Il16 (interleukin 16) - Rat Genome Database

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Gene: Il16 (interleukin 16) Rattus norvegicus
Analyze
Symbol: Il16
Name: interleukin 16
RGD ID: 1583872
Description: Predicted to enable CD4 receptor binding activity and cytokine activity. Predicted to be involved in several processes, including cytokine-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of inflammatory response. Predicted to act upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutrophil activation. Predicted to be located in cytoplasm; extracellular space; and nucleus. Biomarker of borna disease; glioblastoma; and periodontal disease. Human ortholog(s) of this gene implicated in asthma; colorectal adenocarcinoma; and prostate cancer. Orthologous to human IL16 (interleukin 16); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Il16_mapped; interleukin 16 (mapped); pro-interleukin-16
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,026,852 - 147,127,177 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1147,027,097 - 147,127,023 (-)EnsemblGRCr8
mRatBN7.21137,617,702 - 137,718,022 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1137,617,944 - 137,718,130 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1145,553,251 - 145,642,842 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01152,722,266 - 152,811,849 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01145,597,458 - 145,687,037 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01145,781,923 - 145,881,538 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,781,928 - 145,870,912 (-)Ensemblrn6Rnor6.0
Rnor_5.01146,710,705 - 146,810,341 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41139,908,061 - 140,000,146 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1129,639,197 - 129,728,515 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-Hydroxypyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-butoxyethanol  (ISO)
2-tert-butylhydroquinone  (ISO)
3-Hydroxybenzo[a]pyrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-methylhistamine  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asperentin  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brevetoxin B  (ISO)
Brevianamide A  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
cimetidine  (ISO)
clobenpropit  (ISO)
cocaine  (EXP)
cyclophosphamide  (ISO)
dexamethasone  (ISO)
dibutylstannane  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
Dimaprit  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
farnesol  (ISO)
FR900359  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
graphene oxide  (ISO)
histamine  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
melphalan  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
microcystin-LR  (ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluoroundecanoic acid  (ISO)
Phytolaccoside E  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sterigmatocystin  (ISO)
Thioperamide  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Interleukin 16 (IL-16) in asthma and allergic rhinitis. A comparison between upper and lower airways. Afifi SS, etal., Egypt J Immunol. 2004;11(2):31-6.
2. A polymorphism in the promoter region of the human interleukin-16 gene is not associated with asthma or atopy in an Australian population. Akesson LS, etal., Clin Exp Allergy. 2005 Mar;35(3):327-31.
3. IL-16 variability and modulation by antiallergic drugs in a murine experimental allergic rhinitis model. Akiyama K, etal., Int Arch Allergy Immunol. 2009;149(4):315-22. Epub 2009 Mar 17.
4. Association of asthma with a functional promoter polymorphism in the IL16 gene. Burkart KM, etal., J Allergy Clin Immunol. 2006 Jan;117(1):86-91.
5. [The expression of serum IL-10,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis]. Chen J, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Oct;21(20):913-5.
6. Effect of interleukin-16-blocking peptide on parameters of allergic asthma in a murine model. de Bie JJ, etal., Eur J Pharmacol. 1999 Oct 27;383(2):189-96.
7. Gender differences in plasma biomarker levels in a cohort of COPD patients: a pilot study. de Torres JP, etal., PLoS One. 2011 Jan 18;6(1):e16021.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Expression of interleukin-16 by microglial cells in inflammatory, autoimmune, and degenerative lesions of the rat brain. Guo LH, etal., J Neuroimmunol 2004 Jan;146(1-2):39-45.
10. Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. Kang BW, etal., Anticancer Res. 2016 Jul;36(7):3353-61.
11. The role of interleukin-16 in eosinophilic chronic rhinosinusitis. Lackner A, etal., Eur Arch Otorhinolaryngol. 2007 Aug;264(8):887-93. Epub 2007 Apr 13.
12. Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome. Landi A, etal., Cytokine. 2016 Feb;78:27-36. doi: 10.1016/j.cyto.2015.11.018. Epub 2015 Nov 28.
13. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
14. Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors. Liebrich M, etal., Arch Immunol Ther Exp (Warsz). 2007 Jan-Feb;55(1):41-7.
15. A fusion protein consisting of IL-16 and the encephalitogenic peptide of myelin basic protein constitutes an antigen-specific tolerogenic vaccine that inhibits experimental autoimmune encephalomyelitis. Mannie MD and Abbott DJ, J Immunol. 2007 Aug 1;179(3):1458-65.
16. Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. Pravenec M, etal., J Clin Invest 1995 Oct;96(4):1973-8
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Multiple loci identified in a genome-wide association study of prostate cancer. Thomas G, etal., Nat Genet. 2008 Mar;40(3):310-5. Epub 2008 Feb 10.
22. Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury. Venet F, etal., J Immunol. 2009 Sep 1;183(5):3472-80. Epub 2009 Jul 29.
23. [The changes and significance of interleukin-16 and CXC chemokine receptor 3 expression in pulmonary artery of smokers with chronic obstructive pulmonary disease]. Wan P, etal., Zhonghua Nei Ke Za Zhi. 2009 Oct;48(10):841-5.
24. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases Wang C and Pang BS, Zhonghua Jie He He Hu Xi Za Zhi. 2003 Oct;26(10):586-9.
25. [Effect of fluticasone inhalation combined with xiaoqinglong decoction on pulmonary function and serum interleukin-16 level in asthma patients]. Zhang X, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Jun;23(6):426-9.
26. Early attenuation of lesional interleukin-16 up-regulation by dexamethasone and FTY720 in experimental traumatic brain injury. Zhang Z, etal., Neuropathol Appl Neurobiol. 2008 Jun;34(3):330-9. Epub 2007 Nov 5.
Additional References at PubMed
PMID:9598300   PMID:9637508   PMID:18462471   PMID:23894370   PMID:24942581   PMID:26544695   PMID:30634164   PMID:37086007  


Genomics

Comparative Map Data
Il16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,026,852 - 147,127,177 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1147,027,097 - 147,127,023 (-)EnsemblGRCr8
mRatBN7.21137,617,702 - 137,718,022 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1137,617,944 - 137,718,130 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1145,553,251 - 145,642,842 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01152,722,266 - 152,811,849 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01145,597,458 - 145,687,037 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01145,781,923 - 145,881,538 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,781,928 - 145,870,912 (-)Ensemblrn6Rnor6.0
Rnor_5.01146,710,705 - 146,810,341 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41139,908,061 - 140,000,146 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1129,639,197 - 129,728,515 (-)NCBICelera
Cytogenetic Map1q31NCBI
IL16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381581,182,712 - 81,314,058 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1581,159,575 - 81,314,058 (+)Ensemblhg38GRCh38
GRCh371581,489,220 - 81,606,399 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361579,276,274 - 79,392,157 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341579,262,254 - 79,392,156NCBI
Celera1558,426,593 - 58,543,082 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1558,247,361 - 58,363,403 (+)NCBIHuRef
CHM1_11581,607,068 - 81,723,070 (+)NCBICHM1_1
T2T-CHM13v2.01579,045,899 - 79,178,128 (+)NCBIT2T-CHM13v2.0
Il16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39783,292,027 - 83,395,479 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl783,292,033 - 83,394,934 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38783,642,819 - 83,746,028 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl783,642,825 - 83,745,726 (-)Ensemblmm10GRCm38
MGSCv37790,791,573 - 90,884,000 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36783,519,248 - 83,611,675 (-)NCBIMGSCv36mm8
Celera781,054,416 - 81,146,836 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map747.43NCBI
Il16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541611,893,801 - 11,987,548 (+)Ensembl
ChiLan1.0 EnsemblNW_00495541611,975,593 - 11,987,310 (+)Ensembl
ChiLan1.0NW_00495541611,876,317 - 11,987,548 (+)NCBIChiLan1.0ChiLan1.0
IL16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21670,433,954 - 70,581,447 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11574,629,321 - 74,746,767 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01560,181,827 - 60,299,406 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11579,137,002 - 79,250,861 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1579,122,988 - 79,250,861 (+)EnsemblpanPan2panpan1.1
IL16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1356,473,485 - 56,575,504 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl356,473,486 - 56,575,104 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha359,123,373 - 59,225,302 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0356,897,345 - 56,998,175 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl356,897,361 - 56,997,877 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1356,407,104 - 56,508,890 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0356,612,735 - 56,715,065 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0356,951,626 - 57,053,995 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640126,794,580 - 126,916,478 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648319,418,086 - 19,512,639 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648319,417,580 - 19,512,654 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl749,973,938 - 50,102,346 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1749,973,937 - 50,102,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2755,573,930 - 55,702,247 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1262,080,985 - 2,208,764 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl262,077,228 - 2,208,431 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048139,721,441 - 139,809,839 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476820,597,560 - 20,704,437 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il16
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12116,606,788 - 116,686,078 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il16
676 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:168
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000016289
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
RH132109  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21137,617,840 - 137,618,041 (+)MAPPERmRatBN7.2
Rnor_6.01145,781,825 - 145,782,025NCBIRnor6.0
Rnor_5.01146,710,844 - 146,711,044UniSTSRnor5.0
RGSC_v3.41139,907,958 - 139,908,158UniSTSRGSC3.4
Celera1129,639,094 - 129,639,294UniSTS
RH 3.4 Map11101.7UniSTS
Cytogenetic Map1q31UniSTS
BE106667  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21137,631,386 - 137,631,581 (+)MAPPERmRatBN7.2
Rnor_6.01145,795,369 - 145,795,563NCBIRnor6.0
Rnor_5.01146,724,388 - 146,724,582UniSTSRnor5.0
RGSC_v3.41139,921,502 - 139,921,696UniSTSRGSC3.4
Celera1129,652,630 - 129,652,824UniSTS
RH 3.4 Map11103.3UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001105749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001443583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000016289   ⟹   ENSRNOP00000016289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1147,027,097 - 147,116,867 (-)Ensembl
mRatBN7.2 Ensembl1137,617,944 - 137,707,593 (-)Ensembl
Rnor_6.0 Ensembl1145,781,928 - 145,870,912 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101175   ⟹   ENSRNOP00000083582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1147,027,097 - 147,127,023 (-)Ensembl
mRatBN7.2 Ensembl1137,617,944 - 137,718,130 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101850   ⟹   ENSRNOP00000091335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1147,027,097 - 147,113,988 (-)Ensembl
mRatBN7.2 Ensembl1137,617,944 - 137,704,735 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153733   ⟹   ENSRNOP00000109090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1147,027,097 - 147,125,631 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154763   ⟹   ENSRNOP00000105642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1147,027,097 - 147,113,988 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165706   ⟹   ENSRNOP00000104773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1147,027,097 - 147,082,483 (-)Ensembl
RefSeq Acc Id: NM_001105749   ⟹   NP_001099219
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,027,097 - 147,116,742 (-)NCBI
mRatBN7.21137,617,944 - 137,707,593 (-)NCBI
Rnor_6.01145,781,928 - 145,870,912 (-)NCBI
Rnor_5.01146,710,705 - 146,810,341 (-)NCBI
RGSC_v3.41139,908,061 - 140,000,146 (-)RGD
Celera1129,639,197 - 129,728,515 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229488   ⟹   XP_006229550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,027,092 - 147,114,244 (-)NCBI
mRatBN7.21137,617,702 - 137,705,116 (-)NCBI
Rnor_6.01145,781,923 - 145,869,486 (-)NCBI
Rnor_5.01146,710,705 - 146,810,341 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759600   ⟹   XP_008757822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,027,092 - 147,116,757 (-)NCBI
mRatBN7.21137,617,702 - 137,707,538 (-)NCBI
Rnor_6.01145,781,923 - 145,870,901 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588673   ⟹   XP_017444162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,027,092 - 147,127,177 (-)NCBI
mRatBN7.21137,617,702 - 137,718,022 (-)NCBI
Rnor_6.01145,781,923 - 145,881,538 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588675   ⟹   XP_017444164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,027,092 - 147,125,338 (-)NCBI
mRatBN7.21137,617,702 - 137,716,189 (-)NCBI
Rnor_6.01145,781,923 - 145,880,170 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588676   ⟹   XP_017444165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,026,852 - 147,082,464 (-)NCBI
mRatBN7.21137,617,702 - 137,673,313 (-)NCBI
Rnor_6.01145,781,923 - 145,837,459 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588678   ⟹   XP_017444167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,026,852 - 147,050,622 (-)NCBI
mRatBN7.21137,617,702 - 137,648,452 (-)NCBI
Rnor_6.01145,781,923 - 145,812,486 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112275   ⟹   XP_038968203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,035,310 - 147,121,359 (-)NCBI
mRatBN7.21137,626,524 - 137,713,413 (-)NCBI
RefSeq Acc Id: XM_063266338   ⟹   XP_063122408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,027,092 - 147,126,799 (-)NCBI
RefSeq Acc Id: NP_001099219   ⟸   NM_001105749
- UniProtKB: D4A4I9 (UniProtKB/TrEMBL),   A6JCM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229550   ⟸   XM_006229488
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AF93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757822   ⟸   XM_008759600
- Peptide Label: isoform X4
- UniProtKB: D4A4I9 (UniProtKB/TrEMBL),   A6JCM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444162   ⟸   XM_017588673
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444164   ⟸   XM_017588675
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017444165   ⟸   XM_017588676
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017444167   ⟸   XM_017588678
- Peptide Label: isoform X6
- Sequence:
Ensembl Acc Id: ENSRNOP00000016289   ⟸   ENSRNOT00000016289
RefSeq Acc Id: XP_038968203   ⟸   XM_039112275
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000083582   ⟸   ENSRNOT00000101175
Ensembl Acc Id: ENSRNOP00000091335   ⟸   ENSRNOT00000101850
RefSeq Acc Id: XP_063122408   ⟸   XM_063266338
- Peptide Label: isoform X4
- UniProtKB: A6JCM5 (UniProtKB/TrEMBL),   D4A4I9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105642   ⟸   ENSRNOT00000154763
Ensembl Acc Id: ENSRNOP00000104773   ⟸   ENSRNOT00000165706
Ensembl Acc Id: ENSRNOP00000109090   ⟸   ENSRNOT00000153733
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4I9-F1-model_v2 AlphaFold D4A4I9 1-1323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583872 AgrOrtholog
BioCyc Gene G2FUF-58663 BioCyc
Ensembl Genes ENSRNOG00000011680 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016289 ENTREZGENE
  ENSRNOT00000016289.6 UniProtKB/TrEMBL
  ENSRNOT00000101175 ENTREZGENE
  ENSRNOT00000101175.2 UniProtKB/TrEMBL
  ENSRNOT00000101850 ENTREZGENE
  ENSRNOT00000101850.2 UniProtKB/TrEMBL
  ENSRNOT00000153733 ENTREZGENE
  ENSRNOT00000153733.1 UniProtKB/TrEMBL
  ENSRNOT00000154763.1 UniProtKB/TrEMBL
  ENSRNOT00000165706 ENTREZGENE
  ENSRNOT00000165706.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
InterPro IL-16-like UniProtKB/TrEMBL
  Interleukin-16 UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
KEGG Report rno:116996 UniProtKB/TrEMBL
NCBI Gene 116996 ENTREZGENE
PANTHER PRO-INTERLEUKIN-16 UniProtKB/TrEMBL
  PRO-INTERLEUKIN-16 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
PhenoGen Il16 PhenoGen
PRINTS INTRLEUKIN16 UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011680 RatGTEx
SMART PDZ UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
UniProt A0A8I5ZZI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF93 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LM97_RAT UniProtKB/TrEMBL
  A0ABK0LSV2_RAT UniProtKB/TrEMBL
  A0ABK0LVF7_RAT UniProtKB/TrEMBL
  A6JCM5 ENTREZGENE, UniProtKB/TrEMBL
  D4A4I9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   interleukin 16  Il16  interleukin 16 (mapped)  Name updated 737654 APPROVED
2007-04-13 Il16  interleukin 16 (mapped)  Il16_mapped  interleukin 16 (mapped)  Data merged from RGD:61286 737654 APPROVED
2006-11-19 Il16  interleukin 16 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Il16_mapped  interleukin 16 (mapped)  Il16  interleukin 16  Symbol and Name updated 1556543 APPROVED
2001-08-29 Il16  Interleukin 16      Symbol updated 68687 APPROVED