Rorc (RAR-related orphan receptor C) - Rat Genome Database

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Gene: Rorc (RAR-related orphan receptor C) Rattus norvegicus
Analyze
Symbol: Rorc
Name: RAR-related orphan receptor C
RGD ID: 1595785
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; oxysterol binding activity; and transcription coactivator binding activity. Involved in circadian rhythm. Predicted to be located in external side of plasma membrane. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related orphan receptor C); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC368158; MGC189525; nuclear receptor ROR-gamma; RAR-related orphan receptor gamma; similar to Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Rorcem3Mcwi ; Rorcem5Mcwi
Genetic Models: LEW-Rorcem3Mcwi ; LEW-Rorcem5Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82184,698,779 - 184,723,942 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2184,698,818 - 184,724,566 (+)EnsemblGRCr8
mRatBN7.22182,009,707 - 182,034,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2182,009,286 - 182,034,907 (+)EnsemblmRatBN7.2
Rnor_6.02195,612,471 - 195,636,797 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2195,617,021 - 195,637,630 (+)Ensemblrn6Rnor6.0
RGSC_v3.42189,345,134 - 189,369,442 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2174,560,165 - 174,584,474 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
25-hydroxycholesterol  (ISO)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-phenoxybenzoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
alloxan  (ISO)
alpha-galactosylceramide  (ISO)
alpha-Zearalanol  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
azoxystrobin  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bifenthrin  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromuconazole  (EXP)
Bufotalin  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
chrysene  (ISO)
chrysin  (ISO)
clofibrate  (ISO)
copper(II) chloride  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cycloprothrin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
digoxigenin  (ISO)
digoxin  (ISO)
dihydroouabain  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
flucloxacillin  (ISO)
flutamide  (EXP)
fluvalinate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (EXP)
helveticoside  (ISO)
hexaconazole  (ISO)
hydroxysafflor yellow A  (ISO)
imidacloprid  (EXP)
imiquimod  (ISO)
indoxyl sulfate  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
levamisole  (ISO)
methamphetamine  (EXP,ISO)
mevalonic acid  (ISO)
Mitoquinone  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (ISO)
rofecoxib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
strophanthidin  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thymoquinone  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (ISO)
triflumizole  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
Tryptanthrine  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Regulatory T cell activity is partly inhibited in a mouse model of chronic Pseudomonas aeruginosa lung infection. Ding FM, etal., Exp Lung Res. 2015 Feb;41(1):44-55. doi: 10.3109/01902148.2014.964351. Epub 2014 Nov 14.
2. Expression Profiles of Cytokine mRNAs in the Pleural Fluid Reveal Differences Among Tuberculosis, Malignancies, and Pneumonia-Exudative Pleural Effusions. Espósito DL, etal., Lung. 2015 Dec;193(6):1001-7. doi: 10.1007/s00408-015-9809-4. Epub 2015 Sep 25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Circadian expression of clock genes and clock-controlled genes in the rat retina. Kamphuis W, etal., Biochem Biophys Res Commun. 2005 Apr 29;330(1):18-26.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal dysbiosis in rats through T helper 17/T regulatory cell signaling pathway. Sun Z, etal., J Tradit Chin Med. 2020 Feb;40(1):38-48.
9. The Treg/Th17 imbalance in Toxoplasma gondii-infected pregnant mice. Zhang H, etal., Am J Reprod Immunol. 2012 Feb;67(2):112-21. doi: 10.1111/j.1600-0897.2011.01065.x. Epub 2011 Sep 19.
10. Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines. Zheng Z, etal., Immunology. 2018 Feb;153(2):246-252. doi: 10.1111/imm.12837. Epub 2017 Oct 16.
Additional References at PubMed
PMID:12477932   PMID:14691482   PMID:15010863   PMID:15247480   PMID:16148126   PMID:16990136   PMID:17476214   PMID:17666523   PMID:18164222   PMID:18368049   PMID:18792410   PMID:19965867  
PMID:20427770   PMID:21628546   PMID:21737317   PMID:21853531   PMID:22753030   PMID:23034280   PMID:23723244   PMID:25470037   PMID:27055905   PMID:27545881   PMID:28093217   PMID:30738851  
PMID:32924545   PMID:33834668  


Genomics

Comparative Map Data
Rorc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82184,698,779 - 184,723,942 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2184,698,818 - 184,724,566 (+)EnsemblGRCr8
mRatBN7.22182,009,707 - 182,034,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2182,009,286 - 182,034,907 (+)EnsemblmRatBN7.2
Rnor_6.02195,612,471 - 195,636,797 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2195,617,021 - 195,637,630 (+)Ensemblrn6Rnor6.0
RGSC_v3.42189,345,134 - 189,369,442 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2174,560,165 - 174,584,474 (+)NCBICelera
Cytogenetic Map2q34NCBI
RORC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381151,806,071 - 151,831,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1151,806,071 - 151,831,845 (-)Ensemblhg38GRCh38
GRCh371151,778,547 - 151,804,278 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361150,045,171 - 150,070,972 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341148,591,621 - 148,617,421NCBI
Celera1124,893,230 - 124,919,042 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1123,155,515 - 123,181,337 (-)NCBIHuRef
CHM1_11153,173,871 - 153,199,672 (-)NCBICHM1_1
T2T-CHM13v2.01150,929,559 - 150,955,307 (-)NCBIT2T-CHM13v2.0
Rorc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39394,280,106 - 94,305,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl394,280,101 - 94,305,583 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38394,372,794 - 94,398,276 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl394,372,794 - 94,398,276 (+)Ensemblmm10GRCm38
MGSCv37394,176,748 - 94,202,161 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36394,458,190 - 94,483,992 (+)NCBIMGSCv36mm8
Celera395,819,177 - 95,843,048 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.56NCBI
Rorc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955589590,743 - 616,694 (+)Ensembl
ChiLan1.0NW_004955589590,653 - 616,784 (+)NCBIChiLan1.0ChiLan1.0
RORC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2197,991,871 - 98,017,622 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,743,055 - 97,768,831 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,164,725 - 127,190,479 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11130,808,705 - 130,834,490 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,808,705 - 130,834,490 (-)EnsemblpanPan2panpan1.1
RORC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11760,821,498 - 60,842,485 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1760,821,981 - 60,842,453 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1760,263,366 - 60,285,188 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01761,838,557 - 61,860,379 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1761,837,962 - 61,860,343 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11760,665,332 - 60,687,158 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01760,751,477 - 60,773,308 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01761,480,593 - 61,502,436 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rorc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505822,967,256 - 22,990,222 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,997,640 - 2,020,649 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,997,640 - 2,020,649 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RORC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl497,375,136 - 97,400,209 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1497,374,672 - 97,399,017 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24106,397,490 - 106,421,980 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RORC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12011,854,911 - 11,880,221 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2011,855,005 - 11,879,717 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603811,414,109 - 11,440,149 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rorc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477219,477,093 - 19,501,169 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477219,478,403 - 19,501,184 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rorc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1362,777,762 - 62,803,441 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rorc
159 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:245
Count of miRNA genes:148
Interacting mature miRNAs:188
Transcripts:ENSRNOT00000067042
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH144654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22182,024,606 - 182,024,759 (+)MAPPERmRatBN7.2
Rnor_6.02195,627,323 - 195,627,475NCBIRnor6.0
Rnor_5.02215,106,017 - 215,106,169UniSTSRnor5.0
RGSC_v3.42189,359,964 - 189,360,116UniSTSRGSC3.4
Celera2174,574,996 - 174,575,148UniSTS
RH 3.4 Map21199.1UniSTS
Cytogenetic Map2q34UniSTS


Genetic Models
This gene Rorc is modified in the following models/strains:
LEW-Rorcem3Mcwi     LEW-Rorcem5Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 55 62 81 80 49 88 49 6 326 176 11 36 77 88 31 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000067042   ⟹   ENSRNOP00000058884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2184,698,818 - 184,723,940 (+)Ensembl
mRatBN7.2 Ensembl2182,014,289 - 182,034,907 (+)Ensembl
Rnor_6.0 Ensembl2195,617,021 - 195,637,630 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101844   ⟹   ENSRNOP00000079633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2184,703,355 - 184,724,566 (+)Ensembl
mRatBN7.2 Ensembl2182,009,286 - 182,034,907 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111824   ⟹   ENSRNOP00000089381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2184,709,983 - 184,722,639 (+)Ensembl
mRatBN7.2 Ensembl2182,014,326 - 182,033,606 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118722   ⟹   ENSRNOP00000086848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2184,698,818 - 184,723,940 (+)Ensembl
mRatBN7.2 Ensembl2182,009,617 - 182,034,907 (+)Ensembl
RefSeq Acc Id: NM_001427272   ⟹   NP_001414201
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82184,698,821 - 184,723,942 (+)NCBI
RefSeq Acc Id: XM_017591313   ⟹   XP_017446802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82184,698,779 - 184,723,942 (+)NCBI
mRatBN7.22182,009,707 - 182,034,910 (+)NCBI
Rnor_6.02195,612,471 - 195,636,797 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103783   ⟹   XP_038959711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82184,705,688 - 184,723,942 (+)NCBI
mRatBN7.22182,016,584 - 182,034,910 (+)NCBI
RefSeq Acc Id: XP_017446802   ⟸   XM_017591313
- Peptide Label: isoform X1
- UniProtKB: A0A0G2QC01 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058884   ⟸   ENSRNOT00000067042
RefSeq Acc Id: XP_038959711   ⟸   XM_039103783
- Peptide Label: isoform X2
- UniProtKB: A0A0G2QC01 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086848   ⟸   ENSRNOT00000118722
Ensembl Acc Id: ENSRNOP00000089381   ⟸   ENSRNOT00000111824
Ensembl Acc Id: ENSRNOP00000079633   ⟸   ENSRNOT00000101844
RefSeq Acc Id: NP_001414201   ⟸   NM_001427272
- UniProtKB: A0A8I6GEH3 (UniProtKB/TrEMBL),   A0A0G2QC01 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2QC01-F1-model_v2 AlphaFold A0A0G2QC01 1-487 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595785 AgrOrtholog
BioCyc Gene G2FUF-52167 BioCyc
Ensembl Genes ENSRNOG00000020836 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067042 ENTREZGENE
  ENSRNOT00000067042.5 UniProtKB/TrEMBL
  ENSRNOT00000101844.2 UniProtKB/TrEMBL
  ENSRNOT00000111824.2 UniProtKB/TrEMBL
  ENSRNOT00000118722 ENTREZGENE
  ENSRNOT00000118722.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro NHR_like_domain UniProtKB/TrEMBL
  NR_DBD_ROR UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd_core UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  ROR_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene 368158 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR HR3-RELATED UniProtKB/TrEMBL
  NUCLEAR RECEPTOR ROR-GAMMA UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PhenoGen Rorc PhenoGen
PRINTS RORNUCRECPTR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020836 RatGTEx
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  Str_ncl_receptor UniProtKB/TrEMBL
UniProt A0A0G2QC01 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZN69_RAT UniProtKB/TrEMBL
  A0A8I6A746_RAT UniProtKB/TrEMBL
  A0A8I6GEH3 ENTREZGENE, UniProtKB/TrEMBL
  B5DFL4_RAT UniProtKB/TrEMBL
UniProt Secondary F1LNV3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-11 Rorc  RAR-related orphan receptor C  Rorc  RAR-related orphan receptor c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Rorc  RAR-related orphan receptor c  LOC368158  similar to Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC368158  similar to Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR)      Symbol and Name status set to provisional 70820 PROVISIONAL