Aldh1a1 (aldehyde dehydrogenase 1 family, member A1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Aldh1a1 (aldehyde dehydrogenase 1 family, member A1) Rattus norvegicus
Analyze
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
RGD ID: 2087
Description: Enables benzaldehyde dehydrogenase (NAD+) activity; identical protein binding activity; and retinal dehydrogenase activity. Involved in several processes, including estrous cycle; maintenance of lens transparency; and retinoic acid metabolic process. Predicted to be located in axon; cytosol; and synapse. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1); PARTICIPATES IN retinoic acid metabolic pathway; cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-deoxyglucosone dehydrogenase; Ahd2; Aldehyde dehydrogenase 1; Aldehyde dehydrogenase 1 subfamily A1; Aldehyde dehydrogenase 1, subfamily A1; aldehyde dehydrogenase 1A1; aldehyde dehydrogenase 2; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase family 1, member A1; aldehyde dehydrogenase family 1, subfamily A1; aldehyde dehydrogenase, cytosolic; ALDH-E1; Aldh1; Aldh2; ALHDII; LOC103695056; RALDH 1; ralDH1; retinal dehydrogenase 1; uncharacterized LOC103695056
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,426,939 - 227,579,497 (+)NCBIGRCr8
mRatBN7.21218,000,470 - 218,152,962 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,042,127 - 218,152,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1226,448,507 - 226,490,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,385,074 - 233,427,098 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01226,203,095 - 226,245,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,222,689 - 238,264,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,222,521 - 238,264,330 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,340,587 - 245,562,970 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,731,675 - 223,773,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,895,697 - 223,937,307 (+)NCBI
Celera1215,379,207 - 215,421,068 (+)NCBICelera
Cytogenetic Map1q51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Aldh1a1Ratoral squamous cell carcinoma  ISOALDH1A1 (Homo sapiens)597538586protein:increased expression:oral epitheliumRGD 
Aldh1a1Ratpancreatic cancer  ISOALDH1A1 (Homo sapiens)2325688protein:decreased expression:pancreasRGD 
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Aldh1a1Ratautism spectrum disorder  ISOALDH1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Aldh1a1RatCreutzfeldt-Jakob disease  ISOALDH1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23349890
Aldh1a1RatExperimental Liver Cirrhosis  ISOALDH1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17072980
Aldh1a1Ratliver disease  ISOALDH1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31651977
Aldh1a1Ratmelanoma  ISOALDH1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31580832
Aldh1a1Ratmetabolic dysfunction-associated steatotic liver disease  ISOALDH1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29718361
Aldh1a1RatNeoplastic Cell Transformation  ISOALDH1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26783756 and PMID:29626521
Aldh1a1RatParkinsonism  ISOALDH1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25045800
Aldh1a1Ratrenal cell carcinoma  ISOALDH1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15108329
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Original Reference(s)
Aldh1a1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALDH1A1 mRNA]CTDPMID:31150632
Aldh1a1Rat(1->4)-beta-D-glucan multiple interactionsISOAldh1a1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ALDH1A1 mRNACTDPMID:36331819
Aldh1a1Rat(S)-nicotine multiple interactionsISOAldh1a1 (Mus musculus)6480464[Nicotine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Aldh1a1Rat(S)-nicotine increases activityISOALDH1A1 (Homo sapiens)6480464Nicotine results in increased activity of ALDH1A1 proteinCTDPMID:23219715
Aldh1a1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of ALDH1A1 mRNACTDPMID:17984292
Aldh1a1Rat1,1-dichloroethene increases expressionISOAldh1a1 (Mus musculus)6480464vinylidene chloride results in increased expression of ALDH1A1 mRNACTDPMID:26682919
Aldh1a1Rat1,2-dimethylhydrazine decreases expressionISOAldh1a1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of ALDH1A1 mRNACTDPMID:22206623
Aldh1a1Rat1,2-dimethylhydrazine multiple interactionsISOAldh1a1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ALDH1A1 mRNACTDPMID:22206623
Aldh1a1Rat1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine increases expressionEXP 6480464chlorcyclizine results in increased expression of ALDH1A1 mRNACTDPMID:21058326
Aldh1a1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOAldh1a1 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Aldh1a1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOAldh1a1 (Mus musculus)6480464[Caffeine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Aldh1a1Rat1-naphthyl isothiocyanate multiple interactionsISOALDH1A1 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNACTDPMID:27344345
Aldh1a1Rat1-nitropropane increases expressionEXP 64804641-nitropropane results in increased expression of ALDH1A1 mRNACTDPMID:17070881
Aldh1a1Rat17alpha-ethynylestradiol affects expressionISOAldh1a1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of ALDH1A1 mRNACTDPMID:17555576
Aldh1a1Rat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of ALDH1A1 mRNACTDPMID:20170705 and PMID:26865667
Aldh1a1Rat17alpha-ethynylestradiol affects expressionISOALDH1A1 (Homo sapiens)6480464Ethinyl Estradiol affects the expression of ALDH1A1 mRNACTDPMID:20170705 and PMID:26865667
Aldh1a1Rat17alpha-ethynylestradiol decreases expressionISOALDH1A1 (Homo sapiens)6480464Ethinyl Estradiol results in decreased expression of ALDH1A1 mRNACTDPMID:18936297
Aldh1a1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of ALDH1A1 mRNACTDPMID:12655037 more ...
Aldh1a1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of ALDH1A1 mRNACTDPMID:25543096
Aldh1a1Rat17beta-estradiol affects expressionISOAldh1a1 (Mus musculus)6480464Estradiol affects the expression of ALDH1A1 mRNACTDPMID:39298647

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Biological Process
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Original Reference(s)
Aldh1a1Rat9-cis-retinoic acid biosynthetic process acts_upstream_of_or_withinISOAldh1a1 (Mus musculus)1624291 PMID:11876656RGDPMID:11876656
Aldh1a1Rat9-cis-retinoic acid biosynthetic process acts_upstream_of_or_withinIEAUniProtKB:P24549 and ensembl:ENSMUSP000001534101600115GO_REF:0000107EnsemblGO_REF:0000107
Aldh1a1Rat9-cis-retinoic acid metabolic process  IDA 2306320 RGD 
Aldh1a1Ratapoptotic process acts_upstream_ofISOAldh1a1 (Mus musculus)1624291MGI:1861722 PMID:16207763 and PMID:16611695RGDPMID:16207763 and PMID:16611695
Aldh1a1Ratapoptotic process acts_upstream_ofIEAUniProtKB:P24549 and ensembl:ENSMUSP000001534101600115GO_REF:0000107EnsemblGO_REF:0000107
Aldh1a1Ratcellular detoxification of aldehyde involved_inIMP 2306321PMID:15623782UniProt 
Aldh1a1Ratcellular detoxification of aldehyde involved_inISOALDH1A1 (Homo sapiens)1624291 PMID:15623782RGDPMID:15623782
Aldh1a1Ratembryonic eye morphogenesis acts_upstream_of_or_withinISOAldh1a1 (Mus musculus)1624291MGI:1861722 PMID:16207763 and PMID:16611695RGDPMID:16207763 and PMID:16611695
Aldh1a1Ratembryonic eye morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P24549 and ensembl:ENSMUSP000001534101600115GO_REF:0000107EnsemblGO_REF:0000107
Aldh1a1Ratestrous cycle  IEP 2306318 RGD 
Aldh1a1Ratfructosamine catabolic process involved_inISSUniProtKB:P003521600115GO_REF:0000024UniProtGO_REF:0000024
Aldh1a1Ratfructosamine catabolic process involved_inISOALDH1A1 (Homo sapiens)1624291 PMID:17175089RGDPMID:17175089
Aldh1a1Ratfructose catabolic process involved_inIEAUniProtKB:P24549 and ensembl:ENSMUSP000001534101600115GO_REF:0000107EnsemblGO_REF:0000107
Aldh1a1Ratfructose catabolic process involved_inISOAldh1a1 (Mus musculus)1624291 PMID:29414685 and PMID:4343087RGDPMID:29414685 and PMID:4343087
Aldh1a1Ratgamma-aminobutyric acid biosynthetic process involved_inISSUniProtKB:P245491600115GO_REF:0000024UniProtGO_REF:0000024
Aldh1a1Ratgamma-aminobutyric acid biosynthetic process involved_inIEAUniProtKB:P24549 and ensembl:ENSMUSP000001534101600115GO_REF:0000107EnsemblGO_REF:0000107
Aldh1a1Ratgamma-aminobutyric acid biosynthetic process involved_inISOAldh1a1 (Mus musculus)1624291 PMID:26430123RGDPMID:26430123
Aldh1a1Ratkidney development  IEP 2306322 RGD 
Aldh1a1Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Aldh1a1Ratliver development  IEP 1643117 RGD 
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Cellular Component
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Original Reference(s)
Aldh1a1Rataxon located_inISSUniProtKB:P245491600115GO_REF:0000024UniProtGO_REF:0000024
Aldh1a1Rataxon located_inIEAUniProtKB-SubCell:SL-02791600115GO_REF:0000044UniProtGO_REF:0000044
Aldh1a1Rataxon located_inIEAUniProtKB:P24549 and ensembl:ENSMUSP000001534101600115GO_REF:0000107EnsemblGO_REF:0000107
Aldh1a1Rataxon located_inISOAldh1a1 (Mus musculus)1624291 PMID:26430123RGDPMID:26430123
Aldh1a1Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Aldh1a1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Aldh1a1Ratcytosol located_inISOALDH1A1 (Homo sapiens)1624291 PMID:12941160RGDGO_REF:0000052 and PMID:12941160
Aldh1a1Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Aldh1a1Ratcytosol located_inISSUniProtKB:Q8MI171600115GO_REF:0000024UniProtGO_REF:0000024
Aldh1a1Ratsynapse located_inIEAUniProtKB:P24549 and ensembl:ENSMUSP000001534101600115GO_REF:0000107EnsemblGO_REF:0000107
Aldh1a1Ratsynapse located_inISOAldh1a1 (Mus musculus)1624291 PMID:26430123RGDPMID:26430123
Aldh1a1Ratsynapse located_inISSUniProtKB:P245491600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Original Reference(s)
Aldh1a1Rat3-chloroallyl aldehyde dehydrogenase activity enablesIEAUniProtKB:P24549 and ensembl:ENSMUSP000001534101600115GO_REF:0000107EnsemblGO_REF:0000107
Aldh1a1Rat3-chloroallyl aldehyde dehydrogenase activity  TAS 628400 RGD 
Aldh1a1Rat3-chloroallyl aldehyde dehydrogenase activity enablesISOAldh1a1 (Mus musculus)1624291 PMID:12610736RGDPMID:12610736
Aldh1a1Rat3-deoxyglucosone dehydrogenase activity enablesISSUniProtKB:P003521600115GO_REF:0000024UniProtGO_REF:0000024
Aldh1a1Rat3-deoxyglucosone dehydrogenase activity enablesIEARHEA:672441600115GO_REF:0000116RHEAGO_REF:0000116
Aldh1a1Rat3-deoxyglucosone dehydrogenase activity enablesISOALDH1A1 (Homo sapiens)1624291 PMID:17175089RGDPMID:17175089
Aldh1a1Ratacetaldehyde dehydrogenase (NAD+) activity enablesIEARHEA:252941600115GO_REF:0000116RHEAGO_REF:0000116
Aldh1a1Rataldehyde dehydrogenase (NAD+) activity enablesIMP 2306321PMID:15623782UniProt 
Aldh1a1Rataldehyde dehydrogenase (NAD+) activity  IDA 2306339 RGD 
Aldh1a1Rataldehyde dehydrogenase (NAD+) activity enablesIEARHEA:161851600115GO_REF:0000116RHEAGO_REF:0000116
Aldh1a1Rataldehyde dehydrogenase (NAD+) activity enablesISOALDH1A1 (Homo sapiens)1624291 PMID:12941160 more ...RGDPMID:12941160 more ...
Aldh1a1Rataminobutyraldehyde dehydrogenase (NAD+) activity enablesISSUniProtKB:P245491600115GO_REF:0000024UniProtGO_REF:0000024
Aldh1a1Rataminobutyraldehyde dehydrogenase (NAD+) activity enablesISOAldh1a1 (Mus musculus)1624291 PMID:26430123RGDPMID:26430123
Aldh1a1Rataminobutyraldehyde dehydrogenase (NAD+) activity enablesIEARHEA:191051600115GO_REF:0000116RHEAGO_REF:0000116
Aldh1a1Rataminobutyraldehyde dehydrogenase (NAD+) activity enablesIEAUniProtKB:P24549 and ensembl:ENSMUSP000001534101600115GO_REF:0000107EnsemblGO_REF:0000107
Aldh1a1Ratbenzaldehyde dehydrogenase (NAD+) activity enablesIBAPANTHER:PTN002619026 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Aldh1a1Ratbenzaldehyde dehydrogenase (NAD+) activity  IDA 2306339 RGD 
Aldh1a1Ratbenzaldehyde dehydrogenase (NAD+) activity enablesIEARHEA:118401600115GO_REF:0000116RHEAGO_REF:0000116
Aldh1a1Ratidentical protein binding  IPIAldh1a1 (Rattus norvegicus)2306339homotetramerizationRGD 
Aldh1a1RatNAD binding enablesISSUniProtKB:Q2839912793038PMID:12693930CAFA 
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RGD Manual Annotations


  
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Original Reference(s)
Aldh1a1Ratretinoic acid metabolic pathway   TAS 6484672 RGD 
Aldh1a1Ratretinoic acid metabolic pathway   IMP 6771354 RGD 

Imported Annotations - KEGG (archival)

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1 to 15 of 15 rows
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Original Reference(s)
Aldh1a1Ratalcohol preference  IAGP 2306323DNA:polymorphismRGD 

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#
Reference Title
Reference Citation
1. Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Bateman OA, etal., Biochemistry. 2003 Apr 22;42(15):4349-56.
2. Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation. Bhat PV, etal., Gene 1995 Dec 12;166(2):303-6.
3. Kinetic properties of chimeric class I aldehyde dehydrogenases for retinal isomers. Brodeur H, etal., Biochem Cell Biol. 2006 Oct;84(5):799-804.
4. Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. Choudhary S, etal., Invest Ophthalmol Vis Sci. 2005 Jan;46(1):259-67.
5. Estrogen suppresses retinaldehyde dehydrogenase 1 expression in the anterior pituitary glands of female rats. Fujiwara K, etal., Endocr J. 2008 Mar;55(1):91-6. Epub 2008 Jan 17.
6. Reduction of retinaldehyde dehydrogenase 1 expression and production in estrogen-induced prolactinoma of rat. Fujiwara K, etal., Med Mol Morphol. 2008 Sep;41(3):126-31. Epub 2008 Sep 20.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Characterization of the rat RALDH1 promoter. A functional CCAAT and octamer motif are critical for basal promoter activity. Guimond J, etal., Biochim Biophys Acta 2002 Dec 12;1579(2-3):81-91.
10. A preliminary report on the cloning of a constitutively expressed rat liver cytosolic ALDH cDNA by PCR. Kathmann EC and Lipsky JJ, Adv Exp Med Biol 1997;414:69-72.
11. Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase. Kathmann EC and Lipsky JJ, Biochem Biophys Res Commun 1997 Jul 18;236(2):527-31.
12. Rat liver constitutive and phenobarbital-inducible cytosolic aldehyde dehydrogenases are highly homologous proteins that function as distinct isozymes. Kathmann EC, etal., Biochemistry. 2000 Sep 12;39(36):11170-6.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Kiefer FW, etal., Nat Med. 2012 Jun;18(6):918-25. doi: 10.1038/nm.2757.
15. A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid. Labrecque J, etal., Biochem J. 1995 Jan 15;305 ( Pt 2):681-4.
16. Combined class I histone deacetylase and mTORC1/C2 inhibition suppresses the initiation and recurrence of oral squamous cell carcinomas by repressing SOX2. Liang X, etal., Cancer Lett. 2019 Jul 10;454:108-119. doi: 10.1016/j.canlet.2019.04.010. Epub 2019 Apr 11.
17. Expression of retinoic acid-synthesizing and -metabolizing enzymes during nephrogenesis in the rat. Marlier A and Gilbert T, Gene Expr Patterns. 2004 Dec;5(2):179-85.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver. Moon KH, etal., FEBS Lett. 2007 Aug 21;581(21):3967-72. Epub 2007 Jul 25.
20. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
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PMID:224930   PMID:4015840   PMID:10191271   PMID:11876656   PMID:12610736   PMID:12808103   PMID:12851412   PMID:15489334   PMID:15682487   PMID:16207763   PMID:16611695   PMID:17180597  
PMID:17257171   PMID:17497177   PMID:18971422   PMID:19056867   PMID:19199708   PMID:19671997   PMID:22170038   PMID:23028851   PMID:23376485   PMID:23533145   PMID:25450233   PMID:27618414  
PMID:28392548   PMID:33400378   PMID:35909581   PMID:36535138   PMID:36587924   PMID:37816196  



Aldh1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,426,939 - 227,579,497 (+)NCBIGRCr8
mRatBN7.21218,000,470 - 218,152,962 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,042,127 - 218,152,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1226,448,507 - 226,490,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,385,074 - 233,427,098 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01226,203,095 - 226,245,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,222,689 - 238,264,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,222,521 - 238,264,330 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,340,587 - 245,562,970 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,731,675 - 223,773,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,895,697 - 223,937,307 (+)NCBI
Celera1215,379,207 - 215,421,068 (+)NCBICelera
Cytogenetic Map1q51NCBI
ALDH1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38972,900,671 - 72,953,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl972,900,671 - 73,080,442 (-)EnsemblGRCh38hg38GRCh38
GRCh37975,515,587 - 75,567,969 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,705,407 - 74,757,789 (-)NCBINCBI36Build 36hg18NCBI36
Build 34972,745,141 - 72,797,523NCBI
Celera946,088,447 - 46,140,830 (-)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef945,338,144 - 45,390,773 (-)NCBIHuRef
CHM1_1975,662,616 - 75,715,255 (-)NCBICHM1_1
T2T-CHM13v2.0985,051,589 - 85,103,957 (-)NCBIT2T-CHM13v2.0
Aldh1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,469,947 - 20,620,827 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,470,079 - 20,620,829 (+)EnsemblGRCm39 Ensembl
GRCm381920,492,583 - 20,643,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,492,715 - 20,643,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv371920,676,472 - 20,717,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361920,669,079 - 20,710,559 (+)NCBIMGSCv36mm8
Celera1921,323,202 - 21,366,435 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.91NCBI
ALDH1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21172,085,972 - 72,265,332 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1972,091,914 - 72,271,273 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0951,737,305 - 51,916,648 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1971,680,352 - 71,859,144 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,680,890 - 71,814,085 (-)Ensemblpanpan1.1panPan2
ALDH1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1184,940,411 - 84,994,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl184,940,411 - 84,994,789 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,406,217 - 85,460,597 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,390,369 - 85,444,756 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,390,360 - 85,444,756 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,159,477 - 85,213,817 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0184,862,384 - 84,917,606 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,621,439 - 85,676,732 (+)NCBIUU_Cfam_GSD_1.0
Aldh1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947132,159,211 - 132,303,931 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365038,868,961 - 8,918,532 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365038,869,073 - 8,953,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,161,299 - 226,217,308 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,163,347 - 226,217,342 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,778,605 - 252,808,516 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11283,949,529 - 84,092,452 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1283,949,399 - 84,009,003 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603872,378,038 - 72,569,020 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624811505,101 - 563,855 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624811505,297 - 563,795 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Aldh1a1
1280 total Variants

Predicted Target Of
Summary Value
Count of predictions:208
Count of miRNA genes:139
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000024000
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 84 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1207987464234238494Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
5508828Leukc3Leukocyte quantity QTL 3eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1218108584224054420Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat

1 to 10 of 84 rows
RH94633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21218,152,697 - 218,152,876 (+)MAPPERmRatBN7.2
Rnor_6.01238,264,117 - 238,264,295NCBIRnor6.0
Rnor_5.01245,562,706 - 245,562,884UniSTSRnor5.0
RGSC_v3.41223,773,021 - 223,773,199UniSTSRGSC3.4
Celera1215,420,804 - 215,420,982UniSTS
Cytogenetic Map1q51UniSTS
D1Bda57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21218,152,592 - 218,152,800 (+)MAPPERmRatBN7.2
Rnor_6.01238,264,012 - 238,264,219NCBIRnor6.0
Rnor_5.01245,562,601 - 245,562,808UniSTSRnor5.0
RGSC_v3.41223,772,916 - 223,773,123UniSTSRGSC3.4
Celera1215,420,699 - 215,420,906UniSTS
Cytogenetic Map1q51UniSTS
RH137275  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21218,152,663 - 218,152,850 (+)MAPPERmRatBN7.2
Rnor_6.01238,264,083 - 238,264,269NCBIRnor6.0
Rnor_5.01245,562,672 - 245,562,858UniSTSRnor5.0
RGSC_v3.41223,772,987 - 223,773,173UniSTSRGSC3.4
Celera1215,420,770 - 215,420,956UniSTS
Cytogenetic Map1q51UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000024000   ⟹   ENSRNOP00000024000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1218,110,834 - 218,152,961 (+)Ensembl
Rnor_6.0 Ensembl1238,222,521 - 238,264,330 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112107   ⟹   ENSRNOP00000090793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1218,042,127 - 218,152,961 (+)Ensembl
RefSeq Acc Id: NM_022407   ⟹   NP_071852
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,537,620 - 227,579,497 (+)NCBI
mRatBN7.21218,111,085 - 218,152,962 (+)NCBI
Rnor_6.01238,222,689 - 238,264,381 (+)NCBI
Rnor_5.01245,340,587 - 245,562,970 (+)NCBI
RGSC_v3.41223,731,675 - 223,773,285 (+)RGD
Celera1215,379,207 - 215,421,068 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093858   ⟹   XP_038949786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,426,939 - 227,579,435 (+)NCBI
mRatBN7.21218,000,471 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_039093900   ⟹   XP_038949828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,426,994 - 227,579,435 (+)NCBI
mRatBN7.21218,000,477 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_039093931   ⟹   XP_038949859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,426,939 - 227,579,435 (+)NCBI
mRatBN7.21218,000,470 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_039093967   ⟹   XP_038949895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,427,115 - 227,579,435 (+)NCBI
mRatBN7.21218,000,574 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_063279927   ⟹   XP_063135997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,427,017 - 227,579,435 (+)NCBI
RefSeq Acc Id: XM_063279950   ⟹   XP_063136020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,427,017 - 227,579,435 (+)NCBI
RefSeq Acc Id: NP_071852   ⟸   NM_022407
- UniProtKB: O09184 (UniProtKB/Swiss-Prot),   P51647 (UniProtKB/Swiss-Prot),   A6I0L3 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024000   ⟸   ENSRNOT00000024000
RefSeq Acc Id: XP_038949859   ⟸   XM_039093931
- Peptide Label: isoform X2
- UniProtKB: P51647 (UniProtKB/Swiss-Prot),   O09184 (UniProtKB/Swiss-Prot),   A6I0L3 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949786   ⟸   XM_039093858
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP49 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949828   ⟸   XM_039093900
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP49 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
Aldehyde dehydrogenase

Name Modeler Protein Id AA Range Protein Structure
AF-P51647-F1-model_v2 AlphaFold P51647 1-501 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56179 BioCyc
BioCyc Pathway PWY-6872 [retinoate biosynthesis I] BioCyc
BioCyc Pathway Image PWY-6872 BioCyc
Ensembl Genes ENSRNOG00000017619 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024000 ENTREZGENE
  ENSRNOT00000112107 ENTREZGENE
Gene3D-CATH Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6921926 IMAGE-MGC_LOAD
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH_dom UniProtKB/Swiss-Prot
KEGG Report rno:24188 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72648 IMAGE-MGC_LOAD
NCBI Gene 24188 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PharmGKB ALDH1A1 RGD
PhenoGen Aldh1a1 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017619 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot
UniProt A0A0H2UHP1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP49 ENTREZGENE, UniProtKB/TrEMBL
  A6I0L3 ENTREZGENE, UniProtKB/TrEMBL
  AL1A1_RAT UniProtKB/Swiss-Prot
  O09184 ENTREZGENE
  P51647 ENTREZGENE
UniProt Secondary O09184 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Aldh1a1  aldehyde dehydrogenase 1 family, member A1  LOC103695056  uncharacterized LOC103695056  Data merged from RGD:9330766 737654 PROVISIONAL
2014-08-25 LOC103695056  uncharacterized LOC103695056      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-26 Aldh1a1  aldehyde dehydrogenase 1 family, member A1  Aldh1a1  aldehyde dehydrogenase family 1, subfamily A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Aldh1a1  aldehyde dehydrogenase family 1, subfamily A1  Aldh1a1  aldehyde dehydrogenase 1 family, member A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Aldh1a1  aldehyde dehydrogenase 1 family, member A1  Aldh1a1  aldehyde dehydrogenase family 1, member A1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Aldh1a1  aldehyde dehydrogenase family 1, member A1     Aldehyde dehydrogenase 1, subfamily A1  Name updated 629478 APPROVED
2001-06-12 Aldh1a1  Aldehyde dehydrogenase 1, subfamily A1      Symbol and Name updated to reflect Human and Mouse nomenclature 62408 APPROVED
2001-06-12 Aldh1  Aldehyde dehydrogenase 2      Symbol and Name withdrawn 62408 WITHDRAWN

Note Type Note Reference
gene_domains high luciferase activity is seen in the cloned 1360-bp promoter, mutation in the CCAAT box (-72 to -68) abolished the luciferase activity, octamer (Oct)-binding site (-56 to -49) and the CCAAT-binding proteins help in the regulation of the gene 628383
gene_domains high luciferase activity is seen in the cloned 1360-bp promoter, mutation in the CCAAT box (-72 to -68) abolished the luciferase activity, octamer (Oct)-binding site (-56 to -49) and the CCAAT-binding proteins help in the regulation of the gene 628400
gene_expression high levels are observed in developing kidneys and in stomach and intestine but weakly expressed in the liver 628383
gene_expression high levels are observed in developing kidneys and in stomach and intestine but weakly expressed in the liver 628400
gene_function catalyzes the oxidation of retinal to retinoic acid 628383
gene_function catalyzes the oxidation of retinal to retinoic acid 628400
gene_process involved in the prduction of RA required for proper differentiation of the epithelia 628383
gene_process involved in the prduction of RA required for proper differentiation of the epithelia 628400