Cyp2ab1 (cytochrome P450, family 2, subfamily ab, polypeptide 1) - Rat Genome Database

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Gene: Cyp2ab1 (cytochrome P450, family 2, subfamily ab, polypeptide 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp2ab1
Name: cytochrome P450, family 2, subfamily ab, polypeptide 1
RGD ID: 1586963
Description: Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in arachidonic acid metabolic process and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytochrome P450 2J2; LOC682122; similar to cytochrome P450, family 2, subfamily J, polypeptide 2, B
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,085,653 - 94,095,280 (+)NCBIGRCr8
mRatBN7.21180,582,633 - 80,591,217 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,582,938 - 80,590,873 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01184,506,074 - 84,514,164 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,506,703 - 84,514,328 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,571,034 - 87,578,447 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1179,423,120 - 79,431,087 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Cyp2ab1
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:77
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000066953
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3
Low 1 6 14 10 6
Below cutoff 2 19 18 12 2 12 3 4 3 14 18 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066953   ⟹   ENSRNOP00000063536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,582,938 - 80,590,873 (+)Ensembl
Rnor_6.0 Ensembl1184,506,703 - 84,514,328 (+)Ensembl
RefSeq Acc Id: XM_017598186   ⟹   XP_017453675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,085,653 - 94,095,280 (+)NCBI
mRatBN7.21180,582,633 - 80,591,217 (+)NCBI
Rnor_6.01184,506,074 - 84,514,164 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_017453675 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77990 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063536
  ENSRNOP00000063536.3
Reference Protein Sequences
RefSeq Acc Id: XP_017453675   ⟸   XM_017598186
- UniProtKB: A6JSB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063536   ⟸   ENSRNOT00000066953

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZX4-F1-model_v2 AlphaFold D3ZZX4 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586963 AgrOrtholog
BioCyc Gene G2FUF-20719 BioCyc
Ensembl Genes ENSRNOG00000042367 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066953.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene Cyp2ab1 ENTREZGENE
PANTHER CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
  CYTOCHROME P450, FAMILY 2, SUBFAMILY AB, POLYPEPTIDE 1 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp2ab1 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042367 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A6JSB6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZX4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-02 Cyp2ab1  cytochrome P450, family 2, subfamily ab, polypeptide 1  LOC679979  similar to cytochrome P450, family 2, subfamily J, polypeptide 2, B  Data merged from RGD:1598091 1643240 APPROVED
2007-07-06 Cyp2ab1  cytochrome P450, family 2, subfamily ab, polypeptide 1  LOC682122  similar to cytochrome P450, family 2, subfamily J, polypeptide 2, B  Name updated 1299863 APPROVED
2006-11-20 LOC679979  similar to cytochrome P450, family 2, subfamily J, polypeptide 2, B      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682122  similar to cytochrome P450, family 2, subfamily J, polypeptide 2, B      Symbol and Name status set to provisional 70820 PROVISIONAL