Capza1 (capping actin protein of muscle Z-line subunit alpha 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Capza1 (capping actin protein of muscle Z-line subunit alpha 1) Rattus norvegicus
Analyze
Symbol: Capza1
Name: capping actin protein of muscle Z-line subunit alpha 1
RGD ID: 1587438
Description: Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization; barbed-end actin filament capping; and cell junction assembly. Predicted to be located in brush border; cell-cell junction; and membrane. Predicted to be part of F-actin capping protein complex and WASH complex. Predicted to be active in cortical cytoskeleton. Orthologous to human CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: capping actin protein of muscle Z-line alpha subunit 1; capping protein (actin filament) muscle Z-line, alpha 1; capZ alpha-1; F-actin capping protein alpha-1 subunit; F-actin-capping protein subunit alpha-1; LOC691149; similar to capping protein (actin filament) muscle Z-line, alpha 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Capza1-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82195,008,035 - 195,053,100 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2195,008,039 - 195,053,100 (-)EnsemblGRCr8
mRatBN7.22192,319,696 - 192,364,755 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,319,702 - 192,364,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2199,914,034 - 199,959,128 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02197,786,335 - 197,831,387 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02192,603,278 - 192,648,331 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02207,305,748 - 207,350,812 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,305,752 - 207,350,812 (-)Ensemblrn6Rnor6.0
Rnor_5.02226,722,331 - 226,767,300 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42200,080,802 - 200,125,881 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2184,785,867 - 184,830,762 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
clobetasol  (ISO)
diallyl trisulfide  (ISO)
dicrotophos  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
Mesaconitine  (EXP)
methimazole  (EXP)
methylseleninic acid  (ISO)
microcystin RR  (ISO)
Monobutylphthalate  (ISO)
nocodazole  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
propiconazole  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. Dynactin. Schroer TA, Annu Rev Cell Dev Biol. 2004;20:759-79.
Additional References at PubMed
PMID:8889548   PMID:11604420   PMID:12060780   PMID:12477932   PMID:17656356   PMID:18076569   PMID:18556119   PMID:18723693   PMID:19056867   PMID:19922875   PMID:20458337   PMID:21752999  
PMID:22114352   PMID:22871113   PMID:22891260   PMID:23106098   PMID:23533145   PMID:23793062   PMID:24625528   PMID:25468996   PMID:29476059   PMID:30053369   PMID:35352799  


Genomics

Comparative Map Data
Capza1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82195,008,035 - 195,053,100 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2195,008,039 - 195,053,100 (-)EnsemblGRCr8
mRatBN7.22192,319,696 - 192,364,755 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,319,702 - 192,364,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2199,914,034 - 199,959,128 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02197,786,335 - 197,831,387 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02192,603,278 - 192,648,331 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02207,305,748 - 207,350,812 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,305,752 - 207,350,812 (-)Ensemblrn6Rnor6.0
Rnor_5.02226,722,331 - 226,767,300 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42200,080,802 - 200,125,881 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2184,785,867 - 184,830,762 (-)NCBICelera
Cytogenetic Map2q34NCBI
CAPZA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381112,619,832 - 112,671,616 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1112,619,173 - 112,671,616 (+)Ensemblhg38GRCh38
GRCh371113,162,454 - 113,214,238 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361112,963,598 - 113,015,764 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341112,874,508 - 112,926,276NCBI
Celera1111,392,601 - 111,444,712 (+)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1111,020,785 - 111,072,609 (+)NCBIHuRef
CHM1_11113,276,956 - 113,329,490 (+)NCBICHM1_1
T2T-CHM13v2.01112,632,399 - 112,684,197 (+)NCBIT2T-CHM13v2.0
Capza1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393104,730,097 - 104,771,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3104,730,095 - 104,771,821 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383104,822,781 - 104,864,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3104,822,779 - 104,864,505 (-)Ensemblmm10GRCm38
MGSCv373104,625,703 - 104,667,423 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363104,950,989 - 104,992,450 (-)NCBIMGSCv36mm8
Celera3107,016,204 - 107,060,141 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.88NCBI
Capza1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543516,048,213 - 16,087,814 (+)Ensembl
ChiLan1.0NW_00495543516,048,213 - 16,087,814 (+)NCBIChiLan1.0ChiLan1.0
CAPZA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21114,364,650 - 114,414,963 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11113,512,795 - 113,563,084 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01115,273,497 - 115,324,353 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11125,028,519 - 125,078,892 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1125,028,519 - 125,078,892 (-)EnsemblpanPan2panpan1.1
CAPZA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11762,900,062 - 62,948,164 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1762,901,422 - 62,948,084 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1762,413,590 - 62,462,117 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01764,073,256 - 64,122,047 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1764,042,029 - 64,121,389 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11762,807,805 - 62,856,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01762,866,060 - 62,914,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01763,625,654 - 63,674,438 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Capza1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505816,254,005 - 16,293,011 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366901,184,625 - 1,223,732 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366901,184,644 - 1,223,732 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPZA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4107,768,079 - 107,821,819 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14107,769,570 - 107,821,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24117,802,093 - 117,816,637 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAPZA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12020,968,348 - 21,017,256 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2020,969,828 - 20,991,971 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603823,785,324 - 23,834,427 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Capza1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247728,407,883 - 8,455,734 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Capza1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1353,245,567 - 53,293,360 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Capza1
311 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:543
Count of miRNA genes:256
Interacting mature miRNAs:315
Transcripts:ENSRNOT00000056015
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
U16740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22192,319,951 - 192,320,181 (+)MAPPERmRatBN7.2
Rnor_6.02207,306,004 - 207,306,235NCBIRnor6.0
Rnor_5.02226,722,587 - 226,722,818UniSTSRnor5.0
RGSC_v3.42200,081,058 - 200,081,289UniSTSRGSC3.4
Celera2184,786,123 - 184,786,354UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000056015   ⟹   ENSRNOP00000052868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2195,008,039 - 195,030,361 (-)Ensembl
mRatBN7.2 Ensembl2192,319,720 - 192,364,470 (-)Ensembl
Rnor_6.0 Ensembl2207,305,752 - 207,350,812 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108033   ⟹   ENSRNOP00000085539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2195,008,039 - 195,030,493 (-)Ensembl
mRatBN7.2 Ensembl2192,320,389 - 192,364,480 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109484   ⟹   ENSRNOP00000094230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2195,008,039 - 195,053,100 (-)Ensembl
mRatBN7.2 Ensembl2192,319,702 - 192,341,575 (-)Ensembl
RefSeq Acc Id: NM_001109625   ⟹   NP_001103095
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82195,008,035 - 195,053,100 (-)NCBI
mRatBN7.22192,319,696 - 192,364,755 (-)NCBI
Rnor_6.02207,305,748 - 207,350,812 (-)NCBI
Rnor_5.02226,722,331 - 226,767,300 (-)NCBI
RGSC_v3.42200,080,802 - 200,125,881 (-)RGD
Celera2184,785,867 - 184,830,762 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103095 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66464 (Get FASTA)   NCBI Sequence Viewer  
  B2GUZ5 (Get FASTA)   NCBI Sequence Viewer  
  EDL85450 (Get FASTA)   NCBI Sequence Viewer  
  EDL85451 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000085539.1
  ENSRNOP00000094230
RefSeq Acc Id: NP_001103095   ⟸   NM_001109625
- UniProtKB: B2GUZ5 (UniProtKB/Swiss-Prot),   A6K3Q0 (UniProtKB/TrEMBL),   A0A8I6AZU8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052868   ⟸   ENSRNOT00000056015
Ensembl Acc Id: ENSRNOP00000085539   ⟸   ENSRNOT00000108033
Ensembl Acc Id: ENSRNOP00000094230   ⟸   ENSRNOT00000109484

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUZ5-F1-model_v2 AlphaFold B2GUZ5 1-286 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691639
Promoter ID:EPDNEW_R2164
Type:multiple initiation site
Name:Capza1_1
Description:capping actin protein of muscle Z-line alpha subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02207,350,537 - 207,350,597EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587438 AgrOrtholog
BioCyc Gene G2FUF-51759 BioCyc
Ensembl Genes ENSRNOG00000013538 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000108033.1 UniProtKB/Swiss-Prot
  ENSRNOT00000109484 ENTREZGENE
Gene3D-CATH 3.30.1140.60 UniProtKB/Swiss-Prot
  3.90.1150.210 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9030793 IMAGE-MGC_LOAD
InterPro CapZ_alpha UniProtKB/Swiss-Prot
  CapZ_alpha/beta UniProtKB/Swiss-Prot
  CapZ_alpha/beta_2 UniProtKB/Swiss-Prot
  CapZ_alpha_1 UniProtKB/Swiss-Prot
  F-actin_cap_asu_CS UniProtKB/Swiss-Prot
KEGG Report rno:691149 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187803 IMAGE-MGC_LOAD
NCBI Gene 691149 ENTREZGENE
PANTHER F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot
  PTHR10653 UniProtKB/Swiss-Prot
Pfam F-actin_cap_A UniProtKB/Swiss-Prot
PhenoGen Capza1 PhenoGen
PRINTS FACTINCAPA UniProtKB/Swiss-Prot
PROSITE F_ACTIN_CAPPING_A_1 UniProtKB/Swiss-Prot
  F_ACTIN_CAPPING_A_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013538 RatGTEx
Superfamily-SCOP SSF90096 UniProtKB/Swiss-Prot
UniProt A0A8I6AZU8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QPP4_RAT UniProtKB/TrEMBL
  A6K3Q0 ENTREZGENE, UniProtKB/TrEMBL
  B2GUZ5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Capza1  capping actin protein of muscle Z-line subunit alpha 1  Capza1  capping actin protein of muscle Z-line alpha subunit 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Capza1  capping actin protein of muscle Z-line alpha subunit 1  Capza1  capping protein (actin filament) muscle Z-line, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-10 Capza1  capping protein (actin filament) muscle Z-line, alpha 1  LOC691149  similar to capping protein (actin filament) muscle Z-line, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691149  similar to capping protein (actin filament) muscle Z-line, alpha 1  LOC684096  similar to capping protein (actin filament) muscle Z-line, alpha 1  Data merged from RGD:1595152 1643240 APPROVED
2006-11-20 LOC684096  similar to capping protein (actin filament) muscle Z-line, alpha 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC691149  similar to capping protein (actin filament) muscle Z-line, alpha 1      Symbol and Name status set to provisional 70820 PROVISIONAL