkowski AR, etal., Epilepsia. 2015 Mar;56(3):422-30. doi: 10.1111/epi.12914. Epub 2015 Feb 5.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Genotype-phenotype correlations in alternating hemiplegia of childhood. Sasaki M, etal., Neurology. 2014 Feb 11;82(6):482-90. doi: 10.1212/WNL.0000000000000102. Epub 2014 Jan 15.
27. Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain. Shull GE, etal., Biochemistry 1986 Dec 16;25(25):8125-32.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Genome sequencing identifies a novel mutation in ATP1A3 in a family with dystonia in females only. Wilcox R, etal., J Neurol. 2015 Jan;262(1):187-93. doi: 10.1007/s00415-014-7547-9. Epub 2014 Oct 31.
30. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
Additional References at PubMed
PMID:10636900   PMID:10837135   PMID:14593108   PMID:15260953   PMID:17008770   PMID:17234593   PMID:17634366   PMID:18418421   PMID:19376779   PMID:19751721   PMID:21080065   PMID:21196491  
PMID:21272290   PMID:22120110   PMID:22871113   PMID:23195960   PMID:23467881   PMID:24356962   PMID:24391932   PMID:24769233   PMID:25274047   PMID:29476059   PMID:31686426   PMID:32357304  
PMID:38796484  


Genomics

Comparative Map Data
Atp1a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,700,645 - 89,729,782 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl189,700,649 - 89,729,825 (-)EnsemblGRCr8
mRatBN7.2180,572,790 - 80,601,936 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,572,796 - 80,601,918 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx185,965,362 - 85,994,505 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,516,223 - 94,545,362 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,721,120 - 87,750,267 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,852,423 - 81,881,565 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,852,429 - 81,881,549 (-)Ensemblrn6Rnor6.0
Rnor_5.0183,104,725 - 83,133,845 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,280,714 - 80,309,834 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,018,852 - 75,047,865 (-)NCBICelera
RGSC_v3.1180,358,824 - 80,387,945 (-)NCBI
RH 3.4 Map1842.5RGD
RH 2.0 Map1501.2RGD
Cytogenetic Map1q21NCBI
ATP1A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,966,582 - 41,994,230 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,966,582 - 41,997,497 (-)Ensemblhg38GRCh38
GRCh371942,470,734 - 42,498,382 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,162,574 - 47,190,222 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341947,162,575 - 47,190,222NCBI
Celera1939,270,362 - 39,298,001 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,902,456 - 38,930,242 (-)NCBIHuRef
CHM1_11942,472,364 - 42,500,045 (-)NCBICHM1_1
T2T-CHM13v2.01944,785,945 - 44,813,592 (-)NCBIT2T-CHM13v2.0
Atp1a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,677,592 - 24,705,338 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,677,592 - 24,705,383 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38724,978,167 - 25,006,077 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,978,167 - 25,005,958 (-)Ensemblmm10GRCm38
MGSCv37725,763,186 - 25,790,914 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36724,686,927 - 24,714,655 (-)NCBIMGSCv36mm8
Celera719,593,974 - 19,621,705 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.73NCBI
Atp1a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555869,325 - 893,542 (+)Ensembl
ChiLan1.0NW_004955555869,508 - 892,510 (+)NCBIChiLan1.0ChiLan1.0
ATP1A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,071,671 - 48,099,363 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,940,042 - 49,967,977 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,854,243 - 38,882,034 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,357,926 - 47,383,736 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,358,281 - 47,384,716 (-)EnsemblpanPan2panpan1.1
ATP1A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,325,988 - 112,346,056 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,325,289 - 112,346,916 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1111,758,069 - 111,778,105 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01112,945,619 - 112,965,659 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,945,448 - 112,986,321 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,498,938 - 112,518,971 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,135,175 - 112,155,359 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,061,496 - 113,081,538 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atp1a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,130,267 - 16,147,315 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706477,107 - 495,525 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936706476,473 - 494,659 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,905,847 - 49,927,633 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,905,851 - 49,927,437 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,929,174 - 45,946,082 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP1A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,166,586 - 36,195,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,166,262 - 36,195,363 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607314,408,818 - 14,437,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907715,094 - 736,432 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624907715,109 - 736,040 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Atp1a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12169,699,584 - 169,728,408 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atp1a3
120 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000027497
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat

Markers in Region
D1Mco17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,602,576 - 80,602,732 (+)MAPPERmRatBN7.2
Rnor_6.0181,882,206 - 81,882,361NCBIRnor6.0
Rnor_5.0183,134,502 - 83,134,657UniSTSRnor5.0
RGSC_v3.4180,310,490 - 80,310,646RGDRGSC3.4
RGSC_v3.4180,310,491 - 80,310,646UniSTSRGSC3.4
Celera175,048,522 - 75,048,677UniSTS
RGSC_v3.1180,388,601 - 80,388,757RGD
Cytogenetic Map1q21UniSTS
D1Bda7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,572,832 - 80,573,172 (+)MAPPERmRatBN7.2
Rnor_6.0181,852,466 - 81,852,805NCBIRnor6.0
Rnor_5.0183,104,762 - 83,105,101UniSTSRnor5.0
RGSC_v3.4180,280,751 - 80,281,090UniSTSRGSC3.4
Celera175,018,889 - 75,019,228UniSTS
Cytogenetic Map1q21UniSTS
RH94467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,572,832 - 80,572,992 (+)MAPPERmRatBN7.2
Rnor_6.0181,852,466 - 81,852,625NCBIRnor6.0
Rnor_5.0183,104,762 - 83,104,921UniSTSRnor5.0
RGSC_v3.4180,280,751 - 80,280,910UniSTSRGSC3.4
Celera175,018,889 - 75,019,048UniSTS
RH 3.4 Map1842.5UniSTS
Cytogenetic Map1q21UniSTS
UniSTS:480319  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,573,589 - 80,575,216 (+)MAPPERmRatBN7.2
Rnor_6.0181,853,223 - 81,854,849NCBIRnor6.0
Rnor_5.0183,105,519 - 83,107,145UniSTSRnor5.0
RGSC_v3.4180,281,508 - 80,283,134UniSTSRGSC3.4
Celera175,019,646 - 75,021,264UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 348 192 11 136 73 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027497   ⟹   ENSRNOP00000027497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,700,649 - 89,729,825 (-)Ensembl
mRatBN7.2 Ensembl180,572,796 - 80,601,918 (-)Ensembl
Rnor_6.0 Ensembl181,852,429 - 81,881,549 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105436   ⟹   ENSRNOP00000080189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,700,649 - 89,724,960 (-)Ensembl
mRatBN7.2 Ensembl180,572,796 - 80,597,111 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150678   ⟹   ENSRNOP00000105932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,700,649 - 89,728,808 (-)Ensembl
RefSeq Acc Id: NM_012506   ⟹   NP_036638
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,700,649 - 89,729,769 (-)NCBI
mRatBN7.2180,572,796 - 80,601,920 (-)NCBI
Rnor_6.0181,852,429 - 81,881,549 (-)NCBI
Rnor_5.0183,104,725 - 83,133,845 (-)NCBI
RGSC_v3.4180,280,714 - 80,309,834 (-)RGD
Celera175,018,852 - 75,047,865 (-)RGD
Sequence:
RefSeq Acc Id: XM_017588775   ⟹   XP_017444264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,700,645 - 89,729,782 (-)NCBI
mRatBN7.2180,572,790 - 80,601,936 (-)NCBI
Rnor_6.0181,852,423 - 81,881,565 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036638   ⟸   NM_012506
- UniProtKB: A0A8I5ZQ22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444264   ⟸   XM_017588775
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QEN5 (UniProtKB/TrEMBL),   A0A8I5ZQ22 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027497   ⟸   ENSRNOT00000027497
Ensembl Acc Id: ENSRNOP00000080189   ⟸   ENSRNOT00000105436
Ensembl Acc Id: ENSRNOP00000105932   ⟸   ENSRNOT00000150678
Protein Domains
Cation-transporting P-type ATPase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06687-F1-model_v2 AlphaFold P06687 1-1013 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689809
Promoter ID:EPDNEW_R334
Type:initiation region
Name:Atp1a3_1
Description:ATPase Na+/K+ transporting subunit alpha 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0181,881,559 - 81,881,619EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2169 AgrOrtholog
BioCyc Gene G2FUF-60407 BioCyc
Ensembl Genes ENSRNOG00000020263 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027497 ENTREZGENE
  ENSRNOT00000150678 ENTREZGENE
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, transmembrane domain UniProtKB/Swiss-Prot
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  Cation_transp_ATPase_P-type UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  P-type_ATPase_IIC UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot
KEGG Report rno:24213 UniProtKB/Swiss-Prot
NCBI Gene 24213 ENTREZGENE
PANTHER SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA UniProtKB/Swiss-Prot
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-3 UniProtKB/Swiss-Prot
Pfam Cation_ATPase UniProtKB/Swiss-Prot
  Cation_ATPase_C UniProtKB/Swiss-Prot
  Cation_ATPase_N UniProtKB/Swiss-Prot
  E1-E2_ATPase UniProtKB/Swiss-Prot
PhenoGen Atp1a3 PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot
  NAKATPASE UniProtKB/Swiss-Prot
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020263 RatGTEx
SMART Cation_ATPase_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81660 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
TIGR TC219862
UniProt A0A8I5ZQ22 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QEN5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJY0_RAT UniProtKB/TrEMBL
  A6J933_RAT UniProtKB/TrEMBL
  A6J935_RAT UniProtKB/TrEMBL
  AT1A3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q16732 UniProtKB/Swiss-Prot
  Q9Z1G6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp1a3  ATPase Na+/K+ transporting subunit alpha 3  Atp1a3  ATPase, Na+/K+ transporting, alpha 3 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Atp1a3  ATPase, Na+K+ transporting, alpha 3 subunit      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression 4.5 kb mRNA form is expressed in most tissues while the 6 kb form is expressed only in fetal brain, adult brain, heart, and skeletal muscle 631773
gene_expression may be specifically expressed in afferent and efferent axons innervating skeletal muscle stretch receptors 631774
gene_regulation may be regulated by FXYD7 in brain 631775
gene_transcript consists of two mRNA species with differential expression patterns 631773