RGD Reference Report - ACP1 genetic polymorphism and coronary artery disease: an association study. - Rat Genome Database

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ACP1 genetic polymorphism and coronary artery disease: an association study.

Authors: Banci, M  Saccucci, P  D'Annibale, F  Dofcaci, A  Trionfera, G  Magrini, A  Bottini, N  Bottini, E  Gloria-Bottini, F 
Citation: Banci M, etal., Cardiology. 2009;113(4):236-42. Epub 2009 Feb 25.
RGD ID: 2313179
Pubmed: PMID:19246900   (View Abstract at PubMed)
DOI: DOI:10.1159/000203405   (Journal Full-text)

OBJECTIVES: Assuming an immune component in the pathogenesis of atherosclerosis, we have investigated a possible association between coronary artery disease (CAD) and the acid phosphatase locus 1 (ACP1) genetic polymorphism, which has previously been found to be associated with immune disorders. METHODS: 226 subjects admitted to the hospital for CAD, 358 consecutive newborn infants, 279 adult subjects with type 2 diabetes without CAD and 137 adults without diabetes and without CAD from the Caucasian population of Rome were studied. The ACP1 genotype was determined by DNA analysis. Statistical analyses were performed using the SPSS package. RESULTS: CAD females showed an excess of ACP1 *A/*C and *B/*C genotypes and a deficiency of ACP1 *B/*B genotype compared to controls, while CAD males did not show significant differences. Among diabetic women the proportion of *C allele carriers was much greater in those with CAD than in those without CAD. This difference was much less evident in nondiabetic women. CONCLUSION: ACP1 may be involved in susceptibility to CAD. Since ACP1 has been found to be associated with immunological diseases, our observation reinforces the notion of an immune component in the pathogenesis of atherosclerosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
coronary artery disease  IAGP 2313179 RGD 
coronary artery disease  ISOACP1 (Homo sapiens)2313179; 2313179 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Acp1  (acid phosphatase 1)

Genes (Mus musculus)
Acp1  (acid phosphatase 1, soluble)

Genes (Homo sapiens)
ACP1  (acid phosphatase 1)


Additional Information