RGD Reference Report - Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes. - Rat Genome Database

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Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes.

Authors: Reguenga, C  Oliveira, ME  Gouveia, AM  Eckerskorn, C  Sa-Miranda, C  Azevedo, JE 
Citation: Reguenga C, etal., Biochim Biophys Acta. 1999 Jun 9;1445(3):337-41.
RGD ID: 8554507
Pubmed: PMID:10366717   (View Abstract at PubMed)

A 24 kDa protein from rat liver peroxisomal membrane was isolated and subjected to Edman degradation. Using the N-terminal sequence of this polypeptide we have identified several rat and human expressed sequence tags in the GenBank Database. The complete sequence of a human cDNA clone was determined. The open reading frame encodes an extremely basic protein 212 amino acid residues long. A high similarity between this mammalian protein and hypothetical proteins from Caenorhabditis elegans and Neurospora crassa was found. Hydropathy analysis reveals the existence of two putative membrane-spanning domains in conserved regions of the three homologous proteins.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
peroxisomal membrane located_inIDA 8554507PMID:10366717UniProt 
peroxisome located_inIDA 8554507; 8554507PMID:10366717UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Abcd3  (ATP binding cassette subfamily D member 3)
Pxmp2  (peroxisomal membrane protein 2)
Pxmp4  (peroxisomal membrane protein 4)


Additional Information