RGD Reference Report - Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3). - Rat Genome Database

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Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3).

Authors: Mynett-Johnson, L  Murphy, V  McCormack, J  Shields, DC  Claffey, E  Manley, P  McKeon, P 
Citation: Mynett-Johnson L, etal., Biol Psychiatry 1998 Jul 1;44(1):47-51.
RGD ID: 1358437
Pubmed: PMID:9646882   (View Abstract at PubMed)

BACKGROUND: Disturbances in central nervous system Na+, K+ adenosine triphosphatase (ATPase) activity have previously been proposed as being involved in the pathophysiology of bipolar mood disorder. METHODS: We have examined one particular alpha subunit of this enzyme for allelic association in a sample of 85 Irish bipolar patients and 85 matched controls. RESULTS: There was evidence for an overall allelic association between the disease and a dinucleotide polymorphism within the ATP1A3 gene (p = .022). Subjects were then analyzed on the basis of a number of criteria, and the significance of the association increased when cases were divided based on the nature of the first episode. Patients who presented with a depressive episode first showed a significant association (p = .001) with this polymorphism. CONCLUSIONS: The results presented here provide preliminary evidence of an association between bipolar disorder and an alpha subunit of Na+, K+ ATPase, the expression of which predominates in the brain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bipolar disorder  IAGP 1358437 RGD 
bipolar disorder  ISOATP1A3 (Homo sapiens)1358437; 1358437 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atp1a3  (ATPase Na+/K+ transporting subunit alpha 3)

Genes (Mus musculus)
Atp1a3  (ATPase, Na+/K+ transporting, alpha 3 polypeptide)

Genes (Homo sapiens)
ATP1A3  (ATPase Na+/K+ transporting subunit alpha 3)


Additional Information