Arnt2 (aryl hydrocarbon receptor nuclear translocator 2) - Rat Genome Database

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Gene: Arnt2 (aryl hydrocarbon receptor nuclear translocator 2) Rattus norvegicus
Analyze
Symbol: Arnt2
Name: aryl hydrocarbon receptor nuclear translocator 2
RGD ID: 2154
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; aryl hydrocarbon receptor binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of apoptotic process; response to estradiol; and response to hypoxia. Located in nucleus. Orthologous to human ARNT2 (aryl hydrocarbon receptor nuclear translocator 2); PARTICIPATES IN hypoxia inducible factor pathway; renal cell carcinoma pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ARNT protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,645,354 - 147,801,986 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1147,599,058 - 147,801,997 (-)EnsemblGRCr8
mRatBN7.21138,236,235 - 138,392,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1138,189,940 - 138,393,153 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1146,183,308 - 146,345,124 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,352,320 - 153,514,126 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01146,227,516 - 146,389,330 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01146,399,217 - 146,556,437 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,399,217 - 146,556,171 (-)Ensemblrn6Rnor6.0
Rnor_5.01147,280,828 - 147,485,173 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41140,535,823 - 140,646,838 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1130,254,815 - 130,411,200 (-)NCBICelera
RGSC_v3.11140,618,128 - 140,771,554 (-)NCBI
Cytogenetic Map1q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
captan  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
esketamine  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
malathion  (ISO)
maneb  (ISO)
Mesaconitine  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
progesterone  (EXP)
propiconazole  (EXP)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zalcitabine  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Two splice variants of the hypoxia-inducible factor HIF-1alpha as potential dimerization partners of ARNT2 in neurons. Drutel G, etal., Eur J Neurosci. 2000 Oct;12(10):3701-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gaf-1b is an alternative splice variant of Gaf-1/Rip11. Kawase K, etal., Biochem Biophys Res Commun 2003 Apr 18;303(4):1042-6.
5. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Keith B, etal., Nat Rev Cancer. 2011 Dec 15;12(1):9-22. doi: 10.1038/nrc3183.
6. Identification of novel splice variants of ARNT and ARNT2 in the rat. Korkalainen M, etal., Biochem Biophys Res Commun 2003 Apr 18;303(4):1095-100.
7. The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia. Maltepe E, etal., Biochem Biophys Res Commun. 2000 Jun 24;273(1):231-8.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Estrogen increases messenger RNA and immunoreactivity of aryl-hydrocarbon receptor nuclear translocator 2 in the rat mediobasal hypothalamus. Mitsushima D, etal., Biochem Biophys Res Commun 2003 Jul 25;307(2):248-53.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8657146   PMID:8927054   PMID:11318878   PMID:11782478   PMID:12239177   PMID:12502753   PMID:14701734   PMID:23861074   PMID:24022475   PMID:24465693   PMID:27782878  


Genomics

Comparative Map Data
Arnt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,645,354 - 147,801,986 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1147,599,058 - 147,801,997 (-)EnsemblGRCr8
mRatBN7.21138,236,235 - 138,392,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1138,189,940 - 138,393,153 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1146,183,308 - 146,345,124 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,352,320 - 153,514,126 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01146,227,516 - 146,389,330 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01146,399,217 - 146,556,437 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,399,217 - 146,556,171 (-)Ensemblrn6Rnor6.0
Rnor_5.01147,280,828 - 147,485,173 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41140,535,823 - 140,646,838 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1130,254,815 - 130,411,200 (-)NCBICelera
RGSC_v3.11140,618,128 - 140,771,554 (-)NCBI
Cytogenetic Map1q31NCBI
ARNT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381580,404,382 - 80,597,933 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1580,404,315 - 80,597,937 (+)Ensemblhg38GRCh38
GRCh371580,696,724 - 80,890,274 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361578,483,747 - 78,677,333 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341578,483,888 - 78,677,327NCBI
Celera1557,634,149 - 57,827,949 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1557,454,998 - 57,648,448 (+)NCBIHuRef
CHM1_11580,814,701 - 81,008,291 (+)NCBICHM1_1
T2T-CHM13v2.01578,267,966 - 78,461,516 (+)NCBIT2T-CHM13v2.0
Arnt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39783,895,486 - 84,059,201 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl783,895,486 - 84,059,384 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38784,246,274 - 84,411,741 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl784,246,278 - 84,410,176 (-)Ensemblmm10GRCm38
MGSCv37791,394,788 - 91,510,183 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36784,122,463 - 84,286,144 (-)NCBIMGSCv36mm8
Celera781,653,324 - 81,768,781 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.35NCBI
Arnt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541611,308,846 - 11,429,365 (+)Ensembl
ChiLan1.0NW_00495541611,279,866 - 11,429,365 (+)NCBIChiLan1.0ChiLan1.0
ARNT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21669,662,301 - 69,859,201 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11573,824,509 - 74,021,481 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01559,376,993 - 59,573,925 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11578,370,762 - 78,530,228 (+)NCBIPanPan1.1PanPan1.1panPan2
ARNT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,005,106 - 57,139,585 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,008,570 - 57,159,713 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha359,655,962 - 59,811,362 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0357,429,824 - 57,585,366 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,429,242 - 57,585,462 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1356,940,023 - 57,064,985 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,146,234 - 57,298,136 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0357,482,842 - 57,638,341 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arnt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640126,115,254 - 126,292,816 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648320,041,657 - 20,218,965 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648320,041,712 - 20,218,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARNT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl749,259,651 - 49,450,461 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1749,259,118 - 49,450,471 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2754,768,266 - 54,959,560 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARNT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1262,790,059 - 2,990,760 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl262,794,372 - 2,990,814 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048138,893,800 - 139,095,860 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arnt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476821,166,554 - 21,319,594 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476821,166,554 - 21,319,462 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Arnt2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12115,945,070 - 116,098,782 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arnt2
1118 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:590
Count of miRNA genes:270
Interacting mature miRNAs:365
Transcripts:ENSRNOT00000017636
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
D1Rat273  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81147,753,973 - 147,754,134 (+)Marker Load Pipeline
mRatBN7.21138,344,856 - 138,345,017 (+)MAPPERmRatBN7.2
Rnor_6.01146,507,930 - 146,508,090NCBIRnor6.0
Rnor_5.01147,436,666 - 147,436,826UniSTSRnor5.0
RGSC_v3.41140,644,473 - 140,644,634RGDRGSC3.4
RGSC_v3.41140,644,474 - 140,644,634UniSTSRGSC3.4
Celera1130,363,335 - 130,363,495UniSTS
RGSC_v3.11140,722,879 - 140,723,040RGD
SHRSP x BN Map171.12UniSTS
SHRSP x BN Map171.12RGD
Cytogenetic Map1q31UniSTS
D63644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21138,239,989 - 138,240,139 (+)MAPPERmRatBN7.2
Rnor_6.01146,402,972 - 146,403,121NCBIRnor6.0
Rnor_5.01147,331,707 - 147,331,856UniSTSRnor5.0
RGSC_v3.41140,539,578 - 140,539,727UniSTSRGSC3.4
Celera1130,258,570 - 130,258,719UniSTS
Cytogenetic Map1q31UniSTS
BG381198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21138,236,350 - 138,236,555 (+)MAPPERmRatBN7.2
Rnor_6.01146,399,333 - 146,399,537NCBIRnor6.0
Rnor_5.01147,328,068 - 147,328,272UniSTSRnor5.0
RGSC_v3.41140,535,939 - 140,536,143UniSTSRGSC3.4
Celera1130,254,931 - 130,255,135UniSTS
RH 3.4 Map11104.0UniSTS
Cytogenetic Map1q31UniSTS
BE110521  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21138,238,007 - 138,238,160 (+)MAPPERmRatBN7.2
Rnor_6.01146,400,990 - 146,401,142NCBIRnor6.0
Rnor_5.01147,329,725 - 147,329,877UniSTSRnor5.0
RGSC_v3.41140,537,596 - 140,537,748UniSTSRGSC3.4
Celera1130,256,588 - 130,256,740UniSTS
RH 3.4 Map11111.9UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 89 88 57 48 57 6 310 148 11 139 81 92 31 15 15

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY264366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ223732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U61157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U61405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017636   ⟹   ENSRNOP00000017636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1138,237,664 - 138,345,239 (-)Ensembl
Rnor_6.0 Ensembl1146,399,217 - 146,556,171 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105581   ⟹   ENSRNOP00000084711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1147,599,058 - 147,801,997 (-)Ensembl
mRatBN7.2 Ensembl1138,189,940 - 138,393,153 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107318   ⟹   ENSRNOP00000087722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1138,189,940 - 138,393,153 (-)Ensembl
RefSeq Acc Id: NM_012781   ⟹   NP_036913
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,645,354 - 147,801,883 (-)NCBI
mRatBN7.21138,236,235 - 138,392,766 (-)NCBI
Rnor_6.01146,399,217 - 146,556,437 (-)NCBI
Rnor_5.01147,280,828 - 147,485,173 (-)NCBI
RGSC_v3.41140,535,823 - 140,646,838 (-)RGD
Celera1130,254,815 - 130,411,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229496   ⟹   XP_006229558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,645,360 - 147,763,385 (-)NCBI
mRatBN7.21138,236,235 - 138,354,266 (-)NCBI
Rnor_6.01146,399,217 - 146,518,692 (-)NCBI
Rnor_5.01147,280,828 - 147,485,173 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229498   ⟹   XP_006229560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,649,317 - 147,801,985 (-)NCBI
mRatBN7.21138,236,235 - 138,392,868 (-)NCBI
Rnor_6.01146,403,141 - 146,556,133 (-)NCBI
Rnor_5.01147,280,828 - 147,485,173 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759606   ⟹   XP_008757828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,645,360 - 147,757,255 (-)NCBI
mRatBN7.21138,236,235 - 138,348,137 (-)NCBI
Rnor_6.01146,399,217 - 146,511,809 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588812   ⟹   XP_017444301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,645,360 - 147,801,984 (-)NCBI
mRatBN7.21138,236,235 - 138,392,868 (-)NCBI
Rnor_6.01146,399,217 - 146,556,133 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101491   ⟹   XP_038957419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,645,360 - 147,764,997 (-)NCBI
mRatBN7.21138,236,235 - 138,392,866 (-)NCBI
RefSeq Acc Id: XM_063281490   ⟹   XP_063137560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,645,360 - 147,764,881 (-)NCBI
RefSeq Acc Id: XM_063281500   ⟹   XP_063137570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,645,360 - 147,801,744 (-)NCBI
RefSeq Acc Id: XM_063281503   ⟹   XP_063137573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,645,360 - 147,765,011 (-)NCBI
RefSeq Acc Id: XM_063281511   ⟹   XP_063137581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,649,317 - 147,801,986 (-)NCBI
RefSeq Acc Id: XM_063281516   ⟹   XP_063137586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,645,360 - 147,750,345 (-)NCBI
RefSeq Acc Id: NP_036913   ⟸   NM_012781
- UniProtKB: Q63646 (UniProtKB/Swiss-Prot),   Q63643 (UniProtKB/Swiss-Prot),   Q30B64 (UniProtKB/Swiss-Prot),   Q80T24 (UniProtKB/Swiss-Prot),   Q78E60 (UniProtKB/Swiss-Prot),   A6JCN8 (UniProtKB/TrEMBL),   A0A8L2Q903 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229558   ⟸   XM_006229496
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q903 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229560   ⟸   XM_006229498
- Peptide Label: isoform X3
- UniProtKB: A6JCN9 (UniProtKB/TrEMBL),   A0A8L2Q903 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757828   ⟸   XM_008759606
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q903 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444301   ⟸   XM_017588812
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q903 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017636   ⟸   ENSRNOT00000017636
RefSeq Acc Id: XP_038957419   ⟸   XM_039101491
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q903 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087722   ⟸   ENSRNOT00000107318
Ensembl Acc Id: ENSRNOP00000084711   ⟸   ENSRNOT00000105581
RefSeq Acc Id: XP_063137570   ⟸   XM_063281500
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q903 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137573   ⟸   XM_063281503
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q903 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137560   ⟸   XM_063281490
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q903 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137586   ⟸   XM_063281516
- Peptide Label: isoform X5
- UniProtKB: A0A8L2Q903 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137581   ⟸   XM_063281511
- Peptide Label: isoform X4
- UniProtKB: A0A8L2Q903 (UniProtKB/TrEMBL)
Protein Domains
bHLH   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q78E60-F1-model_v2 AlphaFold Q78E60 1-712 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2154 AgrOrtholog
BioCyc Gene G2FUF-58651 BioCyc
Ensembl Genes ENSRNOG00000013017 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000063992 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000105581 ENTREZGENE
  ENSRNOT00000105581.1 UniProtKB/Swiss-Prot
  ENSRNOT00000107318.1 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
  PAS domain UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  Circadian_TF UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Nuc_translocat UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  PAS_fold UniProtKB/Swiss-Prot
KEGG Report rno:25243 UniProtKB/Swiss-Prot
NCBI Gene 25243 ENTREZGENE
PANTHER CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS_11 UniProtKB/Swiss-Prot
PhenoGen Arnt2 PhenoGen
PRINTS NCTRNSLOCATR UniProtKB/Swiss-Prot
PROSITE BHLH UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013017 RatGTEx
  ENSRNOG00000063992 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
TIGR TC202887
UniProt A0A8L2Q903 ENTREZGENE
  A6JCN8 ENTREZGENE, UniProtKB/TrEMBL
  A6JCN9 ENTREZGENE, UniProtKB/TrEMBL
  ARNT2_RAT UniProtKB/Swiss-Prot
  Q30B64 ENTREZGENE
  Q63643 ENTREZGENE
  Q63646 ENTREZGENE
  Q78E60 ENTREZGENE
  Q80T24 ENTREZGENE
UniProt Secondary Q30B64 UniProtKB/Swiss-Prot
  Q63643 UniProtKB/Swiss-Prot
  Q63646 UniProtKB/Swiss-Prot
  Q80T24 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Arnt2  Aryl hydrocarbon receptor nuclear translocator 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs estradiol benzoate (E(2)) significantly increases the expression of Arnt2 mRNA 631760
gene_expression expressed in the mediobasal hypothalamus 631760
gene_process functions in environmental carcinogen detoxification 631760
gene_transcript splicing variant exists with insertion found at 5' end of exon 19 that disrupts the functionally critical transactivation domain in the protein 631796