Kng2l1 (kininogen 2-like 1) - Rat Genome Database

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Pathways
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Gene: Kng2l1 (kininogen 2-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Kng2l1 (Ensembl: Kng2)
Name: kininogen 2-like 1 (Ensembl:kininogen 2)
RGD ID: 1594590
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including blood coagulation; inflammatory response; and vasodilation. Predicted to be located in extracellular region and membrane. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1); PARTICIPATES IN coagulation cascade pathway; complement system pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: K-kininogen; kininogen; kininogen 2; kininogen-1; KINKG; KINKH; Kng; Kng1; Kng2; Kngk; LOC102551949; LOC25087; uncharacterized LOC102551949
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,483,419 - 91,507,564 (+)NCBIGRCr8
mRatBN7.21177,978,795 - 78,002,976 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,909,612 - 78,002,971 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,729,283 - 86,753,432 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,369,580 - 79,393,805 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,443,596 - 78,467,745 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01181,554,941 - 81,558,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01184,457,798 - 84,489,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1176,853,537 - 76,877,681 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2413018   PMID:2439509   PMID:3029068   PMID:3356189   PMID:3818598   PMID:9321484   PMID:12477932   PMID:17293494  


Genomics

Variants

.
Variants in Kng2l1
176 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat

Markers in Region
RH137220  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01184,462,284 - 84,462,471UniSTSRnor5.0
Celera1176,875,178 - 76,875,365UniSTS
RH 3.4 Map11643.8UniSTS
Cytogenetic Map11q23UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000080562   ⟹   ENSRNOP00000075573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 77,936,246 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080949   ⟹   ENSRNOP00000069578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 77,934,579 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096169   ⟹   ENSRNOP00000077820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 78,002,971 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100483   ⟹   ENSRNOP00000093913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,909,612 - 77,936,254 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102748   ⟹   ENSRNOP00000086253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,978,923 - 78,001,486 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103089   ⟹   ENSRNOP00000084194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 78,001,323 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109164   ⟹   ENSRNOP00000076561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 77,936,139 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115073   ⟹   ENSRNOP00000081425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,978,824 - 78,001,323 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116873   ⟹   ENSRNOP00000091640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,913,876 - 78,001,396 (+)Ensembl
RefSeq Acc Id: NM_001102418   ⟹   NP_001095888
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,483,419 - 91,507,564 (+)NCBI
mRatBN7.21177,978,824 - 78,002,971 (+)NCBI
Rnor_5.01184,457,798 - 84,489,384 (-)NCBI
Celera1176,853,537 - 76,877,681 (+)RGD
Sequence:
RefSeq Acc Id: NM_012741   ⟹   NP_036873
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,483,518 - 91,506,079 (+)NCBI
mRatBN7.21177,978,923 - 78,001,486 (+)NCBI
Rnor_5.01184,457,798 - 84,489,384 (-)NCBI
Celera1176,853,636 - 76,876,196 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036873   ⟸   NM_012741
- Peptide Label: isoform 1 precursor
- UniProtKB: P08933 (UniProtKB/Swiss-Prot),   P08934 (UniProtKB/Swiss-Prot),   A0A8I6GER1 (UniProtKB/TrEMBL),   A6JS39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001095888   ⟸   NM_001102418
- Peptide Label: isoform 2 precursor
- UniProtKB: Q5M8A0 (UniProtKB/TrEMBL),   A6JS35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000077820   ⟸   ENSRNOT00000096169
RefSeq Acc Id: ENSRNOP00000084194   ⟸   ENSRNOT00000103089
RefSeq Acc Id: ENSRNOP00000091640   ⟸   ENSRNOT00000116873
RefSeq Acc Id: ENSRNOP00000086253   ⟸   ENSRNOT00000102748
RefSeq Acc Id: ENSRNOP00000093913   ⟸   ENSRNOT00000100483
RefSeq Acc Id: ENSRNOP00000075573   ⟸   ENSRNOT00000080562
RefSeq Acc Id: ENSRNOP00000069578   ⟸   ENSRNOT00000080949
RefSeq Acc Id: ENSRNOP00000081425   ⟸   ENSRNOT00000115073
RefSeq Acc Id: ENSRNOP00000076561   ⟸   ENSRNOT00000109164
Protein Domains
Cystatin kininogen-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08934-F1-model_v2 AlphaFold P08934 1-639 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594590 AgrOrtholog
BioCyc Gene G2FUF-20838 BioCyc
Ensembl Genes ENSRNOG00000065935 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080949.2 UniProtKB/TrEMBL
  ENSRNOT00000096169.1 UniProtKB/TrEMBL
  ENSRNOT00000100483.1 UniProtKB/TrEMBL
  ENSRNOT00000102748 ENTREZGENE
  ENSRNOT00000102748.1 UniProtKB/TrEMBL
  ENSRNOT00000103089.1 UniProtKB/TrEMBL
  ENSRNOT00000109164.1 UniProtKB/TrEMBL
  ENSRNOT00000115073.1 UniProtKB/TrEMBL
  ENSRNOT00000116873.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7369450 IMAGE-MGC_LOAD
InterPro Cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kininogen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kininogen-type_cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inh_cystat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25087 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108732 IMAGE-MGC_LOAD
NCBI Gene 25087 ENTREZGENE
PANTHER FETUIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KININOGEN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kng2l1 PhenoGen
PRINTS KININOGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTATIN_KININOGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000065935 RatGTEx
SMART SM00043 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVQ5_RAT UniProtKB/TrEMBL
  A0A8I5Y6S4_RAT UniProtKB/TrEMBL
  A0A8I5ZK39_RAT UniProtKB/TrEMBL
  A0A8I5ZRM0_RAT UniProtKB/TrEMBL
  A0A8I5ZWQ0_RAT UniProtKB/TrEMBL
  A0A8I6ACG6_RAT UniProtKB/TrEMBL
  A0A8I6AXR2_RAT UniProtKB/TrEMBL
  A0A8I6GER1 ENTREZGENE, UniProtKB/TrEMBL
  A6JS35 ENTREZGENE, UniProtKB/TrEMBL
  A6JS39 ENTREZGENE, UniProtKB/TrEMBL
  KNG1_RAT UniProtKB/Swiss-Prot
  P08933 ENTREZGENE
  P08934 ENTREZGENE
  Q5M8A0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P08933 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Kng2l1  kininogen 2-like 1  Kng2l1  kininogen 2-like 1  Data merged from RGD:149736197 737654 PROVISIONAL
2021-08-09 Kng2l1  kininogen 2-like 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-03-09 Kng2l1  kininogen 2-like 1  LOC102551949  uncharacterized LOC102551949  Data merged from RGD:7527060 737654 PROVISIONAL
2016-04-18 Kng2l1  kininogen 2-like 1  Kng2  kininogen 2  Name and Symbol changed 629549 APPROVED
2013-12-17 LOC102551949  uncharacterized LOC102551949      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-04 Kng2  kininogen 2  LOC25087  K-kininogen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC25087  K-kininogen      Symbol and Name status set to provisional 70820 PROVISIONAL