Abcd3 (ATP binding cassette subfamily D member 3) - Rat Genome Database

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Gene: Abcd3 (ATP binding cassette subfamily D member 3) Rattus norvegicus
Analyze
Symbol: Abcd3
Name: ATP binding cassette subfamily D member 3
RGD ID: 2007
Description: Enables ATP binding activity and identical protein binding activity. Involved in response to xenobiotic stimulus. Located in mitochondrion and peroxisomal membrane. Human ortholog(s) of this gene implicated in Zellweger syndrome and congenital bile acid synthesis defect 5. Orthologous to human ABCD3 (ATP binding cassette subfamily D member 3); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 70 kDa peroxisomal membrane protein; 70-kDa peroxisomal membrane protein; ATP-binding cassette sub-family D member 3; ATP-binding cassette, sub-family D (ALD), member 3; ATP-binding cassette, subfamily D (ALD), member 3; Peroxisomal membrane protein 1; PMP70; PMP70, 70-kDa peroxisomal membrane protein; Pxmp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82212,536,791 - 212,590,379 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2212,536,791 - 212,590,504 (-)EnsemblGRCr8
mRatBN7.22209,852,087 - 209,905,763 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,852,087 - 209,906,020 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2217,515,099 - 217,568,654 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,422,840 - 215,476,397 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,264,674 - 210,318,230 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,335,708 - 225,389,120 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,335,718 - 225,389,120 (-)Ensemblrn6Rnor6.0
Rnor_5.02243,374,189 - 243,409,604 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42218,396,071 - 218,432,172 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2202,282,471 - 202,317,962 (-)NCBICelera
RGSC_v3.12218,359,132 - 218,395,230 (-)NCBI
RH 3.4 Map21501.0RGD
Cytogenetic Map2q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7-ketocholesterol  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clothianidin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
epoxiconazole  (ISO)
fenofibrate  (ISO)
finasteride  (EXP)
fluoranthene  (EXP)
folic acid  (ISO)
fomesafen  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
GW 7647  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
MeIQx  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Muraglitazar  (EXP)
nickel atom  (ISO)
oleic acid  (ISO)
Oxyfluorfen  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pravastatin  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulindac  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (ISO)
triacsin C  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
mitochondrion  (IDA)
organelle membrane  (IEA)
peroxisomal matrix  (IEA,ISO)
peroxisomal membrane  (IBA,IDA,IEA,ISO)
peroxisome  (IDA,IEA,ISO,NAS)

References

References - curated
# Reference Title Reference Citation
1. Fenofibrate differently alters expression of genes encoding ATP-binding transporter proteins of the peroxisomal membrane. Albet S, etal., FEBS Lett. 1997 Apr 1;405(3):394-7.
2. Restoration of peroxisome biogenesis in a peroxisome-deficient mammalian cell line by expression of either the 35 kDa or the 70 kDa peroxisomal membrane proteins. Gartner J, etal., J Inherit Metab Dis 1994;17(3):327-9.
3. Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome. Gartner J, etal., Nat Genet. 1992 Apr;1(1):16-23.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily. Kamijo K, etal., J Biol Chem 1990 Mar 15;265(8):4534-40.
7. Nucleotide-induced conformational changes of PMP70, an ATP binding cassette transporter on rat liver peroxisomal membranes. Kashiwayama Y, etal., Biochem Biophys Res Commun 2002 Mar 15;291(5):1245-51.
8. 70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins. Kashiwayama Y, etal., Exp Cell Res. 2009 Jan 15;315(2):190-205. doi: 10.1016/j.yexcr.2008.10.031. Epub 2008 Nov 3.
9. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
15. Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes. Reguenga C, etal., Biochim Biophys Acta. 1999 Jun 9;1445(3):337-41.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1). Tanaka AR, etal., J Biol Chem. 2002 Oct 18;277(42):40142-7. Epub 2002 Aug 9.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Differential induction of peroxisomal populations in subcellular fractions of rat liver. Wilcke M and Alexson SE, Biochim Biophys Acta. 2001 Jan 12;1544(1-2):358-69.
Additional References at PubMed
PMID:9425230   PMID:9765053   PMID:9922452   PMID:10527525   PMID:10704444   PMID:11248239   PMID:11453642   PMID:12865426   PMID:12915479   PMID:14651853   PMID:16344115   PMID:17542813  
PMID:17609205   PMID:18178290   PMID:18614015   PMID:18992293   PMID:19479899   PMID:19686593   PMID:19946888   PMID:20007743   PMID:21460186   PMID:21502359   PMID:21525035   PMID:22871113  
PMID:25168382   PMID:31505169  


Genomics

Comparative Map Data
Abcd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82212,536,791 - 212,590,379 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2212,536,791 - 212,590,504 (-)EnsemblGRCr8
mRatBN7.22209,852,087 - 209,905,763 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,852,087 - 209,906,020 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2217,515,099 - 217,568,654 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,422,840 - 215,476,397 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,264,674 - 210,318,230 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,335,708 - 225,389,120 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,335,718 - 225,389,120 (-)Ensemblrn6Rnor6.0
Rnor_5.02243,374,189 - 243,409,604 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42218,396,071 - 218,432,172 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2202,282,471 - 202,317,962 (-)NCBICelera
RGSC_v3.12218,359,132 - 218,395,230 (-)NCBI
RH 3.4 Map21501.0RGD
Cytogenetic Map2q42NCBI
ABCD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,385,131 - 94,518,663 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,418,242 - 94,518,666 (+)Ensemblhg38GRCh38
GRCh37194,883,945 - 94,984,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,656,599 - 94,756,672 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34194,596,031 - 94,696,105NCBI
Celera193,137,599 - 93,238,680 (+)NCBICelera
Cytogenetic Map1p21.3ENTREZGENE
HuRef193,005,619 - 93,105,917 (+)NCBIHuRef
CHM1_1194,998,783 - 95,099,070 (+)NCBICHM1_1
T2T-CHM13v2.0194,233,380 - 94,366,700 (+)NCBIT2T-CHM13v2.0
Abcd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393121,552,553 - 121,609,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3121,552,423 - 121,608,951 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383121,758,904 - 121,815,302 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,758,774 - 121,815,302 (-)Ensemblmm10GRCm38
MGSCv373121,461,828 - 121,518,133 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363121,750,933 - 121,807,238 (-)NCBIMGSCv36mm8
Celera3128,155,294 - 128,218,276 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
Abcd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423280,497 - 359,711 (-)Ensembl
ChiLan1.0NW_004955423280,497 - 359,711 (-)NCBIChiLan1.0ChiLan1.0
ABCD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21132,505,970 - 132,606,599 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11131,660,847 - 131,761,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,079,326 - 97,179,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,808,027 - 95,907,864 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,808,027 - 95,907,864 (+)EnsemblpanPan2panpan1.1
ABCD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1654,740,704 - 54,816,854 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,742,111 - 54,817,235 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha657,449,009 - 57,525,742 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0655,116,365 - 55,193,330 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,116,488 - 55,193,330 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1654,797,137 - 54,873,570 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0654,781,385 - 54,858,240 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,234,335 - 55,310,979 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abcd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058104,201,915 - 104,288,290 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365374,659,484 - 4,746,616 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365374,659,685 - 4,745,992 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4122,847,927 - 122,953,257 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14122,847,925 - 122,929,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24134,491,144 - 134,572,292 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12038,750,147 - 38,846,011 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2038,748,787 - 38,845,989 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603379,200,937 - 79,302,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,142,570 - 3,236,728 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247423,146,000 - 3,236,473 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Abcd3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1338,051,431 - 38,105,989 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Abcd3
356 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:537
Count of miRNA genes:263
Interacting mature miRNAs:318
Transcripts:ENSRNOT00000016739
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2209350500221678003Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2205135267225627153Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat

Markers in Region
D2Arb23  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82212,537,540 - 212,537,839 (+)Marker Load Pipeline
mRatBN7.22209,852,836 - 209,853,134 (+)MAPPERmRatBN7.2
Rnor_6.02225,336,447 - 225,336,744NCBIRnor6.0
Rnor_5.02243,374,928 - 243,375,225UniSTSRnor5.0
RGSC_v3.42218,396,809 - 218,397,107RGDRGSC3.4
RGSC_v3.42218,396,810 - 218,397,107UniSTSRGSC3.4
Celera2202,283,210 - 202,283,507UniSTS
RGSC_v3.12218,359,871 - 218,360,169RGD
Cytogenetic Map2q41UniSTS
RH128671  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,852,127 - 209,852,336 (+)MAPPERmRatBN7.2
Rnor_6.02225,335,738 - 225,335,946NCBIRnor6.0
Rnor_5.02243,374,219 - 243,374,427UniSTSRnor5.0
RGSC_v3.42218,396,101 - 218,396,309UniSTSRGSC3.4
Celera2202,282,501 - 202,282,709UniSTS
RH 3.4 Map21501.4UniSTS
Cytogenetic Map2q41UniSTS
RH94667  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,852,706 - 209,852,860 (+)MAPPERmRatBN7.2
Rnor_6.02225,336,317 - 225,336,470NCBIRnor6.0
Rnor_5.02243,374,798 - 243,374,951UniSTSRnor5.0
RGSC_v3.42218,396,680 - 218,396,833UniSTSRGSC3.4
Celera2202,283,080 - 202,283,233UniSTS
RH 3.4 Map21501.0UniSTS
Cytogenetic Map2q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016739   ⟹   ENSRNOP00000016739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2212,536,791 - 212,590,379 (-)Ensembl
mRatBN7.2 Ensembl2209,852,087 - 209,905,680 (-)Ensembl
Rnor_6.0 Ensembl2225,335,718 - 225,389,120 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106914   ⟹   ENSRNOP00000085866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2212,536,791 - 212,590,504 (-)Ensembl
mRatBN7.2 Ensembl2209,852,087 - 209,906,020 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110813   ⟹   ENSRNOP00000094858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2212,536,791 - 212,590,379 (-)Ensembl
mRatBN7.2 Ensembl2209,852,087 - 209,905,680 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119497   ⟹   ENSRNOP00000079442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2212,536,791 - 212,590,504 (-)Ensembl
mRatBN7.2 Ensembl2209,852,087 - 209,905,680 (-)Ensembl
RefSeq Acc Id: NM_012804   ⟹   NP_036936
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82212,536,791 - 212,590,379 (-)NCBI
mRatBN7.22209,852,087 - 209,905,680 (-)NCBI
Rnor_6.02225,335,708 - 225,389,120 (-)NCBI
Rnor_5.02243,374,189 - 243,409,604 (-)NCBI
RGSC_v3.42218,396,071 - 218,432,172 (-)RGD
Celera2202,282,471 - 202,317,962 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101772   ⟹   XP_038957700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82212,536,791 - 212,590,340 (-)NCBI
mRatBN7.22209,852,087 - 209,905,763 (-)NCBI
RefSeq Acc Id: XM_039101774   ⟹   XP_038957702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82212,536,791 - 212,590,345 (-)NCBI
mRatBN7.22209,852,087 - 209,905,647 (-)NCBI
RefSeq Acc Id: XM_063281326   ⟹   XP_063137396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82212,536,791 - 212,589,904 (-)NCBI
RefSeq Acc Id: NP_036936   ⟸   NM_012804
- UniProtKB: P16970 (UniProtKB/Swiss-Prot),   A0A8I6ANP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016739   ⟸   ENSRNOT00000016739
RefSeq Acc Id: XP_038957700   ⟸   XM_039101772
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZN14 (UniProtKB/TrEMBL),   A0A8I6ANP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957702   ⟸   XM_039101774
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A495 (UniProtKB/TrEMBL),   A0A8I6ANP9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085866   ⟸   ENSRNOT00000106914
Ensembl Acc Id: ENSRNOP00000079442   ⟸   ENSRNOT00000119497
Ensembl Acc Id: ENSRNOP00000094858   ⟸   ENSRNOT00000110813
RefSeq Acc Id: XP_063137396   ⟸   XM_063281326
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A495 (UniProtKB/TrEMBL),   A0A8I6ANP9 (UniProtKB/TrEMBL)
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16970-F1-model_v2 AlphaFold P16970 1-659 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691720
Promoter ID:EPDNEW_R2245
Type:initiation region
Name:Abcd3_1
Description:ATP binding cassette subfamily D member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02225,389,173 - 225,389,233EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2007 AgrOrtholog
BioCyc Gene G2FUF-51390 BioCyc
Ensembl Genes ENSRNOG00000011929 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016739 ENTREZGENE
  ENSRNOT00000016739.7 UniProtKB/Swiss-Prot
  ENSRNOT00000106914 ENTREZGENE
  ENSRNOT00000119497 ENTREZGENE
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  ABC_transporter_sub-D UniProtKB/Swiss-Prot
  FA_transporter UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:25270 UniProtKB/Swiss-Prot
NCBI Gene 25270 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3 UniProtKB/Swiss-Prot
  ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER UniProtKB/Swiss-Prot
Pfam ABC_membrane_2 UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PhenoGen Abcd3 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011929 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF90123 UniProtKB/Swiss-Prot
TIGR TC229511
UniProt A0A8I5ZN14 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A495 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANP9 ENTREZGENE, UniProtKB/TrEMBL
  A6HVF3_RAT UniProtKB/TrEMBL
  A6HVF4_RAT UniProtKB/TrEMBL
  A6HVF5_RAT UniProtKB/TrEMBL
  ABCD3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcd3  ATP binding cassette subfamily D member 3  Abcd3  ATP-binding cassette, subfamily D (ALD), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcd3  ATP-binding cassette, subfamily D (ALD), member 3  Abcd3  ATP-binding cassette, sub-family D (ALD), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Abcd3  ATP-binding cassette, sub-family D (ALD), member 3      Symbol and Name status set to approved 70586 APPROVED
2001-04-19 Pxmp1  Peroxisomal membrane protein 1      Symbol withdrawn, duplicate entry of Abcd3(RGD:2007) 61478 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the peroxisomal membrane 631711
gene_domains contains an ATP-binding domain 631711
gene_function may form an ATP-binding channel 631711
gene_homology has similarity to MalK and Mdr ATP-binding proteins 631711
gene_process may play a role in active transport in peroxisomes 631711
gene_product peroxisomal membrane protein 631711
gene_product member of the P-glycoprotein related ATP binding protein superfamily 631711
gene_protein 70-kDa 631711