Acp1 (acid phosphatase 1) - Rat Genome Database

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Gene: Acp1 (acid phosphatase 1) Rattus norvegicus
Analyze
Symbol: Acp1
Name: acid phosphatase 1
RGD ID: 2020
Description: Enables SH3 domain binding activity; acid phosphatase activity; and protein tyrosine phosphatase activity. Involved in chemical synaptic transmission. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and sarcolemma. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; riboflavin metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acid phosphatase 1 soluble; acid phosphatase 1, soluble; LMW-PTP; LMW-PTP-I low molecular weight phosphotyrosine protein phosphatase isozyme 1; LMW-PTP-I, low molecular weight phosphotyrosine protein phosphatase isozyme 1; LMW-PTPase; low molecular weight cytosolic acid phosphatase; low molecular weight phosphotyrosine protein phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Acp1-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8653,233,937 - 53,249,576 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl653,233,948 - 53,251,959 (-)EnsemblGRCr8
mRatBN7.2647,506,380 - 47,522,021 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl647,506,380 - 47,522,021 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx647,812,337 - 47,827,906 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0648,127,247 - 48,142,816 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0647,572,321 - 47,587,872 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0649,836,064 - 49,851,714 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl649,836,075 - 49,851,714 (-)Ensemblrn6Rnor6.0
Rnor_5.0658,515,986 - 58,531,100 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4648,784,243 - 48,798,868 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera646,711,467 - 46,727,154 (-)NCBICelera
RGSC_v3.1648,785,927 - 48,801,957 (-)NCBI
Cytogenetic Map6q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenyl phosphate  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aminoglutethimide  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
clofibrate  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
fenthion  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
lead(0)  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium nitrite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
thiazolidines  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ACP1 genetic polymorphism and coronary artery disease: an association study. Banci M, etal., Cardiology. 2009;113(4):236-42. Epub 2009 Feb 25.
2. Enzyme polymorphism and clinical variability of diseases: study of acid phosphatase locus 1 (ACP1) in obese subjects. Bottini E, etal., Hum Biol. 1990 Jun;62(3):403-11.
3. Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex. Bottini N, etal., Diabetes Metab Res Rev. 2005 Jul-Aug;21(4):353-8.
4. Genotypes of cytosolic low-molecular-weight protein-tyrosine-phosphatase correlate with age at onset of type 1 diabetes in a sex-specific manner. Bottini N, etal., Metabolism. 2002 Apr;51(4):419-22.
5. Type 2 diabetes and the genetics of signal transduction: a study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms. Bottini N, etal., Metabolism. 2004 Aug;53(8):995-1001.
6. Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women. Bottini N, etal., Mol Genet Metab. 2002 Nov;77(3):226-9.
7. Association between the low molecular weight cytosolic acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome. Bottini N, etal., Neurosci Lett 2002 Sep 20;330(2):198-200.
8. Kinetic studies on rat liver low M(r) phosphotyrosine protein phosphatases. The activation mechanism of the isoenzyme AcP2 by cGMP. Cirri P, etal., Biochim Biophys Acta 1995 Jan 18;1243(1):129-35.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Phosphotyrosine protein phosphatases and diabetic pregnancy: an association between low molecular weight acid phosphatase and degree of glycemic control. Gloria-Bottini F, etal., Experientia. 1996 Apr 15;52(4):340-3.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Low-molecular-weight acid phosphatase (ACP1), obesity, and blood lipid levels in subjects with non-insulin-dependent diabetes mellitus. Lucarini N, etal., Hum Biol. 1997 Aug;69(4):509-15.
14. Smoking and the genetics of signal transduction: an association study on retinopathy in type 1 diabetes. Magrini A, etal., Am J Med Sci. 2002 Dec;324(6):310-3.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain. Nicolas G, etal., Mol Cell Biol. 2002 May;22(10):3527-36.
18. Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice. Pandey SK, etal., J Biol Chem. 2007 May 11;282(19):14291-9. Epub 2007 Mar 12.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Dephosphorylation of tyrosine phosphorylated synthetic peptides by rat liver phosphotyrosine protein phosphatase isoenzymes. Stefani M, etal., FEBS Lett. 1993 Jul 12;326(1-3):131-4.
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Abundance of low molecular weight phosphotyrosine protein phosphatase in the nerve-ending fraction in the brain. Tanino H, etal., Biol Pharm Bull 1999 Aug;22(8):794-8.
Additional References at PubMed
PMID:198184   PMID:1388675   PMID:1914521   PMID:7323947   PMID:7444718   PMID:9824304   PMID:10940933   PMID:15489334   PMID:15632090   PMID:16893901   PMID:19056867   PMID:23376485  
PMID:23533145   PMID:26213100   PMID:26316108   PMID:30053369  


Genomics

Comparative Map Data
Acp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8653,233,937 - 53,249,576 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl653,233,948 - 53,251,959 (-)EnsemblGRCr8
mRatBN7.2647,506,380 - 47,522,021 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl647,506,380 - 47,522,021 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx647,812,337 - 47,827,906 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0648,127,247 - 48,142,816 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0647,572,321 - 47,587,872 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0649,836,064 - 49,851,714 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl649,836,075 - 49,851,714 (-)Ensemblrn6Rnor6.0
Rnor_5.0658,515,986 - 58,531,100 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4648,784,243 - 48,798,868 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera646,711,467 - 46,727,154 (-)NCBICelera
RGSC_v3.1648,785,927 - 48,801,957 (-)NCBI
Cytogenetic Map6q16NCBI
ACP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382264,947 - 278,283 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2264,140 - 279,100 (+)Ensemblhg38GRCh38
GRCh372264,947 - 278,283 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362254,872 - 268,283 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342254,895 - 268,280NCBI
Celera2327,509 - 340,926 (+)NCBICelera
Cytogenetic Map2p25.3NCBI
HuRef2261,431 - 274,847 (+)NCBIHuRef
CHM1_12264,806 - 278,220 (+)NCBICHM1_1
T2T-CHM13v2.02265,202 - 278,542 (+)NCBIT2T-CHM13v2.0
Acp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391230,943,325 - 30,961,616 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1230,943,325 - 30,961,588 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381230,893,326 - 30,911,619 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1230,893,326 - 30,911,589 (-)Ensemblmm10GRCm38
MGSCv371231,578,191 - 31,596,477 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361231,479,378 - 31,497,608 (-)NCBIMGSCv36mm8
Celera1232,346,148 - 32,364,519 (-)NCBICelera
Cytogenetic Map12A2NCBI
cM Map1213.0NCBI
Acp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955487290,557 - 302,547 (+)Ensembl
ChiLan1.0NW_004955487290,434 - 302,405 (+)NCBIChiLan1.0ChiLan1.0
ACP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212126,269,693 - 126,283,122 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A126,273,669 - 126,287,098 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A257,892 - 271,320 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A253,645 - 267,086 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A253,656 - 267,086 (+)EnsemblpanPan2panpan1.1
ACP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.117243,757 - 251,151 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl17243,713 - 250,758 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha17230,458 - 243,370 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.017298,408 - 311,318 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl17298,504 - 312,878 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.117225,421 - 238,323 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.017243,384 - 256,562 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.017248,297 - 261,206 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629245,375,753 - 45,390,385 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936532132,350 - 145,285 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936532130,799 - 145,285 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3132,667,045 - 132,684,674 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13132,671,408 - 132,684,793 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23142,383,352 - 142,396,021 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114107,449,327 - 107,465,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660454,476,886 - 4,492,471 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248461,736,038 - 1,747,009 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248461,735,944 - 1,748,495 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1744,294,451 - 44,309,889 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acp1
100 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:95
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000007287
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)64005241156848866Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63902865963457441Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
RH141069  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001135562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF171072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM059981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ150453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007287   ⟹   ENSRNOP00000007287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl653,233,948 - 53,251,959 (-)Ensembl
mRatBN7.2 Ensembl647,506,380 - 47,521,977 (-)Ensembl
Rnor_6.0 Ensembl649,836,075 - 49,851,677 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077442   ⟹   ENSRNOP00000072548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl653,233,948 - 53,249,576 (-)Ensembl
mRatBN7.2 Ensembl647,506,391 - 47,522,021 (-)Ensembl
Rnor_6.0 Ensembl649,836,075 - 49,851,714 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108337   ⟹   ENSRNOP00000093729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl653,234,675 - 53,249,510 (-)Ensembl
mRatBN7.2 Ensembl647,507,118 - 47,521,955 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109768   ⟹   ENSRNOP00000095909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl653,234,559 - 53,249,522 (-)Ensembl
mRatBN7.2 Ensembl647,507,002 - 47,521,967 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111535   ⟹   ENSRNOP00000081086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl653,233,948 - 53,242,636 (-)Ensembl
mRatBN7.2 Ensembl647,506,380 - 47,515,081 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158528   ⟹   ENSRNOP00000103823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl653,233,948 - 53,251,959 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167568   ⟹   ENSRNOP00000112560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl653,233,948 - 53,248,732 (-)Ensembl
RefSeq Acc Id: NM_001135562   ⟹   NP_001129034
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8653,233,937 - 53,249,576 (-)NCBI
mRatBN7.2647,506,380 - 47,522,021 (-)NCBI
Rnor_6.0649,836,064 - 49,851,714 (-)NCBI
Rnor_5.0658,515,986 - 58,531,100 (-)NCBI
RGSC_v3.4648,784,243 - 48,798,868 (-)RGD
Celera646,711,467 - 46,727,154 (-)RGD
Sequence:
RefSeq Acc Id: NM_001313735   ⟹   NP_001300664
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8653,234,559 - 53,249,522 (-)NCBI
mRatBN7.2647,507,002 - 47,521,967 (-)NCBI
Rnor_6.0649,836,686 - 49,851,660 (-)NCBI
Celera646,712,090 - 46,727,100 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001313740   ⟹   NP_001300669
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8653,234,675 - 53,249,510 (-)NCBI
mRatBN7.2647,507,118 - 47,521,955 (-)NCBI
Rnor_6.0649,836,802 - 49,851,648 (-)NCBI
Celera646,712,206 - 46,727,088 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021262   ⟹   NP_067085
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8653,233,941 - 53,249,539 (-)NCBI
mRatBN7.2647,506,384 - 47,521,984 (-)NCBI
Rnor_6.0649,836,068 - 49,851,677 (-)NCBI
Rnor_5.0658,515,986 - 58,531,100 (-)NCBI
RGSC_v3.4648,784,243 - 48,798,868 (-)RGD
Celera646,711,471 - 46,727,117 (-)NCBI
Sequence:
RefSeq Acc Id: NP_067085   ⟸   NM_021262
- Peptide Label: isoform A
- UniProtKB: Q9R138 (UniProtKB/Swiss-Prot),   P41498 (UniProtKB/Swiss-Prot),   A6HB36 (UniProtKB/TrEMBL),   Z4YNF4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129034   ⟸   NM_001135562
- Peptide Label: isoform B
- UniProtKB: B0BNC1 (UniProtKB/TrEMBL),   A0A0G2K394 (UniProtKB/TrEMBL),   A0A9K3Y7U9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300664   ⟸   NM_001313735
- Peptide Label: isoform C
- UniProtKB: A0A8I6AMP6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300669   ⟸   NM_001313740
- Peptide Label: isoform D
- UniProtKB: A0A8I6AKL4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072548   ⟸   ENSRNOT00000077442
Ensembl Acc Id: ENSRNOP00000007287   ⟸   ENSRNOT00000007287
Ensembl Acc Id: ENSRNOP00000095909   ⟸   ENSRNOT00000109768
Ensembl Acc Id: ENSRNOP00000081086   ⟸   ENSRNOT00000111535
Ensembl Acc Id: ENSRNOP00000093729   ⟸   ENSRNOT00000108337
Ensembl Acc Id: ENSRNOP00000112560   ⟸   ENSRNOT00000167568
Ensembl Acc Id: ENSRNOP00000103823   ⟸   ENSRNOT00000158528
Protein Domains
Phosphotyrosine protein phosphatase I

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41498-F1-model_v2 AlphaFold P41498 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694538
Promoter ID:EPDNEW_R5063
Type:initiation region
Name:Acp1_1
Description:acid phosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0649,851,679 - 49,851,739EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2020 AgrOrtholog
BioCyc Gene G2FUF-37930 BioCyc
Ensembl Genes ENSRNOG00000005260 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007287.8 UniProtKB/Swiss-Prot
  ENSRNOT00000077442 ENTREZGENE
  ENSRNOT00000109768 ENTREZGENE
  ENSRNOT00000111535 ENTREZGENE
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918194 IMAGE-MGC_LOAD
  IMAGE:7109165 IMAGE-MGC_LOAD
  IMAGE:9032684 IMAGE-MGC_LOAD
InterPro LMW_PTPase UniProtKB/Swiss-Prot
  Ptyr_pPase UniProtKB/Swiss-Prot
  Ptyr_pPase_sf UniProtKB/Swiss-Prot
  Tyr_Pase_low_mol_wt_mml UniProtKB/Swiss-Prot
  Tyr_phospatase_low_mol_wt UniProtKB/Swiss-Prot
KEGG Report rno:24161 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187819 IMAGE-MGC_LOAD
  MGC:188015 IMAGE-MGC_LOAD
  MGC:72846 IMAGE-MGC_LOAD
NCBI Gene 24161 ENTREZGENE
PANTHER LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
  LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE UniProtKB/Swiss-Prot
Pfam LMWPc UniProtKB/Swiss-Prot
PhenoGen Acp1 PhenoGen
PRINTS LMWPTPASE UniProtKB/Swiss-Prot
  MAMMALPTPASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005260 RatGTEx
SMART LMWPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52788 UniProtKB/Swiss-Prot
UniProt A0A0G2K394 ENTREZGENE
  A0A8I5ZQW7_RAT UniProtKB/TrEMBL
  A0A8I6AKL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMP6 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y7U9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L3H8_RAT UniProtKB/TrEMBL
  A0ABK0M0V3_RAT UniProtKB/TrEMBL
  A6HB36 ENTREZGENE, UniProtKB/TrEMBL
  B0BNC1 ENTREZGENE, UniProtKB/TrEMBL
  P41498 ENTREZGENE, UniProtKB/Swiss-Prot
  Q9R138 ENTREZGENE
  Z4YNF4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q9R138 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-28 Acp1  acid phosphatase 1  Acp1  acid phosphatase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Acp1  acid phosphatase 1, soluble    Acid phosphatase 1, soluble  Name updated 629478 APPROVED
2002-06-10 Acp1  Acid phosphatase 1, soluble      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to nerve endings 631746
gene_expression expressed in liver 631727
gene_expression protein detected in brain 631746
gene_function catalyzes the hydrolysis of p-nitrophenyl phosphate 631727
gene_process may play a role in synaptic function 631746
gene_regulation not activated by cyclic GMP and guanosine 631727