Aldh1a1 (aldehyde dehydrogenase 1 family, member A1) - Rat Genome Database

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Gene: Aldh1a1 (aldehyde dehydrogenase 1 family, member A1) Rattus norvegicus
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Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
RGD ID: 2087
Description: Enables benzaldehyde dehydrogenase (NAD+) activity; identical protein binding activity; and retinal dehydrogenase (NAD+) activity. Involved in several processes, including estrous cycle; maintenance of lens transparency; and retinoic acid metabolic process. Predicted to be located in axon and synapse. Predicted to be active in cytosol. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1); PARTICIPATES IN retinoic acid metabolic pathway; cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-deoxyglucosone dehydrogenase; Ahd2; Aldehyde dehydrogenase 1; Aldehyde dehydrogenase 1 subfamily A1; Aldehyde dehydrogenase 1, subfamily A1; aldehyde dehydrogenase 1A1; aldehyde dehydrogenase 2; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase family 1, member A1; aldehyde dehydrogenase family 1, subfamily A1; aldehyde dehydrogenase, cytosolic; ALDH-E1; Aldh1; Aldh2; ALHDII; LOC103695056; RALDH 1; ralDH1; retinal dehydrogenase 1; uncharacterized LOC103695056
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,426,939 - 227,579,497 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1227,427,070 - 227,579,500 (+)EnsemblGRCr8
mRatBN7.21218,000,470 - 218,152,962 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,042,127 - 218,152,961 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1226,448,507 - 226,490,531 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,385,074 - 233,427,098 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01226,203,095 - 226,245,121 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,222,689 - 238,264,381 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,222,521 - 238,264,330 (+)Ensemblrn6Rnor6.0
Rnor_5.01245,340,587 - 245,562,970 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41223,731,675 - 223,773,285 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1215,379,207 - 215,421,068 (+)NCBICelera
RGSC_v3.11223,895,697 - 223,937,307 (+)NCBI
Cytogenetic Map1q51NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-acetamidofluorene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hexenal  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitroanisole  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-hydroxyacetophenone  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(diethylamino)benzaldehyde  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-Amino-2-nitrophenol  (EXP)
4-dimethylaminocinnamaldehyde  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitrophenol  (ISO)
4-nitrophenyl acetate  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxythalidomide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-bromoindirubin-3'-oxime  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7H-xanthine  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinal  (EXP,ISO)
9H-xanthine  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetic acid  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
adenosine 5'-monophosphate  (ISO)
aflatoxin B1  (EXP,ISO)
Aldophosphamide  (ISO)
all-trans-retinal  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
amphetamine  (ISO)
anthracen-2-amine  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
auramine O  (ISO)
azathioprine  (EXP)
Azoxymethane  (ISO)
bacitracin  (EXP)
benzaldehyde  (EXP,ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenone  (EXP)
benzyl isothiocyanate  (ISO)
beta-naphthoflavone  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chloroform  (EXP)
chlorohydrocarbon  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (EXP)
cimetidine  (ISO)
ciprofibrate  (EXP,ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
clomipramine  (EXP)
clothianidin  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (EXP)
coumarin  (EXP)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cyproconazole  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichlorvos  (EXP)
dicrotophos  (ISO)
dicyclanil  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diheptyl phthalate  (EXP)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disulfiram  (EXP,ISO)
diuron  (EXP)
doxorubicin  (ISO)
Echimidine  (EXP)
endosulfan  (EXP)
enilconazole  (EXP,ISO)
epoxiconazole  (EXP)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
felbamate  (EXP)
fentin chloride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (EXP)
gadodiamide hydrate  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (EXP)
graphene oxide  (ISO)
Heliotrine  (EXP)
hexanal  (ISO)
hydrogen peroxide  (ISO)
imipramine  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
lapatinib  (ISO)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
Licochalcone B  (ISO)
limonin  (ISO)
lipopolysaccharide  (ISO)
magnesium atom  (EXP)
magnesium dichloride  (EXP)
malonaldehyde  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
miconazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
monuron  (EXP)
Muraglitazar  (EXP)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitroglycerin  (EXP)
Nivalenol  (ISO)
non-2-enal  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oltipraz  (ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
para-Cresidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phencyclidine  (ISO)
phenethyl isothiocyanate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
progesterone  (ISO)
propanal  (EXP,ISO)
propiconazole  (EXP,ISO)
pyrazinecarboxamide  (EXP)
pyrogallol  (ISO)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
Salinomycin  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
Soman  (EXP)
spironolactone  (ISO)
streptozocin  (EXP)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
thiacloprid  (EXP,ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
trametinib  (ISO)
transplatin  (ISO)
triadimefon  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP,ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
Tungsten carbide  (ISO)
ubiquinone-0  (ISO)
uracil  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
XAV939  (ISO)
XMU-MP-1  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO,ISS)
cytosol  (IBA,IEA,ISO,ISS)
synapse  (IEA,ISO,ISS)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Bateman OA, etal., Biochemistry. 2003 Apr 22;42(15):4349-56.
2. Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation. Bhat PV, etal., Gene 1995 Dec 12;166(2):303-6.
3. Kinetic properties of chimeric class I aldehyde dehydrogenases for retinal isomers. Brodeur H, etal., Biochem Cell Biol. 2006 Oct;84(5):799-804.
4. Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. Choudhary S, etal., Invest Ophthalmol Vis Sci. 2005 Jan;46(1):259-67.
5. Estrogen suppresses retinaldehyde dehydrogenase 1 expression in the anterior pituitary glands of female rats. Fujiwara K, etal., Endocr J. 2008 Mar;55(1):91-6. Epub 2008 Jan 17.
6. Reduction of retinaldehyde dehydrogenase 1 expression and production in estrogen-induced prolactinoma of rat. Fujiwara K, etal., Med Mol Morphol. 2008 Sep;41(3):126-31. Epub 2008 Sep 20.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Characterization of the rat RALDH1 promoter. A functional CCAAT and octamer motif are critical for basal promoter activity. Guimond J, etal., Biochim Biophys Acta 2002 Dec 12;1579(2-3):81-91.
10. A preliminary report on the cloning of a constitutively expressed rat liver cytosolic ALDH cDNA by PCR. Kathmann EC and Lipsky JJ, Adv Exp Med Biol 1997;414:69-72.
11. Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase. Kathmann EC and Lipsky JJ, Biochem Biophys Res Commun 1997 Jul 18;236(2):527-31.
12. Rat liver constitutive and phenobarbital-inducible cytosolic aldehyde dehydrogenases are highly homologous proteins that function as distinct isozymes. Kathmann EC, etal., Biochemistry. 2000 Sep 12;39(36):11170-6.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Kiefer FW, etal., Nat Med. 2012 Jun;18(6):918-25. doi: 10.1038/nm.2757.
15. A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid. Labrecque J, etal., Biochem J. 1995 Jan 15;305 ( Pt 2):681-4.
16. Combined class I histone deacetylase and mTORC1/C2 inhibition suppresses the initiation and recurrence of oral squamous cell carcinomas by repressing SOX2. Liang X, etal., Cancer Lett. 2019 Jul 10;454:108-119. doi: 10.1016/j.canlet.2019.04.010. Epub 2019 Apr 11.
17. Expression of retinoic acid-synthesizing and -metabolizing enzymes during nephrogenesis in the rat. Marlier A and Gilbert T, Gene Expr Patterns. 2004 Dec;5(2):179-85.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver. Moon KH, etal., FEBS Lett. 2007 Aug 21;581(21):3967-72. Epub 2007 Jul 25.
20. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system. Nishiguchi M, etal., Alcohol Alcohol. 2002 Jan-Feb;37(1):9-12.
23. Postnatal changes in gene expression of retinal dehydrogenase and retinoid receptors in liver of rats. Ogura Y, etal., Life Sci. 2004 Feb 6;74(12):1519-28.
24. Developmental changes of the expression of the genes regulated by retinoic acid in the small intestine of rats. Ogura Y, etal., Life Sci. 2005 Oct 14;77(22):2804-13.
25. Zoxazolamine-induced paralysis in two rat substrains: differences in hepatic drug metabolism. Pappas P, etal., Eur J Drug Metab Pharmacokinet. 1998 Oct-Dec;23(4):461-7.
26. Cloning of a rat cDNA encoding retinal dehydrogenase isozyme type I and its expression in E. coli. Penzes P, etal., Gene 1997 Jun 3;191(2):167-72.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. GOA pipeline RGD automated data pipeline
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Identification of pancreatic cancer invasion-related proteins by proteomic analysis. Walsh N, etal., Proteome Sci. 2009 Feb 14;7:3.
33. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, etal., J Biol Chem. 2011 Feb 25;286(8):6542-53. Epub 2010 Dec 7.
34. Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development. Yoon M, etal., Toxicol Sci. 2006 Feb;89(2):386-98. Epub 2005 Nov 16.
35. Cellular expression of retinal dehydrogenase types 1 and 2: effects of vitamin A status on testis mRNA. Zhai Y, etal., J Cell Physiol. 2001 Feb;186(2):220-32.
Additional References at PubMed
PMID:224930   PMID:4015840   PMID:10191271   PMID:11876656   PMID:12610736   PMID:12808103   PMID:12851412   PMID:15489334   PMID:15682487   PMID:16207763   PMID:16611695   PMID:17180597  
PMID:17257171   PMID:17497177   PMID:18971422   PMID:19056867   PMID:19199708   PMID:19671997   PMID:22170038   PMID:23028851   PMID:23376485   PMID:23533145   PMID:25450233   PMID:27618414  
PMID:28392548   PMID:33400378   PMID:35909581   PMID:36535138   PMID:36587924   PMID:37816196  


Genomics

Comparative Map Data
Aldh1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,426,939 - 227,579,497 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1227,427,070 - 227,579,500 (+)EnsemblGRCr8
mRatBN7.21218,000,470 - 218,152,962 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,042,127 - 218,152,961 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1226,448,507 - 226,490,531 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,385,074 - 233,427,098 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01226,203,095 - 226,245,121 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,222,689 - 238,264,381 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,222,521 - 238,264,330 (+)Ensemblrn6Rnor6.0
Rnor_5.01245,340,587 - 245,562,970 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41223,731,675 - 223,773,285 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1215,379,207 - 215,421,068 (+)NCBICelera
RGSC_v3.11223,895,697 - 223,937,307 (+)NCBI
Cytogenetic Map1q51NCBI
ALDH1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38972,900,671 - 72,953,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl972,900,670 - 73,080,442 (-)Ensemblhg38GRCh38
GRCh37975,515,587 - 75,567,969 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,705,407 - 74,757,789 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34972,745,141 - 72,797,523NCBI
Celera946,088,447 - 46,140,830 (-)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef945,338,144 - 45,390,773 (-)NCBIHuRef
CHM1_1975,662,616 - 75,715,255 (-)NCBICHM1_1
T2T-CHM13v2.0985,051,589 - 85,103,957 (-)NCBIT2T-CHM13v2.0
Aldh1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,469,947 - 20,620,827 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,470,079 - 20,620,829 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381920,492,583 - 20,643,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,492,715 - 20,643,465 (+)Ensemblmm10GRCm38
MGSCv371920,676,472 - 20,717,952 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361920,669,079 - 20,710,559 (+)NCBIMGSCv36mm8
Celera1921,323,202 - 21,366,435 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.91NCBI
ALDH1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21172,085,972 - 72,265,332 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1972,091,914 - 72,271,273 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0951,737,305 - 51,916,648 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1971,680,352 - 71,859,144 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,680,890 - 71,814,085 (-)EnsemblpanPan2panpan1.1
ALDH1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1184,940,411 - 84,994,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl184,940,411 - 84,994,789 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha185,406,217 - 85,460,597 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0185,390,369 - 85,444,756 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,390,360 - 85,444,756 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,159,477 - 85,213,817 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0184,862,384 - 84,917,606 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,621,439 - 85,676,732 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aldh1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947132,159,211 - 132,303,931 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365038,868,961 - 8,918,532 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365038,869,073 - 8,953,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,161,299 - 226,217,308 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11226,163,347 - 226,217,342 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,778,605 - 252,808,516 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11283,949,529 - 84,092,452 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1283,949,399 - 84,009,003 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603872,378,038 - 72,569,020 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624811505,101 - 563,855 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624811505,297 - 563,795 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Aldh1a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1220,626,239 - 20,676,233 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aldh1a1
740 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:208
Count of miRNA genes:139
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000024000
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
5508828Leukc3Leukocyte quantity QTL 3eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1227535119233480676Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1221820316234540296Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1223964326236074012Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat

Markers in Region
RH94633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21218,152,697 - 218,152,876 (+)MAPPERmRatBN7.2
Rnor_6.01238,264,117 - 238,264,295NCBIRnor6.0
Rnor_5.01245,562,706 - 245,562,884UniSTSRnor5.0
RGSC_v3.41223,773,021 - 223,773,199UniSTSRGSC3.4
Celera1215,420,804 - 215,420,982UniSTS
Cytogenetic Map1q51UniSTS
D1Bda57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21218,152,592 - 218,152,800 (+)MAPPERmRatBN7.2
Rnor_6.01238,264,012 - 238,264,219NCBIRnor6.0
Rnor_5.01245,562,601 - 245,562,808UniSTSRnor5.0
RGSC_v3.41223,772,916 - 223,773,123UniSTSRGSC3.4
Celera1215,420,699 - 215,420,906UniSTS
Cytogenetic Map1q51UniSTS
RH137275  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21218,152,663 - 218,152,850 (+)MAPPERmRatBN7.2
Rnor_6.01238,264,083 - 238,264,269NCBIRnor6.0
Rnor_5.01245,562,672 - 245,562,858UniSTSRnor5.0
RGSC_v3.41223,772,987 - 223,773,173UniSTSRGSC3.4
Celera1215,420,770 - 215,420,956UniSTS
Cytogenetic Map1q51UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 55 59 6 319 155 11 138 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024000   ⟹   ENSRNOP00000024000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,539,153 - 227,579,500 (+)Ensembl
mRatBN7.2 Ensembl1218,110,834 - 218,152,961 (+)Ensembl
Rnor_6.0 Ensembl1238,222,521 - 238,264,330 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112107   ⟹   ENSRNOP00000090793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,427,070 - 227,579,434 (+)Ensembl
mRatBN7.2 Ensembl1218,042,127 - 218,152,961 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128602   ⟹   ENSRNOP00000109570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,427,070 - 227,579,434 (+)Ensembl
RefSeq Acc Id: NM_022407   ⟹   NP_071852
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,537,620 - 227,579,497 (+)NCBI
mRatBN7.21218,111,085 - 218,152,962 (+)NCBI
Rnor_6.01238,222,689 - 238,264,381 (+)NCBI
Rnor_5.01245,340,587 - 245,562,970 (+)NCBI
RGSC_v3.41223,731,675 - 223,773,285 (+)RGD
Celera1215,379,207 - 215,421,068 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093858   ⟹   XP_038949786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,426,939 - 227,579,435 (+)NCBI
mRatBN7.21218,000,471 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_039093900   ⟹   XP_038949828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,426,994 - 227,579,435 (+)NCBI
mRatBN7.21218,000,477 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_039093931   ⟹   XP_038949859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,426,939 - 227,579,435 (+)NCBI
mRatBN7.21218,000,470 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_039093967   ⟹   XP_038949895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,427,115 - 227,579,435 (+)NCBI
mRatBN7.21218,000,574 - 218,152,901 (+)NCBI
RefSeq Acc Id: XM_063279927   ⟹   XP_063135997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,427,017 - 227,579,435 (+)NCBI
RefSeq Acc Id: XM_063279950   ⟹   XP_063136020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,427,017 - 227,579,435 (+)NCBI
RefSeq Acc Id: NP_071852   ⟸   NM_022407
- UniProtKB: O09184 (UniProtKB/Swiss-Prot),   P51647 (UniProtKB/Swiss-Prot),   A6I0L3 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024000   ⟸   ENSRNOT00000024000
RefSeq Acc Id: XP_038949859   ⟸   XM_039093931
- Peptide Label: isoform X2
- UniProtKB: P51647 (UniProtKB/Swiss-Prot),   O09184 (UniProtKB/Swiss-Prot),   A6I0L3 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949786   ⟸   XM_039093858
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP49 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949828   ⟸   XM_039093900
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP49 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949895   ⟸   XM_039093967
- Peptide Label: isoform X2
- UniProtKB: P51647 (UniProtKB/Swiss-Prot),   O09184 (UniProtKB/Swiss-Prot),   A6I0L3 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090793   ⟸   ENSRNOT00000112107
RefSeq Acc Id: XP_063135997   ⟸   XM_063279927
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP49 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136020   ⟸   XM_063279950
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP49 (UniProtKB/TrEMBL),   A0A0H2UHP1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000109570   ⟸   ENSRNOT00000128602
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51647-F1-model_v2 AlphaFold P51647 1-501 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2087 AgrOrtholog
BioCyc Gene G2FUF-56179 BioCyc
BioCyc Pathway PWY-6872 [retinoate biosynthesis I] BioCyc
BioCyc Pathway Image PWY-6872 BioCyc
Ensembl Genes ENSRNOG00000017619 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024000 ENTREZGENE
  ENSRNOT00000112107 ENTREZGENE
Gene3D-CATH Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6921926 IMAGE-MGC_LOAD
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH_dom UniProtKB/Swiss-Prot
KEGG Report rno:24188 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72648 IMAGE-MGC_LOAD
NCBI Gene 24188 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PharmGKB ALDH1A1 RGD
PhenoGen Aldh1a1 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017619 RatGTEx
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot
UniProt A0A0H2UHP1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP49 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LVQ2_RAT UniProtKB/TrEMBL
  A6I0L3 ENTREZGENE, UniProtKB/TrEMBL
  AL1A1_RAT UniProtKB/Swiss-Prot
  O09184 ENTREZGENE
  P51647 ENTREZGENE
UniProt Secondary O09184 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Aldh1a1  aldehyde dehydrogenase 1 family, member A1  LOC103695056  uncharacterized LOC103695056  Data merged from RGD:9330766 737654 PROVISIONAL
2014-08-25 LOC103695056  uncharacterized LOC103695056      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-26 Aldh1a1  aldehyde dehydrogenase 1 family, member A1  Aldh1a1  aldehyde dehydrogenase family 1, subfamily A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Aldh1a1  aldehyde dehydrogenase family 1, subfamily A1  Aldh1a1  aldehyde dehydrogenase 1 family, member A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Aldh1a1  aldehyde dehydrogenase 1 family, member A1  Aldh1a1  aldehyde dehydrogenase family 1, member A1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Aldh1a1  aldehyde dehydrogenase family 1, member A1     Aldehyde dehydrogenase 1, subfamily A1  Name updated 629478 APPROVED
2001-06-12 Aldh1  Aldehyde dehydrogenase 2      Symbol and Name withdrawn 62408 WITHDRAWN
2001-06-12 Aldh1a1  Aldehyde dehydrogenase 1, subfamily A1      Symbol and Name updated to reflect Human and Mouse nomenclature 62408 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains high luciferase activity is seen in the cloned 1360-bp promoter, mutation in the CCAAT box (-72 to -68) abolished the luciferase activity, octamer (Oct)-binding site (-56 to -49) and the CCAAT-binding proteins help in the regulation of the gene 628383
gene_domains high luciferase activity is seen in the cloned 1360-bp promoter, mutation in the CCAAT box (-72 to -68) abolished the luciferase activity, octamer (Oct)-binding site (-56 to -49) and the CCAAT-binding proteins help in the regulation of the gene 628400
gene_expression high levels are observed in developing kidneys and in stomach and intestine but weakly expressed in the liver 628383
gene_expression high levels are observed in developing kidneys and in stomach and intestine but weakly expressed in the liver 628400
gene_function catalyzes the oxidation of retinal to retinoic acid 628383
gene_function catalyzes the oxidation of retinal to retinoic acid 628400
gene_process involved in the prduction of RA required for proper differentiation of the epithelia 628383
gene_process involved in the prduction of RA required for proper differentiation of the epithelia 628400