RGD Reference Report - Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development. - Rat Genome Database

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Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development.

Authors: Yoon, M  Madden, MC  Barton, HA 
Citation: Yoon M, etal., Toxicol Sci. 2006 Feb;89(2):386-98. Epub 2005 Nov 16.
RGD ID: 2300311
Pubmed: PMID:16291827   (View Abstract at PubMed)
DOI: DOI:10.1093/toxsci/kfj045   (Journal Full-text)

Metabolism is one of the major determinants for age-related changes in susceptibility to chemicals. Aldehydes are highly reactive molecules present in the environment that also can be produced during biotransformation of xenobiotics and endogenous metabolism. Although the lung is a major target for aldehyde toxicity, early development of aldehyde dehydrogenases (ALDHs) in lung has been poorly studied. The expression of ALDH in liver and lung across ages (postnatal day 1, 8, 22, and 60) was investigated in Wistar-Han rats. In adult, the majority of hepatic ALDH activity was found in mitochondria, while cytosolic ALDH activity was the highest contributor in lung. Total aldehyde oxidation capability in liver increases with age, but stays constant in lung. These overall developmental profiles of ALDH expression in a tissue appear to be determined by the different composition of ALDH isoforms within the tissue and their independent temporal and tissue-specific development. ALDH2 showed the most notable tissue-specific development. Hepatic ALDH2 was increased with age, while the pulmonary form did not. ALDH1 was at its maximum value at postnatal day 1 (PND1) and decreased thereafter both in liver and lung. ALDH3 increased with age in liver and lung, although ALDH3A1 was only detectible in lung. Collectively, the present study indicates that, in the case of aldehyde exposure, the in vivo responses would be tissue and age dependent.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
liver development  IEP 2300311 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aldh2  (aldehyde dehydrogenase 2 family member)

Objects referenced in this article
Gene Aldh1a1 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus
Gene Aldh3a1 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus

Additional Information