Srsf1 (serine and arginine rich splicing factor 1) - Rat Genome Database

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Gene: Srsf1 (serine and arginine rich splicing factor 1) Rattus norvegicus
Analyze
Symbol: Srsf1
Name: serine and arginine rich splicing factor 1
RGD ID: 1587490
Description: Enables protein kinase B binding activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; liver regeneration; and positive regulation of RNA splicing. Located in nuclear envelope. Used to study myocardial infarction. Biomarker of hepatocellular carcinoma and renovascular hypertension. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities. Orthologous to human SRSF1 (serine and arginine rich splicing factor 1); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102554532; LOC689890; serine/arginine-rich splicing factor 1; Sfrs1; similar to splicing factor, arginine/serine-rich 1 (ASF/SF2); splicing factor, arginine/serine-rich 1; splicing factor, arginine/serine-rich 1B; uncharacterized LOC102554532
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,335,519 - 73,342,549 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1073,336,422 - 73,342,548 (+)EnsemblGRCr8
mRatBN7.21072,838,926 - 72,859,066 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,839,274 - 72,845,336 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1077,449,632 - 77,455,683 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,954,574 - 76,960,625 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,419,074 - 72,425,125 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,334,200 - 75,341,197 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,335,146 - 75,341,197 (+)Ensemblrn6Rnor6.0
Rnor_5.01074,759,412 - 74,765,821 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41076,339,824 - 76,344,552 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1071,749,406 - 71,755,457 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic UMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
AM-251  (ISO)
amitrole  (EXP)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-nitrosodimethylamine  (ISO)
nitrates  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenol  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
catalytic step 2 spliceosome  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
exon-exon junction complex  (IEA,ISO)
nuclear envelope  (IDA)
nuclear speck  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. Mitogenic insulin receptor-A is overexpressed in human hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA splicing factors. Chettouh H, etal., Cancer Res. 2013 Jul 1;73(13):3974-86. doi: 10.1158/0008-5472.CAN-12-3824. Epub 2013 Apr 30.
3. Arginine/serine-rich protein interaction domain-dependent modulation of a tau exon 10 splicing enhancer: altered interactions and mechanisms for functionally antagonistic FTDP-17 mutations Delta280K AND N279K. D'Souza I and Schellenberg GD, J Biol Chem. 2006 Feb 3;281(5):2460-9. Epub 2005 Nov 23.
4. The oncoprotein SF2/ASF promotes non-small cell lung cancer survival by enhancing survivin expression. Ezponda T, etal., Clin Cancer Res. 2010 Aug 15;16(16):4113-25. doi: 10.1158/1078-0432.CCR-10-0076. Epub 2010 Aug 3.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma. Gout S, etal., PLoS One. 2012;7(10):e46539. doi: 10.1371/journal.pone.0046539. Epub 2012 Oct 10.
7. Effects of hypophysectomy of liver donor on net synthesis of specific plasma proteins by the isolated perfused rat liver. Modulation of synthesis of albumin, fibrinogen, alpha 1-acid glycoprotein, alpha 2-(acute phase)-globulin, and haptoglobin by insulin, cortisol, triiodothyronine, and growth hormone. Griffin EE and Miller LL, J Biol Chem. 1974 Aug 25;249(16):5062-9.
8. Involvement of the dual-specificity tyrosine phosphorylation-regulated kinase 1A-alternative splicing factor-calcium/calmodulin-dependent protein kinase IIdelta signaling pathway in myocardial infarction-induced heart failure of rats. He J, etal., J Card Fail. 2015 Sep;21(9):751-60. doi: 10.1016/j.cardfail.2015.05.015. Epub 2015 Jun 9.
9. Alterations in expression pattern of splicing factors in epithelial ovarian cancer and its clinical impact. Iborra S, etal., Int J Gynecol Cancer. 2013 Jul;23(6):990-6. doi: 10.1097/IGC.0b013e31829783e3.
10. The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Karni R, etal., Nat Struct Mol Biol. 2007 Mar;14(3):185-93. Epub 2007 Feb 18.
11. RNA splicing factors regulated by HPV16 during cervical tumour progression. Mole S, etal., J Pathol. 2009 Nov;219(3):383-91. doi: 10.1002/path.2608.
12. Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. Patel NA, etal., J Biol Chem. 2005 Apr 8;280(14):14302-9. Epub 2005 Jan 31.
13. Alternative splicing of iodothyronine deiodinases in pituitary adenomas. Regulation by oncoprotein SF2/ASF. Piekielko-Witkowska A, etal., Biochim Biophys Acta. 2013 Jun;1832(6):763-72. doi: 10.1016/j.bbadis.2013.02.013. Epub 2013 Feb 24.
14. Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors. Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway. Thorsen K, etal., Mol Cell Proteomics. 2011 Jan;10(1):M110.002998. doi: 10.1074/mcp.M110.002998. Epub 2010 Oct 11.
19. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
20. PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer. Wang E, etal., J Cell Biochem. 2006 Apr 1;97(5):999-1016.
21. Alternative splicing factor ASF/SF2 is down regulated in inflamed muscle. Xiong Z, etal., J Clin Pathol. 2006 Aug;59(8):855-61. Epub 2006 Mar 30.
22. Dyrk1A-ASF-CaMKIIδ Signaling Is Involved in Valsartan Inhibition of Cardiac Hypertrophy in Renovascular Hypertensive Rats. Yao J, etal., Cardiology. 2016;133(3):198-204. doi: 10.1159/000441695. Epub 2015 Dec 1.
23. Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing. Zerbe LK, etal., Mol Carcinog. 2004 Dec;41(4):187-96.
24. Alternative expression of TCRzeta related genes in patients with chronic myeloid leukemia. Zha X, etal., J Hematol Oncol. 2012 Dec 10;5:74. doi: 10.1186/1756-8722-5-74.
Additional References at PubMed
PMID:8940107   PMID:9611241   PMID:9885563   PMID:11991638   PMID:15615787   PMID:15652482   PMID:15798186   PMID:16314458   PMID:19561594   PMID:20729808   PMID:20797886   PMID:21191184  
PMID:21630459   PMID:21984414   PMID:22658674   PMID:22681889   PMID:23376485   PMID:24449914   PMID:24625528   PMID:25931508   PMID:28799539   PMID:29974845   PMID:31505169   PMID:33450132  


Genomics

Comparative Map Data
Srsf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,335,519 - 73,342,549 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1073,336,422 - 73,342,548 (+)EnsemblGRCr8
mRatBN7.21072,838,926 - 72,859,066 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,839,274 - 72,845,336 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1077,449,632 - 77,455,683 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,954,574 - 76,960,625 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,419,074 - 72,425,125 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,334,200 - 75,341,197 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,335,146 - 75,341,197 (+)Ensemblrn6Rnor6.0
Rnor_5.01074,759,412 - 74,765,821 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41076,339,824 - 76,344,552 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1071,749,406 - 71,755,457 (+)NCBICelera
Cytogenetic Map10q26NCBI
SRSF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381757,989,038 - 58,007,246 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,000,919 - 58,007,346 (-)Ensemblhg38GRCh38
GRCh371756,066,399 - 56,084,607 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,433,279 - 53,439,706 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341753,435,853 - 53,439,587NCBI
Celera1752,540,069 - 52,546,497 (-)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1751,439,237 - 51,445,664 (-)NCBIHuRef
CHM1_11756,143,411 - 56,149,838 (-)NCBICHM1_1
T2T-CHM13v2.01758,863,040 - 58,881,254 (-)NCBIT2T-CHM13v2.0
Srsf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,937,325 - 87,944,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,938,199 - 87,944,581 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381188,046,499 - 88,053,757 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1188,047,373 - 88,053,755 (+)Ensemblmm10GRCm38
MGSCv371187,861,173 - 87,867,259 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361187,863,972 - 87,867,844 (+)NCBIMGSCv36mm8
Celera1187,395,560 - 87,401,471 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.4NCBI
Srsf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,992,634 - 4,999,029 (+)Ensembl
ChiLan1.0NW_0049554514,992,634 - 4,996,619 (+)NCBIChiLan1.0ChiLan1.0
SRSF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21974,179,536 - 74,185,632 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11778,975,993 - 78,996,573 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,083,676 - 52,087,454 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11756,937,295 - 56,944,874 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1756,937,295 - 56,944,425 (-)EnsemblpanPan2panpan1.1
SRSF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1932,692,517 - 32,696,325 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl932,694,073 - 32,696,285 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha931,930,816 - 31,934,636 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0933,500,269 - 33,504,092 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl933,500,274 - 33,504,046 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,284,909 - 32,288,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0932,568,190 - 32,572,012 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0932,651,906 - 32,655,725 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srsf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,015,932 - 32,019,748 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364905,055,253 - 5,059,116 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364905,055,258 - 5,059,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRSF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,272,956 - 34,282,162 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11234,278,363 - 34,282,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21235,278,498 - 35,284,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRSF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11635,392,573 - 35,396,815 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1635,392,873 - 35,394,982 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660776,208,339 - 6,216,079 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srsf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1982,760,214 - 82,764,254 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srsf1
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:766
Count of miRNA genes:313
Interacting mature miRNAs:413
Transcripts:ENSRNOT00000073005
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106743947373950209Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)106747660873695498Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)106747660873695498Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AI482334  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,845,087 - 72,845,221 (+)MAPPERmRatBN7.2
Rnor_6.01075,340,949 - 75,341,082NCBIRnor6.0
Rnor_5.01074,759,527 - 74,759,660UniSTSRnor5.0
RGSC_v3.41076,346,467 - 76,346,600UniSTSRGSC3.4
Celera1071,755,209 - 71,755,342UniSTS
Cytogenetic Map10q26UniSTS
UniSTS:236692  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,844,868 - 72,845,156 (+)MAPPERmRatBN7.2
Rnor_6.01075,340,730 - 75,341,017NCBIRnor6.0
Rnor_5.01074,759,592 - 74,759,879UniSTSRnor5.0
RGSC_v3.41076,346,248 - 76,346,535UniSTSRGSC3.4
Celera1071,754,990 - 71,755,277UniSTS
Cytogenetic Map10q26UniSTS
MARC_12219-12220:1004719985:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,842,005 - 72,842,424 (+)MAPPERmRatBN7.2
Rnor_6.01075,337,867 - 75,338,285NCBIRnor6.0
Rnor_5.01074,762,324 - 74,762,742UniSTSRnor5.0
RGSC_v3.41076,343,385 - 76,343,803UniSTSRGSC3.4
Celera1071,752,127 - 71,752,545UniSTS
Cytogenetic Map10q26UniSTS
PMC310730P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,841,430 - 72,841,626 (+)MAPPERmRatBN7.2
Rnor_6.01075,337,292 - 75,337,487NCBIRnor6.0
Rnor_5.01074,763,122 - 74,763,317UniSTSRnor5.0
RGSC_v3.41076,342,810 - 76,343,005UniSTSRGSC3.4
Celera1071,751,552 - 71,751,747UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000073005   ⟹   ENSRNOP00000064933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1073,336,534 - 73,342,548 (+)Ensembl
mRatBN7.2 Ensembl1072,839,285 - 72,845,336 (+)Ensembl
Rnor_6.0 Ensembl1075,335,146 - 75,341,197 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109821   ⟹   ENSRNOP00000097972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1073,336,422 - 73,340,216 (+)Ensembl
mRatBN7.2 Ensembl1072,839,274 - 72,841,514 (+)Ensembl
RefSeq Acc Id: NM_001109552   ⟹   NP_001103022
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,336,498 - 73,342,549 (+)NCBI
mRatBN7.21072,839,285 - 72,845,336 (+)NCBI
Rnor_6.01075,335,146 - 75,341,197 (+)NCBI
Rnor_5.01074,759,412 - 74,765,821 (-)NCBI
RGSC_v3.41076,339,824 - 76,344,552 (+)RGD
Celera1071,749,406 - 71,755,457 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086869   ⟹   XP_038942797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,335,519 - 73,340,225 (+)NCBI
mRatBN7.21072,838,927 - 72,845,336 (+)NCBI
RefSeq Acc Id: XR_005489946
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,335,519 - 73,340,225 (+)NCBI
mRatBN7.21072,838,927 - 72,845,336 (+)NCBI
RefSeq Acc Id: XR_010055258
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,335,519 - 73,340,225 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001103022 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942797 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05624 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064933
  ENSRNOP00000064933.1
  ENSRNOP00000097972.1
RefSeq Acc Id: NP_001103022   ⟸   NM_001109552
- UniProtKB: D4A9L2 (UniProtKB/TrEMBL),   A6HHW7 (UniProtKB/TrEMBL),   A6HHW9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064933   ⟸   ENSRNOT00000073005
RefSeq Acc Id: XP_038942797   ⟸   XM_039086869
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000097972   ⟸   ENSRNOT00000109821
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9L2-F1-model_v2 AlphaFold D4A9L2 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697578
Promoter ID:EPDNEW_R8103
Type:initiation region
Name:Srsf1_1
Description:serine and arginine rich splicing factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01075,335,183 - 75,335,243EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587490 AgrOrtholog
BioCyc Gene G2FUF-23731 BioCyc
Ensembl Genes ENSRNOG00000050323 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073005 ENTREZGENE
  ENSRNOT00000073005.3 UniProtKB/TrEMBL
  ENSRNOT00000109821.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  RRT5_SRSF_SR UniProtKB/TrEMBL
  SRSF1_RRM1 UniProtKB/TrEMBL
  SRSF1_RRM2 UniProtKB/TrEMBL
KEGG Report rno:689890 UniProtKB/TrEMBL
NCBI Gene 689890 ENTREZGENE
PANTHER RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  SERINE_ARGININE-RICH SPLICING FACTOR 1 UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
PhenoGen Srsf1 PhenoGen
PROSITE RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050323 RatGTEx
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8I6GMR8_RAT UniProtKB/TrEMBL
  A6HHW7 ENTREZGENE, UniProtKB/TrEMBL
  A6HHW9 ENTREZGENE, UniProtKB/TrEMBL
  D4A9L2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Srsf1  serine and arginine rich splicing factor 1  LOC102554532  uncharacterized LOC102554532  Data merged from RGD:7546533 737654 PROVISIONAL
2016-06-15 Srsf1  serine and arginine rich splicing factor 1  Srsf1  serine/arginine-rich splicing factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-17 LOC102554532  uncharacterized LOC102554532      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-08-01 Srsf1  serine/arginine-rich splicing factor 1  Sfrs1  splicing factor, arginine/serine-rich 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-22 Sfrs1  splicing factor, arginine/serine-rich 1  Srsf1  serine/arginine-rich splicing factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-13 Srsf1  serine/arginine-rich splicing factor 1  Sfrs1  splicing factor, arginine/serine-rich 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-20 Sfrs1  splicing factor, arginine/serine-rich 1  Srsf1  serine/arginine-rich splicing factor 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-14 Srsf1  serine/arginine-rich splicing factor 1   Sfrs1  splicing factor, arginine/serine-rich 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Sfrs1  splicing factor, arginine/serine-rich 1  LOC688114  similar to splicing factor, arginine/serine-rich 1 (ASF/SF2)  Data merged from RGD:1592445 1643240 APPROVED
2008-03-06 Sfrs1  splicing factor, arginine/serine-rich 1  LOC689890  similar to splicing factor, arginine/serine-rich 1 (ASF/SF2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC688114  similar to splicing factor, arginine/serine-rich 1 (ASF/SF2)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC689890  similar to splicing factor, arginine/serine-rich 1 (ASF/SF2)      Symbol and Name status set to provisional 70820 PROVISIONAL