CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) - Rat Genome Database

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Gene: CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) Chlorocebus sabaeus
Analyze
Symbol: CAPZA1
Name: capping actin protein of muscle Z-line subunit alpha 1
RGD ID: 18386778
Description: ENCODES a protein that exhibits actin filament binding (ortholog); INVOLVED IN barbed-end actin filament capping (ortholog); cell junction assembly (ortholog); PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH amenorrhea (ortholog); esophagus squamous cell carcinoma (ortholog); hereditary spastic paraplegia 47 (ortholog); FOUND IN brush border (ortholog); cell-cell junction (ortholog); cortical cytoskeleton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: capping actin protein of muscle Z-line alpha subunit 1; F-actin-capping protein subunit alpha-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12020,968,348 - 21,017,256 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2020,969,828 - 20,991,971 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603823,785,324 - 23,834,427 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CAPZA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12020,968,348 - 21,017,256 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2020,969,828 - 20,991,971 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603823,785,324 - 23,834,427 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CAPZA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381112,619,832 - 112,671,616 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1112,619,805 - 112,671,616 (+)EnsemblGRCh38hg38GRCh38
GRCh371113,162,454 - 113,214,238 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361112,963,598 - 113,015,764 (+)NCBINCBI36Build 36hg18NCBI36
Build 341112,874,508 - 112,926,276NCBI
Celera1111,392,601 - 111,444,712 (+)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1111,020,785 - 111,072,609 (+)NCBIHuRef
CHM1_11113,276,956 - 113,329,490 (+)NCBICHM1_1
T2T-CHM13v2.01112,632,399 - 112,684,197 (+)NCBIT2T-CHM13v2.0
Capza1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393104,730,097 - 104,771,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3104,730,095 - 104,771,821 (-)EnsemblGRCm39 Ensembl
GRCm383104,822,781 - 104,864,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3104,822,779 - 104,864,505 (-)EnsemblGRCm38mm10GRCm38
MGSCv373104,625,703 - 104,667,423 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363104,950,989 - 104,992,450 (-)NCBIMGSCv36mm8
Celera3107,016,204 - 107,060,141 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.88NCBI
Capza1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82195,008,035 - 195,053,100 (-)NCBIGRCr8
mRatBN7.22192,319,696 - 192,364,755 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,319,702 - 192,364,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2199,914,034 - 199,959,128 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02197,786,335 - 197,831,387 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02192,603,278 - 192,648,331 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02207,305,748 - 207,350,812 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,305,752 - 207,350,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02226,722,331 - 226,767,300 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,080,802 - 200,125,881 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2184,785,867 - 184,830,762 (-)NCBICelera
Cytogenetic Map2q34NCBI
Capza1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543516,048,213 - 16,087,814 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543516,048,213 - 16,087,814 (+)NCBIChiLan1.0ChiLan1.0
CAPZA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21114,364,650 - 114,414,963 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11113,512,795 - 113,563,084 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01115,273,497 - 115,324,353 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11125,028,519 - 125,078,892 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1125,028,519 - 125,078,892 (-)Ensemblpanpan1.1panPan2
CAPZA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11762,900,062 - 62,948,164 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1762,901,422 - 62,948,084 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1762,413,590 - 62,462,117 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01764,073,256 - 64,122,047 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1764,042,029 - 64,121,389 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11762,807,805 - 62,856,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01762,866,060 - 62,914,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01763,625,654 - 63,674,438 (-)NCBIUU_Cfam_GSD_1.0
Capza1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505816,254,005 - 16,293,011 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366901,184,644 - 1,223,732 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPZA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4107,768,079 - 107,821,819 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14107,769,570 - 107,821,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24117,802,093 - 117,816,637 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Capza1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247728,407,883 - 8,455,734 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 60
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007977556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000016941   ⟹   ENSCSAP00000016436
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2020,969,828 - 20,991,971 (-)Ensembl
RefSeq Acc Id: XM_007977556   ⟹   XP_007975747
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12020,968,348 - 21,017,256 (-)NCBI
Vero_WHO_p1.0NW_02366603823,785,324 - 23,834,427 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007975747 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016436
  ENSCSAP00000016436.1
Reference Protein Sequences
RefSeq Acc Id: XP_007975747   ⟸   XM_007977556
- UniProtKB: A0A0D9S6E7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000016436   ⟸   ENSCSAT00000016941


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001594 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016941.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1140.60 UniProtKB/TrEMBL
  3.90.1150.210 UniProtKB/TrEMBL
InterPro CapZ_alpha UniProtKB/TrEMBL
  CapZ_alpha/beta UniProtKB/TrEMBL
  CapZ_alpha/beta_2 UniProtKB/TrEMBL
  CapZ_alpha_1 UniProtKB/TrEMBL
  F-actin_cap_asu_CS UniProtKB/TrEMBL
NCBI Gene CAPZA1 ENTREZGENE
PANTHER F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA-1 UniProtKB/TrEMBL
  PTHR10653 UniProtKB/TrEMBL
Pfam F-actin_cap_A UniProtKB/TrEMBL
PRINTS FACTINCAPA UniProtKB/TrEMBL
PROSITE F_ACTIN_CAPPING_A_1 UniProtKB/TrEMBL
  F_ACTIN_CAPPING_A_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF90096 UniProtKB/TrEMBL
UniProt A0A0D9S6E7 ENTREZGENE, UniProtKB/TrEMBL