RGD Reference Report - The spliceosome: design principles of a dynamic RNP machine. - Rat Genome Database

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The spliceosome: design principles of a dynamic RNP machine.

Authors: Wahl, MC  Will, CL  Luhrmann, R 
Citation: Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
RGD ID: 9686089
Pubmed: PMID:19239890   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cell.2009.02.009   (Journal Full-text)

Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its regulation. Whereas most RNP enzymes are stable in composition and harbor preformed active sites, the spliceosome, which removes noncoding introns from precursor messenger RNAs (pre-mRNAs), follows fundamentally different strategies. In order to provide both accuracy to the recognition of reactive splice sites in the pre-mRNA and flexibility to the choice of splice sites during alternative splicing, the spliceosome exhibits exceptional compositional and structural dynamics that are exploited during substrate-dependent complex assembly, catalytic activation, and active site remodeling.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
spliceosome pathway   TAS 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089; 9686089 RGD 
spliceosome pathway   ISODDX23 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOHNRNPA1 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOHNRNPA3 (Homo sapiens)9686089 RGD 
spliceosome pathway   ISOHNRNPC (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOHNRNPK (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOHNRNPM (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOHNRNPU (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOLSM2 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOLSM3 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOLSM4 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOLSM5 (Homo sapiens)9686089 RGD 
spliceosome pathway   ISOLSM6 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOLSM7 (Homo sapiens)9686089 RGD 
spliceosome pathway   ISOLSM8 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOPRPF3 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOPRPF31 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOPRPF4 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOPRPF6 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISORBMX (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSF1 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSNRPB (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSNRPD1 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSNRPD2 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSNRPD3 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSNRPE (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSNRPF (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSNRPG (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSNU13 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSRSF1 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSRSF10 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSRSF3 (Homo sapiens)9686089 RGD 
spliceosome pathway   ISOSRSF4 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSRSF5 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSRSF6 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSRSF7 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOSRSF9 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOTXNL4A (Homo sapiens)9686089 RGD 
spliceosome pathway   ISOU2AF1 (Homo sapiens)9686089; 9686089 RGD 
spliceosome pathway   ISOU2AF2 (Homo sapiens)9686089; 9686089 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ddx23  (DEAD-box helicase 23)
Hnrnpa1  (heterogeneous nuclear ribonucleoprotein A1)
Hnrnpc  (heterogeneous nuclear ribonucleoprotein C)
Hnrnpk  (heterogeneous nuclear ribonucleoprotein K)
Hnrnpm  (heterogeneous nuclear ribonucleoprotein M)
Hnrnpu  (heterogeneous nuclear ribonucleoprotein U)
Lsm2  (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm3  (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm4  (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm6  (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm7  (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm8  (LSM8 homolog, U6 small nuclear RNA associated)
Prpf3  (pre-mRNA processing factor 3)
Prpf31  (pre-mRNA processing factor 31)
Prpf4  (pre-mRNA splicing tri-snRNP complex factor 4)
Prpf6  (pre-mRNA processing factor 6)
Rbmx  (RNA binding motif protein, X-linked)
Sf1  (splicing factor 1)
Snrpb  (small nuclear ribonucleoprotein polypeptides B and B1)
Snrpd1  (small nuclear ribonucleoprotein D1 polypeptide)
Snrpd2  (small nuclear ribonucleoprotein D2 polypeptide)
Snrpd3  (small nuclear ribonucleoprotein D3 polypeptide)
Snrpe  (small nuclear ribonucleoprotein polypeptide E)
Snrpf  (small nuclear ribonucleoprotein polypeptide F)
Snrpg  (small nuclear ribonucleoprotein polypeptide G)
Snu13  (small nuclear ribonucleoprotein 13)
Srsf1  (serine and arginine rich splicing factor 1)
Srsf10  (serine and arginine rich splicing factor 10)
Srsf4  (serine and arginine rich splicing factor 4)
Srsf5  (serine and arginine rich splicing factor 5)
Srsf6  (serine and arginine rich splicing factor 6)
Srsf7  (serine and arginine rich splicing factor 7)
Srsf9  (serine and arginine rich splicing factor 9)
U2af1  (U2 small nuclear RNA auxiliary factor 1)
U2af2  (U2 small nuclear RNA auxiliary factor 2)

Genes (Mus musculus)
Ddx23  (DEAD box helicase 23)
Hnrnpa1  (heterogeneous nuclear ribonucleoprotein A1)
Hnrnpa3  (heterogeneous nuclear ribonucleoprotein A3)
Hnrnpc  (heterogeneous nuclear ribonucleoprotein C)
Hnrnpk  (heterogeneous nuclear ribonucleoprotein K)
Hnrnpm  (heterogeneous nuclear ribonucleoprotein M)
Hnrnpu  (heterogeneous nuclear ribonucleoprotein U)
Lsm2  (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm3  (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm4  (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm5  (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm6  (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm8  (LSM8 homolog, U6 small nuclear RNA associated)
Prpf3  (pre-mRNA processing factor 3)
Prpf31  (pre-mRNA processing factor 31)
Prpf4  (pre-mRNA processing factor 4)
Prpf6  (pre-mRNA splicing factor 6)
Rbmx  (RNA binding motif protein, X chromosome)
Sf1  (splicing factor 1)
Snrpb  (small nuclear ribonucleoprotein B)
Snrpd1  (small nuclear ribonucleoprotein D1)
Snrpd2  (small nuclear ribonucleoprotein D2)
Snrpd3  (small nuclear ribonucleoprotein D3)
Snrpe  (small nuclear ribonucleoprotein E)
Snrpf  (small nuclear ribonucleoprotein polypeptide F)
Snrpg  (small nuclear ribonucleoprotein polypeptide G)
Snu13  (SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5))
Srsf1  (serine and arginine-rich splicing factor 1)
Srsf10  (serine and arginine-rich splicing factor 10)
Srsf3  (serine and arginine-rich splicing factor 3)
Srsf4  (serine and arginine-rich splicing factor 4)
Srsf5  (serine and arginine-rich splicing factor 5)
Srsf6  (serine and arginine-rich splicing factor 6)
Srsf7  (serine and arginine-rich splicing factor 7)
Srsf9  (serine and arginine-rich splicing factor 9)
Txnl4a  (thioredoxin-like 4A)
U2af1  (U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1)
U2af2  (U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2)

Genes (Homo sapiens)
DDX23  (DEAD-box helicase 23)
HNRNPA1  (heterogeneous nuclear ribonucleoprotein A1)
HNRNPA3  (heterogeneous nuclear ribonucleoprotein A3)
HNRNPC  (heterogeneous nuclear ribonucleoprotein C)
HNRNPK  (heterogeneous nuclear ribonucleoprotein K)
HNRNPM  (heterogeneous nuclear ribonucleoprotein M)
HNRNPU  (heterogeneous nuclear ribonucleoprotein U)
LSM2  (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM3  (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM4  (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM5  (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM6  (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM7  (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM8  (LSM8 homolog, U6 small nuclear RNA associated)
PRPF3  (pre-mRNA processing factor 3)
PRPF31  (pre-mRNA processing factor 31)
PRPF4  (pre-mRNA splicing tri-snRNP complex factor PRPF4)
PRPF6  (pre-mRNA processing factor 6)
RBMX  (RNA binding motif protein X-linked)
SF1  (splicing factor 1)
SNRPB  (small nuclear ribonucleoprotein polypeptides B and B1)
SNRPD1  (small nuclear ribonucleoprotein D1 polypeptide)
SNRPD2  (small nuclear ribonucleoprotein D2 polypeptide)
SNRPD3  (small nuclear ribonucleoprotein D3 polypeptide)
SNRPE  (small nuclear ribonucleoprotein polypeptide E)
SNRPF  (small nuclear ribonucleoprotein polypeptide F)
SNRPG  (small nuclear ribonucleoprotein polypeptide G)
SNU13  (small nuclear ribonucleoprotein 13)
SRSF1  (serine and arginine rich splicing factor 1)
SRSF10  (serine and arginine rich splicing factor 10)
SRSF3  (serine and arginine rich splicing factor 3)
SRSF4  (serine and arginine rich splicing factor 4)
SRSF5  (serine and arginine rich splicing factor 5)
SRSF6  (serine and arginine rich splicing factor 6)
SRSF7  (serine and arginine rich splicing factor 7)
SRSF9  (serine and arginine rich splicing factor 9)
TXNL4A  (thioredoxin like 4A)
U2AF1  (U2 small nuclear RNA auxiliary factor 1)
U2AF2  (U2 small nuclear RNA auxiliary factor 2)


Additional Information