RGD Reference Report - [Effect of fluticasone inhalation combined with xiaoqinglong decoction on pulmonary function and serum interleukin-16 level in asthma patients]. - Rat Genome Database

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[Effect of fluticasone inhalation combined with xiaoqinglong decoction on pulmonary function and serum interleukin-16 level in asthma patients].

Authors: Zhang, X  Wang, L  Shi, Q 
Citation: Zhang X, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Jun;23(6):426-9.
RGD ID: 5024930
Pubmed: PMID:12872394   (View Abstract at PubMed)

OBJECTIVE: To observe the effect of Fluticasone inhalation combined with Xiaoqinglong decoction (XQLD) on pulmonary function and serum interleukin-16 (IL-16) level in asthma patients. METHODS: Fifty-four mild or severe asthma patients were selected and randomly divided into three groups. The treated group was treated with Fluticasone inhalation combined with XQLD, Fluticasone group treated with Fluticasone inhalation, and XQLD group treated with XQLD respectively. Meanwhile ten healthy volunteers were selected as healthy control group. The conventional pulmonary function FEV1 and respiratory impedance R5 were measured before and after 4 weeks treatment. The IL-16 levels were determined by using ELISA. RESULTS: FEV1 were obviously increased and R5 decreased in the three groups after treatment (P < 0.05 or P < 0.01), but the improvement was more significant in the treated group (P < 0.01). Before treatment, serum levels of IL-16 in all the three groups were significantly higher than those in the healthy control group (P < 0.01) and lowered after treatment respectively, the treated group was significantly lower than those of the other two groups (P < 0.05 or P < 0.01). The serum level of IL-16 was negatively correlated with FEV1 and positively with R5(r1 = -0.67, r2 = 0.71, P < 0.01). CONCLUSION: The effects of Fluticasone inhalation combined with XQLD on pulmonary function and serum IL-16 levels were superior to those of Fluticasone inhalation and XQLD alone in asthma patients. So it could become an important therapeutical method in treating mild and severe asthma patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma severityIEP 5024930protein:increased expression:serumRGD 
asthma severityISOIL16 (Homo sapiens)5024930; 5024930protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il16  (interleukin 16)

Genes (Mus musculus)
Il16  (interleukin 16)

Genes (Homo sapiens)
IL16  (interleukin 16)


Additional Information