Acvr2b (activin A receptor type 2B) - Rat Genome Database

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Gene: Acvr2b (activin A receptor type 2B) Rattus norvegicus
Analyze
Symbol: Acvr2b
Name: activin A receptor type 2B
RGD ID: 2028
Description: Enables activin binding activity and inhibin binding activity. Involved in adrenal gland development and response to activity. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in visceral heterotaxy 4. Orthologous to human ACVR2B (activin A receptor type 2B); PARTICIPATES IN activin signaling pathway; cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activin A receptor, type IIB; activin receptor IIB; activin receptor type IIB; activin receptor type-2B; Activine receptor 2b (transmembrane serine kinase); ACTR-IIB; ActRIIB type II activin receptor B; ActRIIB, type II activin receptor B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,016,589 - 128,056,193 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8128,016,526 - 128,048,171 (+)EnsemblGRCr8
mRatBN7.28119,138,901 - 119,178,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,138,812 - 119,170,458 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,720,902 - 124,752,235 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,919,922 - 122,951,256 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,753,489 - 120,784,964 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,087,308 - 128,126,776 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,087,345 - 128,118,746 (+)Ensemblrn6Rnor6.0
Rnor_5.08127,294,071 - 127,331,625 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,364,330 - 124,395,748 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,290,038 - 118,321,362 (+)NCBICelera
RGSC_v3.18124,383,832 - 124,415,475 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
Activin A  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
fenarimol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
L-methionine  (ISO)
LY294002  (ISO)
lycopene  (EXP)
methiocarb  (EXP)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phorone  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
retinyl acetate  (ISO)
SB 431542  (ISO)
simazine  (EXP)
sodium arsenate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
Testosterone propionate  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IBA,ISO)
adrenal gland development  (IEA,IEP)
anterior/posterior pattern specification  (ISO)
artery development  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
BMP signaling pathway  (ISO)
cell communication  (IEA)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cellular response to growth factor stimulus  (IBA)
determination of left/right symmetry  (ISO)
embryonic foregut morphogenesis  (ISO)
gastrulation with mouth forming second  (ISO)
heart development  (ISO)
insulin secretion  (ISO)
intracellular iron ion homeostasis  (ISO)
kidney development  (ISO)
lung development  (ISO)
lymphangiogenesis  (IEA,ISO)
lymphatic endothelial cell differentiation  (IEA,ISO)
mesoderm development  (ISO)
negative regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
negative regulation of ossification  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
organ growth  (ISO)
pancreas development  (ISO)
pattern specification process  (IBA,ISO)
positive regulation of activin receptor signaling pathway  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of osteoblast differentiation  (ISO)
post-embryonic development  (ISO)
protein phosphorylation  (TAS)
regulation of DNA-templated transcription  (ISO)
regulation of signal transduction  (ISO)
response to activity  (IEP)
response to glucose  (ISO)
retina vasculature development in camera-type eye  (IEA,ISO)
roof of mouth development  (ISO)
sexual reproduction  (NAS)
signal transduction  (ISO)
signaling  (IEA)
skeletal system development  (ISO)
skeletal system morphogenesis  (ISO)
venous blood vessel development  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors. Chapman SC, etal., Mol Cell Endocrinol. 2002 Oct 31;196(1-2):79-93.
2. The transforming growth factor-beta superfamily of receptors. de Caestecker M Cytokine Growth Factor Rev. 2004 Feb;15(1):1-11.
3. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
4. Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise. Dutra DB, etal., Clin Exp Pharmacol Physiol. 2012 May;39(5):417-22. doi: 10.1111/j.1440-1681.2012.05690.x.
5. Upregulation of Extracellular Vesicles-Encapsulated miR-132 Released From Mesenchymal Stem Cells Attenuates Ischemic Neuronal Injury by Inhibiting Smad2/c-jun Pathway via Acvr2b Suppression. Feng B, etal., Front Cell Dev Biol. 2021 Mar 8;8:568304. doi: 10.3389/fcell.2020.568304. eCollection 2020.
6. Expression of type II activin receptor genes in the male and female reproductive tissues of the rat. Feng ZM, etal., Endocrinology 1993 Jun;132(6):2593-600.
7. Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism. Fournier B, etal., Mol Cell Biol. 2012 Jul;32(14):2871-9. doi: 10.1128/MCB.06575-11. Epub 2012 May 14.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Kosaki R, etal., Am J Med Genet. 1999 Jan 1;82(1):70-6. doi: 10.1002/(sici)1096-8628(19990101)82:1<70::aid-ajmg14>3.0.co;2-y.
11. Genetic architecture of laterality defects revealed by whole exome sequencing. Li AH, etal., Eur J Hum Genet. 2019 Apr;27(4):563-573. doi: 10.1038/s41431-018-0307-z. Epub 2019 Jan 8.
12. Downstream mRNA Target Analysis in Neonatal Hypoxic-Ischaemic Encephalopathy Identifies Novel Marker of Severe Injury: a Proof of Concept Paper. Looney AM, etal., Mol Neurobiol. 2017 Dec;54(10):8420-8428. doi: 10.1007/s12035-016-0330-4. Epub 2016 Dec 12.
13. Mutations in ZIC3 and ACVR2B are a common cause of heterotaxy and associated cardiovascular anomalies. Ma L, etal., Cardiol Young. 2012 Apr;22(2):194-201. doi: 10.1017/S1047951111001181. Epub 2011 Aug 25.
14. Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury. Magga J, etal., Mol Ther. 2019 Mar 6;27(3):600-610. doi: 10.1016/j.ymthe.2019.01.013. Epub 2019 Jan 24.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Activin inhibition limits early innate immune response in rat kidney allografts-a pilot study. Palin NK, etal., Transpl Int. 2017 Jan;30(1):96-107. doi: 10.1111/tri.12876. Epub 2016 Nov 23.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. [Value of electrocardiography in the selection of persons for work under high altitude conditions]. Pukach LP, Voen Med Zh. 1978 Nov;(11):49-51.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function. Szabó Z, etal., FASEB J. 2020 Aug;34(8):9911-9924. doi: 10.1096/fj.201903074RR. Epub 2020 May 19.
25. Novel ActRIIB ligand trap increases muscle mass and improves bone geometry in a mouse model of severe osteogenesis imperfecta. Tauer JT and Rauch F, Bone. 2019 Nov;128:115036. doi: 10.1016/j.bone.2019.115036. Epub 2019 Aug 13.
26. ACVR2A promoter polymorphism rs1424954 in the Activin-A signaling pathway in trophoblasts. Thulluru HK, etal., Placenta. 2015 Apr;36(4):345-9. doi: 10.1016/j.placenta.2015.01.010. Epub 2015 Jan 26.
27. Activin signal transduction in the fetal rat adrenal gland and in human H295R cells. Wang EY, etal., J Endocrinol 2003 Jul;178(1):137-48.
28. MiR-195 participates in the placental disorder of preeclampsia via targeting activin receptor type-2B in trophoblastic cells. Wu H, etal., J Hypertens. 2016 Jul;34(7):1371-9. doi: 10.1097/HJH.0000000000000948.
Additional References at PubMed
PMID:1310075   PMID:1312838   PMID:1326537   PMID:8622651   PMID:8721982   PMID:9242489   PMID:9872992   PMID:10452853   PMID:10921901   PMID:11459935   PMID:11714685   PMID:12414726  
PMID:12477932   PMID:12660162   PMID:14517293   PMID:14738881   PMID:14993131   PMID:15304227   PMID:15542835   PMID:16330774   PMID:16806156   PMID:16845371   PMID:16991118   PMID:17849440  
PMID:17936261   PMID:18326817   PMID:18436533   PMID:19903896   PMID:21539891   PMID:24019467   PMID:31315975  


Genomics

Comparative Map Data
Acvr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,016,589 - 128,056,193 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8128,016,526 - 128,048,171 (+)EnsemblGRCr8
mRatBN7.28119,138,901 - 119,178,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,138,812 - 119,170,458 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,720,902 - 124,752,235 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,919,922 - 122,951,256 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,753,489 - 120,784,964 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,087,308 - 128,126,776 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,087,345 - 128,118,746 (+)Ensemblrn6Rnor6.0
Rnor_5.08127,294,071 - 127,331,625 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,364,330 - 124,395,748 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,290,038 - 118,321,362 (+)NCBICelera
RGSC_v3.18124,383,832 - 124,415,475 (+)NCBI
Cytogenetic Map8q32NCBI
ACVR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,453,890 - 38,493,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,453,890 - 38,493,142 (+)Ensemblhg38GRCh38
GRCh37338,495,381 - 38,534,633 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,470,794 - 38,509,637 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34338,470,813 - 38,499,868NCBI
Celera338,431,705 - 38,470,515 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,561,058 - 38,576,879 (+)NCBIHuRef
CHM1_1338,447,458 - 38,486,272 (+)NCBICHM1_1
T2T-CHM13v2.0338,459,967 - 38,499,186 (+)NCBIT2T-CHM13v2.0
Acvr2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,231,081 - 119,271,214 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,231,184 - 119,264,061 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389119,401,583 - 119,442,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,402,118 - 119,434,995 (+)Ensemblmm10GRCm38
MGSCv379119,311,619 - 119,342,633 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369119,251,199 - 119,282,213 (+)NCBIMGSCv36mm8
Celera9119,872,378 - 119,903,791 (+)NCBICelera
Cytogenetic Map9F3NCBI
Acvr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,438,652 - 25,467,360 (-)Ensembl
ChiLan1.0NW_00495542725,438,652 - 25,467,360 (-)NCBIChiLan1.0ChiLan1.0
ACVR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,406,484 - 38,445,488 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,411,248 - 38,440,592 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,350,838 - 38,389,839 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,633,097 - 38,671,843 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,633,093 - 38,662,063 (+)EnsemblpanPan2panpan1.1
ACVR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,211,555 - 8,225,596 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,192,483 - 8,218,894 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha238,227,583 - 8,268,772 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0238,476,238 - 8,517,658 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,475,184 - 8,509,405 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,290,311 - 8,331,505 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,431,051 - 8,471,999 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,424,247 - 8,465,433 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acvr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,654,498 - 194,692,968 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,815,399 - 27,822,476 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,816,366 - 27,822,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,237,699 - 23,267,373 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11323,237,699 - 23,276,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,422,228 - 25,450,766 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACVR2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115923,222 - 962,438 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660639,653,424 - 9,692,815 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acvr2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,566,063 - 2,600,035 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247312,557,993 - 2,600,250 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Acvr2b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18110,635,325 - 110,665,446 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:67
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000019777
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat

Markers in Region
MARC_4816-4817:991938566:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,166,793 - 119,167,167 (+)MAPPERmRatBN7.2
Rnor_6.08128,115,089 - 128,115,462NCBIRnor6.0
Rnor_5.08127,321,850 - 127,322,223UniSTSRnor5.0
RGSC_v3.48124,392,074 - 124,392,447UniSTSRGSC3.4
Celera8118,317,688 - 118,318,061UniSTS
Cytogenetic Map8q32UniSTS
PMC202382P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,169,625 - 119,169,747 (+)MAPPERmRatBN7.2
Rnor_6.08128,117,921 - 128,118,042NCBIRnor6.0
Rnor_5.08127,324,682 - 127,324,803UniSTSRnor5.0
RGSC_v3.48124,394,906 - 124,395,027UniSTSRGSC3.4
Celera8118,320,520 - 118,320,641UniSTS
Cytogenetic Map8q32UniSTS
Acvr2b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,169,435 - 119,170,397 (+)MAPPERmRatBN7.2
Rnor_6.08128,117,731 - 128,118,692NCBIRnor6.0
Rnor_5.08127,324,492 - 127,325,453UniSTSRnor5.0
RGSC_v3.48124,394,716 - 124,395,677UniSTSRGSC3.4
Celera8118,320,330 - 118,321,291UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 85 59 6 349 185 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019777   ⟹   ENSRNOP00000019777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8128,016,526 - 128,048,171 (+)Ensembl
mRatBN7.2 Ensembl8119,138,812 - 119,170,458 (+)Ensembl
Rnor_6.0 Ensembl8128,087,345 - 128,118,746 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118049   ⟹   ENSRNOP00000090538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8128,016,526 - 128,048,171 (+)Ensembl
mRatBN7.2 Ensembl8119,138,812 - 119,170,458 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129875   ⟹   ENSRNOP00000111171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8128,022,321 - 128,048,164 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170763   ⟹   ENSRNOP00000106039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8128,037,987 - 128,048,171 (+)Ensembl
RefSeq Acc Id: NM_031554   ⟹   NP_113742
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,016,763 - 128,048,181 (+)NCBI
mRatBN7.28119,139,049 - 119,170,468 (+)NCBI
Rnor_6.08128,087,345 - 128,118,763 (+)NCBI
Rnor_5.08127,294,071 - 127,331,625 (+)NCBI
RGSC_v3.48124,364,330 - 124,395,748 (+)RGD
Celera8118,290,038 - 118,321,362 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244072   ⟹   XP_006244134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,016,589 - 128,056,193 (+)NCBI
mRatBN7.28119,138,901 - 119,178,477 (+)NCBI
Rnor_6.08128,087,308 - 128,126,776 (+)NCBI
Rnor_5.08127,294,071 - 127,331,625 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080874   ⟹   XP_038936802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,017,060 - 128,056,193 (+)NCBI
mRatBN7.28119,143,496 - 119,178,477 (+)NCBI
RefSeq Acc Id: XM_039080875   ⟹   XP_038936803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,017,064 - 128,056,193 (+)NCBI
mRatBN7.28119,143,499 - 119,178,477 (+)NCBI
RefSeq Acc Id: XM_039080876   ⟹   XP_038936804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,017,062 - 128,056,193 (+)NCBI
mRatBN7.28119,143,497 - 119,178,477 (+)NCBI
RefSeq Acc Id: XR_005487744
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,017,060 - 128,056,193 (+)NCBI
mRatBN7.28119,143,496 - 119,178,477 (+)NCBI
RefSeq Acc Id: NP_113742   ⟸   NM_031554
- Peptide Label: precursor
- UniProtKB: Q4V8J8 (UniProtKB/Swiss-Prot),   P38445 (UniProtKB/Swiss-Prot),   A0A0G2JSN4 (UniProtKB/TrEMBL),   A6I3W5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244134   ⟸   XM_006244072
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A9R2 (UniProtKB/TrEMBL),   A6I3W4 (UniProtKB/TrEMBL),   A6I3W6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019777   ⟸   ENSRNOT00000019777
RefSeq Acc Id: XP_038936802   ⟸   XM_039080874
- Peptide Label: isoform X1
- UniProtKB: A6I3W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936804   ⟸   XM_039080876
- Peptide Label: isoform X4
- UniProtKB: Q4V8J8 (UniProtKB/Swiss-Prot),   P38445 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038936803   ⟸   XM_039080875
- Peptide Label: isoform X3
- UniProtKB: Q4V8J8 (UniProtKB/Swiss-Prot),   P38445 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000090538   ⟸   ENSRNOT00000118049
Ensembl Acc Id: ENSRNOP00000106039   ⟸   ENSRNOT00000170763
Ensembl Acc Id: ENSRNOP00000111171   ⟸   ENSRNOT00000129875
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P38445-F1-model_v2 AlphaFold P38445 1-513 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696372
Promoter ID:EPDNEW_R6897
Type:single initiation site
Name:Acvr2b_1
Description:activin A receptor type 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08128,087,417 - 128,087,477EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2028 AgrOrtholog
BioCyc Gene G2FUF-28788 BioCyc
Ensembl Genes ENSRNOG00000014477 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019777 ENTREZGENE
  ENSRNOT00000118049 ENTREZGENE
  ENSRNOT00000129875 ENTREZGENE
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7442221 IMAGE-MGC_LOAD
InterPro Activin_recp UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Snake_toxin-like_sf UniProtKB/Swiss-Prot
  TGFB_receptor UniProtKB/Swiss-Prot
KEGG Report rno:25366 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114390 IMAGE-MGC_LOAD
NCBI Gene 25366 ENTREZGENE
PANTHER ACTIVIN RECEPTOR TYPE-2B UniProtKB/Swiss-Prot
  PTHR23255 UniProtKB/Swiss-Prot
Pfam Activin_recp UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PharmGKB ACVR2B RGD
PhenoGen Acvr2b PhenoGen
PRINTS ACTIVIN2R UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014477 RatGTEx
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
  SSF57302 UniProtKB/Swiss-Prot
UniProt A0A0G2JSN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9R2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L7A9_RAT UniProtKB/TrEMBL
  A0ABK0LZD3_RAT UniProtKB/TrEMBL
  A6I3W4 ENTREZGENE, UniProtKB/TrEMBL
  A6I3W5 ENTREZGENE, UniProtKB/TrEMBL
  A6I3W6 ENTREZGENE, UniProtKB/TrEMBL
  AVR2B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8J8 ENTREZGENE
UniProt Secondary Q4V8J8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Acvr2b  activin A receptor type 2B  Acvr2b  activin A receptor, type IIB  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Acvr2b  activin A receptor, type IIB  Acvr2b  activin receptor IIB  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Acvr2b  activin receptor IIB    Activine receptor 2b (transmembrane serine kinase)  Name updated 625702 APPROVED
2002-06-10 Acvr2b  Activine receptor 2b (transmembrane serine kinase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in rat testis during all developmental stages tested 70656
gene_expression expressed in fetal airway 631799
gene_process plays a role in reproductive physiology and endocrinology 70656