RGD Reference Report - Smoking and the genetics of signal transduction: an association study on retinopathy in type 1 diabetes. - Rat Genome Database

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Smoking and the genetics of signal transduction: an association study on retinopathy in type 1 diabetes.

Authors: Magrini, A  Bottini, N  Nicotra, M  Cosmi, E  Bottini, E  Bergamaschi, A 
Citation: Magrini A, etal., Am J Med Sci. 2002 Dec;324(6):310-3.
RGD ID: 2313184
Pubmed: PMID:12495297   (View Abstract at PubMed)

BACKGROUND: Recent studies suggest a complex association between smoking and retinopathy that probably depends on the interaction between many variables. We have reported an association between ACP1 phenotype and retinopathy in type 1 diabetes. Additionally, the deleterious effects of smoking on intrauterine growth are dependent on ACP1, a low-molecular-weight tyrosine phosphatase that modifies signal transduction. We examine here the interaction between smoking and ACP1 as a mediator of susceptibility to diabetic retinopathy in a sample of puerperae with type 1 diabetes. SUBJECTS AND METHODS: Seventy-eight women who had just delivered live infants were studied. ACP1 phenotype was determined by starch gel electrophoresis. Three-way contingency tables were analyzed. RESULTS: There is a significant epistatic interaction between smoking and ACP1 phenotype concerning their effects on retinopathy. In subjects with low ACP1 activity, frequency of retinopathy was slightly higher in smokers than in nonsmokers. However, in subjects with medium-high ACP1 activity, frequency of retinopathy was significantly lower in smokers than in nonsmokers. A logistic regression analysis using retinopathy as the dependent variable revealed that smoking, ACP1, and ACP1 by smoking interaction, as well as the interaction between smoking and age of the women, are the most robust predictors of retinopathy. CONCLUSIONS: The effect of smoking on retinopathy in women with type 1 diabetes depends on many variables, which supports the hypothesis of complex interactions between smoking and other variables in the pathogenesis of this disease. Variability of genetic factors involved in signal transduction may affect endothelium proliferation through the regulation of growth factors and through regulation of glycemic levels. Because cigarette smoke influences signal transduction, its impact on diabetic retinopathy may be mediated by ACP1.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diabetic retinopathy  IDA 2313184associated with Diabetes Mellitus and Insulin-DependentRGD 
diabetic retinopathy  ISOACP1 (Homo sapiens)2313184; 2313184associated with Diabetes Mellitus and Insulin-DependentRGD 

Objects Annotated

Genes (Rattus norvegicus)
Acp1  (acid phosphatase 1)

Genes (Mus musculus)
Acp1  (acid phosphatase 1, soluble)

Genes (Homo sapiens)
ACP1  (acid phosphatase 1)


Additional Information