Retnlb (resistin like beta) - Rat Genome Database

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Gene: Retnlb (resistin like beta) Rattus norvegicus
Analyze
Symbol: Retnlb
Name: resistin like beta
RGD ID: 1624215
Description: Predicted to enable hormone activity. Predicted to be involved in epithelial cell proliferation. Predicted to act upstream of or within response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human RETNLB (resistin like beta); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; bisphenol A; capsaicin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: resistin-like beta
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,446,433 - 65,448,319 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,446,434 - 65,448,319 (-)EnsemblGRCr8
mRatBN7.21151,983,482 - 51,985,368 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,983,483 - 51,985,368 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1160,746,551 - 60,748,437 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,408,333 - 53,410,219 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01152,513,099 - 52,514,985 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,565,471 - 54,567,578 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,565,472 - 54,567,357 (-)Ensemblrn6Rnor6.0
Rnor_5.01157,727,746 - 57,729,632 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41153,226,992 - 53,228,878 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,583,301 - 51,585,187 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11209052   PMID:12782128   PMID:23012479   PMID:28681425   PMID:39094924  


Genomics

Comparative Map Data
Retnlb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,446,433 - 65,448,319 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,446,434 - 65,448,319 (-)EnsemblGRCr8
mRatBN7.21151,983,482 - 51,985,368 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,983,483 - 51,985,368 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1160,746,551 - 60,748,437 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,408,333 - 53,410,219 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01152,513,099 - 52,514,985 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,565,471 - 54,567,578 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,565,472 - 54,567,357 (-)Ensemblrn6Rnor6.0
Rnor_5.01157,727,746 - 57,729,632 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41153,226,992 - 53,228,878 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,583,301 - 51,585,187 (-)NCBICelera
Cytogenetic Map11q21NCBI
RETNLB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383108,755,638 - 108,757,410 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3108,743,424 - 108,757,410 (-)Ensemblhg38GRCh38
GRCh373108,474,485 - 108,476,257 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363109,957,176 - 109,958,820 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343109,956,502 - 109,958,820NCBI
Celera3106,871,477 - 106,873,121 (-)NCBICelera
Cytogenetic Map3q13.13NCBI
HuRef3105,848,267 - 105,849,911 (-)NCBIHuRef
CHM1_13108,438,568 - 108,440,212 (-)NCBICHM1_1
T2T-CHM13v2.03111,476,011 - 111,477,791 (-)NCBIT2T-CHM13v2.0
Retnlb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391648,637,219 - 48,639,255 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1648,637,219 - 48,639,255 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381648,816,856 - 48,818,892 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1648,816,856 - 48,818,892 (+)Ensemblmm10GRCm38
MGSCv371648,816,969 - 48,819,005 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361648,736,482 - 48,738,518 (+)NCBIMGSCv36mm8
Celera1649,177,733 - 49,179,773 (+)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1630.75NCBI
RETNLB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22106,732,379 - 106,734,137 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13106,737,158 - 106,738,916 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03105,881,419 - 105,882,812 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13112,812,103 - 112,813,734 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3112,812,103 - 112,813,734 (-)EnsemblpanPan2panpan1.1
RETNLB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13313,980,710 - 13,982,586 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3314,086,218 - 14,088,141 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03314,146,376 - 14,148,256 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3314,146,363 - 14,148,412 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13314,015,664 - 14,017,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03314,082,060 - 14,083,984 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03314,494,347 - 14,496,270 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Retnlb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602140,442,139 - 140,444,628 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366452,400,948 - 2,403,686 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366452,400,948 - 2,403,714 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RETNLB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13150,716,889 - 150,718,395 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113150,716,863 - 150,718,405 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213159,846,269 - 159,847,801 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RETNLB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12272,039,331 - 72,046,810 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2272,040,456 - 72,041,825 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604194,428,198 - 94,429,783 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Retnlb
12 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:12
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000046890
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
12 1 14 5 12 2 6 2 22 8 13 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000046890   ⟹   ENSRNOP00000040075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,446,434 - 65,448,319 (-)Ensembl
mRatBN7.2 Ensembl1151,983,483 - 51,985,368 (-)Ensembl
Rnor_6.0 Ensembl1154,565,472 - 54,567,357 (-)Ensembl
RefSeq Acc Id: NM_001024281   ⟹   NP_001019452
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,446,433 - 65,448,319 (-)NCBI
mRatBN7.21151,983,482 - 51,985,368 (-)NCBI
Rnor_6.01154,565,471 - 54,567,357 (-)NCBI
Rnor_5.01157,727,746 - 57,729,632 (-)NCBI
RGSC_v3.41153,226,992 - 53,228,878 (-)RGD
Celera1151,583,301 - 51,585,187 (-)RGD
Sequence:
RefSeq Acc Id: XM_063270701   ⟹   XP_063126771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,446,433 - 65,448,085 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001019452 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126771 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT64902 (Get FASTA)   NCBI Sequence Viewer  
  EDM11110 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040075
  ENSRNOP00000040075.3
RefSeq Acc Id: NP_001019452   ⟸   NM_001024281
- Peptide Label: precursor
- UniProtKB: Q6DV77 (UniProtKB/TrEMBL),   A6IQV7 (UniProtKB/TrEMBL),   F6T678 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040075   ⟸   ENSRNOT00000046890
RefSeq Acc Id: XP_063126771   ⟸   XM_063270701
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6DV77-F1-model_v2 AlphaFold Q6DV77 1-105 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698126
Promoter ID:EPDNEW_R8651
Type:single initiation site
Name:Retnlb_1
Description:resistin like beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01154,567,379 - 54,567,439EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1624215 AgrOrtholog
BioCyc Gene G2FUF-21421 BioCyc
Ensembl Genes ENSRNOG00000032187 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046890 ENTREZGENE
  ENSRNOT00000046890.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.4230 UniProtKB/TrEMBL
  6.10.250.3290 UniProtKB/TrEMBL
InterPro Resistin UniProtKB/TrEMBL
  Resistin-like_sf UniProtKB/TrEMBL
KEGG Report rno:498074 UniProtKB/TrEMBL
NCBI Gene 498074 ENTREZGENE
PANTHER Resistin UniProtKB/TrEMBL
  RESISTIN-LIKE BETA UniProtKB/TrEMBL
Pfam Resistin UniProtKB/TrEMBL
PhenoGen Retnlb PhenoGen
RatGTEx ENSRNOG00000032187 RatGTEx
Superfamily-SCOP Resistin UniProtKB/TrEMBL
UniProt A6IQV7 ENTREZGENE, UniProtKB/TrEMBL
  F6T678 ENTREZGENE, UniProtKB/TrEMBL
  Q6DV77 ENTREZGENE
UniProt Secondary Q6DV77 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-05-03 Retnlb  resistin like beta      Symbol and Name status set to provisional 70820 PROVISIONAL