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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595785
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rorc
Name: RAR-related orphan receptor C
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rorcdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of RORC mRNAPMID:32145629 PMID:35192832
Rorcincreases expressionEXP 6480464CTDbisphenol A results in increased expression of RORC mRNAPMID:25181051
Rorcaffects methylationISORorc (Mus musculus)6480464CTDbisphenol A affects the methylation of RORC promoterPMID:27334623
Rorcdecreases expressionISORorc (Mus musculus)6480464CTDbisphenol A results in decreased expression of RORC mRNAPMID:14967926
Rorcincreases expressionISORorc (Mus musculus)6480464CTDbisphenol A results in increased expression of RORC mRNA; bisphenol A results in increased expression of RORC mRNA alternative form; bisphenol A results in increased expression of RORC proteinPMID:27693988 PMID:32702508 PMID:35357751
Rorcmultiple interactionsISORORC (Homo sapiens)6480464CTDbisphenol A analog binds to and results in decreased activity of RORC protein; bisphenol A analog inhibits the reaction [25-hydroxycholesterol binds to RORC protein]PMID:22659100
Rorcmultiple interactionsISORorc (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of RORC mRNA; Cholecalciferol inhibits the reaction [bisphenol A results in increased expression of RORC mRNA alternative form]PMID:28433925 PMID:32702508
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