Kng2l1 (kininogen 2-like 1) - Rat Genome Database

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Gene: Kng2l1 (kininogen 2-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Kng2l1
Name: kininogen 2-like 1
RGD ID: 1594590
Description: Enables cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in several processes, including negative regulation of T cell proliferation; positive regulation of cell population proliferation; and regulation of proteolysis. Located in extracellular space and perikaryon. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1); PARTICIPATES IN coagulation cascade pathway; complement system pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: K-kininogen; kininogen; kininogen 2; kininogen-1; KINKG; KINKH; Kng; Kng1; Kng2; Kngk; LOC102551949; LOC25087; uncharacterized LOC102551949
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,483,419 - 91,507,564 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1191,483,402 - 91,506,159 (+)EnsemblGRCr8
mRatBN7.21177,978,795 - 78,002,976 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,909,612 - 78,002,971 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1186,729,283 - 86,753,432 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,369,580 - 79,393,805 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,443,596 - 78,467,745 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01181,554,941 - 81,558,110 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01184,457,798 - 84,489,384 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1176,853,537 - 76,877,681 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1611479   PMID:2413018   PMID:2439509   PMID:3029068   PMID:3356189   PMID:3818598   PMID:6685967   PMID:9321484   PMID:12477932   PMID:15664626   PMID:16140359   PMID:16378635  
PMID:17293494  


Genomics


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
RH137220  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01184,462,284 - 84,462,471UniSTSRnor5.0
Celera1176,875,178 - 76,875,365UniSTS
RH 3.4 Map11643.8UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
1 1 2 9 2 35 14 11 1 20 3

Sequence


Ensembl Acc Id: ENSRNOT00000080562   ⟹   ENSRNOP00000075573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 77,936,246 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080949   ⟹   ENSRNOP00000069578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 77,934,579 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096169   ⟹   ENSRNOP00000077820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 78,002,971 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100483   ⟹   ENSRNOP00000093913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,909,612 - 77,936,254 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102748   ⟹   ENSRNOP00000086253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,483,402 - 91,506,159 (+)Ensembl
mRatBN7.2 Ensembl1177,978,923 - 78,001,486 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103089   ⟹   ENSRNOP00000084194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 78,001,323 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109164   ⟹   ENSRNOP00000076561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 77,936,139 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115073   ⟹   ENSRNOP00000081425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,483,404 - 91,506,079 (+)Ensembl
mRatBN7.2 Ensembl1177,978,824 - 78,001,323 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116873   ⟹   ENSRNOP00000091640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 78,001,396 (+)Ensembl
RefSeq Acc Id: NM_001102418   ⟹   NP_001095888
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,483,419 - 91,507,564 (+)NCBI
mRatBN7.21177,978,824 - 78,002,971 (+)NCBI
Rnor_5.01184,457,798 - 84,489,384 (-)NCBI
Celera1176,853,537 - 76,877,681 (+)RGD
Sequence:
RefSeq Acc Id: NM_012741   ⟹   NP_036873
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,483,518 - 91,506,079 (+)NCBI
mRatBN7.21177,978,923 - 78,001,486 (+)NCBI
Rnor_5.01184,457,798 - 84,489,384 (-)NCBI
Celera1176,853,636 - 76,876,196 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036873   ⟸   NM_012741
- Peptide Label: isoform 1 precursor
- UniProtKB: P08933 (UniProtKB/Swiss-Prot),   P08934 (UniProtKB/Swiss-Prot),   A0A8I6GER1 (UniProtKB/TrEMBL),   A6JS39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001095888   ⟸   NM_001102418
- Peptide Label: isoform 2 precursor
- UniProtKB: Q5M8A0 (UniProtKB/TrEMBL),   A6JS35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000077820   ⟸   ENSRNOT00000096169
Ensembl Acc Id: ENSRNOP00000084194   ⟸   ENSRNOT00000103089
Ensembl Acc Id: ENSRNOP00000091640   ⟸   ENSRNOT00000116873
Ensembl Acc Id: ENSRNOP00000086253   ⟸   ENSRNOT00000102748
Ensembl Acc Id: ENSRNOP00000093913   ⟸   ENSRNOT00000100483
Ensembl Acc Id: ENSRNOP00000075573   ⟸   ENSRNOT00000080562
Ensembl Acc Id: ENSRNOP00000069578   ⟸   ENSRNOT00000080949
Ensembl Acc Id: ENSRNOP00000081425   ⟸   ENSRNOT00000115073
Ensembl Acc Id: ENSRNOP00000076561   ⟸   ENSRNOT00000109164
Protein Domains
Cystatin kininogen-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08934-F1-model_v2 AlphaFold P08934 1-639 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594590 AgrOrtholog
BioCyc Gene G2FUF-20838 BioCyc
Ensembl Genes ENSRNOG00000065935 Ensembl
  ENSRNOG00000079266 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000102748 ENTREZGENE
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7369450 IMAGE-MGC_LOAD
InterPro Cystatin_dom UniProtKB/Swiss-Prot
  Cystatin_sf UniProtKB/Swiss-Prot
  Kininogen UniProtKB/Swiss-Prot
  Kininogen-type_cystatin_dom UniProtKB/Swiss-Prot
  Kininogen_Fetuin_HRG UniProtKB/Swiss-Prot
  Prot_inh_cystat_CS UniProtKB/Swiss-Prot
KEGG Report rno:25087 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108732 IMAGE-MGC_LOAD
NCBI Gene 25087 ENTREZGENE
PANTHER FETUIN UniProtKB/Swiss-Prot
  KININOGEN-1 UniProtKB/Swiss-Prot
Pfam Cystatin UniProtKB/Swiss-Prot
PhenoGen Kng2l1 PhenoGen
PRINTS KININOGEN UniProtKB/Swiss-Prot
PROSITE CYSTATIN UniProtKB/Swiss-Prot
  CYSTATIN_KININOGEN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000065935 RatGTEx
  ENSRNOG00000079266 RatGTEx
SMART SM00043 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot
UniProt A0A0G2JVQ5_RAT UniProtKB/TrEMBL
  A0A8I5ZK39_RAT UniProtKB/TrEMBL
  A0A8I5ZRM0_RAT UniProtKB/TrEMBL
  A0A8I6AXR2_RAT UniProtKB/TrEMBL
  A0A8I6GER1 ENTREZGENE, UniProtKB/TrEMBL
  A6JS35 ENTREZGENE, UniProtKB/TrEMBL
  A6JS39 ENTREZGENE, UniProtKB/TrEMBL
  KNG1_RAT UniProtKB/Swiss-Prot
  P08933 ENTREZGENE
  P08934 ENTREZGENE
  Q5M8A0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P08933 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Kng2l1  kininogen 2-like 1  Kng2l1  kininogen 2-like 1  Data merged from RGD:149736197 737654 PROVISIONAL
2021-08-09 Kng2l1  kininogen 2-like 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-03-09 Kng2l1  kininogen 2-like 1  LOC102551949  uncharacterized LOC102551949  Data merged from RGD:7527060 737654 PROVISIONAL
2016-04-18 Kng2l1  kininogen 2-like 1  Kng2  kininogen 2  Name and Symbol changed 629549 APPROVED
2013-12-17 LOC102551949  uncharacterized LOC102551949      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-04 Kng2  kininogen 2  LOC25087  K-kininogen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC25087  K-kininogen      Symbol and Name status set to provisional 70820 PROVISIONAL